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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2626
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fos
Name: Fos proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:32509
Term: pirinixic acid
Definition: An aryl sulfide that has formula C14H14ClN3O2S.
Chemical ID: MESH:C006253
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fosincreases expressionISOFos (Mus musculus)6480464CTDpirinixic acid results in increased expression of FOS mRNAPMID:18445702 PMID:8764118
Fosmultiple interactionsISOFOS (Homo sapiens)6480464CTD[FOS protein co-treated with JUN protein] inhibits the reaction [pirinixic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SPP1 protein]]; pirinixic acid inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [[FOS protein binds to JUN protein modified form] which binds to SPP1 promoter]]; pirinixic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOS mRNA]; pirinixic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOS protein]PMID:17360982
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