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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2626
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fos
Name: Fos proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:18357
Term: (R)-noradrenaline
Definition: The R-enantiomer of noradrenaline.
Chemical ID: MESH:D009638
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fosincreases expressionEXP 6480464CTDNorepinephrine results in increased expression of FOS; Norepinephrine results in increased expression of FOS mRNAPMID:19225867 PMID:7605896 PMID:7905536
Fosmultiple interactionsEXP 6480464CTD1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of FOS mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased expression of FOS mRNA]; bisindolylmaleimide inhibits the reaction [Norepinephrine results in increased expression of FOS mRNA]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of FOS mRNA]; Tetradecanoylphorbol Acetate promotes the reaction [Norepinephrine results in increased expression of FOS mRNA]PMID:19225867
Fosincreases expressionISOFos (Mus musculus)6480464CTDNorepinephrine results in increased expression of FOS mRNAPMID:12729908
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