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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2626
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fos
Name: Fos proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:17967
Term: urethane
Definition: A carbamate ester obtained by the formal condensation of ethanol with carbamic acid. It has been found in alcoholic beverages.
Chemical ID: MESH:D014520
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fosincreases expressionEXP 6480464CTDUrethane results in increased expression of FOS proteinPMID:11442774 PMID:1527597
Fosmultiple interactionsEXP 6480464CTD[Nitroprusside co-treated with Urethane co-treated with Chloralose] results in increased expression of FOS protein; [Nitroprusside co-treated with Urethane] affects the expression of FOS protein; Flurbiprofen promotes the reaction [Urethane inhibits the reaction [Carrageenan results in increased expression of FOS protein]]; Urethane inhibits the reaction [Carrageenan results in increased expression of FOS protein]; Urethane inhibits the reaction [Cocaine results in increased expression of FOS protein]; Urethane inhibits the reaction [Flurbiprofen inhibits the reaction [Carrageenan results in increased expression of FOS protein]]PMID:11164833 PMID:11588591 PMID:12088752 PMID:15219685
Fosdecreases expressionISOFos (Mus musculus)6480464CTDUrethane results in decreased expression of FOS mRNAPMID:12810352
Fosincreases expressionISOFos (Mus musculus)6480464CTDUrethane results in increased expression of FOS mRNAPMID:16289808 PMID:18465119
Fosincreases expressionISOFOS (Homo sapiens)6480464CTDUrethane results in increased expression of FOS mRNAPMID:28818685
Fosmultiple interactionsISOFos (Mus musculus)6480464CTD[Urethane co-treated with troglitazone] results in increased expression of FOS mRNA; IFNG protein inhibits the reaction [Urethane results in decreased expression of FOS mRNA]PMID:12810352 PMID:18465119
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