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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2626
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fos
Name: Fos proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:90705
Term: SB 203580
Definition: A member of the class of imidazoles carrying 4-methylsulfinylphenyl, 4-pyridyl and 4-fluorophenyl substituents at positions 2, 4 and 5 respectively. An inhibitor of mitogen-activated protein kinase.
Chemical ID: MESH:C093642
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fosdecreases expressionEXP 6480464CTDSB 203580 results in decreased expression of FOS mRNAPMID:11053056 PMID:21084678
Fosmultiple interactionsEXP 6480464CTDSB 203580 promotes the reaction [diphenylarsinic acid results in increased expression of and results in increased phosphorylation of FOS protein]PMID:28087833
Fosincreases expressionISOFOS (Homo sapiens)6480464CTDSB 203580 results in increased expression of FOS proteinPMID:26814129
Fosmultiple interactionsISOFos (Mus musculus)6480464CTDSB 203580 inhibits the reaction [icariin results in increased expression of FOS protein]PMID:18423597
Fosmultiple interactionsISOFOS (Homo sapiens)6480464CTDSB 203580 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased expression of FOS protein]; SB 203580 inhibits the reaction [IL1B protein results in increased expression of FOS mRNA]; SB 203580 inhibits the reaction [IL1B protein results in increased phosphorylation of FOS protein]; SB 203580 inhibits the reaction [Nicotine results in increased phosphorylation of FOS protein]; SB 203580 inhibits the reaction [TNF protein results in increased expression of FOS mRNA]; SB 203580 promotes the reaction [sodium arsenite results in increased expression of FOS mRNA]PMID:12547826 PMID:15322261 PMID:18982426 PMID:21219922 PMID:27393034 PMID:34171359
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