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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2626
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fos
Name: Fos proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fosdecreases expressionEXP 6480464CTDresveratrol results in decreased expression of FOS proteinPMID:27093858
Fosdecreases activityISOFOS (Homo sapiens)6480464CTDresveratrol results in decreased activity of FOS proteinPMID:14623829
Fosdecreases expressionISOFOS (Homo sapiens)6480464CTDresveratrol results in decreased expression of FOSPMID:21238464
Fosincreases expressionISOFOS (Homo sapiens)6480464CTDResveratrol metabolite results in increased expression of FOS mRNA; Resveratrol results in increased expression of FOS mRNA; Resveratrol results in increased expression of FOS proteinPMID:11889192 PMID:15542774 PMID:19496085 PMID:20080969 PMID:24753227 PMID:25436977
Fosmultiple interactionsISOFos (Mus musculus)6480464CTD[Ellagic Acid co-treated with resveratrol] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of FOS mRNA]; [Glucaric Acid co-treated with resveratrol] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of FOS mRNA]; [resveratrol co-treated with Plant Extracts] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of FOS mRNA]; resveratrol inhibits the reaction [4-hydroxy-2-nonenal results in decreased expression of FOS protein]; resveratrol inhibits the reaction [oxaliplatin results in increased expression of FOS protein]; resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of [JUN protein binds to FOS protein]]; resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of FOS protein]; resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOS mRNA]PMID:10381133 PMID:16322078 PMID:18551458 PMID:20103723 PMID:24908156
Fosmultiple interactionsISOFOS (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased expression of FOS mRNA]; [Resveratrol results in decreased expression of [RELA co-treated with FOS]] which results in decreased expression of MMP9; EGF protein inhibits the reaction [Resveratrol results in increased expression of FOS mRNA]; Resveratrol affects the localization of and results in increased activity of FOS protein; Resveratrol inhibits the reaction [Hydrogen Peroxide results in increased activity of FOS protein]; Resveratrol inhibits the reaction [JUN protein binds to FOS protein]; Resveratrol inhibits the reaction [Oxygen deficiency results in increased expression of FOS mRNA]; Resveratrol inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]]; Resveratrol results in increased expression of and results in increased activity of FOS proteinPMID:10843709 PMID:11889192 PMID:12663506 PMID:14623829 PMID:15542774 PMID:16761963 PMID:16928824 PMID:21238464 PMID:23452621 PMID:25149975
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