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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2626
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fos
Name: Fos proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fosaffects localizationEXP 6480464CTDLipopolysaccharides affects the localization of FOS proteinPMID:12559087
Fosincreases expressionEXP 6480464CTDLipopolysaccharides results in increased expression of FOS proteinPMID:12559087 PMID:12646303 PMID:16039792
Fosmultiple interactionsEXP 6480464CTD[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of FOS mRNA; Indomethacin affects the reaction [Lipopolysaccharides results in increased expression of FOS protein]PMID:12646303 PMID:16415329
Fosaffects localizationISOFos (Mus musculus)6480464CTDLipopolysaccharides affects the localization of FOS proteinPMID:23256447 PMID:25451593
Fosdecreases expressionISOFos (Mus musculus)6480464CTDLipopolysaccharides results in decreased expression of FOS mRNA; Lipopolysaccharides results in decreased expression of FOS proteinPMID:12057914 PMID:27339419 PMID:30048646
Fosdecreases expressionISOFOS (Homo sapiens)6480464CTDLipopolysaccharides results in decreased expression of FOS mRNAPMID:35811015
Fosincreases expressionISOFos (Mus musculus)6480464CTDLipopolysaccharides results in increased expression of FOS mRNA; Lipopolysaccharides results in increased expression of FOS proteinPMID:12057914 PMID:16864405 PMID:20423518 PMID:21232528 PMID:29441825 PMID:29470957 PMID:30048646
Fosincreases phosphorylationISOFOS (Homo sapiens)6480464CTDLipopolysaccharides results in increased phosphorylation of FOS proteinPMID:24967690 PMID:30794626
Fosmultiple interactionsISOFos (Mus musculus)6480464CTD[Drugs, Chinese Herbal co-treated with niuhuang] promotes the reaction [Lipopolysaccharides affects the localization of FOS protein]; [Lipopolysaccharides co-treated with Ozone] results in increased expression of FOS mRNA; flavokawain A inhibits the reaction [Lipopolysaccharides affects the localization of [JUN protein binds to FOS protein]]; kaempferol 7-O-glucoside inhibits the reaction [Lipopolysaccharides results in increased expression of FOS protein]; licochalcone B analog inhibits the reaction [Lipopolysaccharides affects the localization of FOS protein]; Lipopolysaccharides affects the localization of [JUN protein binds to FOS protein]; Lipopolysaccharides results in increased expression of and results in increased activity of FOS protein; Lipopolysaccharides results in increased phosphorylation of and results in increased activity of FOS protein; phenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of FOS mRNA]; Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of FOS mRNA]; Thymol promotes the reaction [Lipopolysaccharides results in decreased expression of FOS protein]; Xanthones inhibits the reaction [Lipopolysaccharides results in increased expression of FOS protein]PMID:10755711 PMID:16864405 PMID:20423518 PMID:21232528 PMID:23106696 PMID:23256447 PMID:23727179 PMID:25451593 PMID:29470957 PMID:30048646
Fosmultiple interactionsISOFOS (Homo sapiens)6480464CTD[Glucose co-treated with Lipopolysaccharides] results in increased expression of FOS protein; [Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in increased expression of FOS mRNA; [S-(1,2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of FOS mRNA; ebselen inhibits the reaction [Lipopolysaccharides affects the localization of and affects the activity of FOS protein]; EIF2AK2 protein affects the reaction [Lipopolysaccharides promotes the reaction [TNFSF11 protein results in increased expression of FOS protein]]; eupafolin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of FOS protein]; GW 506033X inhibits the reaction [Lipopolysaccharides promotes the reaction [TNFSF11 protein results in increased expression of FOS protein]]; Lipopolysaccharides affects the localization of and affects the activity of FOS protein; Lipopolysaccharides promotes the reaction [TNFSF11 protein results in increased expression of FOS protein]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of FOS protein]; Selenocysteine inhibits the reaction [Lipopolysaccharides affects the localization of and affects the activity of FOS protein]; Selenomethionine inhibits the reaction [Lipopolysaccharides affects the localization of and affects the activity of FOS protein]PMID:14572605 PMID:18180316 PMID:24967690 PMID:27718290 PMID:35811015 PMID:9122163
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