GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Fos | increases expression | EXP | | 6480464 | CTD | Estradiol results in increased expression of FOS mRNA; Estradiol results in increased expression of FOS protein | PMID:19022888 PMID:2118345 PMID:24236210 PMID:32145629 PMID:9607780 | Fos | multiple interactions | EXP | | 6480464 | CTD | [EGF protein co-treated with Estradiol] results in increased expression of FOS mRNA; Cycloheximide promotes the reaction [[EGF protein co-treated with Estradiol] results in increased expression of FOS mRNA]; Dactinomycin inhibits the reaction [[EGF protein co-treated with Estradiol] results in increased expression of FOS mRNA]; Dexamethasone promotes the reaction [[EGF protein co-treated with Estradiol] results in increased expression of FOS mRNA]; INS1 protein promotes the reaction [[EGF protein co-treated with Estradiol] results in increased expression of FOS mRNA]; NPVF protein inhibits the reaction [Estradiol results in increased expression of FOS protein] | PMID:12632255 PMID:19022888 | Fos | affects expression | ISO | Fos (Mus musculus) | 6480464 | CTD | Estradiol affects the expression of FOS mRNA | PMID:15598610 PMID:9094091 | Fos | affects expression | ISO | FOS (Homo sapiens) | 6480464 | CTD | Estradiol affects the expression of FOS mRNA | PMID:11896290 PMID:22574217 | Fos | decreases expression | ISO | FOS (Homo sapiens) | 6480464 | CTD | Estradiol results in decreased expression of FOS mRNA | PMID:19167446 PMID:20106945 PMID:21632981 | Fos | increases expression | ISO | Fos (Mus musculus) | 6480464 | CTD | Estradiol results in increased expression of FOS mRNA; Estradiol results in increased expression of FOS protein | PMID:11285193 PMID:11473722 PMID:11506814 PMID:15289156 PMID:20049119 PMID:20667977 PMID:20826375 PMID:23552522 PMID:23684557 PMID:25210133 PMID:7497467 | Fos | increases expression | ISO | FOS (Homo sapiens) | 6480464 | CTD | Estradiol results in increased expression of FOS mRNA; Estradiol results in increased expression of FOS protein | PMID:10478842 PMID:10620335 PMID:15072547 PMID:15090535 PMID:15223131 PMID:16029874 PMID:16204943 PMID:17142977 PMID:18556351 PMID:19153601 PMID:19432593 PMID:19496085 PMID:19619570 PMID:20875696 PMID:23094148 PMID:24308608 PMID:25616260 PMID:26224478 PMID:30682495 PMID:31614463 PMID:31646340 | Fos | multiple interactions | ISO | Fos (Mus musculus) | 6480464 | CTD | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased expression of FOS mRNA]; [Estradiol co-treated with Progesterone] results in increased expression of FOS mRNA; daidzein inhibits the reaction [Estradiol results in increased expression of FOS mRNA]; Drugs, Chinese Herbal inhibits the reaction [Estradiol results in increased expression of FOS mRNA]; Drugs, Chinese Herbal inhibits the reaction [Estradiol results in increased expression of FOS protein]; ESR1 affects the reaction [Estradiol results in increased expression of FOS mRNA]; ESR1 protein affects the reaction [Estradiol results in increased expression of FOS mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of FOS mRNA]; Estradiol promotes the reaction [ARNT protein binds to FOS promoter]; Estradiol promotes the reaction [ESR1 protein binds to FOS promoter]; Estradiol promotes the reaction [FOS protein binds to CCND1 promoter]; GPER1 affects the reaction [Estradiol results in increased expression of FOS mRNA]; RTKI cpd inhibits the reaction [Estradiol results in increased expression of FOS mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [Estradiol promotes the reaction [ARNT protein binds to FOS promoter]]; Toremifene inhibits the reaction [Estradiol results in increased expression of FOS mRNA]; Toremifene inhibits the reaction [Estradiol results in increased expression of FOS protein] | PMID:11285193 PMID:11473722 PMID:11506814 PMID:12079510 PMID:17991765 PMID:18556351 PMID:20667977 PMID:21813366 PMID:23552522 PMID:23684557 | Fos | multiple interactions | ISO | FOS (Homo sapiens) | 6480464 | CTD | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased expression of FOS mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased expression of FOS protein]; [Estradiol co-treated with EGF protein] results in increased expression of FOS mRNA; [Estradiol co-treated with Progesterone] results in increased expression of FOS mRNA; [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of FOS mRNA; [Estradiol co-treated with TGFB1 protein] results in decreased expression of FOS mRNA; [Progesterone co-treated with Estradiol] results in decreased expression of FOS mRNA; AG 1879 inhibits the reaction [Estradiol results in increased expression of FOS protein]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of FOS mRNA]]; Cycloheximide inhibits the reaction [Estradiol results in increased expression of FOS protein]; ESR1 protein promotes the reaction [Estradiol results in increased expression of FOS protein]; Estradiol inhibits the reaction [Fulvestrant results in increased expression of FOS mRNA]; Estradiol promotes the reaction [FOS protein binds to MMP1 promoter]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of FOS mRNA]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of FOS protein]; GPER1 protein affects the reaction [Estradiol results in increased expression of FOS protein]; GPER1 protein promotes the reaction [Estradiol results in increased expression of FOS mRNA]; GPER1 protein promotes the reaction [Estradiol results in increased expression of FOS protein]; MAPK3 gene mutant form inhibits the reaction [Estradiol results in increased expression of FOS protein]; MEN1 protein inhibits the reaction [Estradiol results in increased expression of FOS mRNA]; Pertussis Toxin inhibits the reaction [Estradiol results in increased expression of FOS protein]; RTKI cpd inhibits the reaction [Estradiol results in increased expression of FOS protein]; Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of FOS mRNA]; TGFB3 protein inhibits the reaction [Estradiol results in increased expression of FOS mRNA] | PMID:10478842 PMID:10620335 PMID:15090535 PMID:17157789 PMID:18692832 PMID:19619570 PMID:20660070 PMID:20875696 PMID:24758408 PMID:25616260 PMID:26224478 PMID:30165855 PMID:30682495 PMID:31646340 | | ||||||||||||||||||||||
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