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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2626
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fos
Name: Fos proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:28201
Term: rotenone
Definition: A member of the class of rotenones that consists of 1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one substituted at position 2 by a prop-1-en-2-yl group and at positions 8 and 9 by methoxy groups (the 2R,6aS,12aS-isomer). A non-systemic insecticide, it is the principal insecticidal constituent of derris (the dried rhizome and root of Derris elliptica).
Chemical ID: MESH:D012402
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fosdecreases expressionEXP 6480464CTDRotenone results in decreased expression of FOS mRNAPMID:28374803
Fosmultiple interactionsEXP 6480464CTDRisperidone promotes the reaction [Rotenone results in increased expression of FOS mRNA]PMID:17442543
Fosincreases expressionISOFOS (Homo sapiens)6480464CTDRotenone results in increased expression of FOS mRNAPMID:32368861
Fosmultiple interactionsISOFOS (Homo sapiens)6480464CTDRotenone inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]; Rotenone inhibits the reaction [TNFSF11 protein results in increased expression of FOS protein]PMID:19900598
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