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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2626
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fos
Name: Fos proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:47426
Term: furosemide
Definition: A chlorobenzoic acid that is 4-chlorobenzoic acid substituted by a (furan-2-ylmethyl)amino and a sulfamoyl group at position 2 and 5 respectively. It is a diuretic used in the treatment of congestive heart failure.
Chemical ID: MESH:D005665
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fosincreases expressionEXP 6480464CTDFurosemide results in increased expression of FOS proteinPMID:10760498
Fosincreases expressionISOFos (Mus musculus)6480464CTDFurosemide results in increased expression of FOS proteinPMID:15528393
Fosmultiple interactionsISOFos (Mus musculus)6480464CTDLosartan inhibits the reaction [Furosemide results in increased expression of FOS protein]PMID:15528393
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