Nqo1 (NAD(P)H quinone dehydrogenase 1) - Rat Genome Database

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Gene: Nqo1 (NAD(P)H quinone dehydrogenase 1) Rattus norvegicus
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Symbol: Nqo1
Name: NAD(P)H quinone dehydrogenase 1
RGD ID: 2503
Description: Enables NADH dehydrogenase (quinone) (non-electrogenic) activity and superoxide dismutase activity. Involved in several processes, including regulation of apoptotic process; response to ischemia; and response to tetrachloromethane. Located in dendrite and neuronal cell body. Used to study several diseases, including chronic kidney disease; colon cancer; hypertension; liver cirrhosis; and membranous glomerulonephritis. Biomarker of several diseases, including cerebrovascular disease (multiple); liver disease (multiple); overactive bladder syndrome; status epilepticus; and ureteral obstruction. Human ortholog(s) of this gene implicated in several diseases, including hematologic cancer (multiple); hypertension; lung disease (multiple); macular degeneration; and small cell carcinoma. Orthologous to human NQO1 (NAD(P)H quinone dehydrogenase 1); PARTICIPATES IN nuclear factor, erythroid 2 like 2 signaling pathway; oxidative stress response pathway; doxorubicin pharmacokinetics pathway; INTERACTS WITH (+)-catechin; (-)-selegiline; (3,4-dihydroxyphenyl)acetic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: azoreductase; Dia4; Diaphorase (NADH/NADPH); DT-diaphorase; DTD; menadione reductase; MGC93075; NAD(P)H dehydrogenase [quinone] 1; NAD(P)H dehydrogenase, quinone 1; NAD(P)H:menadione oxidoreductase; NAD(P)H:quinone oxidoreductase 1; phylloquinone reductase; QR1; quinone reductase 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   WF.DA-(D19Mit1-D19Mit6)/Kop  
Candidate Gene For: Tcas1 Tcas5 Eau8
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81952,205,374 - 52,220,267 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1952,205,314 - 52,220,260 (-)EnsemblGRCr8
mRatBN7.21935,295,633 - 35,310,528 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1935,295,573 - 35,310,557 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1942,111,093 - 42,125,986 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01942,764,452 - 42,779,347 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01945,069,378 - 45,085,238 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01938,422,210 - 38,437,103 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1938,422,164 - 38,437,180 (+)Ensemblrn6Rnor6.0
Rnor_5.01949,291,903 - 49,306,856 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41937,251,147 - 37,266,040 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1934,717,059 - 34,731,947 (-)NCBICelera
RGSC_v3.11937,255,967 - 37,270,906 (-)NCBI
Cytogenetic Map19q12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (IEP,ISO)
Acute Lung Injury  (IDA,IEP)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
alcohol-associated liver disease  (ISO)
alcoholic hepatitis  (ISO)
asthma  (ISO)
autism spectrum disorder  (ISO)
Brain Injuries  (IEP)
breast cancer  (IEP,ISO)
Breast Neoplasms  (ISO)
Carbon Tetrachloride Poisoning  (IEP)
Cerebral Hemorrhage  (IEP)
Chemical and Drug Induced Liver Injury  (IDA,IEP,ISO)
cholestasis  (IEP,ISO)
Chromosome 8, Trisomy  (ISO)
Chronic Experimental Pancreatitis  (IEP)
chronic kidney disease  (IDA)
chronic myeloid leukemia  (ISO)
chronic obstructive pulmonary disease  (IEP,ISO)
colon cancer  (IDA)
Colorectal Neoplasms  (ISO)
contact dermatitis  (ISO)
depressive disorder  (IEP)
Diabetic Nephropathies  (IEP)
disease of cellular proliferation  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Neoplasms  (IEP)
Experimental Neoplasms  (ISO)
Experimental Seizures  (IEP)
hemolytic-uremic syndrome  (ISO)
Hemorrhage  (ISO)
hyperglycemia  (ISO)
Hyperoxia  (IDA)
Hyperoxic Lung Injury  (ISO)
hypertension  (IDA,ISO)
Intestinal Reperfusion Injury  (IEP)
kidney disease  (ISO)
Kidney Reperfusion Injury  (IEP)
Lead Poisoning  (IEP)
Left Ventricular Hypertrophy  (IEP)
leukemia  (ISO)
liver benign neoplasm  (IEP)
liver cirrhosis  (IDA)
liver disease  (ISO)
lung disease  (ISO)
Lung Injury  (IEP)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
Lung Reperfusion Injury  (IEP)
macular degeneration  (ISO)
membranous glomerulonephritis  (IDA)
Mercury Poisoning  (IEP)
metabolic dysfunction-associated steatotic liver disease  (IEP,ISO)
middle cerebral artery infarction  (IEP)
multiple myeloma  (ISO)
myelodysplastic syndrome  (ISO)
myeloid leukemia  (ISO)
myeloid neoplasm  (ISO)
neurodegenerative disease  (IEP)
obesity  (ISO)
Occupational Diseases  (ISO)
overactive bladder syndrome  (IEP)
papilloma  (ISO)
Parkinson's disease  (ISO)
Poisoning  (ISO)
Prostatic Neoplasms  (ISO)
prostatitis  (IEP)
pulmonary emphysema  (ISO)
renal fibrosis  (ISO)
small cell carcinoma  (ISO)
Spinal Cord Injuries  (IEP)
spinocerebellar ataxia 17  (ISO)
status epilepticus  (IEP)
steatotic liver disease  (IEP)
Subarachnoid Hemorrhage  (IEP)
toxic encephalopathy  (ISO)
transient cerebral ischemia  (IEP)
ureteral obstruction  (IEP)
urinary bladder cancer  (IDA,ISO)
urinary system cancer  (ISO)
warfarin sensitivity  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-albicanol  (ISO)
(+)-catechin  (EXP)
(+)-epicatechin-3-O-gallate  (ISO)
(+)-pilocarpine  (ISO)
(+)-schisandrin B  (ISO)
(+)-taxifolin  (ISO)
(+)-trans-(S)-allethrin  (ISO)
(+/-)-Aegeline  (ISO)
(-)-citrinin  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(-)-selegiline  (EXP,ISO)
(1->4)-beta-D-glucan  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(3,4-dihydroxyphenyl)acetic acid  (EXP)
(E)-cinnamyl alcohol  (ISO)
(R)-lipoic acid  (EXP,ISO)
(R,R,R)-alpha-tocopherol  (EXP,ISO)
(RS)-coclaurine  (ISO)
(RS)-norcoclaurine  (ISO)
(S)-coclaurine  (ISO)
(S)-naringenin  (ISO)
(Z)-ligustilide  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2,4-trichlorobenzene  (ISO)
1,2-dibromoethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,2-naphthoquinone  (ISO)
1,3-benzothiazole-2-thiol  (ISO)
1,3-dichloropropan-2-ol  (EXP)
1,3-Dinitropyrene  (EXP)
1,4-benzoquinone  (ISO)
1,4-dithiothreitol  (ISO)
1,4-phenylenediamine  (ISO)
1,6-Dinitropyrene  (EXP)
1,8-Dinitropyrene  (EXP)
1-benzofuran  (ISO)
1-bromopropane  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-Cyano-2-hydroxy-3-butene  (EXP)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
15-oxo-ETE  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
1H-pyrazole  (ISO)
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2-Bis(bromomethyl)propane-1,3-diol  (ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-diaminotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,5-dihydroxybenzoic acid  (ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2,6-dichloroindophenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
2-(chloromethyl)pyridine  (ISO)
2-acetamidofluorene  (EXP,ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP,ISO)
2-amino-4,6-dinitrotoluene  (EXP)
2-aminophenol  (ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
2-butoxyethanol  (ISO)
2-hydroxyethyl methacrylate  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methoxy-1,4-naphthoquinone  (EXP)
2-nitroanisole  (EXP)
2-nitrofluorene  (EXP)
2-tert-butylhydroquinone  (EXP,ISO)
26-hydroxycholesterol  (ISO)
3'-phospho-5'-adenylyl sulfate  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3'-diindolylmethane  (ISO)
3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol  (EXP)
3,4-dihydroxybenzoic acid  (EXP,ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (EXP,ISO)
3-Nitrobenzanthrone  (ISO)
3-nitropropanoic acid  (EXP)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (EXP,ISO)
4'-hydroxydiclofenac  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-amino-2,6-dinitrotoluene  (EXP)
4-Hydroxybenzyl isothiocyanate  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrobenzyl bromide  (ISO)
4-nitrophenol  (ISO)
4-nitroquinoline N-oxide  (EXP,ISO)
4-phenyl-3-furoxancarbonitrile  (ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-azacytidine  (ISO)
5-bromo-2'-deoxyuridine  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP,ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-Methoxyflavone  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP,ISO)
7,8-dihydroxycoumarin  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
7beta-aminocephalosporanic acid  (ISO)
9,10-phenanthroquinone  (ISO)
9-cis-retinoic acid  (ISO)
[6]-Shogaol  (ISO)
acetamide  (EXP)
acetone  (ISO)
acetyl-CoA  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (EXP,ISO)
acrylamide  (EXP,ISO)
acrylonitrile  (ISO)
Actein  (EXP)
actinomycin D  (EXP,ISO)
adefovir pivoxil  (ISO)
Aescin  (ISO)
aflatoxin B1  (EXP,ISO)
AL 8810  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
allethrin  (EXP)
allicin  (ISO)
allopurinol  (ISO)
alloxan  (EXP)
allyl isothiocyanate  (EXP)
allyl methyl disulfide  (ISO)
alpha,alpha-trehalose  (EXP)
alpha-D-galactose  (EXP,ISO)
alpha-hexachlorocyclohexane  (EXP)
alpha-hexylcinnamaldehyde  (ISO)
alpha-linolenic acid  (EXP)
alpha-naphthoflavone  (EXP)
alpha-Solamarine  (ISO)
aminoguanidine  (ISO)
amiodarone  (ISO)
amitraz  (EXP)
amlexanox  (ISO)
ammonium chloride  (EXP)
ammonium hexachloroplatinate  (ISO)
amoxicillin  (ISO)
amphetamine  (EXP)
ampicillin  (ISO)
andrographolide  (EXP,ISO)
Anetholtrithion  (EXP)
angelica lactone  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimonite  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
Apaziquone  (EXP)
arachidonic acid  (EXP)
Aristolactam I  (ISO)
aristolochic acid A  (EXP,ISO)
aristolochic acids  (EXP)
Aroclor 1254  (EXP,ISO)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
asiatic acid  (EXP)
asperuloside  (ISO)
astaxanthin  (EXP,ISO)
astilbin  (ISO)
Atipamezole  (EXP)
atrazine  (EXP,ISO)
aureusidin  (EXP,ISO)
avobenzone  (ISO)
azathioprine  (ISO)
azoxystrobin  (ISO)
Bandrowski's base  (ISO)
Bardoxolone methyl  (ISO)
beauvericin  (ISO)
belinostat  (ISO)
benfotiamine  (ISO)
benzene  (EXP,ISO)
Benzo[a]fluorene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[a]pyrene-7,8-diol  (EXP,ISO)
benzo[a]pyrene-7,8-dione  (ISO)
benzo[b]fluoranthene  (EXP,ISO)
Benzo[b]fluorene  (EXP,ISO)
Benzo[c]fluorene  (ISO)
benzo[d]isothiazol-3-one  (ISO)
Benzo[ghi]perylene  (ISO)
Benzo[k]fluoranthene  (ISO)
benzoic acid  (ISO)
benzophenones  (ISO)
benzopyran  (EXP)
benzoquinones  (ISO)
benzyl cinnamate  (ISO)
benzyl isothiocyanate  (EXP,ISO)
Benzyl viologen  (EXP)
benzylpenicillin  (ISO)
berberine  (EXP,IEP)
Bergenin  (EXP)
beta-carboline  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (EXP,ISO)
beta-tocopherol  (EXP)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
boric acid  (ISO)
bortezomib  (EXP,ISO)
bosentan  (ISO)
bromobenzene  (EXP,ISO)
Bromochloroacetonitrile  (ISO)
Brusatol  (EXP)
buta-1,3-diene  (ISO)
butan-1-ol  (ISO)
butylated hydroxyanisole  (EXP,ISO)
butyric acid  (ISO)
cadmium acetate  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cafestol  (EXP,ISO)
caffeine  (EXP,ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP,ISO)
captan  (ISO)
carbamazepine  (EXP,ISO)
carbon disulfide  (EXP)
carbon nanotube  (ISO)
carboplatin  (EXP)
carnosic acid  (ISO)
carrageenan  (EXP)
carvacrol  (EXP)
catalpol  (ISO)
catechol  (ISO)
cefaloridine  (EXP)
celastrol  (EXP)
ceric oxide  (ISO)
chalcone  (ISO)
chalcones  (EXP)
chenodeoxycholic acid  (ISO)
CHIR 99021  (ISO)
chitosan  (EXP)
chloroacetaldehyde  (ISO)
Chloroacetonitrile  (ISO)
chlorogenic acid  (ISO)
chlorohydrocarbon  (EXP)
chloromethylisothiazolinone  (ISO)
chlorophyllin  (ISO)
chloropicrin  (ISO)
chloroprene  (EXP,ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (EXP)
cholic acid  (ISO)
choline  (ISO)
chromium atom  (EXP,ISO)
chromium trioxide  (ISO)
chromium(6+)  (EXP,ISO)
chrysene  (EXP)
chrysin  (EXP)
cidofovir anhydrous  (ISO)
ciguatoxin CTX1B  (ISO)
cilostazol  (EXP)
cinnamyl alcohol  (ISO)
ciprofibrate  (EXP)
cisplatin  (EXP,ISO)
citraconic acid  (EXP)
citral  (EXP)
clobetasol  (ISO)
clodronic acid  (ISO)
clofibrate  (EXP,ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
coniferyl aldehyde  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(I) chloride  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cortisol  (EXP,ISO)
cortisone  (EXP)
coumarin  (EXP,ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
crocin-1  (EXP)
CU-O LINKAGE  (ISO)
cumene hydroperoxide  (ISO)
Cuprizon  (EXP,ISO)
curcumin  (EXP,ISO)
cyanocob(III)alamin  (ISO)
cycloheximide  (EXP,ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (ISO)
cyfluthrin  (ISO)
cyhalothrin  (EXP)
Cynaropicrin  (ISO)
cypermethrin  (EXP,ISO)
cyproconazole  (EXP,ISO)
D-glucose  (EXP,ISO)
daidzein  (ISO)
daunorubicin  (EXP,ISO)
DDT  (ISO)
decabromodiphenyl ether  (EXP,ISO)
deguelin  (ISO)
delta-tocopherol  (EXP)
demethoxycurcumin  (ISO)
Dendrobine  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dexmedetomidine  (EXP)
dextran sulfate  (ISO)
diallyl disulfide  (EXP,ISO)
Diallyl sulfide  (EXP,ISO)
diallyl trisulfide  (EXP,ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (ISO)
diaziquone  (ISO)
Dibenz[a,c]anthracene  (ISO)
dibenz[a,h]anthracene  (EXP,ISO)
dibenzo[a,l]pyrene  (EXP,ISO)
dibenzofuran  (EXP)
dibenzofurans  (ISO)
Dibromoacetonitrile  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
Dichloroacetonitrile  (ISO)
dichloroacetyl chloride  (ISO)
dichloromethane  (ISO)
dichlorvos  (ISO)
diclofenac  (EXP,ISO)
dicoumarol  (EXP,ISO)
diethyl maleate  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (EXP)
dihydrolipoic acid  (ISO)
dihydrosanguinarine  (EXP)
Diisodecyl phthalate  (ISO)
dimercaprol  (ISO)
dimethyl fumarate  (EXP,ISO)
dimethyl sulfoxide  (EXP)
dimethylarsinic acid  (ISO)
dimethylarsinous acid  (ISO)
dinoseb  (ISO)
dioscin  (EXP)
diosmetin  (EXP)
dioxygen  (EXP,ISO)
diphenyl diselenide  (EXP)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diprotium oxide  (ISO)
diquat  (ISO)
disodium selenite  (EXP,ISO)
disulfiram  (EXP,ISO)
dithianon  (ISO)
diuron  (EXP)
divanadium pentaoxide  (ISO)
dopaminechrome (enol form)  (EXP,ISO)
doramapimod  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
duroquinone  (ISO)
ebselen  (EXP)
elemental selenium  (EXP,ISO)
ellagic acid  (ISO)
emodin  (EXP,ISO)
endosulfan  (EXP)
enniatin  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
epalrestat  (ISO)
epichlorohydrin  (ISO)
epoxiconazole  (EXP)
eriodictyol  (ISO)
Erucin  (ISO)
erythromycin A  (ISO)
esculetin  (ISO)
ethanol  (EXP,ISO)
ethoxyquin  (EXP,ISO)
ethyl methanesulfonate  (ISO)
etofenprox  (EXP)
etoposide  (ISO)
eugenol  (ISO)
farnesol  (EXP)
farrerol  (ISO)
felbamate  (EXP)
fenamidone  (ISO)
fenpyroximate  (ISO)
fenvalerate  (EXP)
ferric oxide  (EXP)
ferrosoferric oxide  (ISO)
finasteride  (EXP)
fipronil  (EXP)
fisetin  (EXP)
flavonoids  (EXP)
fluoranthene  (EXP,ISO)
fluorescein 5-isothiocyanate  (ISO)
fluprostenol  (ISO)
flurbiprofen  (ISO)
flutamide  (EXP)
flutriafol  (ISO)
fluvalinate  (ISO)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
formononetin  (ISO)
Forsythiaside  (ISO)
fulvestrant  (EXP)
fumonisin B1  (ISO)
furan  (EXP,ISO)
furosemide  (EXP)
gabapentin  (EXP)
galactose  (EXP,ISO)
galangin  (EXP,ISO)
gallic acid  (ISO)
gallocatechin  (ISO)
gamma-tocopherol  (EXP)
Gastrodin  (EXP)
geldanamycin  (ISO)
gemcitabine  (ISO)
Genipin  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
geranial  (EXP)
geraniol  (EXP)
Gingerenone A  (ISO)
Ginkgolide C  (EXP)
ginsenoside Rg1  (ISO)
Ginsenoside Rh4  (EXP)
glafenine  (EXP)
glucobrassicin  (ISO)
glucoerucin  (EXP)
glucoerucin(1-)  (EXP)
glucoraphanin  (EXP,ISO)
glucose  (EXP,ISO)
glutamine  (IEP)
glutathione  (EXP,ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
graphene oxide  (ISO)
griseofulvin  (ISO)
guggulsterone  (ISO)
GW 4064  (ISO)
haloperidol  (ISO)
harman  (ISO)
hemin  (ISO)
hesperetin  (EXP,ISO)
Hexachloro-1,3-butadiene  (EXP)
hexachlorobenzene  (EXP)
hexadecanoic acid  (ISO)
hexamethylene diisocyanate  (ISO)
hexane  (ISO)
homoeriodictyol  (ISO)
Honokiol  (EXP)
hydrogen chloride  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
hydroquinone O-beta-D-glucopyranoside  (EXP)
hypochlorous acid  (ISO)
hypoxanthine  (ISO)
iberin  (EXP)
ibuprofen  (ISO)
ifosfamide  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indirubin  (EXP)
indole-3-methanol  (EXP,ISO)
indoles  (EXP)
indolin-2-one  (ISO)
indometacin  (EXP,ISO)
inulin  (ISO)
iohexol  (EXP)
irinotecan  (ISO)
iron atom  (EXP,ISO)
iron dichloride  (ISO)
iron trichloride  (ISO)
iron(0)  (EXP,ISO)
iron(2+) sulfate (anhydrous)  (EXP)
iron(III) citrate  (ISO)
iron(III) nitrilotriacetate  (ISO)
isoeugenol  (ISO)
isoflavones  (ISO)
isoflurane  (ISO)
isoliquiritigenin  (ISO)
isoniazide  (EXP,ISO)
isopimpinellin  (ISO)
isoprenaline  (EXP)
isorhamnetin  (ISO)
isothiocyanate  (ISO)
itraconazole  (ISO)
ivermectin  (ISO)
kaempferol  (ISO)
kahweol  (EXP,ISO)
ketamine  (EXP)
ketoconazole  (EXP,ISO)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (EXP,ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-methionine  (ISO)
lanthanum trichloride  (ISO)
lapatinib  (ISO)
laquinimod  (EXP)
lawsone  (EXP)
lead diacetate  (EXP,ISO)
lead nitrate  (EXP)
lead(0)  (EXP,ISO)
lead(II) chloride  (ISO)
leflunomide  (EXP)
Leonurine  (EXP)
Licochalcone A  (ISO)
lignan  (ISO)
linalool  (ISO)
linoleic acid  (ISO)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
liquiritigenin  (EXP,ISO)
liquiritin  (EXP,ISO)
lithium atom  (ISO)
lithium chloride  (EXP,ISO)
lithium hydride  (ISO)
lithocholic acid  (ISO)
lovastatin  (ISO)
lutein  (ISO)
luteolin  (ISO)
Luteolin 7-methyl ether  (EXP)
LY294002  (EXP,ISO)
lycopene  (ISO)
Magnolol  (EXP)
malathion  (ISO)
maneb  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
mangiferin  (EXP)
mefenamic acid  (ISO)
melatonin  (EXP,ISO)
menadione  (EXP,ISO)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
mercury(0)  (ISO)
metformin  (EXP,ISO)
methamphetamine  (ISO)
methapyrilene  (EXP)
methotrexate  (EXP,IEP,ISO)
methyl methacrylate  (ISO)
methyl methanesulfonate  (ISO)
methyl non-2-ynoate  (ISO)
methyl salicylate  (ISO)
methylarsonic acid  (ISO)
methylene blue  (ISO)
methylglyoxal  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
methylseleninic acid  (ISO)
microcystin-LR  (ISO)
mifepristone  (EXP,ISO)
mitomycin C  (EXP,ISO)
Mitoquinone  (ISO)
molybdenum trioxide  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (EXP)
monosodium L-glutamate  (ISO)
morin  (EXP)
muconic acid  (ISO)
N'-(2,4-dimethylphenyl)-N-methylformamidine  (EXP)
N,N-diethyl-m-toluamide  (EXP)
N,N-dimethylformamide  (ISO)
N-(1-naphthyl)ethylenediamine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-1,4-benzoquinone imine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetyl-S-phenyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-butyl-N-(4-hydroxybutyl)nitrosamine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methylnicotinate  (ISO)
N-Methylolacrylamide  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
NAD zwitterion  (EXP)
NAD(+)  (EXP)
NADP zwitterion  (EXP,ISO)
NADP(+)  (EXP,ISO)
naled  (ISO)
naphthalene  (EXP)
naphthalene-1,5-diamine  (ISO)
naphthalenes  (ISO)
naringin  (EXP)
NCX-4040  (ISO)
nectandrin B  (ISO)
nefazodone  (EXP)
neoastilbin  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nicotinamide  (ISO)
nimesulide  (EXP,ISO)
nitisinone  (ISO)
nitrofurantoin  (ISO)
nitrogen dioxide  (ISO)
nitroprusside  (EXP,ISO)
nitrososulfamethoxazole  (ISO)
NMN zwitterion  (ISO)
Nonidet P-40  (ISO)
notoginsenoside R1  (EXP)
Nutlin-3  (ISO)
o-anisidine  (EXP,ISO)
ochratoxin A  (EXP,ISO)
Octachlorostyrene  (ISO)
okadaic acid  (ISO)
oleanolic acid  (EXP,ISO)
oleic acid  (ISO)
oltipraz  (EXP,ISO)
omaveloxolone  (ISO)
omeprazole  (EXP,ISO)
oxaliplatin  (ISO)
oxfendazole  (EXP)
oxidopamine  (EXP,ISO)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
p-cresol  (ISO)
p-toluidine  (EXP)
Paeonol  (EXP)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pelargonidin  (ISO)
pentachloronitrobenzene  (ISO)
pentachlorophenol  (ISO)
perfluorobutyric acid  (ISO)
perfluorodecanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanesulfonamide  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoropentanoic acid  (ISO)
permethrin  (EXP)
Pf-06840003  (ISO)
phalloidin  (ISO)
phenanthrene  (EXP,ISO)
phenethyl isothiocyanate  (EXP,ISO)
phenformin  (EXP)
phenindione  (ISO)
phenobarbital  (EXP,ISO)
phenol  (ISO)
phenoxymethylpenicillin  (ISO)
phenylarsine oxide  (ISO)
phenylmercury acetate  (ISO)
phenytoin  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phorone  (ISO)
phosphoramide mustard  (EXP)
picoxystrobin  (ISO)
pioglitazone  (ISO)
piperonyl butoxide  (EXP,ISO)
pirinixic acid  (EXP,ISO)
plumbagin  (ISO)
Polpunonic acid  (ISO)
poly(vinylpyrrolidone)  (EXP)
Potassium 2,6-dihydroxytriazinecarboxylate  (ISO)
potassium bromate  (ISO)
potassium chromate  (ISO)
potassium dichromate  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
probucol  (EXP)
prochloraz  (EXP)
procyanidin  (ISO)
procyanidin B2  (EXP)
progesterone  (EXP)
propan-2-ol  (ISO)
propiconazole  (EXP,ISO)
pterostilbene  (ISO)
puerarin  (EXP)
pyocyanine  (ISO)
pyrene  (EXP)
pyrethrins  (EXP)
Pyridostigmine bromide  (EXP)
pyrimidifen  (ISO)
pyruvate ester  (EXP)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-galactopyranoside  (EXP)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
rac-1,2-dichloropropane  (ISO)
rac-lactic acid  (ISO)
radon atom  (ISO)
radon(0)  (ISO)
raloxifene  (ISO)
ranitidine  (EXP)
raspberry ketone  (ISO)
Resazurin  (ISO)
reserpine  (ISO)
resolvin D1  (ISO)
resorcinol  (ISO)
resveratrol  (EXP,ISO)
Rhynchophylline  (EXP,ISO)
riddelliine  (EXP)
rimonabant  (EXP)
Ro 31-8220  (ISO)
rofecoxib  (ISO)
roflumilast  (EXP,ISO)
rosmarinic acid  (ISO)
rotenone  (EXP,ISO)
rottlerin  (ISO)
Rutecarpine  (ISO)
rutin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-allylcysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
Salinomycin  (ISO)
salvianolic acid B  (EXP,ISO)
sanguinarine  (EXP,ISO)
sarin  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
SCH772984  (ISO)
scopolamine  (ISO)
scutellarin  (ISO)
Securinine  (ISO)
selenium atom  (EXP,ISO)
selenocystine  (ISO)
selenomethionine  (ISO)
senecionine  (ISO)
Senkirkine  (ISO)
serotonin  (ISO)
sesquiterpene  (ISO)
sevoflurane  (ISO)
silibinin  (IEP,ISO)
silicon dioxide  (ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
simvastatin  (ISO)
sinapic acid  (EXP)
sirtinol  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (EXP,ISO)
sodium tungstate  (ISO)
solanesol  (ISO)
Soman  (EXP)
spermidine  (ISO)
spermine  (ISO)
staurosporine  (EXP,ISO)
streptonigrin  (ISO)
streptozocin  (EXP,ISO)
styrene  (ISO)
succimer  (ISO)
sucrose  (EXP)
Sudan I  (EXP)
Sudan III  (EXP)
sulfasalazine  (EXP,ISO)
sulfluramid  (ISO)
sulforaphane  (EXP,ISO)
sulindac  (ISO)
sulindac sulfide  (ISO)
sulindac sulfone  (ISO)
sunitinib  (EXP,ISO)
T-2 toxin  (EXP,ISO)
tacrine  (ISO)
tamoxifen  (ISO)
tanespimycin  (ISO)
tangeretin  (EXP,ISO)
Tanshinone I  (ISO)
tebufenpyrad  (ISO)
tectorigenin  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
Testosterone propionate  (IEP)
tetrachloro-1,4-benzoquinone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,IEP,ISO)
tetracycline  (EXP,ISO)
tetraphene  (EXP,ISO)
thapsigargin  (ISO)
thiamine(1+) chloride  (ISO)
thifluzamide  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
tideglusib  (ISO)
Timosaponin b ii  (ISO)
titanium dioxide  (ISO)
toluene  (EXP,ISO)
Torularhodin  (EXP,ISO)
trans-chalcone  (ISO)
trans-ferulic acid  (IEP)
trans-isoeugenol  (ISO)
trans-piceid  (ISO)
trans-rhaponticin  (EXP)
triadimefon  (EXP)
triazines  (ISO)
tricalcium bis(phosphate)  (ISO)
tricetin  (ISO)
Trichloroacetonitrile  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
trilobatin  (EXP,ISO)
trimellitic anhydride  (ISO)
trimethylarsine oxide  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (EXP,ISO)
Tungsten carbide  (ISO)
tunicamycin  (ISO)
uranium atom  (EXP)
urethane  (ISO)
ursodeoxycholic acid  (EXP,ISO)
usnic acid  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
valsartan  (EXP)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vancomycin  (EXP)
verapamil  (EXP)
vinclozolin  (EXP)
vincristine  (EXP)
vitamin E  (EXP,ISO)
vorinostat  (ISO)
warfarin  (ISO)
water  (ISO)
withaferin A  (ISO)
wogonin  (EXP)
wortmannin  (ISO)
xanthohumol  (ISO)
XAV939  (ISO)
yohimbine  (ISO)
zerumbone  (ISO)
zidovudine  (EXP)
zinc atom  (ISO)
zinc oxide  (ISO)
zinc(0)  (ISO)
zingerone  (EXP)
ziprasidone  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)
cytosol  (IBA,IEA,ISO)
dendrite  (IDA)
neuronal cell body  (IDA)
nucleus  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Insights into the potential antidepressant mechanisms of cilostazol in chronically restraint rats: impact on the Nrf2 pathway. Abuelezz SA and Hendawy N, Behav Pharmacol. 2017 Jul 31. doi: 10.1097/FBP.0000000000000335.
2. Metformin attenuates streptozotocin-induced diabetic nephropathy in rats through modulation of oxidative stress genes expression. Alhaider AA, etal., Chem Biol Interact. 2011 Jul 15;192(3):233-42. doi: 10.1016/j.cbi.2011.03.014. Epub 2011 Mar 30.
3. Inhibition of colon carcinogenesis by post-initiation induction of NQO1 in Sprague-Dawley rats. Begleiter A, etal., Oncol Rep. 2009 Jun;21(6):1559-65.
4. Antifibrogenic effect of melatonin in rats with experimental liver cirrhosis induced by carbon tetrachloride. Bona S, etal., JGH Open. 2018 May 24;2(4):117-123. doi: 10.1002/jgh3.12055. eCollection 2018 Aug.
5. Role of the Nrf2-ARE pathway in early brain injury after experimental subarachnoid hemorrhage. Chen G, etal., J Neurosci Res. 2011 Apr;89(4):515-23. doi: 10.1002/jnr.22577. Epub 2011 Jan 21.
6. Molecular basis of the catalytic differences among DT-diaphorase of human, rat, and mouse. Chen S, etal., J Biol Chem. 1997 Jan 17;272(3):1437-9. doi: 10.1074/jbc.272.3.1437.
7. Adipose-derived mesenchymal stem cell protects kidneys against ischemia-reperfusion injury through suppressing oxidative stress and inflammatory reaction. Chen YT, etal., J Transl Med. 2011 May 5;9:51. doi: 10.1186/1479-5876-9-51.
8. Testosterone Propionate Exacerbates the Deficits of Nigrostriatal Dopaminergic System and Downregulates Nrf2 Expression in Reserpine-Treated Aged Male Rats. Cui R, etal., Front Aging Neurosci. 2017 May 31;9:172. doi: 10.3389/fnagi.2017.00172. eCollection 2017.
9. BALT development and augmentation of hyperoxic lung injury in mice deficient in NQO1 and NQO2. Das A, etal., Free Radic Biol Med. 2006 May 15;40(10):1843-56. Epub 2006 Feb 17.
10. Activation of AhR-NQO1 Signaling Pathway Protects Against Alcohol-Induced Liver Injury by Improving Redox Balance. Dong H, etal., Cell Mol Gastroenterol Hepatol. 2021;12(3):793-811. doi: 10.1016/j.jcmgh.2021.05.013. Epub 2021 May 31.
11. Influence of NQO1, ALDH2, and CYP2E1 genetic polymorphisms, smoking, and alcohol drinking on the risk of lung cancer in Koreans. Eom SY, etal., Cancer Causes Control. 2009 Mar;20(2):137-45. Epub 2008 Sep 17.
12. Overabundant FANCD2, alone and combined with NQO1, is a sensitive marker of adverse prognosis in breast cancer. Fagerholm R, etal., Ann Oncol. 2013 Nov;24(11):2780-5. doi: 10.1093/annonc/mdt290. Epub 2013 Jul 29.
13. Differential responses of targeted lung redox enzymes to rat exposure to 60 or 85% oxygen. Gan Z, etal., J Appl Physiol (1985). 2011 Jul;111(1):95-107. doi: 10.1152/japplphysiol.01451.2010. Epub 2011 May 5.
14. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
15. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
16. Functional polymorphism of detoxification gene NQO1 predicts intensity of empirical treatment of childhood asthma. Goodrich GG, etal., Mutat Res. 2009 Mar 31;674(1-2):55-61. Epub 2008 Nov 5.
17. Altered Nrf2/Keap1-Bach1 equilibrium in pulmonary emphysema. Goven D, etal., Thorax. 2008 Oct;63(10):916-24. Epub 2008 Jun 17.
18. Danhong injection attenuates ischemia/reperfusion-induced brain damage which is associating with Nrf2 levels in vivo and in vitro. Guo H, etal., Neurochem Res. 2014 Sep;39(9):1817-24. doi: 10.1007/s11064-014-1384-1. Epub 2014 Jul 29.
19. Yinchen Linggui Zhugan Decoction Ameliorates Nonalcoholic Fatty Liver Disease in Rats by Regulating the Nrf2/ARE Signaling Pathway. Guo Y, etal., Evid Based Complement Alternat Med. 2017;2017:6178358. doi: 10.1155/2017/6178358. Epub 2017 Aug 28.
20. Fine structure and synaptology of the nitrergic neurons in medial septum of the rat brain. Halasy K, etal., Acta Biol Hung. 2017 Mar;68(1):1-13. doi: 10.1556/018.68.2017.1.1.
21. NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism and the risk of eight cancers for Japanese. Hamajima N, etal., Int J Clin Oncol. 2002 Apr;7(2):103-8.
22. Berberine ameliorates CCl4‑induced liver injury in rats through regulation of the Nrf2‑Keap1‑ARE and p53 signaling pathways. Han CY, etal., Mol Med Rep. 2019 Oct;20(4):3095-3102. doi: 10.3892/mmr.2019.10551. Epub 2019 Aug 6.
23. Afferent Pathway-Mediated Effect of a1 Adrenergic Antagonist, Tamsulosin, on the Neurogenic Bladder After Spianl Cord Injury. Han JH, etal., Int Neurourol J. 2017 Sep;21(3):178-188. doi: 10.5213/inj.1734984.492. Epub 2017 Sep 12.
24. Protective effect of glutamine on the main and adjacent organs damaged by ischemia-reperfusion in rats. Hartmann RM, etal., Protoplasma. 2017 Apr 5. doi: 10.1007/s00709-017-1102-3.
25. GSTT1 and GSTM1 deletions, NQO1 C609T polymorphism and risk of chronic myelogenous leukemia in Japanese. Hishida A, etal., Asian Pac J Cancer Prev. 2005 Jul-Sep;6(3):251-5.
26. Electrical stimulation of the hippocampal fimbria facilitates neuronal nitric oxide synthase activity in the medial shell of the rat nucleus accumbens: Modulation by dopamine D1 and D2 receptor activation. Hoque KE, etal., Neuropharmacology. 2017 Sep 5;126:151-157. doi: 10.1016/j.neuropharm.2017.09.005.
27. Hydrogen sulfide specifically alters NAD(P)H quinone dehydrogenase 1 (NQO1) olfactory neurons in the rat. Imamura F, etal., Neuroscience. 2017 Oct 18. pii: S0306-4522(17)30742-X. doi: 10.1016/j.neuroscience.2017.10.014.
28. Disruption of NAD(P)H:quinone oxidoreductase 1 gene in mice leads to radiation-induced myeloproliferative disease. Iskander K, etal., Cancer Res. 2008 Oct 1;68(19):7915-22. doi: 10.1158/0008-5472.CAN-08-0766.
29. NQO1 and NQO2 regulation of humoral immunity and autoimmunity. Iskander K, etal., J Biol Chem. 2006 Oct 13;281(41):30917-24. Epub 2006 Aug 10.
30. Protective effects of erythropoietin in traumatic spinal cord injury by inducing the Nrf2 signaling pathway activation. Jin W, etal., J Trauma Acute Care Surg. 2014 May;76(5):1228-34. doi: 10.1097/TA.0000000000000211.
31. [Association of NQO1 Polymorphism with Multiple Myeloma Risk in Koreans.]. Kang SH, etal., Korean J Lab Med. 2006 Apr;26(2):71-6.
32. Alleviation of Oxidative Damage and Involvement of Nrf2-ARE Pathway in Mesodopaminergic System and Hippocampus of Status Epilepticus Rats Pretreated by Intranasal Pentoxifylline. Kang Y, etal., Oxid Med Cell Longev. 2017;2017:7908072. doi: 10.1155/2017/7908072. Epub 2017 Mar 12.
33. Role of NAD(P)H:quinone oxidoreductase in the progression of neuronal cell death in vitro and following cerebral ischaemia in vivo. Kapinya KJ, etal., J Neurochem 2003 Mar;84(5):1028-39.
34. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
35. Ramalin, an antioxidant compound derived from Antarctic lichen, prevents progression of liver fibrosis induced by dimethylnitrosamine (DNM) in rats. Kim MK, etal., Biochem Biophys Res Commun. 2018 Sep 26;504(1):25-33. doi: 10.1016/j.bbrc.2018.08.103. Epub 2018 Aug 30.
36. Activation of NAD(P)H:quinone oxidoreductase ameliorates spontaneous hypertension in an animal model via modulation of eNOS activity. Kim YH, etal., Cardiovasc Res. 2011 Aug 1;91(3):519-27. doi: 10.1093/cvr/cvr110. Epub 2011 Apr 18.
37. Prevention of salt-induced renal injury by activation of NAD(P)H:quinone oxidoreductase 1, associated with NADPH oxidase. Kim YH, etal., Free Radic Biol Med. 2012 Mar 1;52(5):880-8. doi: 10.1016/j.freeradbiomed.2011.12.007. Epub 2011 Dec 20.
38. Toluene effects on oxidative stress in brain regions of young-adult, middle-age, and senescent Brown Norway rats. Kodavanti PR, etal., Toxicol Appl Pharmacol. 2011 Apr 28.
39. cDNA microarray analysis of gene expression in rat alveolar macrophages in response to organic extract of diesel exhaust particles. Koike E, etal., Toxicol Sci 2002 Jun;67(2):241-6.
40. The NQO1*2/*2 polymorphism is associated with poor overall survival in patients following resection of stages II and IIIa non-small cell lung cancer. Kolesar JM, etal., Oncol Rep. 2011 Jun;25(6):1765-72. doi: 10.3892/or.2011.1249. Epub 2011 Apr 6.
41. [Polymorphism of the genes for antioxidant defense enzymes and their association with the development of chronic obstructive pulmonary disease in the population of Bashkortostan]. Korytina GF, etal., Genetika. 2009 Jul;45(7):967-76.
42. Role of NQO1, MPO and CYP2E1 genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia. Krajinovic M, etal., Int J Cancer. 2002 Jan 10;97(2):230-6.
43. Modulation of rat hepatic and kidney phase II enzymes by cabbage juices: comparison with the effects of indole-3-carbinol and phenethyl isothiocyanate. Krajka-Kuzniak V, etal., Br J Nutr. 2011 Mar;105(6):816-26. Epub 2010 Nov 23.
44. Polymorphisms in the NAD(P)H: quinone oxidoreductase gene and small cell lung cancer risk in a UK population. Lewis SJ, etal., Lung Cancer. 2001 Nov;34(2):177-83.
45. Effects of lemongrass oil and citral on hepatic drug-metabolizing enzymes, oxidative stress, and acetaminophen toxicity in rats. Li CC, etal., J Food Drug Anal. 2018 Jan;26(1):432-438. doi: 10.1016/j.jfda.2017.01.008. Epub 2017 Mar 17.
46. Xiaochaihutang attenuates liver fibrosis by activation of Nrf2 pathway in rats. Li J, etal., Biomed Pharmacother. 2017 Oct 18;96:847-853. doi: 10.1016/j.biopha.2017.10.065.
47. Intranasal Pretreatment with Z-Ligustilide, the Main Volatile Component of Rhizoma Chuanxiong, Confers Prophylaxis against Cerebral Ischemia via Nrf2 and HSP70 Signaling Pathways. Li J, etal., J Agric Food Chem. 2017 Mar 1;65(8):1533-1542. doi: 10.1021/acs.jafc.6b04979. Epub 2017 Feb 16.
48. In vitro and in vivo antioxidative and hepatoprotective activity of aqueous extract of Cortex Dictamni. Li L, etal., World J Gastroenterol. 2017 Apr 28;23(16):2912-2927. doi: 10.3748/wjg.v23.i16.2912.
49. Allicin ameliorates cardiac hypertrophy and fibrosis through enhancing of Nrf2 antioxidant signaling pathways. Li XH, etal., Cardiovasc Drugs Ther. 2012 Dec;26(6):457-65. doi: 10.1007/s10557-012-6415-z.
50. NAD(P)H: Quinone oxidoreductase 1, glutathione S-transferase M1, environmental tobacco smoke exposure, and childhood asthma. Li YF, etal., Mutat Res. 2009 Aug;678(1):53-8. Epub 2009 Jul 8.
51. Genes of the antioxidant response undergo upregulation in a rodent model of nonalcoholic steatohepatitis. Lickteig AJ, etal., J Biochem Mol Toxicol. 2007;21(4):216-20.
52. GSPE reduces lead-induced oxidative stress by activating the Nrf2 pathway and suppressing miR153 and GSK-3ß in rat kidney. Liu B, etal., Oncotarget. 2017 Jun 27;8(26):42226-42237. doi: 10.18632/oncotarget.15033.
53. Distribution of NADPH-diaphorase in rat mesencephalon: a light and electron microscopical study. Lopez-Costa JJ, etal., Biocell 2002 Aug;26(2):247-52.
54. Lack of association of NQO1 and GSTP1 polymorphisms with multiple myeloma risk. Maggini V, etal., Leuk Res. 2008 Jun;32(6):988-90. Epub 2007 Dec 3.
55. Ferulic acid prevents oxidative stress, inflammation, and liver injury via upregulation of Nrf2/HO-1 signaling in methotrexate-induced rats. Mahmoud AM, etal., Environ Sci Pollut Res Int. 2020 Mar;27(8):7910-7921. doi: 10.1007/s11356-019-07532-6. Epub 2019 Dec 31.
56. Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1. Malhotra D, etal., Am J Respir Crit Care Med. 2008 Sep 15;178(6):592-604. Epub 2008 Jun 12.
57. Dietary lipids differentially modulate the initiation of experimental breast carcinogenesis through their influence on hepatic xenobiotic metabolism and DNA damage in the mammary gland. Manzanares MÁ, etal., J Nutr Biochem. 2017 May;43:68-77. doi: 10.1016/j.jnutbio.2017.01.016. Epub 2017 Feb 10.
58. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
59. New developments in anthracycline-induced cardiotoxicity. Mordente A, etal., Curr Med Chem. 2009;16(13):1656-72.
60. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
61. Dimethylfumarate attenuates renal fibrosis via NF-E2-related factor 2-mediated inhibition of transforming growth factor-beta/Smad signaling. Oh CJ, etal., PLoS One. 2012;7(10):e45870. doi: 10.1371/journal.pone.0045870. Epub 2012 Oct 8.
62. Activation of Nrf2-driven antioxidant enzymes by cardamonin confers neuroprotection of PC12 cells against oxidative damage. Peng S, etal., Food Funct. 2017 Mar 22;8(3):997-1007. doi: 10.1039/c7fo00054e.
63. Effects of Lianhua Qingwen on Pulmonary Oxidative Lesions Induced by Fine Particulates (PM2.5) in Rats. Ping F, etal., Chin Med Sci J. 2016 Nov 20;31(4):233-8.
64. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
65. Total Flavonoid Extract from Abelmoschus manihot (L.) Medic Flowers Attenuates d-Galactose-Induced Oxidative Stress in Mouse Liver Through the Nrf2 Pathway. Qiu Y, etal., J Med Food. 2017 Jun;20(6):557-567. doi: 10.1089/jmf.2016.3870. Epub 2017 May 4.
66. Association of human NAD(P)H:quinone oxidoreductase 1 (NQO1) polymorphism with development of acute lung injury. Reddy AJ, etal., J Cell Mol Med. 2009 Aug;13(8B):1784-91.
67. GOA pipeline RGD automated data pipeline
68. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
69. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
70. Prevalence of GSTT1, GSTM1 and NQO1 (609C>T) in Filipino children with ALL (acute lymphoblastic leukaemia). Rimando MG, etal., Biosci Rep. 2008 Jun;28(3):117-24. doi: 10.1042/BSR20070010.
71. The Nrf2-Keap1 cellular defense pathway and heat shock protein 70 (Hsp70) response. Role in protection against oxidative stress in early neonatal unilateral ureteral obstruction (UUO). Rinaldi Tosi ME, etal., Cell Stress Chaperones. 2011 Jan;16(1):57-68. Epub 2010 Aug 24.
72. An association between a NQO1 genetic polymorphism and risk of lung cancer. Saldivar SJ, etal., Mutat Res. 2005 Apr 4;582(1-2):71-8.
73. Induction of NAD(P)H quinone oxidoreductase and glutathione S-transferase activities in livers of female August-Copenhagen Irish rats treated chronically with estradiol: comparison with the Sprague-Dawley rat. Sanchez RI, etal., J Steroid Biochem Mol Biol. 2003 Nov;87(2-3):199-206.
74. Morin enhances hepatic Nrf2 expression in a liver fibrosis rat model. Sang L, etal., World J Gastroenterol. 2017 Dec 21;23(47):8334-8344. doi: 10.3748/wjg.v23.i47.8334.
75. Protective action of glutamine in rats with severe acute liver failure. Schemitt EG, etal., World J Hepatol. 2019 Mar 27;11(3):273-286. doi: 10.4254/wjh.v11.i3.273.
76. Modifying effects of liver tumor promotion in rats subjected to co-administration of indole-3-carbinol and phenobarbital. Segawa R, etal., J Toxicol Sci. 2014 Feb;39(1):129-40.
77. Hyperoside Attenuates Hepatic Ischemia-Reperfusion Injury by Suppressing Oxidative Stress and Inhibiting Apoptosis in Rats. Shi Y, etal., Transplant Proc. 2019 Jul - Aug;51(6):2051-2059. doi: 10.1016/j.transproceed.2019.04.066.
78. A study on the regenerative effect of platelet-rich plasma on experimentally induced hepatic damage in albino rats. Shoeib HM, etal., Can J Physiol Pharmacol. 2018 Jun;96(6):630-636. doi: 10.1139/cjpp-2017-0738. Epub 2018 Feb 14.
79. NAD(P)H:quinone oxidoreductase 1 null genotype is not associated with pediatric de novo acute leukemia. Sirma S, etal., Pediatr Blood Cancer. 2004 Oct;43(5):568-70.
80. Low NAD(P)H:quinone oxidoreductase 1 activity is associated with increased risk of acute leukemia in adults. Smith MT, etal., Blood. 2001 Mar 1;97(5):1422-6.
81. Clinical significance of NQO1 C609T polymorphisms after postoperative radiation therapy in completely resected non-small cell lung cancer. Song SY, etal., Lung Cancer. 2010 May;68(2):278-82.
82. Presence and induction of the enzyme NAD(P)H: quinone oxidoreductase 1 in the central nervous system. Stringer JL, etal., J Comp Neurol. 2004 Apr 5;471(3):289-97.
83. Autologous transplantation of adipose-derived mesenchymal stem cells markedly reduced acute ischemia-reperfusion lung injury in a rodent model. Sun CK, etal., J Transl Med. 2011 Jul 22;9:118.
84. Betulinic acid, isolated from the leaves of Syzygium cumini (L.) Skeels, ameliorates the proteinuria in experimental membranous nephropathy through regulating Nrf2/NF-¿B pathways. Sutariya B, etal., Chem Biol Interact. 2017 Aug 25;274:124-137. doi: 10.1016/j.cbi.2017.07.011. Epub 2017 Jul 13.
85. Association between polymorphism of the NQO1, NOS3 and NFE2L2 genes and AMD. Synowiec E, etal., Front Biosci (Landmark Ed). 2013 Jan 1;18:80-90.
86. Ptgr1 expression is regulated by NRF2 in rat hepatocarcinogenesis and promotes cell proliferation and resistance to oxidative stress. Sánchez-Rodríguez R, etal., Free Radic Biol Med. 2017 Jan;102:87-99. doi: 10.1016/j.freeradbiomed.2016.11.027. Epub 2016 Nov 18.
87. [Clinical consideration with special reference to autopsy cases of malignant tumor in the oral cavity, treated with Bleomycin (author's transl)] Tanaka S, etal., Hiroshima Daigaku Shigaku Zasshi 1975;8(2):168-75.
88. Quantitative trait loci affecting 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in the rat. Tanuma J, etal., Cancer Res 1998 Apr 15;58(8):1660-4
89. Vascular oxidative stress in aging: a homeostatic failure due to dysregulation of Nrf2-mediated antioxidant response. Ungvari ZI, etal., Am J Physiol Heart Circ Physiol. 2011 May 20.
90. Procyanidin B2 ameliorates carrageenan-induced chronic nonbacterial prostatitis in rats via anti-inflammatory and activation of the Nrf2 pathway. Wang W, etal., Biochem Biophys Res Commun. 2017 Aug 24. pii: S0006-291X(17)31648-0. doi: 10.1016/j.bbrc.2017.08.089.
91. Human NAD(P)H:quinone oxidoreductase 1 (NQO1) and sulfotransferase 1A1 (SULT1A1) polymorphisms and urothelial cancer risk in Taiwan. Wang YH, etal., J Cancer Res Clin Oncol. 2008 Feb;134(2):203-9. Epub 2007 Jul 10.
92. Neuroprotective effects of sulfiredoxin-1 during cerebral ischemia/reperfusion oxidative stress injury in rats. Wu J, etal., Brain Res Bull. 2017 Jun;132:99-108. doi: 10.1016/j.brainresbull.2017.05.012. Epub 2017 May 24.
93. Administration of 5-methoxyindole-2-carboxylic acid that potentially targets mitochondrial dihydrolipoamide dehydrogenase confers cerebral preconditioning against ischemic stroke injury. Wu J, etal., Free Radic Biol Med. 2017 Oct 7. pii: S0891-5849(17)30792-X. doi: 10.1016/j.freeradbiomed.2017.10.008.
94. Redox imbalance and mitochondrial abnormalities in the diabetic lung. Wu J, etal., Redox Biol. 2017 Apr;11:51-59. doi: 10.1016/j.redox.2016.11.003. Epub 2016 Nov 17.
95. Carthamus red from Carthamus tinctorius L. exerts antioxidant and hepatoprotective effect against CCl(4)-induced liver damage in rats via the Nrf2 pathway. Wu S, etal., J Ethnopharmacol. 2013 Jul 9;148(2):570-8. doi: 10.1016/j.jep.2013.04.054. Epub 2013 May 14.
96. MicroRNA-27b inhibition promotes Nrf2/ARE pathway activation and alleviates intracerebral hemorrhage-induced brain injury. Xu W, etal., Oncotarget. 2017 Aug 7;8(41):70669-70684. doi: 10.18632/oncotarget.19974. eCollection 2017 Sep 19.
97. High risk of 'de novo' acute myeloid leukaemia in individuals with cytochrome P450 A1 (CYP1A1) and NAD(P)H:quinone oxidoreductase 1 (NQO1) gene defects. Yamaguti GG, etal., Eur J Haematol. 2009 Sep;83(3):270-2. doi: 10.1111/j.1600-0609.2009.01272.x. Epub 2009 Apr 27.
98. Traumatic brain injury induces the activation of the Nrf2-ARE pathway in the lung in rats. Yan W, etal., Brain Inj. 2008 Sep;22(10):802-10.
99. L-cysteine administration attenuates pancreatic fibrosis induced by TNBS in rats by inhibiting the activation of pancreatic stellate cell. Yang L, etal., PLoS One. 2012;7(2):e31807. doi: 10.1371/journal.pone.0031807. Epub 2012 Feb 16.
100. Dioscin Protects ANIT-Induced Intrahepatic Cholestasis Through Regulating Transporters, Apoptosis and Oxidative Stress. Yao H, etal., Front Pharmacol. 2017 Mar 8;8:116. doi: 10.3389/fphar.2017.00116. eCollection 2017.
101. Propofol activation of the Nrf2 pathway is associated with amelioration of acute lung injury in a rat liver transplantation model. Yao W, etal., Oxid Med Cell Longev. 2014;2014:258567. doi: 10.1155/2014/258567. Epub 2014 Feb 11.
102. Ethanol-induced HO-1 and NQO1 are differentially regulated by HIF-1alpha and Nrf2 to attenuate inflammatory cytokine expression. Yeligar SM, etal., J Biol Chem. 2010 Nov 12;285(46):35359-73. Epub 2010 Sep 10.
103. Characterization of the Potent, Selective Nrf2 Activator, 3-(Pyridin-3-Ylsulfonyl)-5-(Trifluoromethyl)-2H-Chromen-2-One, in Cellular and In Vivo Models of Pulmonary Oxidative Stress. Yonchuk JG, etal., J Pharmacol Exp Ther. 2017 Oct;363(1):114-125. doi: 10.1124/jpet.117.241794. Epub 2017 Aug 8.
104. 4-hydroxybenzyl alcohol ameliorates cerebral injury in rats by antioxidant action. Yu SS, etal., Neurochem Res. 2011 Feb;36(2):339-46. Epub 2010 Dec 1.
105. High frequency of NAD(P)H:quinone oxidoreductase 1 (NQO1) C(609)T germline polymorphism in MDS/AML with trisomy 8. Zachaki S, etal., Leuk Res. 2013 Jul;37(7):742-6. doi: 10.1016/j.leukres.2013.04.015. Epub 2013 May 1.
106. Inhibition of urinary bladder carcinogenesis by aqueous extract of sclerotia of Polyporus umbellatus fries and polyporus polysaccharide. Zhang G, etal., Am J Chin Med. 2011;39(1):135-44.
107. Testosterone propionate activated the Nrf2-ARE pathway in ageing rats and ameliorated the age-related changes in liver. Zhang G, etal., Sci Rep. 2019 Dec 9;9(1):18619. doi: 10.1038/s41598-019-55148-0.
108. Dietary luteolin attenuates chronic liver injury induced by mercuric chloride via the Nrf2/NF-¿B/P53 signaling pathway in rats. Zhang H, etal., Oncotarget. 2017 Jun 20;8(25):40982-40993. doi: 10.18632/oncotarget.17334.
109. Recombinant human erythropoietin (rhEPO) alleviates early brain injury following subarachnoid hemorrhage in rats: possible involvement of Nrf2-ARE pathway. Zhang J, etal., Cytokine. 2010 Dec;52(3):252-7. doi: 10.1016/j.cyto.2010.08.011. Epub 2010 Sep 22.
110. Activation of Nrf2/ARE signaling pathway attenuates lanthanum chloride induced injuries in primary rat astrocytes. Zhang L, etal., Metallomics. 2017 Aug 16;9(8):1120-1131. doi: 10.1039/c7mt00182g.
111. Protective effect of dioscin against thioacetamide-induced acute liver injury via FXR/AMPK signaling pathway in vivo. Zheng L, etal., Biomed Pharmacother. 2018 Jan;97:481-488. doi: 10.1016/j.biopha.2017.10.153. Epub 2017 Nov 6.
112. Activation of the Nrf2/ARE signaling pathway by probucol contributes to inhibiting inflammation and neuronal apoptosis after spinal cord injury. Zhou Z, etal., Oncotarget. 2017 Jul 8;8(32):52078-52093. doi: 10.18632/oncotarget.19107. eCollection 2017 Aug 8.
113. The highly expressed and inducible endogenous NAD(P)H:quinone oxidoreductase 1 in cardiovascular cells acts as a potential superoxide scavenger. Zhu H, etal., Cardiovasc Toxicol. 2007;7(3):202-11.
114. S-Allylmercaptocysteine Attenuates  Cisplatin-Induced Nephrotoxicity through  Suppression of Apoptosis, Oxidative Stress, and  Inflammation. Zhu X, etal., Nutrients. 2017 Feb 20;9(2). pii: E166. doi: 10.3390/nu9020166.
115. Effects of Ethyl Pyruvate on Bile Duct Ligation-Induced Liver Fibrosis by Regulating Nrf2 Pathway and Proinflammatory Cytokines in Rats. Zong Y, etal., Gastroenterol Res Pract. 2019 Dec 20;2019:2969802. doi: 10.1155/2019/2969802. eCollection 2019.
Additional References at PubMed
PMID:1703398   PMID:1914521   PMID:2141979   PMID:2480957   PMID:2499768   PMID:2504488   PMID:2963593   PMID:3100515   PMID:3143406   PMID:3144286   PMID:3536915   PMID:7568029  
PMID:10903442   PMID:10945627   PMID:11740593   PMID:12477932   PMID:12634484   PMID:12663061   PMID:12699333   PMID:14564531   PMID:14980808   PMID:15288499   PMID:15386390   PMID:15489334  
PMID:15652701   PMID:16190898   PMID:16392039   PMID:16426587   PMID:17372386   PMID:17626271   PMID:18563540   PMID:18626777   PMID:19180910   PMID:19229058   PMID:19815007   PMID:19821077  
PMID:20593958   PMID:20594978   PMID:20732396   PMID:21636573   PMID:21781119   PMID:22028090   PMID:22031657   PMID:22073370   PMID:22154326   PMID:22658674   PMID:23376485   PMID:23420945  
PMID:23749777   PMID:24300172   PMID:24506563   PMID:24707733   PMID:24769487   PMID:24951727   PMID:25143260   PMID:25164943   PMID:27242267   PMID:28478529   PMID:29706024   PMID:29889218  
PMID:30062552   PMID:31227177   PMID:31915512   PMID:32685505   PMID:34817874   PMID:37002649   PMID:37285672  


Genomics

Comparative Map Data
Nqo1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81952,205,374 - 52,220,267 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1952,205,314 - 52,220,260 (-)EnsemblGRCr8
mRatBN7.21935,295,633 - 35,310,528 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1935,295,573 - 35,310,557 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1942,111,093 - 42,125,986 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01942,764,452 - 42,779,347 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01945,069,378 - 45,085,238 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01938,422,210 - 38,437,103 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1938,422,164 - 38,437,180 (+)Ensemblrn6Rnor6.0
Rnor_5.01949,291,903 - 49,306,856 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41937,251,147 - 37,266,040 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1934,717,059 - 34,731,947 (-)NCBICelera
RGSC_v3.11937,255,967 - 37,270,906 (-)NCBI
Cytogenetic Map19q12NCBI
NQO1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381669,709,401 - 69,726,560 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1669,706,996 - 69,726,668 (-)Ensemblhg38GRCh38
GRCh371669,743,304 - 69,760,463 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361668,300,805 - 68,318,034 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341668,300,809 - 68,317,893NCBI
Celera1654,257,766 - 54,274,991 (-)NCBICelera
Cytogenetic Map16q22.1NCBI
HuRef1655,621,397 - 55,638,606 (-)NCBIHuRef
CHM1_11671,151,192 - 71,168,417 (-)NCBICHM1_1
T2T-CHM13v2.01675,511,583 - 75,528,719 (-)NCBIT2T-CHM13v2.0
Nqo1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398108,114,856 - 108,139,012 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8108,114,857 - 108,129,838 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm388107,388,225 - 107,403,205 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8107,388,225 - 107,403,206 (-)Ensemblmm10GRCm38
MGSCv378109,912,125 - 109,927,105 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv368110,277,349 - 110,292,395 (-)NCBIMGSCv36mm8
Celera8111,617,929 - 111,633,856 (-)NCBICelera
Cytogenetic Map8D3NCBI
cM Map854.08NCBI
Nqo1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554847,012,506 - 7,027,604 (+)Ensembl
ChiLan1.0NW_0049554847,012,373 - 7,028,182 (+)NCBIChiLan1.0ChiLan1.0
NQO1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21879,260,777 - 79,276,881 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11685,172,915 - 85,188,752 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01650,090,696 - 50,106,495 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11669,472,529 - 69,489,731 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1669,470,288 - 69,489,731 (-)EnsemblpanPan2panpan1.1
NQO1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1579,979,593 - 79,990,875 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl579,978,865 - 79,989,860 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha579,968,342 - 79,979,690 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0580,409,927 - 80,421,414 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl580,409,969 - 80,420,809 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1580,237,718 - 80,249,198 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0579,927,217 - 79,938,546 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0580,560,166 - 80,571,660 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nqo1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934939,803,797 - 39,817,919 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647519,769,488 - 19,785,311 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647519,771,384 - 19,785,034 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NQO1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl617,292,770 - 17,302,590 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1617,292,962 - 17,302,593 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2616,238,853 - 16,248,813 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NQO1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1557,676,547 - 57,695,434 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl557,675,981 - 57,716,599 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604720,406,748 - 20,425,872 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nqo1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474616,684,407 - 16,697,479 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474616,684,620 - 16,698,194 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Nqo1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11727,113,177 - 27,129,220 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Nqo1
218 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:384
Count of miRNA genes:216
Interacting mature miRNAs:254
Transcripts:ENSRNOT00000017174
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19799775052997750Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)191922068964220689Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19799775052997750Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)194622677874246245Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)193236531174246245Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)192409397369093973Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat
2303628Vencon9Ventilatory control QTL 90.005respiration trait (VT:0001943)minute ventilation (CMO:0000132)192318858668188586Rat
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194438513474246245Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)193253961574246245Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19799775052997750Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19799775052997750Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)193177788874246245Rat
1554318Bmd5Bone mineral density QTL 512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)192318858668188586Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)192010930665109306Rat
1354607Gmadr1Adrenal mass QTL 15.83adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)194072709254856850Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
1354600Salc2Saline consumption QTL 29.910.001drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)194072709254856850Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)194172254674246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat
1354633Bw28Body weight QTL 286.04body mass (VT:0001259)body weight (CMO:0000012)194072709254856850Rat

Markers in Region
RH128318  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21935,295,622 - 35,295,816 (-)MAPPERmRatBN7.2
Rnor_6.01938,436,920 - 38,437,113NCBIRnor6.0
Rnor_5.01949,306,613 - 49,306,806UniSTSRnor5.0
RGSC_v3.41937,251,137 - 37,251,330UniSTSRGSC3.4
Celera1934,717,049 - 34,717,242UniSTS
RH 3.4 Map19314.8UniSTS
Cytogenetic Map19q12UniSTS


Related Rat Strains
The following Strains have been annotated to Nqo1
WF.DA-(D19Mit1-D19Mit6)/Kop    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000017174   ⟹   ENSRNOP00000017175
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1952,205,314 - 52,220,260 (-)Ensembl
mRatBN7.2 Ensembl1935,295,640 - 35,310,549 (-)Ensembl
Rnor_6.0 Ensembl1938,422,164 - 38,437,180 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112166   ⟹   ENSRNOP00000082814
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1935,295,573 - 35,310,557 (-)Ensembl
RefSeq Acc Id: NM_017000   ⟹   NP_058696
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81952,205,374 - 52,220,267 (-)NCBI
mRatBN7.21935,295,633 - 35,310,528 (-)NCBI
Rnor_6.01938,422,210 - 38,437,103 (+)NCBI
Rnor_5.01949,291,903 - 49,306,856 (+)NCBI
RGSC_v3.41937,251,147 - 37,266,040 (-)RGD
Celera1934,717,059 - 34,731,947 (-)RGD
Sequence:
RefSeq Acc Id: NP_058696   ⟸   NM_017000
- UniProtKB: Q63478 (UniProtKB/Swiss-Prot),   P05982 (UniProtKB/Swiss-Prot),   A6IZ00 (UniProtKB/TrEMBL),   A0A8L2UJ69 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000017175   ⟸   ENSRNOT00000017174
Ensembl Acc Id: ENSRNOP00000082814   ⟸   ENSRNOT00000112166
Protein Domains
Flavodoxin-like fold

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P05982-F1-model_v2 AlphaFold P05982 1-274 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701110
Promoter ID:EPDNEW_R11634
Type:single initiation site
Name:Nqo1_1
Description:NADH quinone dehydrogenase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01938,422,181 - 38,422,241EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2503 AgrOrtholog
BioCyc Gene G2FUF-5759 BioCyc
BioCyc Pathway PWY-7279 [aerobic respiration II (cytochrome c) (yeast)] BioCyc
  PWY-7999 [vitamin K-epoxide cycle] BioCyc
BioCyc Pathway Image PWY-7279 BioCyc
  PWY-7999 BioCyc
Ensembl Genes ENSRNOG00000012772 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000017174 ENTREZGENE
  ENSRNOT00000112166.1 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.360 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7190779 IMAGE-MGC_LOAD
InterPro Flavodoxin_fold UniProtKB/Swiss-Prot
  Flavoprotein-like_sf UniProtKB/Swiss-Prot
  NAD(P)H_dehydrogenase_qn UniProtKB/Swiss-Prot
KEGG Report rno:24314 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93075 IMAGE-MGC_LOAD
NCBI Gene 24314 ENTREZGENE
PANTHER NAD P H OXIDOREDUCTASE-RELATED UniProtKB/Swiss-Prot
  NAD(P)H DEHYDROGENASE [QUINONE] 1 UniProtKB/Swiss-Prot
Pfam Flavodoxin_2 UniProtKB/Swiss-Prot
PharmGKB NQO1 RGD
PhenoGen Nqo1 PhenoGen
RatGTEx ENSRNOG00000012772 RatGTEx
Superfamily-SCOP SSF52218 UniProtKB/Swiss-Prot
UniProt A0A8L2UJ69 ENTREZGENE, UniProtKB/TrEMBL
  A6IZ00 ENTREZGENE, UniProtKB/TrEMBL
  NQO1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q63478 ENTREZGENE
UniProt Secondary Q63478 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-29 Nqo1  NAD(P)H quinone dehydrogenase 1  Nqo1  NAD(P)H dehydrogenase, quinone 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Nqo1  NAD(P)H dehydrogenase, quinone 1  Dia4  Diaphorase (NADH/NADPH)  Symbol and Name updated 625702 APPROVED
2002-06-10 Dia4  Diaphorase (NADH/NADPH)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process induction of activity results in increased neuronal damage following cerebral ischaemia 727509