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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2503
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nqo1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:194147
Term: aristolochic acids
Definition: Organic heterotetracyclic compounds which are a group of nitro phenanthrene organic acids, naturally found in many kinds of plants, such as Aristolochia and Asarum, and widely cultivated in Asia.They are identified as a class 1 human carcinogen by the International Agency for Research on Cancer owing to their carcinogenicity and nephrotoxicity and can pose a significant hazard to food safety and human health.
Chemical ID: MESH:D034341
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nqo1decreases expressionEXP 6480464CTDAristolochic Acids results in decreased expression of NQO1 mRNA; Aristolochic Acids results in decreased expression of NQO1 proteinPMID:19717638 PMID:32660364
Nqo1multiple interactionsEXP 6480464CTDNFE2L2 protein affects the reaction [Aristolochic Acids results in decreased expression of NQO1 protein]PMID:32660364
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