GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nqo1 | multiple interactions | EXP | | 6480464 | CTD | [[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of NQO1 protein; [Antagomirs results in decreased expression of MIR30C1 mRNA] inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of NQO1 protein]; [Antagomirs results in decreased expression of MIR30C1 mRNA] inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of NQO1 protein]; [Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of NQO1 protein; [Oxygen deficiency co-treated with Glucose deficiency] results in decreased expression of NQO1 mRNA; [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of NQO1 mRNA; [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of NQO1 protein; [Oxygen deficiency co-treated with Oxygen] results in increased expression of NQO1 protein; diosmetin promotes the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of NQO1 protein]; diosmetin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of NQO1 mRNA]; diosmetin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of NQO1 protein]; GSK3B protein inhibits the reaction [MIR135A mRNA inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in decreased expression of NQO1 mRNA]]; MIR135A mRNA inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in decreased expression of NQO1 mRNA]; MIR30C1 mRNA promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of NQO1 protein]; MIR30C1 mRNA promotes the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of NQO1 protein]; PHLDA3 protein inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of NQO1 protein]; PHLDA3 protein inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of NQO1 protein] | PMID:29719095 PMID:34217758 PMID:34351043 PMID:35191607 | Nqo1 | affects expression | ISO | Nqo1 (Mus musculus) | 6480464 | CTD | Oxygen deficiency affects the expression of NQO1 mRNA | PMID:25448280 | Nqo1 | decreases expression | ISO | Nqo1 (Mus musculus) | 6480464 | CTD | Oxygen deficiency results in decreased expression of NQO1 mRNA; Oxygen deficiency results in decreased expression of NQO1 protein | PMID:30096613 | Nqo1 | decreases expression | ISO | NQO1 (Homo sapiens) | 6480464 | CTD | Oxygen deficiency results in decreased expression of NQO1 mRNA | PMID:25596134 PMID:26516004 | Nqo1 | increases expression | ISO | Nqo1 (Mus musculus) | 6480464 | CTD | Oxygen deficiency results in increased expression of NQO1 mRNA; Oxygen results in increased expression of NQO1 mRNA; Oxygen results in increased expression of NQO1 protein | PMID:21745492 PMID:23337360 PMID:26272953 PMID:29180065 PMID:29939353 PMID:31610156 | Nqo1 | increases expression | ISO | NQO1 (Homo sapiens) | 6480464 | CTD | Oxygen deficiency results in increased expression of NQO1 mRNA; Oxygen results in increased expression of NQO1 mRNA; Oxygen results in increased expression of NQO1 protein | PMID:25831079 PMID:29966676 | Nqo1 | multiple interactions | ISO | Nqo1 (Mus musculus) | 6480464 | CTD | [beta-Naphthoflavone results in increased expression of NQO1 protein] inhibits the reaction [CYP1A1 gene mutant form results in increased susceptibility to Oxygen]; [beta-Naphthoflavone results in increased expression of NQO1 protein] which results in decreased susceptibility to Oxygen; [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of NQO1 mRNA; [Oxygen deficiency co-treated with Oxygen] results in increased expression of NQO1 mRNA; [Quercetin co-treated with Oxygen] results in increased expression of NQO1 mRNA; [Quercetin co-treated with Oxygen] results in increased expression of NQO1 protein; AHR protein affects the reaction [Oxygen results in increased expression of NQO1 protein]; beta-Naphthoflavone affects the reaction [Oxygen results in increased expression of NQO1 mRNA]; beta-Naphthoflavone promotes the reaction [Oxygen results in increased expression of NQO1 mRNA]; beta-Naphthoflavone promotes the reaction [Oxygen results in increased expression of NQO1 protein]; HIPK2 protein promotes the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of NQO1 mRNA]; MIR144 mRNA inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of NQO1 mRNA]; Omeprazole inhibits the reaction [Oxygen results in increased expression of NQO1 mRNA]; Omeprazole inhibits the reaction [Oxygen results in increased expression of NQO1 protein]; Oxygen inhibits the reaction [beta-Naphthoflavone results in increased expression of NQO1 protein]; Oxygen promotes the reaction [beta-Naphthoflavone results in increased expression of NQO1 mRNA]; PHLPP2 protein inhibits the reaction [Oxygen deficiency results in increased expression of NQO1 mRNA]; sulforaphane inhibits the reaction [Oxygen deficiency results in decreased expression of NQO1 mRNA]; sulforaphane inhibits the reaction [Oxygen deficiency results in decreased expression of NQO1 protein] | PMID:21745492 PMID:23337360 PMID:25922074 PMID:26272953 PMID:28201809 PMID:29180065 PMID:29432836 PMID:29457851 PMID:30096613 PMID:31610156 PMID:31837296 | Nqo1 | multiple interactions | ISO | NQO1 (Homo sapiens) | 6480464 | CTD | [CYP1A2 gene mutant form results in increased susceptibility to Oxygen] which results in increased expression of NQO1 mRNA; [Oxygen deficiency co-treated with Mitomycin] results in decreased activity of NQO1 protein; [Tetrachlorodibenzodioxin co-treated with Mitomycin co-treated with Oxygen deficiency] affects the activity of NQO1 protein; AHR mutant form inhibits the reaction [Oxygen results in increased expression of NQO1 mRNA]; AHR mutant form inhibits the reaction [Oxygen results in increased expression of NQO1 protein]; CYP1A2 gene mutant form inhibits the reaction [Oxygen promotes the reaction [beta-Naphthoflavone results in increased expression of NQO1 protein]] | PMID:16226770 PMID:25831079 PMID:29180065 | | ||||||||||||||||||||||
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