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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2503
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nqo1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:17642
Term: pentachlorophenol
Definition: A chlorophenol that is phenol substituted by 5 chloro groups.
Chemical ID: MESH:D010416
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nqo1increases expressionISONqo1 (Mus musculus)6480464CTDPentachlorophenol results in increased expression of NQO1 mRNAPMID:22972318 PMID:23892564
Nqo1multiple interactionsISONQO1 (Homo sapiens)6480464CTD[Pentachlorophenol co-treated with copper-1,10-phenanthroline] results in decreased expression of NQO1 mRNA; XIAP protein inhibits the reaction [[Pentachlorophenol co-treated with copper-1,10-phenanthroline] results in decreased expression of NQO1 mRNA]PMID:30590774
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