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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2503
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nqo1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:39421
Term: perfluorooctane-1-sulfonic acid
Definition: A perfluoroalkanesulfonic acid that is octane-1-sulfonic acid in which all seventeen of the hydrogens that are attached to carbons hvae been replaced by fluorines.
Chemical ID: MESH:C076994
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nqo1affects expressionEXP 6480464CTDperfluorooctane sulfonic acid affects the expression of NQO1 mRNAPMID:17383973
Nqo1decreases expressionEXP 6480464CTDperfluorooctane sulfonic acid results in decreased expression of NQO1 mRNA; perfluorooctane sulfonic acid results in decreased expression of NQO1 proteinPMID:18692542 PMID:26844784
Nqo1decreases expressionISONQO1 (Homo sapiens)6480464CTDperfluorooctane sulfonic acid results in decreased expression of NQO1 proteinPMID:26844784
Nqo1increases expressionISONqo1 (Mus musculus)6480464CTDperfluorooctane sulfonic acid results in increased expression of NQO1 mRNA; perfluorooctane sulfonic acid results in increased expression of NQO1 proteinPMID:26548598 PMID:32979393 PMID:33096110 PMID:36321694
Nqo1increases expressionISONQO1 (Homo sapiens)6480464CTDperfluorooctane sulfonic acid results in increased expression of NQO1 mRNAPMID:35337807
Nqo1multiple interactionsISONqo1 (Mus musculus)6480464CTD[3,4,5,3',4'-pentachlorobiphenyl co-treated with perfluorooctane sulfonic acid] results in increased expression of NQO1 mRNA; [Dietary Fats co-treated with perfluorooctane sulfonic acid] results in increased expression of NQO1 mRNA; [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of NQO1 mRNA; [perfluorooctane sulfonic acid co-treated with Dietary Fats co-treated with Dietary Carbohydrates] results in increased expression of NQO1 mRNA; [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of NQO1 mRNA; [perfluorooctane sulfonic acid co-treated with Pectins] results in increased expression of NQO1 mRNA; perfluorooctane sulfonic acid inhibits the reaction [NFE2L2 protein binds to NQO1 promoter]PMID:26548598 PMID:32979393 PMID:32991729 PMID:33096110 PMID:36331819
Nqo1multiple interactionsISONQO1 (Homo sapiens)6480464CTDMIR155 mRNA promotes the reaction [perfluorooctane sulfonic acid results in decreased expression of and affects the localization of and results in decreased activity of NQO1 protein]; MIR155 mRNA promotes the reaction [perfluorooctane sulfonic acid results in decreased expression of NQO1 protein]PMID:26844784
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