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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2503
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nqo1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:28619
Term: acrylamide
Definition: A member of the class of acrylamides that results from the formal condensation of acrylic acid with ammonia.
Chemical ID: MESH:D020106
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nqo1increases expressionEXP 6480464CTDAcrylamide results in increased expression of NQO1 mRNA; Acrylamide results in increased expression of NQO1 proteinPMID:28959563 PMID:29426002
Nqo1multiple interactionsEXP 6480464CTD4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Acrylamide results in increased expression of NQO1 mRNA]; pyrazolanthrone inhibits the reaction [Acrylamide results in increased expression of NQO1 mRNA]; U 0126 inhibits the reaction [Acrylamide results in increased expression of NQO1 mRNA]PMID:29426002
Nqo1decreases expressionISONQO1 (Homo sapiens)6480464CTDAcrylamide results in decreased expression of NQO1 mRNAPMID:28159594
Nqo1increases expressionISONqo1 (Mus musculus)6480464CTDAcrylamide results in increased expression of NQO1 mRNA; Acrylamide results in increased expression of NQO1 proteinPMID:27836571 PMID:28526328 PMID:33872730
Nqo1increases expressionISONQO1 (Homo sapiens)6480464CTDAcrylamide results in increased expression of NQO1 mRNAPMID:32763439
Nqo1multiple interactionsISONqo1 (Mus musculus)6480464CTD[NLRP3 gene mutant form affects the susceptibility to Acrylamide] which results in increased expression of NQO1 proteinPMID:32014472
Nqo1multiple interactionsISONQO1 (Homo sapiens)6480464CTDsalvin inhibits the reaction [Acrylamide results in decreased expression of NQO1 mRNA]PMID:28159594
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