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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2503
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nqo1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:75142
Term: N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal
Definition: A tripeptide that is L-leucyl-L-leucyl-L-leucine in which the C-terminal carboxy group has been reduced to the corresponding aldehyde and the N-terminal amino group is protected as its benzyloxycarbonyl derivative.
Chemical ID: MESH:C072553
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nqo1increases expressionEXP 6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of NQO1 proteinPMID:22606287
Nqo1increases expressionISONqo1 (Mus musculus)6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of NQO1 mRNAPMID:20061341
Nqo1increases expressionISONQO1 (Homo sapiens)6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of NQO1 mRNA; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of NQO1 proteinPMID:33434570
Nqo1multiple interactionsISONqo1 (Mus musculus)6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cycloheximide inhibits the reaction [Lead results in increased expression of NQO1 mRNA]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cycloheximide inhibits the reaction [Mercury results in increased expression of NQO1 mRNA]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 mRNA]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cycloheximide promotes the reaction [Copper results in decreased expression of NQO1 mRNA]]PMID:16243960
Nqo1multiple interactionsISONQO1 (Homo sapiens)6480464CTD[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of NQO1 mRNA; [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of NQO1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [NFE2L2 protein binds to NQO1 promoter]PMID:30186748 PMID:33434570
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