GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nqo1 | affects expression | EXP | | 6480464 | CTD | Paraquat affects the expression of NQO1 mRNA | PMID:16854511 | Nqo1 | decreases expression | EXP | | 6480464 | CTD | Paraquat results in decreased expression of NQO1 protein | PMID:35707280 | Nqo1 | increases activity | EXP | | 6480464 | CTD | Paraquat results in increased activity of NQO1 protein | PMID:10699569 PMID:25169090 | Nqo1 | increases expression | EXP | | 6480464 | CTD | Paraquat results in increased expression of NQO1 mRNA; Paraquat results in increased expression of NQO1 protein | PMID:16328009 PMID:17935786 PMID:22846377 PMID:24812154 PMID:32680482 | Nqo1 | multiple interactions | EXP | | 6480464 | CTD | [Mifepristone co-treated with Paraquat] results in increased expression of NQO1 mRNA; Curcumin inhibits the reaction [Paraquat results in increased activity of NQO1 protein]; ginkgolide C inhibits the reaction [Paraquat results in decreased expression of NQO1 protein]; NFE2L2 protein promotes the reaction [[Mifepristone co-treated with Paraquat] results in increased expression of NQO1 mRNA] | PMID:24812154 PMID:25169090 PMID:35707280 | Nqo1 | decreases expression | ISO | Nqo1 (Mus musculus) | 6480464 | CTD | Paraquat results in decreased expression of NQO1 mRNA | PMID:30562684 PMID:33838153 | Nqo1 | decreases expression | ISO | NQO1 (Homo sapiens) | 6480464 | CTD | Paraquat results in decreased expression of NQO1 mRNA | PMID:24866057 | Nqo1 | increases expression | ISO | Nqo1 (Mus musculus) | 6480464 | CTD | Paraquat results in increased expression of NQO1 mRNA | PMID:27788593 PMID:31216030 | Nqo1 | increases expression | ISO | NQO1 (Homo sapiens) | 6480464 | CTD | Paraquat results in increased expression of NQO1 mRNA; Paraquat results in increased expression of NQO1 protein | PMID:17409708 PMID:22493042 PMID:22709784 PMID:23546295 PMID:26649146 PMID:34097952 | Nqo1 | multiple interactions | ISO | Nqo1 (Mus musculus) | 6480464 | CTD | [ABCB1A gene mutant form results in increased susceptibility to Paraquat] which results in increased expression of NQO1 mRNA; [ABCB1B gene mutant form results in increased susceptibility to Paraquat] which results in increased expression of NQO1 mRNA; Paraquat inhibits the reaction [2-tert-butylhydroquinone results in increased expression of NQO1 mRNA]; resolvin D1 analog inhibits the reaction [Paraquat results in decreased expression of NQO1 mRNA]; rhyncophylline inhibits the reaction [Paraquat results in decreased expression of NQO1 mRNA]; SIRT6 promotes the reaction [Paraquat results in increased expression of NQO1 mRNA] | PMID:25015657 PMID:30562684 PMID:31216030 PMID:31368498 PMID:33838153 | Nqo1 | multiple interactions | ISO | NQO1 (Homo sapiens) | 6480464 | CTD | [Paraquat co-treated with Ellagic Acid] results in increased expression of NQO1 mRNA; [Paraquat co-treated with Ellagic Acid] results in increased expression of NQO1 protein; [Paraquat co-treated with naringenin] results in increased expression of NQO1 mRNA; [Paraquat co-treated with Thioctic Acid] results in increased expression of NQO1 mRNA; [Paraquat co-treated with Thioctic Acid] results in increased expression of NQO1 protein; [Plant Extracts co-treated with Paraquat] results in increased expression of NQO1 mRNA; [Silymarin co-treated with Paraquat] results in increased expression of NQO1 mRNA; Resveratrol promotes the reaction [Paraquat results in increased expression of NQO1 mRNA]; Silymarin promotes the reaction [Paraquat results in increased expression of NQO1 protein] | PMID:22493042 PMID:22709784 PMID:23546295 PMID:23649336 PMID:24141985 PMID:24561720 | | ||||||||||||||||||||||
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