GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nqo1 | increases abundance | ISO | NQO1 (Homo sapiens) | 6480464 | CTD | NQO1 protein results in increased abundance of tanespimycin; NQO1 protein results in increased abundance of tanespimycin metabolite | PMID:21156818 | Nqo1 | increases reduction | ISO | NQO1 (Homo sapiens) | 6480464 | CTD | NQO1 protein results in increased reduction of tanespimycin | PMID:21156818 PMID:24552538 | Nqo1 | increases response to substance | ISO | NQO1 (Homo sapiens) | 6480464 | CTD | NQO1 protein results in increased susceptibility to tanespimycin | PMID:10564678 PMID:21156818 | Nqo1 | multiple interactions | ISO | NQO1 (Homo sapiens) | 6480464 | CTD | [5-methoxy-1,2-dimethyl-3-((4-nitrophenoxy)methyl)indole-4,7-dione results in decreased activity of NQO1 protein] which results in decreased abundance of tanespimycin; [5-methoxy-1,2-dimethyl-3-((4-nitrophenoxy)methyl)indole-4,7-dione results in decreased activity of NQO1 protein] which results in decreased abundance of tanespimycin metabolite; [5-methoxy-1,2-dimethyl-3-((4-nitrophenoxy)methyl)indole-4,7-dione results in decreased activity of NQO1 protein] which results in decreased susceptibility to tanespimycin; [NQO1 protein results in increased reduction of tanespimycin] which results in increased chemical synthesis of tanespimycin metabolite; [tanespimycin co-treated with NQO1 protein] results in decreased expression of CDC25C protein; [tanespimycin co-treated with NQO1 protein] results in decreased expression of CDK1 protein | PMID:21156818 | | ||||||||||||||||||||||
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