RGD Reference Report - Antifibrogenic effect of melatonin in rats with experimental liver cirrhosis induced by carbon tetrachloride. - Rat Genome Database

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Antifibrogenic effect of melatonin in rats with experimental liver cirrhosis induced by carbon tetrachloride.

Authors: Bona, Silvia  Rodrigues, Graziella  Moreira, Andrea J  Di Naso, Fábio C  Dias, Alexandre S  Da Silveira, Thêmis R  Marroni, Claudio A  Marroni, Norma P 
Citation: Bona S, etal., JGH Open. 2018 May 24;2(4):117-123. doi: 10.1002/jgh3.12055. eCollection 2018 Aug.
RGD ID: 25823191
Pubmed: PMID:30483575   (View Abstract at PubMed)
PMCID: PMC6206983   (View Article at PubMed Central)
DOI: DOI:10.1002/jgh3.12055   (Journal Full-text)


Background and Aim: Liver diseases are a major public health problem, accounting for a significant number of hospital visits and admissions and an increasing mortality rate. Melatonin (MLT) is a powerful antioxidant molecule that has been shown to be beneficial under various conditions. The objective was to evaluate the effect of MLT on experimental liver cirrhosis induced by carbon tetrachloride (CCl4) in rats.
Methods: Twenty male Wistar rats (230-250 g) were divided into four groups. I: control group (CO); II: CO + MLT; III: CCl4; and IV: CCl4 + MLT. CCl4 was administered intraperitoneally (i.p.) as follows: 10 doses every 5 days, 10 doses every 4 days, and 7 doses every 3 days. MLT was administered i.p. at a dose of 20 mg/kg from the 10th week to the end of the experiment (16th week).
Results: In the CCl4 + MLT group, we found that MLT caused a decrease in the level of F2-isoprostanes and NQO1 expression. We also found that MLT reduced the inflammatory process as shown by decreased expressions of NF-KB/p65 and inducible nitric oxide synthase (iNOS) and a smaller amount of inflammatory infiltrate. MLT reduced the expression of transforming growth factor beta1 (TGF-β1), alpha-smooth muscle actin (α-SMA), and vascular endothelial growth factor (VEGF). Picrosirius staining showed that MLT decreases fibrosis.
Conclusion: MLT has a potent antifibrogenic effect, modulating the parameters of oxidative stress, angiogenesis, and inflammation.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to hormone  IEP 25823191MelatoninRGD 
response to tetrachloromethane  IEP 25823191 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Nqo1  (NAD(P)H quinone dehydrogenase 1)


Additional Information