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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2503
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nqo1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:77319
Term: oltipraz
Definition: A 1,2-dithiole that is 3H-1,2-dithiole-3-thione substituted at positions 4 and 5 by methyl and pyrazin-2-yl groups respectively.
Chemical ID: MESH:C026209
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nqo1increases activityISONQO1 (Homo sapiens)6480464CTDoltipraz results in increased activity of NQO1 proteinPMID:12407167
Nqo1increases expressionISONqo1 (Mus musculus)6480464CTDoltipraz metabolite results in increased expression of NQO1 protein; oltipraz results in increased expression of NQO1 mRNA; oltipraz results in increased expression of NQO1 proteinPMID:11309284 PMID:15919853 PMID:17627975 PMID:18488193 PMID:19144771 PMID:19785463 PMID:22496397 PMID:30114225
Nqo1multiple interactionsISONqo1 (Mus musculus)6480464CTD[oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of NQO1 mRNA; NFE2L2 protein affects the reaction [oltipraz results in increased expression of NQO1 mRNA]; NFE2L2 protein promotes the reaction [oltipraz results in increased expression of NQO1 mRNA]; oltipraz promotes the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NQO1 mRNA]PMID:18488193 PMID:22496397 PMID:30114225
Nqo1multiple interactionsISONQO1 (Homo sapiens)6480464CTDoltipraz promotes the reaction [Cisplatin results in increased expression of NQO1 mRNA]PMID:28959534
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