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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2503
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nqo1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:36904
Term: elemental selenium
Definition: null
Chemical ID: MESH:D012643
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nqo1increases expressionEXP 6480464CTDSelenium deficiency results in increased expression of NQO1 mRNAPMID:11444866
Nqo1multiple interactionsEXP 6480464CTD[Selenium deficiency co-treated with Vitamin E deficiency] results in increased expression of NQO1 mRNA; Selenium promotes the reaction [Plant Extracts results in increased activity of NQO1 protein]PMID:11444866 PMID:19650632
Nqo1affects activityISONqo1 (Mus musculus)6480464CTDSelenium affects the activity of NQO1 proteinPMID:18279678
Nqo1decreases activityISONqo1 (Mus musculus)6480464CTDSelenium results in decreased activity of NQO1 proteinPMID:28810182
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