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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2503
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nqo1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:9287
Term: streptonigrin
Definition: Complex cytotoxic antibiotic obtained from Streptomyces flocculus or S. rufochronmogenus. It is used in advanced carcinoma and causes leukopenia.
Chemical ID: MESH:D013308
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nqo1increases response to substanceISONQO1 (Homo sapiens)6480464CTDNQO1 protein results in increased susceptibility to StreptonigrinPMID:10368308 PMID:8615901
Nqo1multiple interactionsISONQO1 (Homo sapiens)6480464CTD[Dicumarol results in decreased activity of NQO1 protein] which results in decreased susceptibility to Streptonigrin; [Dimethyl Fumarate results in increased activity of NQO1 protein] which results in increased susceptibility to StreptonigrinPMID:15655414
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