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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2503
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nqo1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:77323
Term: ethoxyquin
Definition: A quinoline that is 1,2-dihydroquinoline bearing three methyl substituents at position 2, 2 and 4 as well as an ethoxy substituent at position 6.
Chemical ID: MESH:D005015
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nqo1increases activityEXP 6480464CTDEthoxyquin results in increased activity of NQO1 proteinPMID:16045903 PMID:16906435
Nqo1increases expressionEXP 6480464CTDEthoxyquin results in increased expression of NQO1 mRNAPMID:19695238
Nqo1multiple interactionsEXP 6480464CTDEthoxyquin promotes the reaction [Methylcholanthrene results in increased activity of NQO1 protein]; Methylcholanthrene promotes the reaction [Ethoxyquin results in increased activity of NQO1 protein]PMID:16906435
Nqo1increases expressionISONqo1 (Mus musculus)6480464CTDEthoxyquin results in increased expression of NQO1 mRNA; Ethoxyquin results in increased expression of NQO1 proteinPMID:11309284 PMID:15919853 PMID:17627975 PMID:19144771
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