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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2503
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nqo1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:29852
Term: methylarsonic acid
Definition: An arsonic acid that has formula CH5AsO3.
Chemical ID: MESH:C020300
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nqo1increases expressionISONQO1 (Homo sapiens)6480464CTDmonomethylarsonic acid results in increased expression of NQO1 mRNAPMID:24161444
Nqo1multiple interactionsISONQO1 (Homo sapiens)6480464CTDmonomethylarsonic acid promotes the reaction [sulforaphane results in increased expression of and results in increased activity of NQO1 protein]; monomethylarsonic acid promotes the reaction [sulforaphane results in increased expression of NQO1 mRNA]; monomethylarsonic acid promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of NQO1 protein]; monomethylarsonic acid promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 mRNA]; monomethylarsonic acid results in increased expression of and results in increased activity of NQO1 protein; NFE2L2 mutant form inhibits the reaction [monomethylarsonic acid results in increased expression of NQO1 protein]PMID:24161444
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