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ONTOLOGY REPORT - ANNOTATIONS


Term:pyrimidine nucleotide biosynthetic process
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Accession:GO:0006221 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
Synonyms:exact_synonym: pyrimidine nucleotide anabolism;   pyrimidine nucleotide biosynthesis;   pyrimidine nucleotide formation;   pyrimidine nucleotide synthesis


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pyrimidine nucleotide biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cmpk1 cytidine/uridine monophosphate kinase 1 IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 5:133,759,722...133,786,452
Ensembl chr 5:133,759,735...133,786,452
JBrowse link
'de novo' CTP biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctps1 CTP synthase 1 IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 5:139,475,934...139,505,065
Ensembl chr 5:139,475,934...139,505,065
JBrowse link
G Ctps2 CTP synthase 2 IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr  X:33,383,087...33,522,852
Ensembl chr  X:33,383,087...33,522,836
JBrowse link
'de novo' UMP biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cad carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 6:26,657,507...26,680,459
Ensembl chr 6:26,657,780...26,680,284
JBrowse link
G Dhodh dihydroorotate dehydrogenase (quinone) IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr19:42,066,103...42,087,906
Ensembl chr19:42,066,351...42,082,012
JBrowse link
G Umps uridine monophosphate synthetase IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr11:70,034,181...70,044,590
Ensembl chr11:70,034,139...70,044,628
JBrowse link
CDP biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cmpk1 cytidine/uridine monophosphate kinase 1 IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:3010881, PMID:21873635 RGD:5133253, RGD:13792537 NCBI chr 5:133,759,722...133,786,452
Ensembl chr 5:133,759,735...133,786,452
JBrowse link
CTP biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctps1 CTP synthase 1 ISO
IBA
(PMID:16179339), (PMID:24870241)
PMID:21873635
RGD PMID:16179339, PMID:24870241, PMID:21873635 RGD:13792537 NCBI chr 5:139,475,934...139,505,065
Ensembl chr 5:139,475,934...139,505,065
JBrowse link
G Ctps2 CTP synthase 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:33,383,087...33,522,852
Ensembl chr  X:33,383,087...33,522,836
JBrowse link
G Decr2 2,4-dienoyl-CoA reductase 2 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:15,451,850...15,460,227
Ensembl chr10:15,431,638...15,465,413
JBrowse link
G Nme1 NME/NM23 nucleoside diphosphate kinase 1 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:81,657,152...81,666,542
Ensembl chr10:81,657,153...81,666,523
JBrowse link
G Nme2 NME/NM23 nucleoside diphosphate kinase 2 IDA RGD PMID:1316151 RGD:729254 NCBI chr10:81,648,216...81,653,717
Ensembl chr10:81,648,216...81,653,717
JBrowse link
G Nme3 NME/NM23 nucleoside diphosphate kinase 3 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:14,258,232...14,259,365
Ensembl chr10:14,258,380...14,259,336
JBrowse link
G Nme4 NME/NM23 nucleoside diphosphate kinase 4 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:15,461,567...15,465,422
Ensembl chr10:15,431,638...15,465,413
JBrowse link
G Nme5 NME/NM23 family member 5 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr18:27,357,460...27,374,641
Ensembl chr18:27,357,413...27,374,603
JBrowse link
G Nme6 NME/NM23 nucleoside diphosphate kinase 6 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 8:117,920,912...117,928,148
Ensembl chr 8:117,920,944...117,928,195
JBrowse link
G Nme7 NME/NM23 family member 7 IEA GO_REF:0000002
GO_REF:0000104
InterPro
UniProt
GO_REF:0000002, GO_REF:0000104 NCBI chr13:82,607,844...82,737,383
Ensembl chr13:82,626,685...82,737,343
JBrowse link
CTP salvage term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Uck1 uridine-cytidine kinase 1 IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 3:11,271,874...11,277,757
Ensembl chr 3:11,271,885...11,277,757
JBrowse link
G Uck2 uridine-cytidine kinase 2 IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr13:85,376,716...85,443,976
Ensembl chr13:85,376,716...85,443,976
JBrowse link
G Uckl1 uridine-cytidine kinase 1-like 1 IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 3:177,066,022...177,078,611
Ensembl chr 3:177,066,014...177,078,594
JBrowse link
dCDP biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cmpk1 cytidine/uridine monophosphate kinase 1 IDA RGD PMID:192455 RGD:5133256 NCBI chr 5:133,759,722...133,786,452
Ensembl chr 5:133,759,735...133,786,452
JBrowse link
dTDP biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cmpk2 cytidine/uridine monophosphate kinase 2 IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:192455, PMID:21873635 RGD:5133256, RGD:13792537 NCBI chr 6:45,683,242...45,694,824
Ensembl chr 6:45,683,234...45,694,822
JBrowse link
G Dtymk deoxythymidylate kinase IDA
ISO
IBA
(MGI:77260|PMID:8845311)
PMID:21873635
RGD PMID:8845311, PMID:220041, PMID:21873635 MGI:77260, RGD:5133687, RGD:13792537 NCBI chr 9:100,921,565...100,930,399
Ensembl chr 9:100,921,565...100,930,399
JBrowse link
dTMP biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dctd dCMP deaminase IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr16:47,177,144...47,222,850
Ensembl chr16:47,177,145...47,208,110
JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 ISO (MGI:3849912|PMID:19513116) RGD PMID:19513116 MGI:3849912 NCBI chr10:47,030,813...47,059,216
Ensembl chr10:47,031,050...47,059,216
JBrowse link
G Tyms thymidylate synthetase IDA
IBA
ISO
PMID:21873635
(PMID:11278511), (PMID:15093541), (PMID:8845352)
RGD PMID:8845352, PMID:11278511, PMID:15093541, PMID:9894005, PMID:21873635 RGD:1545055, RGD:13792537 NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564
JBrowse link
dTTP biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cmpk2 cytidine/uridine monophosphate kinase 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:45,683,242...45,694,824
Ensembl chr 6:45,683,234...45,694,822
JBrowse link
G Dtymk deoxythymidylate kinase IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:220041, PMID:21873635 RGD:5133687, RGD:13792537 NCBI chr 9:100,921,565...100,930,399
Ensembl chr 9:100,921,565...100,930,399
JBrowse link
G Tbpl1 TATA-box binding protein like 1 ISO MGI:2182539 (MGI:2159505|PMID:11861477) RGD PMID:11861477 MGI:2159505 NCBI chr 1:23,977,154...24,002,512
Ensembl chr 1:23,977,688...24,002,506
JBrowse link
G Tyms thymidylate synthetase IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564
JBrowse link
dUDP biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cmpk1 cytidine/uridine monophosphate kinase 1 IDA RGD PMID:3010881 RGD:5133253 NCBI chr 5:133,759,722...133,786,452
Ensembl chr 5:133,759,735...133,786,452
JBrowse link
G Cmpk2 cytidine/uridine monophosphate kinase 2 IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:192455, PMID:21873635 RGD:5133256, RGD:13792537 NCBI chr 6:45,683,242...45,694,824
Ensembl chr 6:45,683,234...45,694,822
JBrowse link
G Dtymk deoxythymidylate kinase IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:100,921,565...100,930,399
Ensembl chr 9:100,921,565...100,930,399
JBrowse link
dUMP biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07001512.1 IBA
IEA
PMID:21873635
GO_REF:0000041
UniProt PMID:21873635 GO_REF:0000041, RGD:13792537 Ensembl chr 1:48,565,160...48,565,711 JBrowse link
G Dctd dCMP deaminase IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr16:47,177,144...47,222,850
Ensembl chr16:47,177,145...47,208,110
JBrowse link
G Dut deoxyuridine triphosphatase IDA
IBA
IEA
PMID:21873635
GO_REF:0000041
UniProt PMID:3032103, PMID:21873635, PMID:1315924 GO_REF:0000041, RGD:2300191, RGD:13792537, RGD:2301218 NCBI chr 3:117,514,399...117,525,450
Ensembl chr 3:117,514,444...117,525,446
JBrowse link
pyrimidine ribonucleotide biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhodh dihydroorotate dehydrogenase (quinone) IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:42,066,103...42,087,906
Ensembl chr19:42,066,351...42,082,012
JBrowse link
UDP biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cmpk1 cytidine/uridine monophosphate kinase 1 IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:3010881, PMID:21873635 RGD:5133253, RGD:13792537 NCBI chr 5:133,759,722...133,786,452
Ensembl chr 5:133,759,735...133,786,452
JBrowse link
UMP biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Umps uridine monophosphate synthetase IDA
IBA
ISO
PMID:21873635
(PMID:11730338), (PMID:6893554)
RGD PMID:6893554, PMID:11730338, PMID:6134725, PMID:21873635 RGD:5132277, RGD:13792537 NCBI chr11:70,034,181...70,044,590
Ensembl chr11:70,034,139...70,044,628
JBrowse link
G Uprt uracil phosphoribosyltransferase homolog IDA RGD PMID:1476792 RGD:5132591 NCBI chr  X:75,382,553...75,408,541
Ensembl chr  X:75,382,598...75,407,217
JBrowse link
UMP salvage term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Uck1 uridine-cytidine kinase 1 IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 3:11,271,874...11,277,757
Ensembl chr 3:11,271,885...11,277,757
JBrowse link
G Uck2 uridine-cytidine kinase 2 IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr13:85,376,716...85,443,976
Ensembl chr13:85,376,716...85,443,976
JBrowse link
G Uckl1 uridine-cytidine kinase 1-like 1 IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 3:177,066,022...177,078,611
Ensembl chr 3:177,066,014...177,078,594
JBrowse link
G Upp1 uridine phosphorylase 1 IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr14:89,314,234...89,334,060
Ensembl chr14:89,314,176...89,334,276
JBrowse link
G Upp2 uridine phosphorylase 2 IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 3:44,806,106...44,846,464
Ensembl chr 3:44,806,106...44,846,464
JBrowse link
UTP biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cad carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:10659854, PMID:21873635 RGD:2303528, RGD:13792537 NCBI chr 6:26,657,507...26,680,459
Ensembl chr 6:26,657,780...26,680,284
JBrowse link
G Decr2 2,4-dienoyl-CoA reductase 2 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:15,451,850...15,460,227
Ensembl chr10:15,431,638...15,465,413
JBrowse link
G Nme1 NME/NM23 nucleoside diphosphate kinase 1 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:81,657,152...81,666,542
Ensembl chr10:81,657,153...81,666,523
JBrowse link
G Nme2 NME/NM23 nucleoside diphosphate kinase 2 IDA RGD PMID:1316151 RGD:729254 NCBI chr10:81,648,216...81,653,717
Ensembl chr10:81,648,216...81,653,717
JBrowse link
G Nme3 NME/NM23 nucleoside diphosphate kinase 3 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:14,258,232...14,259,365
Ensembl chr10:14,258,380...14,259,336
JBrowse link
G Nme4 NME/NM23 nucleoside diphosphate kinase 4 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:15,461,567...15,465,422
Ensembl chr10:15,431,638...15,465,413
JBrowse link
G Nme5 NME/NM23 family member 5 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr18:27,357,460...27,374,641
Ensembl chr18:27,357,413...27,374,603
JBrowse link
G Nme6 NME/NM23 nucleoside diphosphate kinase 6 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 8:117,920,912...117,928,148
Ensembl chr 8:117,920,944...117,928,195
JBrowse link
G Nme7 NME/NM23 family member 7 IEA GO_REF:0000002
GO_REF:0000104
InterPro
UniProt
GO_REF:0000002, GO_REF:0000104 NCBI chr13:82,607,844...82,737,383
Ensembl chr13:82,626,685...82,737,343
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    metabolic process 12263
      cellular metabolic process 11073
        heterocycle metabolic process 5619
          heterocycle biosynthetic process 3961
            pyrimidine-containing compound biosynthetic process 31
              pyrimidine nucleotide biosynthetic process 28
                negative regulation of pyrimidine nucleotide biosynthetic process + 0
                positive regulation of pyrimidine nucleotide biosynthetic process 0
                pyrimidine deoxyribonucleotide biosynthetic process + 9
                pyrimidine nucleotide salvage + 5
                pyrimidine ribonucleotide biosynthetic process + 20
                regulation of pyrimidine nucleotide biosynthetic process + 0
Path 2
Term Annotations click to browse term
  biological_process 20020
    metabolic process 12263
      cellular metabolic process 11073
        cellular aromatic compound metabolic process 5700
          nucleobase-containing compound metabolic process 5488
            nucleobase-containing small molecule metabolic process 591
              nucleoside phosphate metabolic process 513
                nucleotide metabolic process 506
                  pyrimidine nucleotide metabolic process 35
                    pyrimidine nucleotide biosynthetic process 28
                      negative regulation of pyrimidine nucleotide biosynthetic process + 0
                      positive regulation of pyrimidine nucleotide biosynthetic process 0
                      pyrimidine deoxyribonucleotide biosynthetic process + 9
                      pyrimidine nucleotide salvage + 5
                      pyrimidine ribonucleotide biosynthetic process + 20
                      regulation of pyrimidine nucleotide biosynthetic process + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.