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ONTOLOGY REPORT - ANNOTATIONS


Term:pyrimidine nucleotide metabolic process
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Accession:GO:0006220 term browser browse the term
Definition:The chemical reactions and pathways involving a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
Synonyms:exact_synonym: pyrimidine nucleotide metabolism
 broad_synonym: pyrimidine metabolic process;   pyrimidine metabolism


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pyrimidine nucleotide metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dck deoxycytidine kinase IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:12808445)
Ensembl
UniProt
RGD
PMID:12808445 GO_REF:0000024, GO_REF:0000107 NCBI chr14:20,935,442...20,952,939
Ensembl chr14:20,935,369...20,953,095
JBrowse link
G Dctd dCMP deaminase IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr16:47,177,144...47,222,850
Ensembl chr16:47,177,145...47,208,110
JBrowse link
G Enpp3 ectonucleotide pyrophosphatase/phosphodiesterase 3 ISS
ISO
GO_REF:0000024
(PMID:11342463)
UniProt
RGD
PMID:11342463 GO_REF:0000024 NCBI chr 1:21,613,148...21,684,483
Ensembl chr 1:21,613,148...21,684,480
JBrowse link
G Upp1 uridine phosphorylase 1 ISO MGI:MGI:3586525 (MGI:MGI:3584214|PMID:15772079) RGD PMID:15772079 MGI:MGI:3584214 NCBI chr14:89,314,234...89,334,060
Ensembl chr14:89,314,176...89,334,276
JBrowse link
'de novo' CTP biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctps1 CTP synthase 1 IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 5:139,475,934...139,505,065
Ensembl chr 5:139,475,934...139,505,065
JBrowse link
G Ctps2 CTP synthase 2 IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr  X:33,383,087...33,522,852
Ensembl chr  X:33,383,087...33,522,836
JBrowse link
'de novo' UMP biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cad carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 6:26,657,507...26,680,459
Ensembl chr 6:26,657,780...26,680,284
JBrowse link
G Dhodh dihydroorotate dehydrogenase (quinone) IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr19:42,066,103...42,087,906
Ensembl chr19:42,066,351...42,082,012
JBrowse link
G Umps uridine monophosphate synthetase IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr11:70,034,181...70,044,590
Ensembl chr11:70,034,139...70,044,628
JBrowse link
CDP biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cmpk1 cytidine/uridine monophosphate kinase 1 IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:3010881, PMID:21873635 RGD:5133253, RGD:13792537 NCBI chr 5:133,759,722...133,786,452
Ensembl chr 5:133,759,735...133,786,452
JBrowse link
CTP biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctps1 CTP synthase 1 ISO
IBA
(PMID:16179339), (PMID:24870241)
PMID:21873635
RGD PMID:16179339, PMID:24870241, PMID:21873635 RGD:13792537 NCBI chr 5:139,475,934...139,505,065
Ensembl chr 5:139,475,934...139,505,065
JBrowse link
G Ctps2 CTP synthase 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:33,383,087...33,522,852
Ensembl chr  X:33,383,087...33,522,836
JBrowse link
G Decr2 2,4-dienoyl-CoA reductase 2 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:15,451,850...15,460,227
Ensembl chr10:15,431,638...15,465,413
JBrowse link
G Nme1 NME/NM23 nucleoside diphosphate kinase 1 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:81,657,152...81,666,542
Ensembl chr10:81,657,153...81,666,523
JBrowse link
G Nme2 NME/NM23 nucleoside diphosphate kinase 2 IDA RGD PMID:1316151 RGD:729254 NCBI chr10:81,648,216...81,653,717
Ensembl chr10:81,648,216...81,653,717
JBrowse link
G Nme3 NME/NM23 nucleoside diphosphate kinase 3 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:14,258,232...14,259,365
Ensembl chr10:14,258,380...14,259,336
JBrowse link
G Nme4 NME/NM23 nucleoside diphosphate kinase 4 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:15,461,567...15,465,422
Ensembl chr10:15,431,638...15,465,413
JBrowse link
G Nme5 NME/NM23 family member 5 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr18:27,357,460...27,374,641
Ensembl chr18:27,357,413...27,374,603
JBrowse link
G Nme6 NME/NM23 nucleoside diphosphate kinase 6 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 8:117,920,912...117,928,148
Ensembl chr 8:117,920,944...117,928,195
JBrowse link
G Nme7 NME/NM23 family member 7 IEA GO_REF:0000002
GO_REF:0000104
InterPro
UniProt
GO_REF:0000002, GO_REF:0000104 NCBI chr13:82,607,844...82,737,383
Ensembl chr13:82,626,685...82,737,343
JBrowse link
CTP salvage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Uck1 uridine-cytidine kinase 1 IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 3:11,271,874...11,277,757
Ensembl chr 3:11,271,885...11,277,757
JBrowse link
G Uck2 uridine-cytidine kinase 2 IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr13:85,376,716...85,443,976
Ensembl chr13:85,376,716...85,443,976
JBrowse link
G Uckl1 uridine-cytidine kinase 1-like 1 IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 3:177,066,022...177,078,611
Ensembl chr 3:177,066,014...177,078,594
JBrowse link
dCDP biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cmpk1 cytidine/uridine monophosphate kinase 1 IDA RGD PMID:192455 RGD:5133256 NCBI chr 5:133,759,722...133,786,452
Ensembl chr 5:133,759,735...133,786,452
JBrowse link
dCTP catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dctpp1 dCTP pyrophosphatase 1 ISO
IBA
ISS
(PMID:24467396)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:24467396, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 1:198,703,459...198,706,852
Ensembl chr 1:198,703,461...198,706,852
JBrowse link
dTDP biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cmpk2 cytidine/uridine monophosphate kinase 2 IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:192455, PMID:21873635 RGD:5133256, RGD:13792537 NCBI chr 6:45,683,242...45,694,824
Ensembl chr 6:45,683,234...45,694,822
JBrowse link
G Dtymk deoxythymidylate kinase IDA
IBA
ISO
PMID:21873635
(MGI:MGI:77260|PMID:8845311)
RGD PMID:8845311, PMID:220041, PMID:21873635 MGI:MGI:77260, RGD:5133687, RGD:13792537 NCBI chr 9:100,921,565...100,930,399
Ensembl chr 9:100,921,565...100,930,399
JBrowse link
dTMP biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dctd dCMP deaminase IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr16:47,177,144...47,222,850
Ensembl chr16:47,177,145...47,208,110
JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 ISO (MGI:MGI:3849912|PMID:19513116) RGD PMID:19513116 MGI:MGI:3849912 NCBI chr10:47,030,813...47,059,216
Ensembl chr10:47,031,050...47,059,216
JBrowse link
G Tyms thymidylate synthetase IDA
IBA
ISO
PMID:21873635
(PMID:11278511), (PMID:15093541), (PMID:8845352)
RGD PMID:8845352, PMID:11278511, PMID:15093541, PMID:9894005, PMID:21873635 RGD:1545055, RGD:13792537 NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564
JBrowse link
dTTP biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cmpk2 cytidine/uridine monophosphate kinase 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:45,683,242...45,694,824
Ensembl chr 6:45,683,234...45,694,822
JBrowse link
G Dtymk deoxythymidylate kinase IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:220041, PMID:21873635 RGD:5133687, RGD:13792537 NCBI chr 9:100,921,565...100,930,399
Ensembl chr 9:100,921,565...100,930,399
JBrowse link
G Tbpl1 TATA-box binding protein like 1 ISO MGI:MGI:2182539 (MGI:MGI:2159505|PMID:11861477) RGD PMID:11861477 MGI:MGI:2159505 NCBI chr 1:23,977,154...24,002,512
Ensembl chr 1:23,977,688...24,002,506
JBrowse link
G Tyms thymidylate synthetase IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564
JBrowse link
dTTP catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dctpp1 dCTP pyrophosphatase 1 NOT ISO (PMID:24467396) RGD PMID:24467396 NCBI chr 1:198,703,459...198,706,852
Ensembl chr 1:198,703,461...198,706,852
JBrowse link
dUDP biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cmpk1 cytidine/uridine monophosphate kinase 1 IDA RGD PMID:3010881 RGD:5133253 NCBI chr 5:133,759,722...133,786,452
Ensembl chr 5:133,759,735...133,786,452
JBrowse link
G Cmpk2 cytidine/uridine monophosphate kinase 2 IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:192455, PMID:21873635 RGD:5133256, RGD:13792537 NCBI chr 6:45,683,242...45,694,824
Ensembl chr 6:45,683,234...45,694,822
JBrowse link
G Dtymk deoxythymidylate kinase IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:100,921,565...100,930,399
Ensembl chr 9:100,921,565...100,930,399
JBrowse link
dUMP biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07001512.1 IBA
IEA
PMID:21873635
GO_REF:0000041
UniProt PMID:21873635 GO_REF:0000041, RGD:13792537 Ensembl chr 1:48,565,160...48,565,711 JBrowse link
G Dctd dCMP deaminase IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr16:47,177,144...47,222,850
Ensembl chr16:47,177,145...47,208,110
JBrowse link
G Dut deoxyuridine triphosphatase IDA
IBA
IEA
PMID:21873635
GO_REF:0000041
UniProt PMID:3032103, PMID:21873635, PMID:1315924 GO_REF:0000041, RGD:2300191, RGD:13792537, RGD:2301218 NCBI chr 3:117,514,399...117,525,450
Ensembl chr 3:117,514,444...117,525,446
JBrowse link
dUMP catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nt5m 5',3'-nucleotidase, mitochondrial ISO (MGI:MGI:2388903|PMID:12234672) RGD PMID:12234672 MGI:MGI:2388903 NCBI chr10:46,216,494...46,244,478
Ensembl chr10:46,216,884...46,243,077
JBrowse link
dUTP catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07001512.1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr 1:48,565,160...48,565,711 JBrowse link
G Dut deoxyuridine triphosphatase IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:3032103, PMID:21873635, PMID:1315924 RGD:2300191, RGD:13792537, RGD:2301218 NCBI chr 3:117,514,399...117,525,450
Ensembl chr 3:117,514,444...117,525,446
JBrowse link
pyrimidine deoxyribonucleotide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nt5c 5', 3'-nucleotidase, cytosolic ISO
IBA
(PMID:10681516)
PMID:21873635
RGD PMID:10681516, PMID:21873635 RGD:13792537 NCBI chr10:104,052,807...104,054,805
Ensembl chr10:104,052,831...104,054,805
JBrowse link
G Nt5m 5',3'-nucleotidase, mitochondrial IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:46,216,494...46,244,478
Ensembl chr10:46,216,884...46,243,077
JBrowse link
pyrimidine nucleotide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cmpk1 cytidine/uridine monophosphate kinase 1 IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 5:133,759,722...133,786,452
Ensembl chr 5:133,759,735...133,786,452
JBrowse link
pyrimidine ribonucleotide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhodh dihydroorotate dehydrogenase (quinone) IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:42,066,103...42,087,906
Ensembl chr19:42,066,351...42,082,012
JBrowse link
UDP biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cmpk1 cytidine/uridine monophosphate kinase 1 IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:3010881, PMID:21873635 RGD:5133253, RGD:13792537 NCBI chr 5:133,759,722...133,786,452
Ensembl chr 5:133,759,735...133,786,452
JBrowse link
UDP catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Entpd4 ectonucleoside triphosphate diphosphohydrolase 4 ISO (PMID:9556635) RGD PMID:9556635 NCBI chr15:51,222,954...51,250,787
Ensembl chr15:51,222,954...51,250,787
JBrowse link
UMP biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Umps uridine monophosphate synthetase IDA
IBA
ISO
PMID:21873635
(PMID:11730338), (PMID:6893554)
RGD PMID:6893554, PMID:11730338, PMID:6134725, PMID:21873635 RGD:5132277, RGD:13792537 NCBI chr11:70,034,181...70,044,590
Ensembl chr11:70,034,139...70,044,628
JBrowse link
G Uprt uracil phosphoribosyltransferase homolog IDA RGD PMID:1476792 RGD:5132591 NCBI chr  X:75,382,553...75,408,541
Ensembl chr  X:75,382,598...75,407,217
JBrowse link
UMP salvage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Uck1 uridine-cytidine kinase 1 IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 3:11,271,874...11,277,757
Ensembl chr 3:11,271,885...11,277,757
JBrowse link
G Uck2 uridine-cytidine kinase 2 IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr13:85,376,716...85,443,976
Ensembl chr13:85,376,716...85,443,976
JBrowse link
G Uckl1 uridine-cytidine kinase 1-like 1 IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 3:177,066,022...177,078,611
Ensembl chr 3:177,066,014...177,078,594
JBrowse link
G Upp1 uridine phosphorylase 1 IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr14:89,314,234...89,334,060
Ensembl chr14:89,314,176...89,334,276
JBrowse link
G Upp2 uridine phosphorylase 2 IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 3:44,806,106...44,846,464
Ensembl chr 3:44,806,106...44,846,464
JBrowse link
UTP biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cad carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:10659854, PMID:21873635 RGD:2303528, RGD:13792537 NCBI chr 6:26,657,507...26,680,459
Ensembl chr 6:26,657,780...26,680,284
JBrowse link
G Decr2 2,4-dienoyl-CoA reductase 2 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:15,451,850...15,460,227
Ensembl chr10:15,431,638...15,465,413
JBrowse link
G Nme1 NME/NM23 nucleoside diphosphate kinase 1 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:81,657,152...81,666,542
Ensembl chr10:81,657,153...81,666,523
JBrowse link
G Nme2 NME/NM23 nucleoside diphosphate kinase 2 IDA RGD PMID:1316151 RGD:729254 NCBI chr10:81,648,216...81,653,717
Ensembl chr10:81,648,216...81,653,717
JBrowse link
G Nme3 NME/NM23 nucleoside diphosphate kinase 3 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:14,258,232...14,259,365
Ensembl chr10:14,258,380...14,259,336
JBrowse link
G Nme4 NME/NM23 nucleoside diphosphate kinase 4 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:15,461,567...15,465,422
Ensembl chr10:15,431,638...15,465,413
JBrowse link
G Nme5 NME/NM23 family member 5 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr18:27,357,460...27,374,641
Ensembl chr18:27,357,413...27,374,603
JBrowse link
G Nme6 NME/NM23 nucleoside diphosphate kinase 6 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 8:117,920,912...117,928,148
Ensembl chr 8:117,920,944...117,928,195
JBrowse link
G Nme7 NME/NM23 family member 7 IEA GO_REF:0000002
GO_REF:0000104
InterPro
UniProt
GO_REF:0000002, GO_REF:0000104 NCBI chr13:82,607,844...82,737,383
Ensembl chr13:82,626,685...82,737,343
JBrowse link
UTP metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ak3 adenylate kinase 3 ISO
IEA
(PMID:11485571)
GO_REF:0000107
RGD
Ensembl
PMID:11485571 GO_REF:0000107 NCBI chr 1:247,144,486...247,169,690
Ensembl chr 1:247,144,491...247,169,693
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20017
    metabolic process 12256
      cellular metabolic process 11064
        heterocycle metabolic process 5634
          pyrimidine-containing compound metabolic process 66
            pyrimidine nucleotide metabolic process 35
              pyrimidine deoxyribonucleotide metabolic process + 12
              pyrimidine nucleotide biosynthetic process + 28
              pyrimidine nucleotide catabolic process + 6
              pyrimidine nucleotide interconversion + 0
              pyrimidine ribonucleotide metabolic process + 22
Path 2
Term Annotations click to browse term
  biological_process 20017
    metabolic process 12256
      cellular metabolic process 11064
        heterocycle metabolic process 5634
          nucleobase-containing compound metabolic process 5483
            nucleobase-containing small molecule metabolic process 590
              nucleoside phosphate metabolic process 510
                nucleotide metabolic process 503
                  pyrimidine nucleotide metabolic process 35
                    pyrimidine deoxyribonucleotide metabolic process + 12
                    pyrimidine nucleotide biosynthetic process + 28
                    pyrimidine nucleotide catabolic process + 6
                    pyrimidine nucleotide interconversion + 0
                    pyrimidine ribonucleotide metabolic process + 22
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.