Uprt (uracil phosphoribosyltransferase homolog)

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Gene: Uprt (uracil phosphoribosyltransferase homolog) Rattus norvegicus

Analyze

Symbol:

Uprt

Name:

uracil phosphoribosyltransferase homolog

RGD ID:

1564806

Description:

Predicted to enable ribosylnicotinamide kinase activity. Involved in several processes, including UMP biosynthetic process; lactation; and response to insulin. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm. Orthologous to human UPRT (uracil phosphoribosyltransferase homolog); PARTICIPATES IN pyrimidine metabolic pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol.

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

LOC317237; RGD1564806; similar to hypothetical protein; uracil phosphoribosyltransferase (FUR1) homolog; uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae)

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	UPRT (uracil phosphoribosyltransferase homolog)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Uprt (uracil phosphoribosyltransferase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Uprt (uracil phosphoribosyltransferase homolog)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	UPRT (uracil phosphoribosyltransferase homolog)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	UPRT (uracil phosphoribosyltransferase homolog)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Uprt (uracil phosphoribosyltransferase homolog)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	UPRT (uracil phosphoribosyltransferase homolog)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	UPRT (uracil phosphoribosyltransferase homolog)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Uprt (uracil phosphoribosyltransferase homolog)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	UPRT (uracil phosphoribosyltransferase homolog)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Uprt (uracil phosphoribosyltransferase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	uprt (uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae))	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	FUR1	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector)
Caenorhabditis elegans (roundworm):	C47B2.2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	kri	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	X	69,516,573 - 69,546,811 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	69,516,738 - 69,546,797 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	X	75,382,553 - 75,408,541 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	75,382,598 - 75,407,217 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	76,184,934 - 76,210,907 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	92,511,044 - 92,535,135 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	X	70,870,490 - 70,896,599 (+)	NCBI		Celera
Cytogenetic Map	X	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

Experimental Diabetes Mellitus (IEP)

genetic disease (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(-)-epigallocatechin 3-gallate (ISO)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2-methylcholine (ISO)

5-fluorouracil (ISO)

acrolein (ISO)

acrylamide (EXP)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

amphetamine (EXP)

atrazine (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

calcitriol (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

dioxygen (ISO)

doxorubicin (ISO)

endosulfan (EXP)

flutamide (EXP)

hydrogen peroxide (ISO)

indole-3-methanol (EXP)

N-nitrosodiethylamine (EXP)

ozone (ISO)

paracetamol (EXP)

potassium chromate (ISO)

resveratrol (ISO)

rotenone (ISO)

temozolomide (ISO)

tetrachloromethane (EXP)

thioacetamide (EXP)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

female pregnancy (IEP)

lactation (IEP)

response to insulin (IEP)

UMP biosynthetic process (IDA)

Cellular Component

cytoplasm (IBA)

intracellular membrane-bounded organelle (ISO)

nucleoplasm (ISO)

Molecular Function

molecular_function (ND)

protein binding (ISO)

ribosylnicotinamide kinase activity (IBA)

Molecular Pathway Annotations Click to see Annotation Detail View

pyrimidine metabolic pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Pyrimidine nucleotide synthesis in the rat mammary gland: changes in the lactation cycle and effects of diabetes.	Kunjara S, etal., Biochem Med Metab Biol. 1992 Dec;48(3):263-74.
3.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
5.	Comprehensive gene review and curation	RGD comprehensive gene curation
6.	Regulation of purine and pyrimidine metabolism by insulin and by resistance to tiazofurin.	Weber G, etal., Adv Enzyme Regul. 1985;23:81-99.

Genomics

Comparative Map Data

Uprt
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	X	69,516,573 - 69,546,811 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	69,516,738 - 69,546,797 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	X	75,382,553 - 75,408,541 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	75,382,598 - 75,407,217 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	76,184,934 - 76,210,907 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	92,511,044 - 92,535,135 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	X	70,870,490 - 70,896,599 (+)	NCBI		Celera
Cytogenetic Map	X	q22	NCBI

UPRT
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	75,156,369 - 75,304,897 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	X	75,156,388 - 75,304,885 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	74,376,204 - 74,524,732 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	74,410,686 - 74,441,159 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	X	74,777,320 - 74,808,158 (+)	NCBI		Celera
Cytogenetic Map	X	q13.3	NCBI
HuRef	X	68,128,874 - 68,159,480 (+)	NCBI		HuRef
CHM1_1	X	74,386,787 - 74,417,624 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	73,590,029 - 73,738,566 (+)	NCBI		T2T-CHM13v2.0

Uprt
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	103,526,409 - 103,555,829 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	103,526,424 - 103,551,096 (+)	Ensembl		GRCm39 Ensembl
GRCm38	X	104,482,803 - 104,512,223 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	104,482,818 - 104,507,490 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	101,678,121 - 101,701,601 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	100,685,501 - 100,708,981 (+)	NCBI		MGSCv36	mm8
Celera	X	91,375,831 - 91,399,185 (+)	NCBI		Celera
Cytogenetic Map	X	D	NCBI

Uprt
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955562	1,385,611 - 1,415,336 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955562	1,385,617 - 1,415,277 (+)	NCBI	ChiLan1.0	ChiLan1.0

UPRT
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	X	74,639,179 - 74,675,221 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	74,639,179 - 74,675,221 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	X	64,524,889 - 64,561,439 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

UPRT
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	58,570,623 - 58,576,980 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	58,543,425 - 58,575,926 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	49,720,058 - 49,753,658 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	59,779,736 - 59,813,343 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	59,779,753 - 59,813,341 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	57,467,583 - 57,501,188 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	59,087,324 - 59,120,928 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	58,686,103 - 58,719,766 (+)	NCBI		UU_Cfam_GSD_1.0

Uprt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	43,493,769 - 43,515,772 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936683	1,431,965 - 1,454,991 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936683	1,432,004 - 1,454,004 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

UPRT
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	60,426,975 - 60,451,480 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	60,426,955 - 60,448,174 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	68,687,968 - 68,709,136 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

UPRT
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	64,815,163 - 64,846,198 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	64,815,183 - 64,849,547 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666067	16,812,530 - 16,843,516 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Uprt
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624836	5,471,168 - 5,502,261 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624836	5,473,129 - 5,502,276 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Uprt
43 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	82
Count of miRNA genes:	68
Interacting mature miRNAs:	74
Transcripts:	ENSRNOT00000033494
Prediction methods:	Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61430	Cia18	Collagen induced arthritis QTL 18	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	X	14843113	120568734	Rat
1598837	Memor13	Memory QTL 13	3.2		exploratory behavior trait (VT:0010471)	difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)	X	41052407	146860749	Rat
738035	Stresp1	Stress response QTL 1	4.96	0.000011	stress-related behavior trait (VT:0010451)	defensive burying - coping	X	41304447	112935181	Rat
61431	Cia19	Collagen induced arthritis QTL 19	4.4		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	X	65612192	120568734	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	1		16		16		2	2	60	27	13	8	2
Low	2	43	40	40	3	40	6	9	14	8	24	3	6
Below cutoff			1	1		1					3

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_001053733	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_228538	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473969	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000422	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000033494 ⟹ ENSRNOP00000038431

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	X	75,382,598 - 75,407,217 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000100029 ⟹ ENSRNOP00000078739

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	69,516,738 - 69,546,797 (+)	Ensembl

RefSeq Acc Id:

XM_228538 ⟹ XP_228538

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	X	69,516,573 - 69,546,811 (+)	NCBI
Rnor_6.0	X	75,382,553 - 75,408,541 (+)	NCBI
Rnor_5.0	X	76,184,934 - 76,210,907 (+)	NCBI
RGSC_v3.4	X	92,511,044 - 92,535,135 (+)	RGD

Sequence:

show sequence

AGTGCGTCTGGTGTGGGCGGGTATGGGACAAAGCGTGCGAAAGGACCGCGGAGGCCTAGGGGGC
TTGATAGCAGCGGGGATAGCCCGGGGCCCCGTGTATGGCCACGGAGTTACAGCGTCCGGACTCC
ATGCCCTGTCACAACCGGCAAGTAAACTCTACTTCTAGCCCAAGTCCCGAGCGCCTGTTAGCCG
AGGACCCGGTCCTGGATCATGCAGAAGAAAATAACGCTGCTATGGCTAAGCTGACTCTCCTCCC
TGGGCACGCCCATTCTAGCGTGCTTTCAGAGCGGGACTCTCCGGCCTGCTGCAGCACTAATCTT
CACTGTGAGAACCACAGTGACAGTAGTGACAGTGGCAACTACGAAGCACCTGTCGGCGACTCCC
TGCTAGGGGACTGTGAACTCTACCCACAGATTGGGGCTCAGCTTAAGTTGCTGCCTATGAATGA
TCAGATCCGGGAGCTGCAGACTATCATCCGGGACAAGACAGCCAGTAGAGGGGACTTCATGTTT
TCTGCGGATCGTTTGATCAGACTTGTTGTAGAAGAGGGATTGAATCAGCTGCCGTATAAAGAAT
GCATGGTGACCACTCCGACAGGGCACAAGTATGAAGGAGTGAAATTTGAGAAAGGAAATTGTGG
GGTCAGCATAATGAGAAGCGGTGAGGCAATGGAACAAGGTTTGCGAGATTGCTGTCGATCCATA
CGGATTGGGAAGATCCTGATTCAGAGCGATGAGGAGACACAAAGGGCCAAAGTATATTATGCCA
AGTTCCCCCCGGACATTCATCGCAGAAAAGTCCTTCTGATGTATCCAATTCTCAGTACTGGAAA
TACAGTAATCGAAGCTGTAAAGGTTCTCATAGAACATGGAGTTCAACCCAGTGTTATTATCCTA
CTCAGTCTGTTCTCCACCCCGCATGGTGCCAAATCAATCATTCAAGAATTTCCAGAGATCACAA
TTTTAACTACTGAAGTTCATCCTGTCGCACCTACACATTTTGGACAGAAATACTTTGGAACAGA
CTAAGTTATTCAACGAAAATGAAATACCTTGCATAATAATATGGTTGTAAATGGATTTCATATC
TGTTTATACTGATTTGTTTGAGGAATAATGGAGGAAATATGTTAGGAATGCCTTTTTAACATTG
GAAGTAGGTGTAGCAACAAGAAATATTGGAAGTTTATTTATTTGATTTGGTTATTTCTTTACAT
GTGGTACCAAATTCAGTAGTGAAGCACAACCATAGTGCTTAGAAAAGATGGAAACGTTAATTGT
ATGTTCATAGAAGTCACTGAATCCTTAGTACATGGAAACTGTAGAACTTGTGAAACACCCCCTC
CCCCTTTCTTGGTTTGGAAGTTGTTGCAGCTGCAAAGAAAACCCAAATGAGAGTTAGTTCTGTG
ACACACTGCAGTTTACATTTTCCTTACTGTGCTTTAGCTCTAGACTGTTTTCCTGTATGTGGGT
CTTGTCACCCTCCGGACTCTATATACTTTATATATGCAGGTACCCTGGAGAGGAGAGAACGAGA
ATATATCCTGGAATTTTATGTTGCCATTTATGTCCTCGCTTAATTTGAAGGCTCAGGATGTCTC
TTAACTTGTCAACTAAGCCGTTGTGTTCCTCATGGCTCATTTCCCCAAGTGGGGATTGAGGGAA
GGTGTTTGCCAAGCTGGAACACAGGGAAAAAGACGAAGGGCCTTTTTAGTAACTGAATCTGTAA
CAGGAGTCTACAGAGACTAAACCGCGGATGCCTGATATTGACCCAAGAGGGCTCAATCAGCCCT
CTACAAAGAAGTTAGTGGATGGAGATCTTTCTAAGGTGTGAGGGAAGTGGAGGCTTTGCATTTC
ATGGCCAATAAGTAAATCAGCACGGTTCTCGGCTGTTGTTTTTCAAGACAGGGTTTCTCTGTGT
TCCTCTGGCTGTTCTGGAACTCACTCTGTAGACCAGGCTGGCCTCTAACTCATGGCGATCCAGC
TGCCTCTGCTTCCCAGGTACTAGGATTAAAGGCAGGCAGCACCACCCAATATGCAATACGGTTC
TTTTAATTTAGTTGTTTCTACTAGTTGCCTTTGATTTGGAACTTAGTTATTTTGCATGTTTTAT
GACTATAACTGTATTAAAGTAGAGAATACGTATGTTCTTTTAAAATATATGATTTGTATCTGTT
CATATTTAAGCTTCTGAAAGGGAGACGAAACAAACTTTGAATCAGACTTTGCACTTTTGAAATG
AACTTATAAAACCCAGATTCCGATTTTACACTGATACTGTGGTGGCTGGGTGATTACTTGATTA
GTTTACATGGCTCATGGCCCAATAGACAGCTGTTGTGAGACTATGTTCGAAAGTATAAGAAAAA
GTACAAGGGAGTCTCTTAGACTGAAGCTGAAGAGGAAGGAAAGCAACCTGGGGTACATGGAATG
GATTTTACCTTATGGTTTTAGCCTGCTAAGCTCCACTGTACTTTTACTTTTGTTGTTGTTCTTG
TTTCTTTGAGACAGAGCTTCTCTGTGTAGCCCTGGCTATCCTGGAACATGCTCT

hide sequence

Protein Sequences


Protein RefSeqs	XP_228538	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM07163	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

XP_228538 ⟸ XM_228538

- UniProtKB:

D4ABC7 (UniProtKB/TrEMBL), A0A8I6G3Q5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MATELQRPDSMPCHNRQVNSTSSPSPERLLAEDPVLDHAEENNAAMAKLTLLPGHAHSSVLSER
DSPACCSTNLHCENHSDSSDSGNYEAPVGDSLLGDCELYPQIGAQLKLLPMNDQIRELQTIIRD
KTASRGDFMFSADRLIRLVVEEGLNQLPYKECMVTTPTGHKYEGVKFEKGNCGVSIMRSGEAME
QGLRDCCRSIRIGKILIQSDEETQRAKVYYAKFPPDIHRRKVLLMYPILSTGNTVIEAVKVLIE
HGVQPSVIILLSLFSTPHGAKSIIQEFPEITILTTEVHPVAPTHFGQKYFGTD

hide sequence

RefSeq Acc Id:

ENSRNOP00000038431 ⟸ ENSRNOT00000033494

RefSeq Acc Id:

ENSRNOP00000078739 ⟸ ENSRNOT00000100029

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4ABC7-F1-model_v2	AlphaFold	D4ABC7	1-309	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701898

Promoter ID:

EPDNEW_R12419

Type:

initiation region

Name:

Uprt_1

Description:

uracil phosphoribosyltransferase homolog

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	X	75,382,587 - 75,382,647	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1564806	AgrOrtholog
BioCyc Gene	G2FUF-1988	BioCyc
Ensembl Genes	ENSRNOG00000021552	Ensembl
	ENSRNOG00000063275	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000078739	ENTREZGENE
	ENSRNOP00000078739.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000100029	ENTREZGENE
	ENSRNOT00000100029.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.2020	UniProtKB/TrEMBL
InterPro	PRibTrfase_dom	UniProtKB/TrEMBL
	PRTase-like	UniProtKB/TrEMBL
NCBI Gene	317237	ENTREZGENE
Pfam	UPRTase	UniProtKB/TrEMBL
PhenoGen	Uprt	PhenoGen
Superfamily-SCOP	SSF53271	UniProtKB/TrEMBL
UniProt	A0A8I6G3Q5	ENTREZGENE, UniProtKB/TrEMBL
	D4ABC7	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-11-25	Uprt	uracil phosphoribosyltransferase homolog	Uprt	uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-07	Uprt	uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae)	RGD1564806_predicted	similar to hypothetical protein (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-07	RGD1564806_predicted	similar to hypothetical protein (predicted)	LOC317237	similar to hypothetical protein	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC317237	similar to hypothetical protein			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)