Cad (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase) - Rat Genome Database

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Gene: Cad (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase) Rattus norvegicus
Analyze
Symbol: Cad
Name: carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
RGD ID: 1588606
Description: Enables several functions, including aspartate carbamoyltransferase activity; carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity; and dihydroorotase activity. Involved in several processes, including 'de novo' pyrimidine nucleobase biosynthetic process; UTP biosynthetic process; and alpha-amino acid metabolic process. Located in neuronal cell body and terminal bouton. Part of protein-containing complex. Used to study hepatocellular carcinoma. Biomarker of hepatocellular carcinoma; renal cell carcinoma; and rhabdomyosarcoma. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 50. Orthologous to human CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; beta-ureidopropionase deficiency pathway; Canavan disease pathway; INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: Cad_mapped; Carbamyl phosphatate synthetase; carbamyl phosphatate synthetase 2; carbamyl phosphatate synthetase 2 (mapped); multifunctional protein CAD
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8631,012,091 - 31,035,098 (-)NCBIGRCr8
mRatBN7.2625,292,133 - 25,315,078 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl625,292,133 - 25,319,861 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx625,592,847 - 25,615,794 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0625,908,706 - 25,931,663 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0625,387,772 - 25,410,661 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0626,657,507 - 26,680,459 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl626,657,780 - 26,680,284 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0636,472,498 - 36,495,450 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4625,272,416 - 25,296,266 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera624,783,039 - 24,805,943 (-)NCBICelera
Cytogenetic Map6q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-palmitoylglycerol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
caffeine  (EXP,ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
decabromodiphenyl ether  (EXP,ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
fipronil  (EXP)
flutamide  (EXP)
FR900359  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
indometacin  (ISO)
ivermectin  (ISO)
leflunomide  (ISO)
methyl methanesulfonate  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
ozone  (ISO)
paracetamol  (ISO)
piroxicam  (ISO)
potassium chromate  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
toluene 2,4-diisocyanate  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

References

References - curated
# Reference Title Reference Citation
1. Regulatory properties and behavior of activity of carbamoyl phosphate synthetase II (glutamine-hydrolyzing) in normal and proliferating tissues. Aoki T, etal., J Biol Chem. 1982 Jan 10;257(1):432-8.
2. Glutamine and ammonium handling by anaesthetized rats. Blade C, etal., Arch Int Physiol Biochim. 1988 Dec;96(5):201-9.
3. Acid inactivation of short-lived rat liver enzymes. Bond JS Biochim Biophys Acta. 1976 Nov 18;451(1):238-49.
4. c-myc null cells misregulate cad and gadd45 but not other proposed c-Myc targets. Bush A, etal., Genes Dev. 1998 Dec 15;12(24):3797-802.
5. Carbamyl phosphate-aspartate transcarbamylase activity in regenerating rat liver. CALVA E and COHEN PP, Cancer Res. 1959 Jul;19(6, Part 1):679-83.
6. Carbamyl phosphate-aspartate transcarbamylase activity in tumors. CALVA E, etal., Cancer Res. 1959 Jan;19(1):101-3.
7. Localization of the multifunctional protein CAD in astrocytes of rodent brain. Cammer W and Downing M, J Histochem Cytochem. 1991 May;39(5):695-700.
8. The role of p53 in regulating genomic stability when DNA and RNA synthesis are inhibited. Chernova OB, etal., Trends Biochem Sci 1995 Oct;20(10):431-4.
9. Mammalian pyrimidine biosynthesis: fresh insights into an ancient pathway. Evans DR and Guy HI, J Biol Chem. 2004 Aug 6;279(32):33035-8. Epub 2004 Apr 19.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Activity of aspartate transcarbamylase in mammary tumours induced by 7,12-dimethyl-benzanthracene in the rat. Gorlich M and Heise E, Nature. 1967 Mar 4;213(5079):934-5.
12. Regulation of carbamoyl phosphate synthetase by MAP kinase. Graves LM, etal., Nature. 2000 Jan 20;403(6767):328-32.
13. Effect of dimethylnitrosamine upon carbamoyl phosphate and ornithine utilization in rat liver. Karsai T, etal., Anticancer Res. 1985 Jul-Aug;5(4):441-4.
14. Pyrimidine nucleotide synthesis in the rat mammary gland: changes in the lactation cycle and effects of diabetes. Kunjara S, etal., Biochem Med Metab Biol. 1992 Dec;48(3):263-74.
15. Lesch-Nyhan syndrome, caffeine model: increase of purine and pyrimidine enzymes in rat brain. Minana MD, etal., J Neurochem. 1984 Dec;43(6):1556-60.
16. Multi-enzyme complex of glutamine-dependent carbamoyl-phosphate synthetase with aspartate carbamoyltransferase and dihydroorotase from rat ascites-hepatoma cells. Purification, molecular properties and limited proteolysis. Mori M and Tatibana M, Eur J Biochem. 1978 May 16;86(2):381-8.
17. Aggregation states and catalytic properties of the multienzyme complex catalyzing the initial steps of pyrimidine biosynthesis in rat liver. Mori M, etal., Biochemistry. 1975 Jun 17;14(12):2622-30.
18. [Ammonia metabolism of liver of the fetus induced experimental IUGR in rats--in respect of the enzymes in pyrimidin biosynthesis and urea cycle system] Nagasaki T Nippon Sanka Fujinka Gakkai Zasshi. 1985 Jan;37(1):24-30.
19. ACTIVITY OF ASPARTATE TRANSCARBAMYLASE IN HEART AND LIVER OF THE DEVELOPING RAT. NORDMANN Y, etal., Nature. 1964 Feb 8;201:616-7.
20. Increased incidence of CAD gene amplification in tumorigenic rat lines as an indicator of genomic instability of neoplastic cells. Otto E, etal., J Biol Chem. 1989 Feb 25;264(6):3390-6.
21. Tissue-specific differential induction of aspartate transcarbamylase by hydrocortisone in rats of various ages. Patnaik SK and Patnaik R, Biochem Int. 1990;20(4):641-7.
22. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
23. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
24. Regulation by insulin of liver carbamoyl-phosphate synthase II (glutamine-hydrolysing). Reardon MA and Weber G, Biochem J. 1987 Jun 1;244(2):345-50.
25. Increased messenger RNA concentration for carbamoyl-phosphate synthase II in hepatoma 3924A. Reardon MA, etal., Biochem Biophys Res Commun. 1987 Aug 31;147(1):494-500.
26. GOA pipeline RGD automated data pipeline
27. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
28. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
29. The dihydroorotase inhibitor 5-aminoorotic acid inhibits the metabolism in the rat of the cardioprotective drug dexrazoxane and its one-ring open metabolites. Schroeder PE, etal., Drug Metab Dispos. 2008 Sep;36(9):1780-5. Epub 2008 May 30.
30. The effect of glutamine concentration on the activity of carbamoyl-phosphate synthase II and on the incorporation of thymidine into DNA in rat mesenteric lymphocytes stimulated by phytohaemagglutinin. Szondy Z and Newsholme EA, Biochem J. 1989 Aug 1;261(3):979-83.
31. Effect of pregnancy and hormones on the activity of aspartate transcarbamylase and the level of nucleic acids in the mammary gland of the rat. Thibodeau PS and Thayer SA, Endocrinology. 1967 Mar;80(3):505-9.
32. Overexpression of cyclin D1 enhances gene amplification. Zhou P, etal., Cancer Res. 1996 Jan 1;56(1):36-9.
Additional References at PubMed
PMID:9525610   PMID:15326225   PMID:15890648   PMID:19946888   PMID:20458337   PMID:24332717   PMID:24746616   PMID:25763846   PMID:30361391  


Genomics

Comparative Map Data
Cad
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8631,012,091 - 31,035,098 (-)NCBIGRCr8
mRatBN7.2625,292,133 - 25,315,078 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl625,292,133 - 25,319,861 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx625,592,847 - 25,615,794 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0625,908,706 - 25,931,663 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0625,387,772 - 25,410,661 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0626,657,507 - 26,680,459 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl626,657,780 - 26,680,284 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0636,472,498 - 36,495,450 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4625,272,416 - 25,296,266 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera624,783,039 - 24,805,943 (-)NCBICelera
Cytogenetic Map6q14NCBI
CAD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38227,217,369 - 27,243,943 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl227,217,369 - 27,243,943 (+)EnsemblGRCh38hg38GRCh38
GRCh37227,440,237 - 27,466,811 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36227,293,762 - 27,320,158 (+)NCBINCBI36Build 36hg18NCBI36
Build 34227,351,908 - 27,378,305NCBI
Celera227,286,585 - 27,312,981 (+)NCBICelera
Cytogenetic Map2p23.3NCBI
HuRef227,181,964 - 27,208,360 (+)NCBIHuRef
CHM1_1227,370,163 - 27,396,559 (+)NCBICHM1_1
T2T-CHM13v2.0227,259,008 - 27,285,579 (+)NCBIT2T-CHM13v2.0
Cad
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39531,211,964 - 31,235,823 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl531,212,124 - 31,235,823 (+)EnsemblGRCm39 Ensembl
GRCm38531,054,620 - 31,078,479 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl531,054,780 - 31,078,479 (+)EnsemblGRCm38mm10GRCm38
MGSCv37531,357,184 - 31,380,852 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36531,331,392 - 31,355,060 (+)NCBIMGSCv36mm8
Celera528,526,834 - 28,551,927 (+)NCBICelera
Cytogenetic Map5B1NCBI
cM Map516.95NCBI
Cad
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554699,203,434 - 9,227,865 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554699,203,433 - 9,227,526 (+)NCBIChiLan1.0ChiLan1.0
CAD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21299,269,360 - 99,295,801 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A99,273,328 - 99,299,769 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A27,218,699 - 27,245,156 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A27,306,488 - 27,332,804 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A27,306,527 - 27,332,804 (+)Ensemblpanpan1.1panPan2
CAD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11721,198,839 - 21,221,897 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1721,197,826 - 21,221,635 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1721,090,639 - 21,113,701 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01721,519,811 - 21,542,872 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1721,514,893 - 21,542,872 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11721,206,567 - 21,229,628 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01721,217,636 - 21,240,698 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01721,264,518 - 21,287,583 (+)NCBIUU_Cfam_GSD_1.0
Cad
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629265,506,657 - 65,529,337 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364935,310,228 - 5,332,918 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364935,308,268 - 5,332,934 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CAD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3111,887,020 - 111,914,492 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13111,887,017 - 111,914,511 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CAD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11480,371,154 - 80,399,193 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1480,371,096 - 80,398,914 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604531,756,113 - 31,783,666 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cad
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247389,318,232 - 9,340,925 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247389,318,213 - 9,340,765 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cad
72 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:188
Count of miRNA genes:128
Interacting mature miRNAs:136
Transcripts:ENSRNOT00000039709
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738023Alc17Alcohol consumption QTL 173.10.003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)6127574569Rat
1354616Despr12Despair related QTL 120.0012locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)6127574569Rat
1549905Stresp10Stress response QTL 106.830.0066stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)6127574569Rat
2300176Bmd51Bone mineral density QTL 5111.70.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)6127574569Rat
2300190Bmd52Bone mineral density QTL 5211.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)6127574569Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)6134235784Rat
1578758Tcas9Tongue tumor susceptibility QTL 93.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)6137618905Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6139036266Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6141223769Rat
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6141223769Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6141223769Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6141223769Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6141223769Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6142487980Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6142487980Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6142487980Rat
7411584Foco4Food consumption QTL 44.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6142838846Rat
738024Sach5Saccharine consumption QTL 53.90.00039consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)6143394190Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449734434305Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)61173566972593685Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)61173566972593685Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
1359023Bp272Blood pressure QTL 2722.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)61653614027261739Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)61653614061536140Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)61653614071636405Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)62033877762613667Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat

Markers in Region
MARC4015-4016  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2625,293,392 - 25,293,827 (+)MAPPERmRatBN7.2
Rnor_6.0626,658,767 - 26,659,201NCBIRnor6.0
Rnor_5.0636,473,758 - 36,474,192UniSTSRnor5.0
RGSC_v3.4625,273,677 - 25,274,111UniSTSRGSC3.4
Celera624,784,303 - 24,784,737UniSTS
Cytogenetic Map6q14UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 26 38 22 19 22 1 1 60 22 34 11 1
Low 1 17 19 19 19 7 10 14 13 7 7
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000039709   ⟹   ENSRNOP00000030030
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl625,292,133 - 25,315,078 (-)Ensembl
Rnor_6.0 Ensembl626,657,780 - 26,680,284 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000101016   ⟹   ENSRNOP00000076628
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl625,292,133 - 25,319,861 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000118536   ⟹   ENSRNOP00000090053
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl625,292,133 - 25,315,078 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000118736   ⟹   ENSRNOP00000079396
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl625,292,133 - 25,319,861 (-)Ensembl
RefSeq Acc Id: NM_001105710   ⟹   NP_001099180
RefSeq Status: INFERRED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8631,012,091 - 31,035,036 (-)NCBI
mRatBN7.2625,292,133 - 25,315,078 (-)NCBI
Rnor_6.0626,657,507 - 26,680,459 (-)NCBI
Rnor_5.0636,472,498 - 36,495,450 (-)NCBI
RGSC_v3.4625,272,416 - 25,296,266 (-)RGD
Celera624,783,039 - 24,805,943 (-)RGD
Sequence:
RefSeq Acc Id: XM_063261542   ⟹   XP_063117612
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8631,012,092 - 31,035,098 (-)NCBI
RefSeq Acc Id: NP_001099180   ⟸   NM_001105710
- UniProtKB: D4A8A0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000030030   ⟸   ENSRNOT00000039709
RefSeq Acc Id: ENSRNOP00000079396   ⟸   ENSRNOT00000118736
RefSeq Acc Id: ENSRNOP00000090053   ⟸   ENSRNOT00000118536
RefSeq Acc Id: ENSRNOP00000076628   ⟸   ENSRNOT00000101016
RefSeq Acc Id: XP_063117612   ⟸   XM_063261542
- Peptide Label: isoform X1
- UniProtKB: A0A8I5Y665 (UniProtKB/TrEMBL),   A6HA80 (UniProtKB/TrEMBL),   A0A8I5ZMM2 (UniProtKB/TrEMBL)
Protein Domains
ATP-grasp   MGS-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A8A0-F1-model_v2 AlphaFold D4A8A0 1-2224 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1588606 AgrOrtholog
BioCyc Gene G2FUF-38342 BioCyc
Ensembl Genes ENSRNOG00000026474 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000039709.7 UniProtKB/TrEMBL
  ENSRNOT00000101016 ENTREZGENE
  ENSRNOT00000101016.1 UniProtKB/TrEMBL
  ENSRNOT00000118536.1 UniProtKB/TrEMBL
  ENSRNOT00000118736.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1030.10 UniProtKB/TrEMBL
  3.30.1490.20 UniProtKB/TrEMBL
  3.40.50.1370 UniProtKB/TrEMBL
  3.40.50.1380 UniProtKB/TrEMBL
  3.40.50.20 UniProtKB/TrEMBL
  3.40.50.880 UniProtKB/TrEMBL
  3.50.30.20 UniProtKB/TrEMBL
  ATP-grasp fold, B domain UniProtKB/TrEMBL
  Metal-dependent hydrolases UniProtKB/TrEMBL
InterPro Amidohydro-rel UniProtKB/TrEMBL
  Asp/Orn_carbamoyltranf_P-bd UniProtKB/TrEMBL
  Asp/Orn_carbamoylTrfase UniProtKB/TrEMBL
  Asp/Orn_carbamoylTrfase_sf UniProtKB/TrEMBL
  Asp_carbamoyltransf_Asp/Orn-bd UniProtKB/TrEMBL
  Asp_carbamoyltransf_euk UniProtKB/TrEMBL
  ATP-grasp UniProtKB/TrEMBL
  ATP_grasp_subdomain_1 UniProtKB/TrEMBL
  CarbamoylP_synth_lsu UniProtKB/TrEMBL
  CarbamoylP_synth_lsu_ATP-bd UniProtKB/TrEMBL
  CarbamoylP_synth_lsu_Gln-dep UniProtKB/TrEMBL
  CarbamoylP_synth_lsu_oligo UniProtKB/TrEMBL
  CarbamoylP_synth_lsu_oligo_sf UniProtKB/TrEMBL
  CarbamoylP_synth_ssu UniProtKB/TrEMBL
  CarbamoylP_synth_ssu_N UniProtKB/TrEMBL
  CarbP_synth_ssu_N_sf UniProtKB/TrEMBL
  Class_I_gatase-like UniProtKB/TrEMBL
  CPSase_GATase1 UniProtKB/TrEMBL
  Dihydroorotase_CS UniProtKB/TrEMBL
  GATASE_1 UniProtKB/TrEMBL
  Metal-dep_hydrolase_composite UniProtKB/TrEMBL
  Metal_Hydrolase UniProtKB/TrEMBL
  MGS UniProtKB/TrEMBL
  MGS-like_dom_sf UniProtKB/TrEMBL
  PreATP-grasp-like UniProtKB/TrEMBL
NCBI Gene 24240 ENTREZGENE
PANTHER ASPARTATE CARBAMOYLTRANSFERASE, CHLOROPLASTIC UniProtKB/TrEMBL
  CAD PROTEIN UniProtKB/TrEMBL
  CARBAMOYLTRANSFERASE FAMILY MEMBER UniProtKB/TrEMBL
Pfam Amidohydro_1 UniProtKB/TrEMBL
  CPSase_L_D2 UniProtKB/TrEMBL
  CPSase_L_D3 UniProtKB/TrEMBL
  CPSase_sm_chain UniProtKB/TrEMBL
  GATase UniProtKB/TrEMBL
  MGS UniProtKB/TrEMBL
  OTCace UniProtKB/TrEMBL
  OTCace_N UniProtKB/TrEMBL
PhenoGen Cad PhenoGen
PRINTS ANTSNTHASEII UniProtKB/TrEMBL
  AOTCASE UniProtKB/TrEMBL
  ATCASE UniProtKB/TrEMBL
  CPSASE UniProtKB/TrEMBL
  CPSGATASE UniProtKB/TrEMBL
  GATASE UniProtKB/TrEMBL
PROSITE ATP_GRASP UniProtKB/TrEMBL
  CARBAMOYLTRANSFERASE UniProtKB/TrEMBL
  CPSASE_1 UniProtKB/TrEMBL
  CPSASE_2 UniProtKB/TrEMBL
  DIHYDROOROTASE_1 UniProtKB/TrEMBL
  DIHYDROOROTASE_2 UniProtKB/TrEMBL
  GATASE_TYPE_1 UniProtKB/TrEMBL
  MGS UniProtKB/TrEMBL
RatGTEx ENSRNOG00000026474 RatGTEx
SMART CPSase_L_D3 UniProtKB/TrEMBL
  CPSase_sm_chain UniProtKB/TrEMBL
  MGS UniProtKB/TrEMBL
Superfamily-SCOP Asp/Orn_carbamoyltranf UniProtKB/TrEMBL
  CarbamoylP_synth_lsu_oligo UniProtKB/TrEMBL
  CP_synthsmall UniProtKB/TrEMBL
  Glutathione synthetase ATP-binding domain-like UniProtKB/TrEMBL
  Metalo_hydrolase UniProtKB/TrEMBL
  MGS-like_dom UniProtKB/TrEMBL
  PreATP-grasp-like UniProtKB/TrEMBL
  SSF51556 UniProtKB/TrEMBL
  SSF52317 UniProtKB/TrEMBL
UniProt A0A8I5Y665 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZMM2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A9Y4_RAT UniProtKB/TrEMBL
  A6HA80 ENTREZGENE, UniProtKB/TrEMBL
  A6HA81_RAT UniProtKB/TrEMBL
  A6HA82_RAT UniProtKB/TrEMBL
  A6HA83_RAT UniProtKB/TrEMBL
  A6HA84_RAT UniProtKB/TrEMBL
  D4A8A0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-03 Cad  carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase  Cad  carbamyl phosphatate synthetase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-04-13   carbamyl phosphatate synthetase 2  Cad  carbamyl phosphatate synthetase 2 (mapped)  Name updated 737654 APPROVED
2007-04-10 Cad  carbamyl phosphatate synthetase 2 (mapped)  Cad_mapped  carbamyl phosphatate synthetase 2 (mapped)  Data merged from RGD:2251 737654 APPROVED
2006-11-19 Cad  carbamyl phosphatate synthetase 2 (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Cad_mapped  carbamyl phosphatate synthetase 2 (mapped)  Cad  carbamyl phosphatate synthetase 2  Symbol and Name updated 1556543 APPROVED
2003-04-09 Cad  carbamyl phosphatate synthetase 2    Carbamyl phosphatate synthetase  Name updated 629478 APPROVED
2002-06-10 Cad  Carbamyl phosphatate synthetase      Symbol and Name status set to approved 70586 APPROVED