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ONTOLOGY REPORT - ANNOTATIONS

Term:spleen development
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Accession:GO:0048536 term browser browse the term
Definition:The process whose specific outcome is the progression of the spleen over time, from its formation to the mature structure. The spleen is a large vascular lymphatic organ composed of white and red pulp, involved both in hemopoietic and immune system functions.


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spleen development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase acts_upstream_of_or_within ISO MGI:2153718 (PMID:2065352) RGD PMID:2065352 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065 		JBrowse link
G Adam17 ADAM metallopeptidase domain 17 involved_in ISO (MGI:3828349|PMID:17371977) RGD PMID:17371977 MGI:3828349 NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639 		JBrowse link
G Ahr aryl hydrocarbon receptor involved_in ISO (MGI:72762|PMID:7732381), (MGI:81320|PMID:8692887) RGD PMID:7732381 PMID:8692887 MGI:72762 MGI:81320 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Barx1 BARX homeobox 1 acts_upstream_of_or_within ISO MGI:3578634 (PMID:17855428) RGD PMID:17855428 NCBI chr17:15,990,412...15,993,887
Ensembl chr17:15,990,412...15,993,887 		JBrowse link
G Bcl2 BCL2, apoptosis regulator involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1197519|MGI:2156165 (PMID:15818405)		 Ensembl
RGD		 PMID:15818405 GO_REF:0000107 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l11 Bcl2-like 11 acts_upstream_of_or_within ISO MGI:88138 (PMID:15818405) RGD PMID:15818405 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Bcl3 BCL3, transcription coactivator acts_upstream_of_or_within ISO MGI:2158443 (PMID:10586052) RGD PMID:10586052 NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607 		JBrowse link
G Cacnb4 calcium voltage-gated channel auxiliary subunit beta 4 acts_upstream_of_or_within ISO MGI:1856936 (PMID:5037658) RGD PMID:5037658 NCBI chr 3:36,906,771...37,169,165
Ensembl chr 3:36,910,427...37,168,944 		JBrowse link
G Cdh17 cadherin 17 involved_in ISO (MGI:3531365|PMID:15688343) RGD PMID:15688343 MGI:3531365 NCBI chr 5:25,262,820...25,314,884
Ensembl chr 5:25,262,758...25,314,884 		JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B acts_upstream_of_or_within ISO MGI:97350|MGI:97495 (PMID:22560297) RGD PMID:22560297 NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050 		JBrowse link
G Cfc1 cripto, FRL-1, cryptic family 1 acts_upstream_of_or_within ISO MGI:2179530 (PMID:10521397) RGD PMID:10521397 NCBI chr 9:36,742,106...36,751,931
Ensembl chr 9:36,739,071...36,751,930 		JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 involved_in ISO (MGI:3054669|PMID:15475956) RGD PMID:15475956 MGI:3054669 NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897 		JBrowse link
G Ctc1 CST telomere replication complex component 1 acts_upstream_of_or_within ISO MGI:5427642 (PMID:22531781) RGD PMID:22531781 NCBI chr10:53,714,614...53,735,298
Ensembl chr10:53,714,644...53,735,298 		JBrowse link
G Dicer1 dicer 1 ribonuclease III acts_upstream_of_or_within ISO (PMID:21307095) RGD PMID:21307095 NCBI chr 6:123,627,529...123,692,278
Ensembl chr 6:123,631,250...123,693,965 		JBrowse link
G Epb42 erythrocyte membrane protein band 4.2 acts_upstream_of_or_within ISO MGI:2182816 (PMID:10359562) RGD PMID:10359562 NCBI chr 3:107,979,709...107,997,932
Ensembl chr 3:107,979,713...107,997,932 		JBrowse link
G Fadd Fas associated via death domain involved_in ISS
ISO		 GO_REF:0000024
UniProtKB:Q9QZL0 (MGI:5291865|PMID:21876153)		 UniProt
RGD		 PMID:21876153 GO_REF:0000024 MGI:5291865 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Fas Fas cell surface death receptor acts_upstream_of_or_within ISO MGI:1856334 (PMID:18199416) RGD PMID:18199416 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Fgf10 fibroblast growth factor 10 acts_upstream_of_or_within ISO MGI:1859647 (PMID:15329346) RGD PMID:15329346 NCBI chr 2:50,801,171...50,878,218
Ensembl chr 2:50,800,992...50,876,866 		JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 acts_upstream_of_or_within ISO MGI:96995 (PMID:22674806) RGD PMID:22674806 NCBI chr12:7,623,930...7,699,474
Ensembl chr12:7,623,930...7,699,474 		JBrowse link
G Flvcr1 FLVCR choline and heme transporter 1 acts_upstream_of_or_within ISO MGI:3776022 (PMID:18258918) RGD PMID:18258918 NCBI chr13:102,586,263...102,608,647
Ensembl chr13:102,586,257...102,608,661 		JBrowse link
G Hoxb4 homeo box B4 acts_upstream_of_or_within ISO MGI:3045971 (PMID:14962901) RGD PMID:14962901 NCBI chr10:81,284,552...81,287,134
Ensembl chr10:81,284,552...81,287,128 		JBrowse link
G Jarid2 jumonji and AT-rich interaction domain containing 2 acts_upstream_of_or_within ISO MGI:1856923 (PMID:9376320) RGD PMID:9376320 NCBI chr17:19,777,487...19,957,696
Ensembl chr17:19,777,266...19,955,690 		JBrowse link
G Kmt2a lysine methyltransferase 2A acts_upstream_of_or_within ISO MGI:95559 (PMID:22674806) RGD PMID:22674806 NCBI chr 8:45,116,763...45,193,320
Ensembl chr 8:45,118,814...45,193,181 		JBrowse link
G Lipa lipase A, lysosomal acid type involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2451080 (PMID:19179613)		 Ensembl
RGD		 PMID:19179613 GO_REF:0000107 NCBI chr 1:232,024,351...232,057,735
Ensembl chr 1:232,024,356...232,057,633 		JBrowse link
G Myb MYB proto-oncogene, transcription factor acts_upstream_of_or_within ISO MGI:2677048 (PMID:19360001) RGD PMID:19360001 NCBI chr 1:15,939,771...15,973,367
Ensembl chr 1:15,939,761...15,973,057 		JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 acts_upstream_of_or_within ISO MGI:2179705 (PMID:10586052) RGD PMID:10586052 NCBI chr 1:245,164,586...245,173,225
Ensembl chr 1:245,165,950...245,173,213 		JBrowse link
G Nfkbiz NFKB inhibitor zeta involved_in ISO MGI:3046930 (PMID:31182790) RGD PMID:31182790 NCBI chr11:44,782,676...44,810,722
Ensembl chr11:44,782,676...44,810,723 		JBrowse link
G Nkx2-3 NK2 homeobox 3 acts_upstream_of_or_within ISO MGI:2386680|MGI:2448069 (PMID:10207146), (PMID:10790368), (PMID:10926756) RGD PMID:10207146 PMID:10790368 PMID:10926756 NCBI chr 1:242,478,130...242,481,083
Ensembl chr 1:242,478,130...242,481,083 		JBrowse link
G Nkx2-5 NK2 homeobox 5 involved_in
acts_upstream_of_or_within		 ISO
ISS
IEA		 (PMID:22560297)
MGI:104737|MGI:97495 (PMID:22560297)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:22560297 GO_REF:0000024 GO_REF:0000107 NCBI chr10:16,340,428...16,347,004
Ensembl chr10:16,344,159...16,346,934 		JBrowse link
G Nkx3-2 NK3 homeobox 2 acts_upstream_of_or_within ISO MGI:1857926|MGI:1931319|MGI:3848005 (PMID:10449756), (PMID:10572046), (PMID:15329346), (PMID:19208343) RGD PMID:10449756 PMID:10572046 PMID:15329346 PMID:19208343 NCBI chr14:69,183,795...69,186,182
Ensembl chr14:69,183,820...69,186,061 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 IEP RGD PMID:17341476 RGD:401827282 NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722 		JBrowse link
G Onecut1 one cut homeobox 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2179340 (PMID:12874218)		 Ensembl
RGD		 PMID:12874218 GO_REF:0000107 NCBI chr 8:75,599,432...75,633,598
Ensembl chr 8:75,599,740...75,627,277 		JBrowse link
G Pbx1 PBX homeobox 1 acts_upstream_of_or_within ISO MGI:104737|MGI:2155612|MGI:97350|MGI:98769 (PMID:15944191), (PMID:22560297) RGD PMID:15944191 PMID:22560297 NCBI chr13:80,278,766...80,588,563
Ensembl chr13:80,278,770...80,588,594 		JBrowse link
G Pcid2 PCI domain containing 2 involved_in ISO (MGI:4839685|PMID:20870947) RGD PMID:20870947 MGI:4839685 NCBI chr16:76,423,245...76,448,712
Ensembl chr16:76,423,245...76,448,712 		JBrowse link
G Pitx2 paired-like homeodomain 2 involved_in ISO (MGI:3054669|PMID:15475956) RGD PMID:15475956 MGI:3054669 NCBI chr 2:217,717,738...217,737,293
Ensembl chr 2:217,717,693...217,737,293 		JBrowse link
G Pkn1 protein kinase N1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:5475202 (PMID:23223530)		 Ensembl
RGD		 PMID:23223530 GO_REF:0000107 NCBI chr19:24,442,130...24,470,107
Ensembl chr19:24,442,122...24,470,107 		JBrowse link
G Polb DNA polymerase beta acts_upstream_of_or_within ISO MGI:5427084 (PMID:24388753) RGD PMID:24388753 NCBI chr16:69,379,438...69,402,710
Ensembl chr16:69,379,400...69,404,812 		JBrowse link
G Ppp2r3c protein phosphatase 2, regulatory subunit B'', gamma involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:3759678 (PMID:16129705)		 Ensembl
RGD		 PMID:16129705 GO_REF:0000107 NCBI chr 6:72,647,025...72,670,885
Ensembl chr 6:72,647,025...72,672,491 		JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit IMP RGD PMID:22981234 RGD:8696027 NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952 		JBrowse link
G Psmb9 proteasome 20S subunit beta 9 IEP RGD PMID:24707720 RGD:9854625 NCBI chr20:4,667,044...4,672,512
Ensembl chr20:4,666,046...4,672,512 		JBrowse link
G Rbm15 RNA binding motif protein 15 acts_upstream_of_or_within ISO MGI:2656539|MGI:3706994 (PMID:18981216) RGD PMID:18981216 NCBI chr 2:194,945,974...194,954,498
Ensembl chr 2:194,945,974...194,954,703 		JBrowse link
G Rc3h1 ring finger and CCCH-type domains 1 acts_upstream_of_or_within ISO MGI:2442789 (PMID:23583643) RGD PMID:23583643 NCBI chr13:73,174,075...73,245,762
Ensembl chr13:73,173,946...73,238,839 		JBrowse link
G Rc3h2 ring finger and CCCH-type domains 2 acts_upstream_of_or_within ISO MGI:2685397 (PMID:23583643) RGD PMID:23583643 NCBI chr 3:21,121,531...21,186,711
Ensembl chr 3:21,110,679...21,179,933 		JBrowse link
G Rcbtb2 RCC1 and BTB domain containing protein 2 acts_upstream_of_or_within ISO (PMID:26291700) RGD PMID:26291700 NCBI chr15:48,319,809...48,364,441
Ensembl chr15:48,323,866...48,383,750 		JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 involved_in ISS
ISO		 GO_REF:0000024
UniProtKB:Q61160 (MGI:5291865|PMID:21876153)		 UniProt
RGD		 PMID:21876153 GO_REF:0000024 MGI:5291865 NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121 		JBrowse link
G Samd9l sterile alpha motif domain containing 9 like acts_upstream_of_or_within ISO (PMID:24029230) RGD PMID:24029230 NCBI chr 4:31,362,054...31,376,412
Ensembl chr 4:31,361,669...31,376,415 		JBrowse link
G Slc40a1 solute carrier family 40 member 1 acts_upstream_of_or_within ISO MGI:1889622 (PMID:15342464) RGD PMID:15342464 NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481 		JBrowse link
G Tcf21 transcription factor 21 involved_in ISS
ISO		 GO_REF:0000024
(MGI:1888654|PMID:10944221)		 UniProt
RGD		 PMID:10944221 GO_REF:0000024 MGI:1888654 NCBI chr 1:22,701,353...22,704,212
Ensembl chr 1:22,701,353...22,704,202 		JBrowse link
G Tet2 tet methylcytosine dioxygenase 2 acts_upstream_of_or_within ISO MGI:5301343 (PMID:21803851) RGD PMID:21803851 NCBI chr 2:221,988,645...222,072,813
Ensembl chr 2:221,988,645...222,072,534 		JBrowse link
G Tlx1 T-cell leukemia, homeobox 1 acts_upstream_of_or_within ISO MGI:3581680|MGI:97495 (PMID:11356032), (PMID:15944191) RGD PMID:11356032 PMID:15944191 NCBI chr 1:244,005,057...244,011,318
Ensembl chr 1:244,005,057...244,011,318 		JBrowse link
G Traf3ip2 Traf3 interacting protein 2 involved_in ISO MGI:3510784 (PMID:22585710) RGD PMID:22585710 NCBI chr20:43,011,405...43,054,654
Ensembl chr20:43,011,450...43,054,667 		JBrowse link
spleen trabecula formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc40a1 solute carrier family 40 member 1 acts_upstream_of_or_within ISO MGI:1889622 (PMID:15342464) RGD PMID:15342464 NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19692
    immune system process 2822
      immune system development 233
        hematopoietic or lymphoid organ development 127
          spleen development 51
            spleen trabecula formation 1
Path 2
Term Annotations click to browse term
  biological_process 19692
    developmental process 6963
      anatomical structure development 6486
        multicellular organism development 5239
          system development 4526
            immune system development 233
              hematopoietic or lymphoid organ development 127
                spleen development 51
                  spleen trabecula formation 1
paths to the root