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ONTOLOGY REPORT - ANNOTATIONS

Term:cytoplasmic pattern recognition receptor signaling pathway
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Accession:GO:0002753 term browser browse the term
Definition:The series of molecular signals initiated by the binding of a ligand from another organism to a cytoplasmic pattern recognition receptor (PRR). PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species.
Comment:This term should be used for annotation when it is not known which cytoplasmic pattern recognition receptor (PRR) has been activated. If the PRR is known, consider instead the child terms. The RIG-like family is composed of at least RIG-I (retinoic acid inducible gene I; also known as DDX58), melanoma differentiation-associated gene 5 (MDA5; also known as helicard or IFIH1) and LGP2.
Synonyms:exact_synonym: cytoplasmic PRR signaling pathway;   cytoplasmic pathogen receptor signaling pathway;   cytoplasmic pattern recognition receptor signalling pathway;   cytosolic PAMP receptor signaling pathway;   cytosolic pattern recognition receptor signaling pathway
 narrow_synonym: cytoplasmic caspase-recruiting domain (CARD) helicase signaling pathway
 alt_id: GO:0039528

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cytoplasmic pattern recognition receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alpk1 alpha kinase 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936563:3,233,913...3,296,671
Ensembl chrNW_004936563:3,235,181...3,296,257 		JBrowse link
G Becn1 beclin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936490:17,518,100...17,531,126
Ensembl chrNW_004936490:17,517,751...17,531,151 		JBrowse link
G Cgas cyclic GMP-AMP synthase involved_in ISO (PMID:23258413) UniProt PMID:23258413 NCBI chrNW_004936859:797,469...807,036 JBrowse link
G Dhx58 DExH-box helicase 58 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936490:16,940,776...16,949,836
Ensembl chrNW_004936490:16,940,540...16,950,085 		JBrowse link
G Ipo5 importin 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936472:12,231,970...12,271,639
Ensembl chrNW_004936472:12,229,922...12,271,964 		JBrowse link
G Irf3 interferon regulatory factor 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936664:3,477,750...3,482,489
Ensembl chrNW_004936664:3,475,543...3,481,533 		JBrowse link
G Irf7 interferon regulatory factor 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936888:445,340...448,801
Ensembl chrNW_004936888:445,549...448,392 		JBrowse link
G Mavs mitochondrial antiviral signaling protein involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936485:14,842,778...14,859,163
Ensembl chrNW_004936485:14,842,160...14,859,202 		JBrowse link
G Rigi RNA sensor RIG-I involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936524:1,141,840...1,200,638
Ensembl chrNW_004936524:1,140,971...1,200,638 		JBrowse link
G Sting1 stimulator of interferon response cGAMP interactor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936531:8,555,966...8,562,829
Ensembl chrNW_004936531:8,555,637...8,562,885 		JBrowse link
G Tbk1 TANK binding kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936545:2,763,755...2,809,229
Ensembl chrNW_004936545:2,763,596...2,809,709 		JBrowse link
G Tifa TRAF interacting protein with forkhead associated domain involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936563:3,151,515...3,159,071
Ensembl chrNW_004936563:3,152,049...3,158,999 		JBrowse link
G Traf3ip3 TRAF3 interacting protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936557:3,315,035...3,337,763
Ensembl chrNW_004936557:3,313,244...3,344,819 		JBrowse link
G Traf6 TNF receptor associated factor 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936533:1,857,685...1,874,973
Ensembl chrNW_004936533:1,857,666...1,876,120 		JBrowse link
G Trim25 tripartite motif containing 25 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936490:5,979,320...5,997,632
Ensembl chrNW_004936490:5,979,425...5,997,639 		JBrowse link
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936538:7,518,283...7,558,458
Ensembl chrNW_004936538:7,517,271...7,558,854 		JBrowse link
cGAS/STING signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cgas cyclic GMP-AMP synthase involved_in ISO (PMID:32911482), (PMID:32912999), (PMID:33542149), (PMID:35322803), (PMID:35438208), (PMID:35460603), (PMID:39322678)
(PMID:39322678)		 UniProt PMID:32911482 PMID:32912999 PMID:33542149 PMID:35322803 PMID:35438208 More... NCBI chrNW_004936859:797,469...807,036 JBrowse link
G Ddx41 DEAD-box helicase 41 involved_in ISO (PMID:35613581) UniProt PMID:35613581 NCBI chrNW_004936597:1,787,830...1,793,352
Ensembl chrNW_004936597:1,787,537...1,793,866 		JBrowse link
G Sting1 stimulator of interferon response cGAMP interactor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936531:8,555,966...8,562,829
Ensembl chrNW_004936531:8,555,637...8,562,885 		JBrowse link
endolysosomal toll-like receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Washc4 WASH complex subunit 4 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:33749590) MGI
Ensembl		 PMID:33749590 GO_REF:0000107 NCBI chrNW_004936492:9,527,889...9,585,345
Ensembl chrNW_004936492:9,530,674...9,585,462 		JBrowse link
inflammasome-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Elp6 elongator acetyltransferase complex subunit 6 acts_upstream_of_or_within ISO (PMID:30097576) MGI PMID:30097576 NCBI chrNW_004936596:1,187,402...1,205,277
Ensembl chrNW_004936596:1,184,314...1,205,377 		JBrowse link
MDA-5 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifih1 interferon induced with helicase C domain 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936469:16,721,306...16,778,249
Ensembl chrNW_004936469:16,721,677...16,774,903 		JBrowse link
G Oas3 2'-5'-oligoadenylate synthetase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936668:2,917,978...2,965,336
Ensembl chrNW_004936668:2,950,124...2,962,572
Ensembl chrNW_004936668:2,950,124...2,962,572 		JBrowse link
negative regulation of AIM2 inflammasome complex assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trim11 tripartite motif containing 11 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004937135:11,350...21,235
Ensembl chrNW_004937135:8,990...21,913 		JBrowse link
negative regulation of cGAS/STING signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aars2 alanyl-tRNA synthetase 2, mitochondrial involved_in ISO (PMID:39322678) UniProt PMID:39322678 NCBI chrNW_004936476:15,772,203...15,784,316
Ensembl chrNW_004936476:15,771,905...15,784,373 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936621:620,163...639,115
Ensembl chrNW_004936621:620,074...639,093 		JBrowse link
G Aurkb aurora kinase B involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936595:1,435,601...1,437,423
Ensembl chrNW_004936595:1,435,852...1,440,351 		JBrowse link
G Banf1 barrier to autointegration nuclear assembly factor 1 involved_in ISO (PMID:32792394) UniProt PMID:32792394 NCBI chrNW_004936599:3,553,190...3,555,167
Ensembl chrNW_004936599:3,553,193...3,555,162 		JBrowse link
G Cgas cyclic GMP-AMP synthase involved_in ISO (PMID:32911482), (PMID:32912999) UniProt PMID:32911482 PMID:32912999 NCBI chrNW_004936859:797,469...807,036 JBrowse link
G LOC101972667 immunity related GTPase M involved_in ISO (PMID:32715615) UniProt PMID:32715615 NCBI chrNW_004936504:4,055,091...4,056,089 JBrowse link
G Lyplal1 lysophospholipase like 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936650:2,933,661...2,960,558
Ensembl chrNW_004936650:2,933,306...2,960,846 		JBrowse link
G Parp1 poly(ADP-ribose) polymerase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936526:3,102,468...3,147,601
Ensembl chrNW_004936526:3,102,039...3,147,642 		JBrowse link
G Pcbp2 poly(rC) binding protein 2 involved_in ISO (PMID:35322803) UniProt PMID:35322803 NCBI chrNW_004936512:10,732,129...10,754,885
Ensembl chrNW_004936512:10,732,151...10,756,912 		JBrowse link
G Ppp6c protein phosphatase 6 catalytic subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936487:13,284,652...13,320,936
Ensembl chrNW_004936487:13,283,931...13,321,526 		JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936590:4,722,914...4,887,615
Ensembl chrNW_004936590:4,722,873...4,890,156 		JBrowse link
G Smpdl3a sphingomyelin phosphodiesterase acid like 3A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936802:1,070,919...1,089,222
Ensembl chrNW_004936802:1,070,683...1,088,614 		JBrowse link
G Spsb3 splA/ryanodine receptor domain and SOCS box containing 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936694:2,212,022...2,217,409
Ensembl chrNW_004936694:2,212,299...2,217,140 		JBrowse link
G Trex1 three prime repair exonuclease 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936529:264,535...266,451
Ensembl chrNW_004936529:264,468...266,422 		JBrowse link
G Zdhhc18 zinc finger DHHC-type palmitoyltransferase 18 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936474:11,246,540...11,272,167
Ensembl chrNW_004936474:11,245,734...11,270,391 		JBrowse link
negative regulation of cytoplasmic pattern recognition receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Itch itchy E3 ubiquitin protein ligase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936561:6,140,236...6,265,734
Ensembl chrNW_004936561:6,140,234...6,265,767 		JBrowse link
G Tarbp2 TARBP2 subunit of RISC loading complex involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936512:10,774,793...10,780,041
Ensembl chrNW_004936512:10,774,213...10,796,268 		JBrowse link
G Tax1bp1 Tax1 binding protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936478:4,305,859...4,375,785
Ensembl chrNW_004936478:4,312,536...4,374,857 		JBrowse link
G Tspan6 tetraspanin 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936584:5,842,549...5,848,533
Ensembl chrNW_004936584:5,840,312...5,848,622 		JBrowse link
negative regulation of MDA-5 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1qbp complement C1q binding protein involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936677:2,371,400...2,376,608
Ensembl chrNW_004936677:2,371,418...2,376,608 		JBrowse link
G Dhx58 DExH-box helicase 58 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936490:16,940,776...16,949,836
Ensembl chrNW_004936490:16,940,540...16,950,085 		JBrowse link
G Riok3 RIO kinase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936550:2,921,272...2,949,288
Ensembl chrNW_004936550:2,921,227...2,950,164 		JBrowse link
G Tkfc triokinase and FMN cyclase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936581:1,697,965...1,710,363
Ensembl chrNW_004936581:1,697,947...1,710,738 		JBrowse link
negative regulation of NLRP3 inflammasome complex assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd17a abhydrolase domain containing 17A, depalmitoylase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936588:1,081,719...1,089,514
Ensembl chrNW_004936588:1,077,817...1,091,073 		JBrowse link
G Cptp ceramide-1-phosphate transfer protein involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936737:1,816,461...1,820,353
Ensembl chrNW_004936737:1,816,475...1,820,320 		JBrowse link
G Csnk1a1 casein kinase 1 alpha 1 involved_in ISO (PMID:34615873) UniProt PMID:34615873 NCBI chrNW_004936504:5,351,354...5,394,856
Ensembl chrNW_004936504:5,351,029...5,396,034 		JBrowse link
G Fbxl2 F-box and leucine rich repeat protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936473:23,567,251...23,659,708
Ensembl chrNW_004936473:23,567,230...23,658,240 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936542:7,577,192...7,581,598
Ensembl chrNW_004936542:7,577,149...7,581,923 		JBrowse link
G Lamp2 lysosomal associated membrane protein 2 involved_in ISO (PMID:36586411) UniProt PMID:36586411 NCBI chrNW_004936479:9,584,221...9,622,330
Ensembl chrNW_004936479:9,584,221...9,610,420 		JBrowse link
G LOC101972667 immunity related GTPase M involved_in ISO (PMID:30612879) UniProt PMID:30612879 NCBI chrNW_004936504:4,055,091...4,056,089 JBrowse link
G Mefv MEFV innate immunity regulator, pyrin involved_in ISO (PMID:26347139) UniProt PMID:26347139 NCBI chrNW_004936694:970,706...980,605 JBrowse link
G Nlrc3 NLR family CARD domain containing 3 involved_in ISO (PMID:25277106) UniProt PMID:25277106 NCBI chrNW_004936694:757,121...773,924 JBrowse link
G Pydc1 pyrin domain containing 1 NOT|involved_in ISO (PMID:24871464) UniProt PMID:24871464 NCBI chrNW_004936501:13,561,927...13,564,392 JBrowse link
G Sirt2 sirtuin 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23502856) Ensembl
MGI		 PMID:23502856 GO_REF:0000107 NCBI chrNW_004936661:1,828,868...1,849,892
Ensembl chrNW_004936661:1,828,831...1,850,000 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:32514138)
(PMID:29887864)		 ARUK-UCL
Ensembl		 PMID:29887864 PMID:32514138 GO_REF:0000107 NCBI chrNW_004936476:18,659,725...18,665,406
Ensembl chrNW_004936476:18,659,815...18,663,940 		JBrowse link
G Trim31 tripartite motif containing 31 involved_in ISO (PMID:27929086) UniProt PMID:27929086 NCBI chrNW_004936723:934,808...945,279 JBrowse link
G Zdhhc12 zinc finger DHHC-type palmitoyltransferase 12 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936487:16,201,288...16,203,818
Ensembl chrNW_004936487:16,199,742...16,203,858 		JBrowse link
negative regulation of non-canonical inflammasome complex assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936762:99,335...137,833
Ensembl chrNW_004936762:99,293...137,874 		JBrowse link
negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnfaip3 TNF alpha induced protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936560:5,124,955...5,138,988
Ensembl chrNW_004936560:5,128,843...5,138,345 		JBrowse link
negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Erbin erbb2 interacting protein involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936480:3,155,934...3,293,224
Ensembl chrNW_004936480:3,154,690...3,293,230 		JBrowse link
G Ptpn22 protein tyrosine phosphatase non-receptor type 22 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936690:2,180,804...2,232,869
Ensembl chrNW_004936690:2,181,047...2,232,958 		JBrowse link
G Tnfaip3 TNF alpha induced protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936560:5,124,955...5,138,988
Ensembl chrNW_004936560:5,128,843...5,138,345 		JBrowse link
G Znrf4 zinc and ring finger 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936588:3,142,687...3,143,793
Ensembl chrNW_004936588:3,142,736...3,143,793 		JBrowse link
negative regulation of RIG-I signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1qbp complement C1q binding protein involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936677:2,371,400...2,376,608
Ensembl chrNW_004936677:2,371,418...2,376,608 		JBrowse link
G Dhx58 DExH-box helicase 58 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936490:16,940,776...16,949,836
Ensembl chrNW_004936490:16,940,540...16,950,085 		JBrowse link
G Gpatch3 G-patch domain containing 3 involved_in IEA InterPro
TreeGrafter
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936474:11,298,802...11,310,609
Ensembl chrNW_004936474:11,298,620...11,310,637 		JBrowse link
G Nlrx1 NLR family member X1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21703540) Ensembl
MGI		 PMID:21703540 GO_REF:0000107 NCBI chrNW_004936542:4,105,980...4,121,176
Ensembl chrNW_004936542:4,109,136...4,122,978 		JBrowse link
G Nploc4 NPL4 homolog, ubiquitin recognition factor involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936594:5,206,222...5,251,042
Ensembl chrNW_004936594:5,205,659...5,251,026 		JBrowse link
G Rnf125 ring finger protein 125 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936682:1,228,903...1,268,651
Ensembl chrNW_004936682:1,231,823...1,268,657 		JBrowse link
G Sec14l1 SEC14 like lipid binding 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936594:2,048,146...2,100,808
Ensembl chrNW_004936594:2,048,054...2,100,859 		JBrowse link
G Ufd1 ubiquitin recognition factor in ER associated degradation 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936619:3,395,130...3,419,704
Ensembl chrNW_004936619:3,395,687...3,419,472 		JBrowse link
negative regulation of toll-like receptor 3 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F2rl1 F2R like trypsin receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936549:142,281...153,575
Ensembl chrNW_004936549:141,512...153,602 		JBrowse link
G Tnfaip3 TNF alpha induced protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936560:5,124,955...5,138,988
Ensembl chrNW_004936560:5,128,843...5,138,345 		JBrowse link
G Ubqln1 ubiquilin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936828:543,651...588,673
Ensembl chrNW_004936828:542,407...588,679 		JBrowse link
negative regulation of toll-like receptor 9 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gramd4 GRAM domain containing 4 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936629:3,348,461...3,431,975
Ensembl chrNW_004936629:3,346,495...3,432,096 		JBrowse link
G Ppt1 palmitoyl-protein thioesterase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936474:21,881,692...21,906,564
Ensembl chrNW_004936474:21,881,712...21,906,569 		JBrowse link
G Ptprs protein tyrosine phosphatase receptor type S involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936588:3,021,418...3,073,080
Ensembl chrNW_004936588:3,022,321...3,072,993 		JBrowse link
G Rab7b RAB7B, member RAS oncogene family involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936557:6,504,562...6,519,219
Ensembl chrNW_004936557:6,504,509...6,519,219 		JBrowse link
NLRP1 inflammasome complex assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nlrp1 NLR family pyrin domain containing 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936677:2,248,153...2,290,802
Ensembl chrNW_004936677:2,248,903...2,289,151 		JBrowse link
NLRP3 inflammasome complex assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atat1 alpha tubulin acetyltransferase 1 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:23502856) Ensembl
MGI		 PMID:23502856 GO_REF:0000107 NCBI chrNW_004936837:300,765...319,742
Ensembl chrNW_004936837:300,715...319,623 		JBrowse link
G Gkn2 gastrokine 2 acts_upstream_of_or_within ISO (PMID:32226647) MGI PMID:32226647 NCBI chrNW_004936491:13,233,729...13,238,305
Ensembl chrNW_004936491:13,233,714...13,306,184 		JBrowse link
G Kcnj8 potassium inwardly rectifying channel subfamily J member 8 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:28928055) Ensembl
MGI		 PMID:28928055 GO_REF:0000107 NCBI chrNW_004936548:5,125,583...5,132,490
Ensembl chrNW_004936548:5,125,555...5,133,078 		JBrowse link
G Nlrp3 NLR family pyrin domain containing 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22753929) Ensembl
MGI		 PMID:22753929 GO_REF:0000107 NCBI chrNW_004936864:709,693...732,119
Ensembl chrNW_004936864:709,709...731,718 		JBrowse link
G Pycard PYD and CARD domain containing involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936501:13,550,702...13,552,774
Ensembl chrNW_004936501:13,550,679...13,552,805 		JBrowse link
G Sirt2 sirtuin 2 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:23502856) Ensembl
MGI		 PMID:23502856 GO_REF:0000107 NCBI chrNW_004936661:1,828,868...1,849,892
Ensembl chrNW_004936661:1,828,831...1,850,000 		JBrowse link
NLRP6 inflammasome complex assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nlrp6 NLR family pyrin domain containing 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936888:145,642...151,716
Ensembl chrNW_004936888:145,642...151,182 		JBrowse link
nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rnf34 ring finger protein 34 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936558:2,901,386...2,918,976
Ensembl chrNW_004936558:2,901,512...2,919,018 		JBrowse link
nucleotide-binding oligomerization domain containing 1 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nfkbia NFKB inhibitor alpha involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18261938) Ensembl
MGI		 PMID:18261938 GO_REF:0000107 NCBI chrNW_004936494:9,537,793...9,541,187
Ensembl chrNW_004936494:9,537,008...9,541,612 		JBrowse link
G Nod1 nucleotide binding oligomerization domain containing 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936478:6,717,354...6,768,293
Ensembl chrNW_004936478:6,715,245...6,768,372 		JBrowse link
G Ripk2 receptor interacting serine/threonine kinase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11894098) Ensembl
MGI		 PMID:11894098 GO_REF:0000107 NCBI chrNW_004936544:3,606,925...3,653,248
Ensembl chrNW_004936544:3,606,879...3,655,532 		JBrowse link
G Tlr4 toll like receptor 4 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:18261938) Ensembl
MGI		 PMID:18261938 GO_REF:0000107 NCBI chrNW_004936487:6,519,140...6,532,018
Ensembl chrNW_004936487:6,518,441...6,533,095 		JBrowse link
G Xiap X-linked inhibitor of apoptosis involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936479:6,677,533...6,724,800
Ensembl chrNW_004936479:6,677,526...6,722,116 		JBrowse link
nucleotide-binding oligomerization domain containing 2 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Inava innate immunity activator involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936567:3,443,053...3,458,184
Ensembl chrNW_004936567:3,443,042...3,464,506 		JBrowse link
G LOC101972667 immunity related GTPase M involved_in ISO (PMID:25891078) UniProt PMID:25891078 NCBI chrNW_004936504:4,055,091...4,056,089 JBrowse link
G LOC101974441 purine nucleoside phosphorylase LACC1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936791:80,245...91,172
Ensembl chrNW_004936791:80,245...93,951 		JBrowse link
G Nfkbia NFKB inhibitor alpha involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18261938) Ensembl
MGI		 PMID:18261938 GO_REF:0000107 NCBI chrNW_004936494:9,537,793...9,541,187
Ensembl chrNW_004936494:9,537,008...9,541,612 		JBrowse link
G Nod2 nucleotide binding oligomerization domain containing 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:12527755)
(PMID:23892723)		 MGI
Ensembl		 PMID:12527755 PMID:23892723 GO_REF:0000107 NCBI chrNW_004936475:3,708,069...3,742,845
Ensembl chrNW_004936475:3,713,362...3,745,982 		JBrowse link
G Otulin OTU deubiquitinase with linear linkage specificity involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936665:1,654,045...1,690,955
Ensembl chrNW_004936665:1,668,311...1,690,918 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:12527755) MGI
Ensembl		 PMID:12527755 GO_REF:0000107 NCBI chrNW_004936599:3,800,142...3,810,583
Ensembl chrNW_004936599:3,801,636...3,809,813 		JBrowse link
G Ripk2 receptor interacting serine/threonine kinase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11894098) Ensembl
MGI		 PMID:11894098 GO_REF:0000107 NCBI chrNW_004936544:3,606,925...3,653,248
Ensembl chrNW_004936544:3,606,879...3,655,532 		JBrowse link
G Tlr4 toll like receptor 4 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:18261938) Ensembl
MGI		 PMID:18261938 GO_REF:0000107 NCBI chrNW_004936487:6,519,140...6,532,018
Ensembl chrNW_004936487:6,518,441...6,533,095 		JBrowse link
G Xiap X-linked inhibitor of apoptosis involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936479:6,677,533...6,724,800
Ensembl chrNW_004936479:6,677,526...6,722,116 		JBrowse link
positive regulation of AIM2 inflammasome complex assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC101961426 guanylate-binding protein 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936991:83,446...95,310
Ensembl chrNW_004936991:83,465...95,416 		JBrowse link
positive regulation of cGAS/STING signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Btk Bruton tyrosine kinase involved_in ISO (PMID:25704810) UniProt PMID:25704810 NCBI chrNW_004936813:429,400...467,481
Ensembl chrNW_004936813:429,224...463,441 		JBrowse link
G Map3k7 mitogen-activated protein kinase kinase kinase 7 involved_in ISO (PMID:37832545) UniProt PMID:37832545 NCBI chrNW_004936510:1,772,971...1,836,075
Ensembl chrNW_004936510:1,772,971...1,837,765 		JBrowse link
G Slc19a1 solute carrier family 19 member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936778:823,376...846,843
Ensembl chrNW_004936778:829,550...848,833 		JBrowse link
G Tab1 TGF-beta activated kinase 1 (MAP3K7) binding protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936492:2,207,147...2,234,573
Ensembl chrNW_004936492:2,210,197...2,234,489 		JBrowse link
G Zdhhc9 zinc finger DHHC-type palmitoyltransferase 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936479:1,711,756...1,743,306
Ensembl chrNW_004936479:1,711,713...1,741,167 		JBrowse link
positive regulation of MDA-5 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ankrd17 ankyrin repeat domain 17 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936598:2,191,604...2,338,832
Ensembl chrNW_004936598:2,191,735...2,340,453 		JBrowse link
G Ddx60 DExD/H-box helicase 60 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936516:649,217...735,499
Ensembl chrNW_004936516:649,191...731,639 		JBrowse link
G Dhx58 DExH-box helicase 58 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936490:16,940,776...16,949,836
Ensembl chrNW_004936490:16,940,540...16,950,085 		JBrowse link
positive regulation of NLRP3 inflammasome complex assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atat1 alpha tubulin acetyltransferase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23502856) Ensembl
MGI		 PMID:23502856 GO_REF:0000107 NCBI chrNW_004936837:300,765...319,742
Ensembl chrNW_004936837:300,715...319,623 		JBrowse link
G Brcc3 BRCA1/BRCA2-containing complex subunit 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936927:341,114...380,817
Ensembl chrNW_004936927:341,253...376,700 		JBrowse link
G Btk Bruton tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936813:429,400...467,481
Ensembl chrNW_004936813:429,224...463,441 		JBrowse link
G Cd36 CD36 molecule (CD36 blood group) involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936810:791,823...838,303
Ensembl chrNW_004936810:758,182...838,365 		JBrowse link
G Ddx3x DEAD-box helicase 3 X-linked involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936502:7,770,896...7,820,555
Ensembl chrNW_004936502:7,804,824...7,820,569 		JBrowse link
G Dhx33 DEAH-box helicase 33 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936677:2,345,153...2,367,247
Ensembl chrNW_004936677:2,345,315...2,364,802 		JBrowse link
G Lats1 large tumor suppressor kinase 1 involved_in ISO (PMID:39173637) UniProt PMID:39173637 NCBI chrNW_004936489:2,607,114...2,649,879
Ensembl chrNW_004936489:2,605,195...2,649,879 		JBrowse link
G Lats2 large tumor suppressor kinase 2 involved_in ISO (PMID:39173637) UniProt PMID:39173637 NCBI chrNW_004936720:735,326...795,596
Ensembl chrNW_004936720:735,524...793,696 		JBrowse link
G LOC101961426 guanylate-binding protein 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936991:83,446...95,310
Ensembl chrNW_004936991:83,465...95,416 		JBrowse link
G LOC101964473 caspase-4-like involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936551:3,242,381...3,269,821 JBrowse link
G Mapk8 mitogen-activated protein kinase 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936728:1,775,746...1,893,895
Ensembl chrNW_004936728:1,775,641...1,893,907 		JBrowse link
G Mark4 microtubule affinity regulating kinase 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936706:1,764,239...1,789,745
Ensembl chrNW_004936706:1,762,869...1,788,821 		JBrowse link
G Mavs mitochondrial antiviral signaling protein involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936485:14,842,778...14,859,163
Ensembl chrNW_004936485:14,842,160...14,859,202 		JBrowse link
G Myd88 MYD88 innate immune signal transduction adaptor involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936473:27,672,237...27,676,339
Ensembl chrNW_004936473:27,671,797...27,676,372 		JBrowse link
G Nek7 NIMA related kinase 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936567:5,685,619...5,815,094
Ensembl chrNW_004936567:5,685,125...5,808,499 		JBrowse link
G P2rx7 purinergic receptor P2X 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936558:3,106,819...3,149,689
Ensembl chrNW_004936558:3,108,283...3,149,765 		JBrowse link
G Plcg2 phospholipase C gamma 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:32514138) ARUK-UCL
Ensembl		 PMID:32514138 GO_REF:0000107 NCBI chrNW_004936475:29,248,533...29,377,335
Ensembl chrNW_004936475:29,248,516...29,377,206 		JBrowse link
G Ppp2ca protein phosphatase 2 catalytic subunit alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936647:1,031,118...1,055,961
Ensembl chrNW_004936647:1,031,119...1,055,149 		JBrowse link
G Prkd1 protein kinase D1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936494:4,469,092...4,601,183
Ensembl chrNW_004936494:4,469,089...4,601,214 		JBrowse link
G Ptpn22 protein tyrosine phosphatase non-receptor type 22 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936690:2,180,804...2,232,869
Ensembl chrNW_004936690:2,181,047...2,232,958 		JBrowse link
G Stmp1 short transmembrane mitochondrial protein 1 involved_in ISO (PMID:31836654) UniProt PMID:31836654 NCBI chrNW_004936592:435,243...447,999 JBrowse link
G Tlr4 toll like receptor 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936487:6,519,140...6,532,018
Ensembl chrNW_004936487:6,518,441...6,533,095 		JBrowse link
G Tlr6 toll like receptor 6 involved_in ISO (PMID:23812099) UniProt PMID:23812099 NCBI chrNW_004936482:6,607,723...6,610,161
Ensembl chrNW_004936482:6,607,753...6,610,143 		JBrowse link
G Usp50 ubiquitin specific peptidase 50 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:28094437) MGI
Ensembl		 PMID:28094437 GO_REF:0000107 NCBI chrNW_004936471:12,522,361...12,552,611
Ensembl chrNW_004936471:12,521,731...12,552,346 		JBrowse link
G Zdhhc1 zinc finger DHHC-type containing 1 involved_in ISO (PMID:39173637) UniProt PMID:39173637 NCBI chrNW_004936475:17,849,772...17,869,140
Ensembl chrNW_004936475:17,849,802...17,861,465 		JBrowse link
G Zdhhc5 zinc finger DHHC-type palmitoyltransferase 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936581:4,839,511...4,865,406
Ensembl chrNW_004936581:4,839,511...4,865,140 		JBrowse link
positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc15a4 solute carrier family 15 member 4 involved_in ISO (PMID:19570976), (PMID:21277849) UniProt PMID:19570976 PMID:21277849 NCBI chrNW_004936660:481,772...493,567 JBrowse link
G Slc46a2 solute carrier family 46 member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936559:670,239...674,061
Ensembl chrNW_004936559:670,231...679,766 		JBrowse link
G Tlr4 toll like receptor 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18261938) Ensembl
MGI		 PMID:18261938 GO_REF:0000107 NCBI chrNW_004936487:6,519,140...6,532,018
Ensembl chrNW_004936487:6,518,441...6,533,095 		JBrowse link
positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC101955831 heat shock 70 kDa protein 1 involved_in ISO (PMID:24790089) UniProt PMID:24790089 NCBI chrNW_004936727:1,718,952...1,721,691 JBrowse link
G LOC101956126 heat shock 70 kDa protein 1 involved_in ISO (PMID:24790089) UniProt PMID:24790089 NCBI chrNW_004936727:1,732,323...1,735,128 JBrowse link
G Nagk N-acetylglucosamine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936491:15,183,493...15,193,069
Ensembl chrNW_004936491:15,183,804...15,192,950 		JBrowse link
G Peli3 pellino E3 ubiquitin protein ligase family member 3 acts_upstream_of_or_within ISO (PMID:23892723) MGI PMID:23892723 NCBI chrNW_004936599:3,099,256...3,110,566
Ensembl chrNW_004936599:3,099,256...3,110,565 		JBrowse link
G Slc15a3 solute carrier family 15 member 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936581:1,985,062...1,996,924
Ensembl chrNW_004936581:1,984,344...1,996,924 		JBrowse link
G Slc15a4 solute carrier family 15 member 4 involved_in ISO (PMID:24695226) UniProt PMID:24695226 NCBI chrNW_004936660:481,772...493,567 JBrowse link
G Tlr4 toll like receptor 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18261938) Ensembl
MGI		 PMID:18261938 GO_REF:0000107 NCBI chrNW_004936487:6,519,140...6,532,018
Ensembl chrNW_004936487:6,518,441...6,533,095 		JBrowse link
positive regulation of RIG-I signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ankrd17 ankyrin repeat domain 17 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936598:2,191,604...2,338,832
Ensembl chrNW_004936598:2,191,735...2,340,453 		JBrowse link
G Ddx60 DExD/H-box helicase 60 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936516:649,217...735,499
Ensembl chrNW_004936516:649,191...731,639 		JBrowse link
G Dhx58 DExH-box helicase 58 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936490:16,940,776...16,949,836
Ensembl chrNW_004936490:16,940,540...16,950,085 		JBrowse link
G Oasl 2'-5'-oligoadenylate synthetase like involved_in ISO (PMID:25925578) ARUK-UCL PMID:25925578 NCBI chrNW_004936668:43,960...50,246 JBrowse link
G Pum1 pumilio RNA binding family member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936474:14,243,325...14,363,461
Ensembl chrNW_004936474:14,243,296...14,363,500 		JBrowse link
G Pum2 pumilio RNA binding family member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936493:11,067,318...11,154,133
Ensembl chrNW_004936493:11,067,202...11,155,377 		JBrowse link
G Trim15 tripartite motif containing 15 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936723:869,019...880,200
Ensembl chrNW_004936723:873,274...880,065 		JBrowse link
G Usp15 ubiquitin specific peptidase 15 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936545:978,318...1,094,729
Ensembl chrNW_004936545:978,280...1,095,659 		JBrowse link
G Zc3hav1 zinc finger CCCH-type containing, antiviral 1 involved_in ISO (PMID:21102435) UniProt PMID:21102435 NCBI chrNW_004936592:3,321,564...3,379,015
Ensembl chrNW_004936592:3,321,454...3,358,983 		JBrowse link
G Zcchc3 zinc finger CCHC-type containing 3 involved_in ISO (PMID:30193849) UniProt PMID:30193849 NCBI chrNW_004936670:3,048,914...3,049,809 JBrowse link
positive regulation of toll-like receptor 13 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Treml4 triggering receptor expressed on myeloid cells like 4 involved_in ISO (PMID:25848864) UniProt PMID:25848864 NCBI chrNW_004936476:18,603,620...18,612,050 JBrowse link
positive regulation of toll-like receptor 3 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav1 caveolin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936589:2,504,235...2,536,778
Ensembl chrNW_004936589:2,504,224...2,537,170 		JBrowse link
G F2rl1 F2R like trypsin receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936549:142,281...153,575
Ensembl chrNW_004936549:141,512...153,602 		JBrowse link
G Flot1 flotillin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936837:387,012...401,076
Ensembl chrNW_004936837:380,288...401,071 		JBrowse link
G LOC101955400 AP-1 complex subunit sigma-3 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936569:5,574,591...5,604,948
Ensembl chrNW_004936569:5,490,319...5,544,250
Ensembl chrNW_004936569:5,490,319...5,544,250 		JBrowse link
G Peli1 pellino E3 ubiquitin protein ligase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19734906) Ensembl
MGI		 PMID:19734906 GO_REF:0000107 NCBI chrNW_004936491:8,985,074...9,040,863
Ensembl chrNW_004936491:8,985,074...9,041,244 		JBrowse link
G Ptpn22 protein tyrosine phosphatase non-receptor type 22 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936690:2,180,804...2,232,869
Ensembl chrNW_004936690:2,181,047...2,232,958 		JBrowse link
G Tirap TIR domain containing adaptor protein involved_in ISO (PMID:17322885) BHF-UCL PMID:17322885 NCBI chrNW_004936572:5,926,193...5,938,621
Ensembl chrNW_004936572:5,924,158...5,938,658 		JBrowse link
G Trim3 tripartite motif containing 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936842:494,460...524,305
Ensembl chrNW_004936842:501,127...524,347 		JBrowse link
positive regulation of toll-like receptor 7 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddx3x DEAD-box helicase 3 X-linked involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936502:7,770,896...7,820,555
Ensembl chrNW_004936502:7,804,824...7,820,569 		JBrowse link
G Ptpn22 protein tyrosine phosphatase non-receptor type 22 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936690:2,180,804...2,232,869
Ensembl chrNW_004936690:2,181,047...2,232,958 		JBrowse link
G Rsad2 radical S-adenosyl methionine domain containing 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936532:3,921,824...3,936,027
Ensembl chrNW_004936532:3,921,807...3,936,042 		JBrowse link
G Slc15a4 solute carrier family 15 member 4 involved_in ISO (PMID:25238095), (PMID:32433612)
(PMID:21045126), (PMID:25238095)		 UniProt PMID:21045126 PMID:25238095 PMID:32433612 NCBI chrNW_004936660:481,772...493,567 JBrowse link
G Tasl TLR adaptor interacting with endolysosomal SLC15A4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936553:6,628,131...6,629,027
Ensembl chrNW_004936553:6,628,131...6,629,027 		JBrowse link
G Treml4 triggering receptor expressed on myeloid cells like 4 involved_in ISO (PMID:25848864) UniProt PMID:25848864 NCBI chrNW_004936476:18,603,620...18,612,050 JBrowse link
positive regulation of toll-like receptor 8 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddx3x DEAD-box helicase 3 X-linked involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936502:7,770,896...7,820,555
Ensembl chrNW_004936502:7,804,824...7,820,569 		JBrowse link
G Slc15a4 solute carrier family 15 member 4 involved_in ISO (PMID:32433612) UniProt PMID:32433612 NCBI chrNW_004936660:481,772...493,567 JBrowse link
G Tasl TLR adaptor interacting with endolysosomal SLC15A4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936553:6,628,131...6,629,027
Ensembl chrNW_004936553:6,628,131...6,629,027 		JBrowse link
positive regulation of toll-like receptor 9 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC101961439 twinfilin-2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936529:3,538,813...3,555,562
Ensembl chrNW_004936529:3,538,862...3,555,593 		JBrowse link
G Ptpn22 protein tyrosine phosphatase non-receptor type 22 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936690:2,180,804...2,232,869
Ensembl chrNW_004936690:2,181,047...2,232,958 		JBrowse link
G Rsad2 radical S-adenosyl methionine domain containing 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936532:3,921,824...3,936,027
Ensembl chrNW_004936532:3,921,807...3,936,042 		JBrowse link
G Rtn4 reticulon 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936491:1,407,414...1,474,031
Ensembl chrNW_004936491:1,407,414...1,474,360 		JBrowse link
G Slc15a4 solute carrier family 15 member 4 involved_in ISO (PMID:25238095)
(PMID:21045126), (PMID:21277849), (PMID:25238095)		 UniProt PMID:21045126 PMID:21277849 PMID:25238095 NCBI chrNW_004936660:481,772...493,567 JBrowse link
G Treml4 triggering receptor expressed on myeloid cells like 4 involved_in ISO (PMID:25848864) UniProt PMID:25848864 NCBI chrNW_004936476:18,603,620...18,612,050 JBrowse link
G Zdhhc3 zinc finger DHHC-type palmitoyltransferase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936695:776,822...830,693
Ensembl chrNW_004936695:776,822...832,361 		JBrowse link
regulation of NLRP3 inflammasome complex assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2ak2 eukaryotic translation initiation factor 2 alpha kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936663:1,127,047...1,157,263
Ensembl chrNW_004936663:1,126,977...1,157,137 		JBrowse link
G Kcnk13 potassium two pore domain channel subfamily K member 13 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936488:17,410,165...17,411,040
Ensembl chrNW_004936488:17,322,431...17,411,923 		JBrowse link
regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc15a2 solute carrier family 15 member 2 involved_in ISO (PMID:29784761) UniProt PMID:29784761 NCBI chrNW_004936536:8,280,537...8,316,011
Ensembl chrNW_004936536:8,280,448...8,316,064 		JBrowse link
G Slc15a4 solute carrier family 15 member 4 involved_in ISO (PMID:29784761) UniProt PMID:29784761 NCBI chrNW_004936660:481,772...493,567 JBrowse link
regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Peli3 pellino E3 ubiquitin protein ligase family member 3 acts_upstream_of_or_within ISO (PMID:23892723) MGI PMID:23892723 NCBI chrNW_004936599:3,099,256...3,110,566
Ensembl chrNW_004936599:3,099,256...3,110,565 		JBrowse link
regulation of RIG-I signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nop53 NOP53 ribosome biogenesis factor involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936664:1,334,487...1,343,867
Ensembl chrNW_004936664:1,334,510...1,342,321 		JBrowse link
regulation of toll-like receptor 3 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Flot2 flotillin 2 NOT|involved_in ISO (PMID:25204797) UniProt PMID:25204797 NCBI chrNW_004936538:5,071,546...5,090,287
Ensembl chrNW_004936538:5,071,546...5,090,313 		JBrowse link
G Hcfc2 host cell factor C2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:28970238) Ensembl
MGI		 PMID:28970238 GO_REF:0000107 NCBI chrNW_004936492:10,390,603...10,426,232
Ensembl chrNW_004936492:10,390,268...10,426,206 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936561:3,826,802...3,844,406
Ensembl chrNW_004936561:3,825,787...3,844,483 		JBrowse link
RIG-I signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clpb ClpB family mitochondrial disaggregase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936498:1,590,655...1,730,815
Ensembl chrNW_004936498:1,590,655...1,730,815 		JBrowse link
G Lsm14a LSM14A mRNA processing body assembly factor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22745163) Ensembl
MGI		 PMID:22745163 GO_REF:0000107 NCBI chrNW_004936570:1,723,966...1,791,784
Ensembl chrNW_004936570:1,729,841...1,791,778 		JBrowse link
G Mavs mitochondrial antiviral signaling protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22745163) Ensembl
MGI		 PMID:22745163 GO_REF:0000107 NCBI chrNW_004936485:14,842,778...14,859,163
Ensembl chrNW_004936485:14,842,160...14,859,202 		JBrowse link
G Oas3 2'-5'-oligoadenylate synthetase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936668:2,917,978...2,965,336
Ensembl chrNW_004936668:2,950,124...2,962,572
Ensembl chrNW_004936668:2,950,124...2,962,572 		JBrowse link
G Phb1 prohibitin 1 involved_in ISO (PMID:31522117) UniProt PMID:31522117 NCBI chrNW_004936490:12,127,065...12,138,870
Ensembl chrNW_004936490:12,127,065...12,138,870 		JBrowse link
G Phb2 prohibitin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936709:854,493...859,182
Ensembl chrNW_004936709:854,698...858,851 		JBrowse link
G Rigi RNA sensor RIG-I involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936524:1,141,840...1,200,638
Ensembl chrNW_004936524:1,140,971...1,200,638 		JBrowse link
G Rnf135 ring finger protein 135 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936538:2,741,308...2,757,042
Ensembl chrNW_004936538:2,741,220...2,757,240 		JBrowse link
G Trim25 tripartite motif containing 25 NOT|involved_in ISO (PMID:31006531) UniProt PMID:31006531 NCBI chrNW_004936490:5,979,320...5,997,632
Ensembl chrNW_004936490:5,979,425...5,997,639 		JBrowse link
toll-like receptor 3 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd86 CD86 molecule involved_in ISO (PMID:25158758) UniProt PMID:25158758 NCBI chrNW_004936536:8,414,491...8,481,712 JBrowse link
G Colec12 collectin subfamily member 12 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936550:169,084...350,209
Ensembl chrNW_004936550:169,084...350,501 		JBrowse link
G Havcr2 hepatitis A virus cellular receptor 2 involved_in ISO (PMID:22842346) UniProt PMID:22842346 NCBI chrNW_004936515:6,001,324...6,015,407 JBrowse link
G Lgals9 galectin 9 involved_in ISO PMID:25158758 UniProt PMID:25158758 RGD:10054077 NCBI chrNW_004936538:4,034,467...4,050,240 JBrowse link
G LOC120891307 2'-5'-oligoadenylate synthase 1-like involved_in IEA Ensembl GO_REF:0000107 Ensembl chrNW_004936668:2,917,900...2,925,397 JBrowse link
G Rftn1 raftlin, lipid raft linker 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:21266579) MGI
Ensembl		 PMID:21266579 GO_REF:0000107 NCBI chrNW_004936473:9,119,234...9,317,696
Ensembl chrNW_004936473:9,117,247...9,317,704 		JBrowse link
G Rnf170 ring finger protein 170 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:31076723) MGI
Ensembl		 PMID:31076723 GO_REF:0000107 NCBI chrNW_004937108:111,111...147,077
Ensembl chrNW_004937108:117,881...150,498 		JBrowse link
G Scara3 scavenger receptor class A member 3 NOT|involved_in ISO (PMID:25204797) UniProt PMID:25204797 NCBI chrNW_004936675:541,829...561,110
Ensembl chrNW_004936675:535,210...561,119 		JBrowse link
G Scimp SLP adaptor and CSK interacting membrane protein involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936677:2,575,255...2,585,969
Ensembl chrNW_004936677:2,579,010...2,586,002 		JBrowse link
G Ticam1 toll like receptor adaptor molecule 1 involved_in ISO (PMID:12471095) UniProt PMID:12471095 NCBI chrNW_004936588:2,818,909...2,827,797 JBrowse link
G Tlr3 toll like receptor 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936554:3,370,766...3,388,125
Ensembl chrNW_004936554:3,369,469...3,385,907 		JBrowse link
G Tnf tumor necrosis factor involved_in ISO PMID:25158758 UniProt PMID:25158758 RGD:10054077 NCBI chrNW_004936727:1,936,066...1,937,766
Ensembl chrNW_004936727:1,936,066...1,937,766 		JBrowse link
G Tnip2 TNFAIP3 interacting protein 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936477:20,810,188...20,841,537
Ensembl chrNW_004936477:20,834,849...20,841,535 		JBrowse link
G Unc93b1 unc-93 homolog B1, TLR signaling regulator involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936599:2,109,292...2,146,006
Ensembl chrNW_004936599:2,109,292...2,117,143 		JBrowse link
toll-like receptor 7 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Havcr2 hepatitis A virus cellular receptor 2 involved_in ISO (PMID:22842346) UniProt PMID:22842346 NCBI chrNW_004936515:6,001,324...6,015,407 JBrowse link
G Pik3ap1 phosphoinositide-3-kinase adaptor protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936636:2,822,100...2,935,252
Ensembl chrNW_004936636:2,821,939...2,938,082 		JBrowse link
G Scimp SLP adaptor and CSK interacting membrane protein involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936677:2,575,255...2,585,969
Ensembl chrNW_004936677:2,579,010...2,586,002 		JBrowse link
G Tlr7 toll like receptor 7 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936470:2,593,544...2,610,972
Ensembl chrNW_004936470:2,607,508...2,610,675 		JBrowse link
G Unc93b1 unc-93 homolog B1, TLR signaling regulator involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936599:2,109,292...2,146,006
Ensembl chrNW_004936599:2,109,292...2,117,143 		JBrowse link
toll-like receptor 8 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Myd88 MYD88 innate immune signal transduction adaptor involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936473:27,672,237...27,676,339
Ensembl chrNW_004936473:27,671,797...27,676,372 		JBrowse link
G Tlr7 toll like receptor 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936470:2,593,544...2,610,972
Ensembl chrNW_004936470:2,607,508...2,610,675 		JBrowse link
G Tlr8 toll like receptor 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936470:2,638,020...2,642,201
Ensembl chrNW_004936470:2,638,014...2,641,133 		JBrowse link
toll-like receptor 9 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Epg5 ectopic P-granules 5 autophagy tethering factor acts_upstream_of_positive_effect
involved_in		 ISO
IEA		 (PMID:29130391) UniProt
Ensembl		 PMID:29130391 GO_REF:0000107 NCBI chrNW_004936517:841,402...941,054
Ensembl chrNW_004936517:841,411...939,581 		JBrowse link
G Havcr2 hepatitis A virus cellular receptor 2 involved_in ISO (PMID:22842346) UniProt PMID:22842346 NCBI chrNW_004936515:6,001,324...6,015,407 JBrowse link
G LOC101961439 twinfilin-2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936529:3,538,813...3,555,562
Ensembl chrNW_004936529:3,538,862...3,555,593 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1 group H member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936492:13,315,265...13,365,186
Ensembl chrNW_004936492:13,315,265...13,374,034 		JBrowse link
G Pik3ap1 phosphoinositide-3-kinase adaptor protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936636:2,822,100...2,935,252
Ensembl chrNW_004936636:2,821,939...2,938,082 		JBrowse link
G Tnip2 TNFAIP3 interacting protein 2 involved_in ISO (PMID:16633345) UniProt PMID:16633345 NCBI chrNW_004936477:20,810,188...20,841,537
Ensembl chrNW_004936477:20,834,849...20,841,535 		JBrowse link
G Unc93b1 unc-93 homolog B1, TLR signaling regulator involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936599:2,109,292...2,146,006
Ensembl chrNW_004936599:2,109,292...2,117,143 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16036
    cellular process 15649
      signal transduction 5693
        intracellular signal transduction 2818
          intracellular receptor signaling pathway 368
            cytoplasmic pattern recognition receptor signaling pathway 176
              MDA-5 signaling pathway + 8
              RIG-I signaling pathway + 27
              cGAS/STING signaling pathway + 22
              endolysosomal toll-like receptor signaling pathway + 46
              endosomal pattern recognition receptor signaling pathway 0
              inflammasome-mediated signaling pathway + 51
              negative regulation of cytoplasmic pattern recognition receptor signaling pathway + 54
              nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway + 24
              regulation of cytoplasmic pattern recognition receptor signaling pathway + 118
Path 2
Term Annotations click to browse term
  biological_process 16036
    response to stimulus 8595
      response to biotic stimulus 1494
        response to external biotic stimulus 1449
          response to other organism 1445
            defense response to other organism 1011
              defense response to symbiont 897
                innate immune response 736
                  regulation of innate immune response 417
                    positive regulation of innate immune response 343
                      activation of innate immune response 281
                        innate immune response-activating signaling pathway 262
                          pattern recognition receptor signaling pathway 258
                            cytoplasmic pattern recognition receptor signaling pathway 176
                              MDA-5 signaling pathway + 8
                              RIG-I signaling pathway + 27
                              cGAS/STING signaling pathway + 22
                              endolysosomal toll-like receptor signaling pathway + 46
                              endosomal pattern recognition receptor signaling pathway 0
                              inflammasome-mediated signaling pathway + 51
                              negative regulation of cytoplasmic pattern recognition receptor signaling pathway + 54
                              nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway + 24
                              regulation of cytoplasmic pattern recognition receptor signaling pathway + 118
paths to the root