Cgas (cyclic GMP-AMP synthase) - Rat Genome Database

Name: Cgas
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Cgas (cyclic GMP-AMP synthase) Ictidomys tridecemlineatus

Analyze

Symbol:

Cgas

Name:

cyclic GMP-AMP synthase

RGD ID:

12591227

Description:

ENCODES a protein that exhibits DNA binding (ortholog); molecular condensate scaffold activity (ortholog); nucleosome binding (ortholog); INVOLVED IN cAMP-mediated signaling (ortholog); cGAS/STING signaling pathway (ortholog); cGMP-mediated signaling (ortholog); ASSOCIATED WITH genetic disease (ortholog); sialuria (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nuclear body (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

Mab-21 domain containing 1; Mb21d1

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CGAS (cyclic GMP-AMP synthase)	NCBI	Ortholog
Mus musculus (house mouse):	Cgas (cyclic GMP-AMP synthase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Cgas (cyclic GMP-AMP synthase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Cgas (cyclic GMP-AMP synthase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CGAS (cyclic GMP-AMP synthase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CGAS (cyclic GMP-AMP synthase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CGAS (cyclic GMP-AMP synthase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CGAS (cyclic GMP-AMP synthase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Cgas (cyclic GMP-AMP synthase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	70,802,542 - 70,812,760 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936859	797,469 - 807,036 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

sialuria (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

activation of innate immune response (IEA)

cAMP-mediated signaling (ISO)

cellular response to exogenous dsRNA (IEA)

cGAS/STING signaling pathway (ISO)

cGMP-mediated signaling (ISO)

cytoplasmic pattern recognition receptor signaling pathway (ISO)

defense response to virus (ISO)

determination of adult lifespan (ISO)

DNA damage response (IEA)

innate immune response (ISO)

negative regulation of cGAS/STING signaling pathway (ISO)

negative regulation of DNA repair (ISO)

negative regulation of double-strand break repair via homologous recombination (IEA)

paracrine signaling (IEA)

pattern recognition receptor signaling pathway (ISO)

positive regulation of cellular senescence (ISO)

positive regulation of defense response to virus by host (IEA)

positive regulation of type I interferon production (IEA)

regulation of immune response (ISO)

regulation of immunoglobulin production (ISO)

regulation of T cell activation (ISO)

regulation of type I interferon production (ISO)

Cellular Component

cytoplasm (ISO)

cytosol (IEA,ISO)

nuclear body (ISO)

nucleoplasm (ISO)

nucleus (IEA,ISO)

plasma membrane (ISO)

site of double-strand break (IEA)

Molecular Function

2',3'-cyclic GMP-AMP synthase activity (IEA)

chromatin binding (IEA)

DNA binding (ISO)

double-stranded DNA binding (IEA)

molecular condensate scaffold activity (ISO)

nucleosome binding (ISO)

phosphatidylinositol-4,5-bisphosphate binding (ISO)

poly-ADP-D-ribose modification-dependent protein binding (ISO)

protein binding (ISO)

protein homodimerization activity (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Cgas
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	70,802,542 - 70,812,760 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936859	797,469 - 807,036 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CGAS
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	73,423,711 - 73,452,297 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	73,413,515 - 73,452,297 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	74,133,434 - 74,162,020 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	74,191,577 - 74,218,764 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	74,191,313 - 74,218,720	NCBI
Celera	6	74,529,415 - 74,556,286 (-)	NCBI		Celera
Cytogenetic Map	6	q13	NCBI
HuRef	6	71,333,337 - 71,360,196 (-)	NCBI		HuRef
CHM1_1	6	74,301,681 - 74,328,872 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	74,600,410 - 74,628,713 (-)	NCBI		T2T-CHM13v2.0

Cgas
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	78,337,800 - 78,350,519 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	78,337,808 - 78,350,519 (-)	Ensembl		GRCm39 Ensembl
GRCm38	9	78,430,518 - 78,443,237 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	78,430,526 - 78,443,237 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	78,278,325 - 78,290,954 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	78,217,019 - 78,228,921 (-)	NCBI		MGSCv36	mm8
Celera	9	75,608,705 - 75,621,402 (-)	NCBI		Celera
Cytogenetic Map	9	E1	NCBI
cM Map	9	43.65	NCBI

Cgas
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	88,172,559 - 88,187,538 (-)	NCBI		GRCr8
mRatBN7.2	8	79,292,282 - 79,306,998 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	79,294,511 - 79,305,496 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	8	85,789,515 - 85,804,008 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	85,789,763 - 85,803,433 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	85,344,976 - 85,353,236 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	8	79,042,110 - 79,053,035 (-)	NCBI		Celera
Cytogenetic Map	8	q31	NCBI

Cgas
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955493	8,593,104 - 8,607,297 (-)	NCBI	ChiLan1.0	ChiLan1.0

CGAS
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	93,404,484 - 93,435,310 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	91,329,355 - 91,359,775 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	71,252,050 - 71,279,121 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	74,542,994 - 74,567,107 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	74,544,251 - 74,566,965 (-)	Ensembl	panpan1.1		panPan2

CGAS
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	35,511,920 - 35,528,759 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	35,512,860 - 35,528,596 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	35,380,775 - 35,399,989 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	36,066,175 - 36,085,892 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	12	36,066,172 - 36,085,743 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	12	35,605,589 - 35,625,008 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	35,627,370 - 35,646,829 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	35,751,269 - 35,770,689 (-)	NCBI		UU_Cfam_GSD_1.0

CGAS
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	92,483,327 - 92,504,307 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	92,483,253 - 92,500,376 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	103,536,112 - 103,553,221 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CGAS
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	1,697,446 - 1,723,626 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	1,697,775 - 1,723,472 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666058	7,609,831 - 7,638,092 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cgas
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624819	643,045 - 680,684 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624819	587,739 - 680,618 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005341267	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_005341267 ⟹ XP_005341324

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404946	70,802,542 - 70,812,760 (-)	NCBI
SpeTri2.0	NW_004936859	797,469 - 807,036 (+)	NCBI

Sequence:

show sequence

ATGCTGGCCTGGTCAGGTTCCAGTGGGGACCTTCTTAATGCTGTGCAGATGGTTGTCTCCGTGC
ATATTTCTGCACCTAATGAATTTGATGTCATGTTTAAACTGGAAGTCCCCAGAATTCAGCTAGA
AGAATATTGTGATAGTGGTGCTCATTACTTTGTGAAGTTCAAAAGAAATCCCAAAGGAAATCCT
CTGAAGCACTTTGTAGAAGAGGAAATATTGTCAGCTTCTAAGATGCTGTTAAAGTTTAGGAAAA
TCATTAAAGATGAAATTAAAAATATTAAAGATATAGACATCACTATGGAGAAGAAAAAACCAGG
GAGTCCTGCTGTAACACTTGTTATTAGAAAATCTGAAGAAATATTTGTGGATATAATTCTGGCT
TTGGAATCAAAAAGTAGCTGGCCTGCTAACACACAGAAAGGTCTGCCCATCAATAACTGGCTTG
GAGCAAAAGTTAGGACCAATCTAAGACGACAGCCATTTTACCTCGTACCCAAGCATGCAAAAAA
AGGAAACGGTTTTCAAGAAGAGACATGGCGGCTCTCTTTCTCTCACATTGAAAAAGACATTTTG
AACAACCATGGACAATCTAAAACATGTTGTGAAACTGATGGAGTTAAATGTTGCAGGAAAGATT
GTTTAAAACTAATGAAATACCTTTTGGAACAGCTGAAAAAAAAGTTTGAAGACCGAAAAGAACT
GGATAAATTCTGTTCTTATCATGTGAAAACTGCCTTCCTGCATGTATGTACCAAGGATCCACAG
GATAGTCAGTGGCACCCCAAAAATCTAGTAGTCTGCTTTGATAACTGTGTGGCATTCTTTCTTG
AGTGTCTTAGGGCAGAACAACTGGAGCATTATTTTATTCCTGTAGTCAATCTATTCTCTCGAAA
CCACATTGACAAAATAAGTAAAGAATTTTTGTGCAAACAAATTGAATATGAAAGAAACAATGGA
TTTCCAATTTTTAATGAATTTTGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005341324	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000032196.1
GenBank Protein	KAG3289794	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005341324 ⟸ XM_005341267

- UniProtKB:

A0A287DF56 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MLAWSGSSGDLLNAVQMVVSVHISAPNEFDVMFKLEVPRIQLEEYCDSGAHYFVKFKRNPKGNP
LKHFVEEEILSASKMLLKFRKIIKDEIKNIKDIDITMEKKKPGSPAVTLVIRKSEEIFVDIILA
LESKSSWPANTQKGLPINNWLGAKVRTNLRRQPFYLVPKHAKKGNGFQEETWRLSFSHIEKDIL
NNHGQSKTCCETDGVKCCRKDCLKLMKYLLEQLKKKFEDRKELDKFCSYHVKTAFLHVCTKDPQ
DSQWHPKNLVVCFDNCVAFFLECLRAEQLEHYFIPVVNLFSRNHIDKISKEFLCKQIEYERNNG
FPIFNEF

hide sequence

Protein Domains

Mab-21-like HhH/H2TH-like Mab-21-like nucleotidyltransferase

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000033587	UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000037102.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.1410.40	UniProtKB/TrEMBL
	3.30.460.90	UniProtKB/TrEMBL
InterPro	Mab-21-like_nuc_Trfase	UniProtKB/TrEMBL
	Mab-21_dom	UniProtKB/TrEMBL
	Mab-21_HhH/H2TH-like	UniProtKB/TrEMBL
NCBI Gene	Mb21d1	ENTREZGENE
PANTHER	CELL FATE DETERMINING PROTEIN MAB21-RELATED	UniProtKB/TrEMBL
	CYCLIC GMP-AMP SYNTHASE	UniProtKB/TrEMBL
Pfam	Mab-21	UniProtKB/TrEMBL
	Mab-21_C	UniProtKB/TrEMBL
SMART	Mab-21	UniProtKB/TrEMBL
UniProt	A0A287DF56	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-10-10	Cgas	cyclic GMP-AMP synthase	Mb21d1	Mab-21 domain containing 1	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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