Otulin (OTU deubiquitinase with linear linkage specificity)

Gene: Otulin (OTU deubiquitinase with linear linkage specificity) Ictidomys tridecemlineatus

Analyze

Symbol:

Otulin

Name:

OTU deubiquitinase with linear linkage specificity

RGD ID:

12525996

Description:

ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); INVOLVED IN innate immune response (inferred); negative regulation of inflammatory response (inferred); nucleotide-binding oligomerization domain containing 2 signaling pathway (inferred); ASSOCIATED WITH autosomal dominant craniometaphyseal dysplasia (ortholog); chondrocalcinosis (ortholog); Chondrocalcinosis 2 (ortholog); FOUND IN cytoplasm (inferred); LUBAC complex (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

Fam105b; family with sequence similarity 105, member B; OTU deubiquitinase with linear linkage specificity, transcript variant X1; OTU deubiquitinase with linear linkage specificity, transcript variant X3; ubiquitin thioesterase otulin

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	233,060,519 - 233,101,743 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936665	1,668,311 - 1,690,918 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936665	1,654,045 - 1,690,955 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant craniometaphyseal dysplasia (ISO)

chondrocalcinosis (ISO)

Chondrocalcinosis 2 (ISO)

genetic disease (ISO)

Immunodeficiency 107 (ISO)

intellectual disability (ISO)

Neurodevelopmental Disorders (ISO)

otulipenia (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

innate immune response (IEA)

negative regulation of inflammatory response (IEA)

nucleotide-binding oligomerization domain containing 2 signaling pathway (IEA)

regulation of canonical Wnt signaling pathway (IEA)

regulation of tumor necrosis factor-mediated signaling pathway (IEA)

sprouting angiogenesis (IEA)

Cellular Component

cytoplasm (IEA)

LUBAC complex (IEA)

Molecular Function

cysteine-type deubiquitinase activity (IEA)

cysteine-type peptidase activity (IEA)

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

Otulin
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	233,060,519 - 233,101,743 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936665	1,668,311 - 1,690,918 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936665	1,654,045 - 1,690,955 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

OTULIN
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	14,664,718 - 14,716,525 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	14,664,664 - 14,699,850 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	14,664,827 - 14,699,959 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	14,717,783 - 14,752,842 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	5	14,688,765 - 14,723,825 (+)	NCBI		Celera
Cytogenetic Map	5	p15.2	NCBI
HuRef	5	14,637,385 - 14,672,668 (+)	NCBI		HuRef
CHM1_1	5	14,664,551 - 14,699,610 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	14,604,209 - 14,656,024 (+)	NCBI		T2T-CHM13v2.0

Otulin
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	27,606,005 - 27,630,793 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	27,542,721 - 27,630,779 (-)	Ensembl		GRCm39 Ensembl
GRCm38	15	27,597,055 - 27,630,977 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	27,542,635 - 27,630,693 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	27,535,674 - 27,560,448 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	27,550,644 - 27,564,262 (-)	NCBI		MGSCv36	mm8
Celera	15	28,353,849 - 28,378,669 (-)	NCBI		Celera
Cytogenetic Map	15	B1	NCBI
cM Map	15	10.31	NCBI

Otulin
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	80,021,381 - 80,046,898 (-)	NCBI		GRCr8
mRatBN7.2	2	78,290,437 - 78,316,633 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	78,290,959 - 78,316,422 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	85,378,457 - 85,403,803 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	83,500,189 - 83,525,533 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	78,532,540 - 78,557,960 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	80,267,724 - 80,293,204 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	80,269,587 - 80,293,181 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	99,932,239 - 99,958,233 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	79,431,094 - 79,454,752 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	2	73,945,074 - 73,970,536 (-)	NCBI		Celera
Cytogenetic Map	2	q22	NCBI

Otulin
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955426	3,953,933 - 3,982,175 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955426	3,953,852 - 3,982,532 (+)	NCBI	ChiLan1.0	ChiLan1.0

OTULIN
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	14,899,381 - 14,951,301 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	13,053,131 - 13,101,256 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	14,969,432 - 15,017,666 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	14,810,187 - 14,857,597 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	14,809,539 - 14,837,750 (+)	Ensembl	panpan1.1		panPan2

OTULIN
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	34	119,307 - 159,419 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	34	122,274 - 159,394 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	34	4,612,695 - 4,652,797 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	34	30,210 - 70,320 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	34	33,189 - 70,303 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	34	42,446 - 82,518 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	34	50,461 - 82,343 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	34	284,839 - 324,953 (-)	NCBI		UU_Cfam_GSD_1.0

OTULIN
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	16	4,063,071 - 4,093,198 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	16	4,063,037 - 4,097,112 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	16	4,402,784 - 4,436,591 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

OTULIN
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	4	14,358,556 - 14,395,539 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	4	14,358,538 - 14,389,987 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666064	14,137,064 - 14,174,630 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Otulin
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624751	11,676,850 - 11,702,061 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624751	11,676,932 - 11,703,143 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_013363540	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021734205	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040272596	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040272597	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040272598	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040272599	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040272600	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_002485263	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010002273	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000014623 ⟹ ENSSTOP00000013100

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936665	1,668,311 - 1,690,918 (-)	Ensembl

RefSeq Acc Id:

XM_013363540 ⟹ XP_013218994

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024407213	233,060,519 - 233,088,373 (-)	NCBI
SpeTri2.0	NW_004936665	1,654,045 - 1,690,955 (-)	NCBI

Sequence:

show sequence

ATGTGAATAAAAAGTCCATAGTAGTACTAGTAAAGTGAAAGCATGTGGAACACTACAGAACATA
GGTGGCTGGTTGAATGTGGAAGTTAGGGAGCAGGAGGAACCTCAAGGGGGATTGTTAGCTTTGA
AGACTTGTAATTGATGTTCTCCTGTCACTAGTTTTAGAGTAGCTGTTGTTATATTTGCTTGTGA
CATGTTACAAAGGTTGGTAATTCGCCTGCATGCTTGTATTAGCACTCTTCCCATCCTAAGAACT
TGAGAGAATCATTTTGAAAGCTTCACTGATAAGATGCATGCTAAGATGCCTAGATGTACATCTG
AGACATTAATAGACATTAATTGAAATGGCCTTAGGACCATGTTGCTGGTGAGTGATGTACATTA
TAAGATATTCTGAAGTAGAAGACAGTGGTGTGATAGAAACATGAACATCTAAGATATAGAACCC
ATATTTGATCAGATTGCTACTATGTAATGTGAGAAGAGTTAAGCTTTTAGTGTCCCATGCATTT
TGTAAGCAGCTGTAGGTTGTGATACATCAGAATATATCAGAGCAACAAGTGTTTTGAAAATGTC
TACTTTGGTGTGATTTCAGCGAGGAGGACATGTACCGTGCTGCAGATGAAATAGAGAAGGAGAA
AGAATTGCTTATACATGAAAGAGGGGCATCAGGGCTACGAGGAGGTTTCTCAGAAATTCACCTC
CATAAGGCGAGTCCGTGGCGATAATTACTGTGCACTGAGGGCCACACTGTTCCAGGCAATGAGC
CAGCTGGCTGCGCTTCCCCTCTGGCTTCAGGATCCGGAGCTCACGCTGTTACCTGAAAAACTGA
TACACAAATACAGCTGGATCAAGCAGTGGAAACTTGGGCTGAAATTTGATGGGAAGAACGAGGA
CCTGGTTGAAAAAATTAAGGAATCCCTCACCTTGCTAAGGAAGAAGTGGGCAAGCCTGGCTGAA
ATGAGAACTGCTGAAGCAAGGCAAATGGCTTGTGATGAACTGTTCACAAATGAAGAAGAGGAAT
ACTGCCTCTATGAAGCTGTAAAATTTCTAATGCTAAACAGAGCCATTGAACTATATGATGATAA
AGAGAAGGGAAAGGAAGTGCCATTTTTCTCTGTGCTCCTGTTTGCTCGGGACACATCGAATGAC
CCTGGACAGCTACTGAGGAACCACTTAAACCAGGTGGGACACACTGGTGGCCTTGAACAGGTTG
AAATGTTCCTTCTTGCCTATGCTGTGCGTCATACCATCCAGGTGTACCGGCTCTCCAAGTACAA
CACTGAGGAGTTCATTACAGTCTATCCCACTGACCCACCCAAGGACTGGCCGGTGGTGACCCTC
ATCGCTGAGGATGATCGGCACTATAATATCCCTGTCAGAATCTGCCCCTGAAACCACCCCCAAA
GCAGCTACGCATCTGAATGTTCAGCACTCATACATATAAATGGAGGAAAAGCCGCTCTGAGGAA
GCATGTAAGGACTTGTCCCTGTGCGGGGCACATCTGAGGGGCACCAGGTGCCCCAAAGCGGGAA
TGCAGCCCTGTGAGGTTCACAGCCACCTTTATGTCCTTACAGCCTTTTTTCTCTGAGGAACAGT
ATGGGTACACAGCACTGAAAACAATAAACACAACAGGACCGCC

hide sequence

RefSeq Acc Id:

XM_021734205 ⟹ XP_021589880

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024407213	233,070,842 - 233,097,406 (-)	NCBI
SpeTri2.0	NW_004936665	1,667,932 - 1,690,954 (-)	NCBI

Sequence:

show sequence

TGTGAATAAAAAGTCCATAGTAGTACTAGTAAAGTGAAAGCATGTGGAACACTACAGAACATAG
GTGGCTGGTTGAATGTGGAAGTTAGGGAGCAGGAGGAACCTCAAGGGGGATTGTTAGCTTTGAA
GACTTGTAATTGATGTTCTCCTGTCACTAGTTTTAGAGTAGCTGTTGTTATATTTGCTTGTGAC
ATGTTACAAAGGTTGGTAATTCGCCTGCATGCTTGTATTAGCACTCTTCCCATCCTAAGAACTT
GAGAGAATCATTTTGAAAGCTTCACTGATAAGATGCATGCTAAGATGCCTAGATGTACATCTGA
GACATTAATAGACATTAATTGAAATGGCCTTAGGACCATGTTGCTGGTGAGTGATGTACATTAT
AAGATATTCTGAAGTAGAAGACAGTGGTGTGATAGAAACATGAACATCTAAGATATAGAACCCA
TATTTGATCAGATTGCTACTATGTAATGTGAGAAGAGTTAAGCTTTTAGTGTCCCATGCATTTT
GTAAGCAGCTGTAGGTTGTGATACATCAGAATATATCAGAGCAACAAGTGTTTTGAAAATGTCT
ACTTTGGTGTGATTTCAGCGAGGAGGACATGTACCGTGCTGCAGATGAAATAGAGAAGGAGAAA
GAATTGCTTATACATGAAAGAGGGGCATCAGGGCTACGAGGAGGTTTCTCAGAAATTCACCTCC
ATAAGGCGAGTCCGTGGCGATAATTACTGTGCACTGAGGGCCACACTGTTCCAGGCAATGAGCC
AGCTGGCTGCGCTTCCCCTCTGGCTTCAGGATCCGGAGCTCACGCTGTTACCTGAAAAACTGAT
ACACAAATACAGCTGGATCAAGCAGTGGAAACTTGGGCTGAAATTTGATGGGAAGAACGAGGAC
CTGGTTGAAAAAATTAAGGAATCCCTCACCTTGCTAAGGAAGAAGTGGGCAAGCCTGGCTGAAA
TGAGAACTGCTGAAGCAAGGCAAATGGCTTGTGATGAACTGTTCACAAATGAAGAAGAGGAATA
CTGCCTCTATGAAGCTGTAAAATTTCTAATGCTAAACAGAGCCATTGAACTATATGATGATAAA
GAGAAGGGAAAGGAAGTGCCATTTTTCTCTGTGCTCCTGTTTGCTCGGGACACATCGAATGACC
CTGGACAGCTACTGAGGAACCACTTAAACCAGGTGGGACACACTGGTGGCCTTGAACAGGTTGA
AATGTTCCTTCTTGCCTATGCTGTGCGTCATACCATCCAGGTGTACCGGCTCTCCAAGTACAAC
ACTGAGGAGTTCATTACAGTCTATCCCACTGACCCACCCAAGGACTGGCCGGTGGTGACCCTCA
TCGCTGAGGATGATCGGCACTATAATATCCCTGTCAGAGTATGTGAGGAGACAAGTCTGTGAGA
GACTCACCTGCCTGGACAGTCTGAGGACATGGCAAAAGTGCACAGGCAGCTCCTCAGCATGGGC
TCAGGCCTCTGCTGGTCTCTAAGAGCAGTCTGTGAGAACTCTTGGGCCCCTGGGAGCCAAGTTG
GACTGGGGTGTTCTGAAGACTAACTTTTCATAATAAGAACAACTGTTTTCCCTTATCTGGGACC
CAATGTGTTTCATTGGGACCTTCAGAGCATACCTTTGGAAAGTGCATACTGCATTTTCGTAAAG
CAAATACTTTGTTTTAGAGGAAACTCATTTTGAAGAATATGTTCATGGTCTCAAGTCAAAATTC
TCTCTACTGGTAAACTGGCTTTTAAGTTTTAAGATGGTAATTTTTCTTTGGTGGAAA

hide sequence

RefSeq Acc Id:

XM_040272596 ⟹ XP_040128530

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024407213	233,070,842 - 233,088,371 (-)	NCBI

RefSeq Acc Id:

XM_040272597 ⟹ XP_040128531

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024407213	233,070,842 - 233,101,743 (-)	NCBI

RefSeq Acc Id:

XM_040272598 ⟹ XP_040128532

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024407213	233,070,842 - 233,090,529 (-)	NCBI

RefSeq Acc Id:

XM_040272599 ⟹ XP_040128533

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024407213	233,070,842 - 233,090,527 (-)	NCBI

RefSeq Acc Id:

XM_040272600 ⟹ XP_040128534

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024407213	233,070,842 - 233,090,527 (-)	NCBI

RefSeq Acc Id:

XR_002485263

Type:

NON-CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024407213	233,060,519 - 233,088,371 (-)	NCBI
SpeTri2.0	NW_004936665	1,654,045 - 1,690,954 (-)	NCBI

Sequence:

show sequence

TGTGAATAAAAAGTCCATAGTAGTACTAGTAAAGTGAAAGCATGTGGAACACTACAGAACATAG
GTGGCTGGTTGAATGTGGAAGTTAGGGAGCAGGAGGAACCTCAAGGGGGATTGTTAGCTTTGAA
GACTTGTAATTGATGTTCTCCTGTCACTAGTTTTAGAGTAGCTGTTGTTATATTTGCTTGTGAC
ATGTTACAAAGGTTGGTAATTCGCCTGCATGCTTGTATTAGCACTCTTCCCATCCTAAGAACTT
GAGAGAATCATTTTGAAAGCTTCACTGATAAGATGCATGCTAAGATGCCTAGATGTACATCTGA
GACATTAATAGACATTAATTGAAATGGCCTTAGGACCATGTTGCTGGTGAGTGATGTACATTAT
AAGATATTCTGAAGTAGAAGACAGTGGTGTGATAGAAACATGAACATCTAAGATATAGAACCCA
TATTTGATCAGATTGCTACTATGTAATGTGAGAAGAGTTAAGCTTTTAGTGTCCCATGCATTTT
GTAAGCAGCTGTAGGTTGTGATACATCAGAATATATCAGAGCAACAAGTGTTTTGAAAATGTCT
ACTTTGGTGTGATTTCAGCGAGGAGGACATGTACCGTGCTGCAGATGAAATAGAGAAGGAGAAA
GAATTGCTTATACATGAAAGAGGGGCATCAGGGCTACGAGGAGGTTTCTCAGAAATTCACCTCC
ATAAGGCGAGTCCGTGGCGATAATTACTGTGCACTGAGGGCCACACTGTTCCAGGCAATGAGCC
AGCTGGCTGCGCTTCCCCTCTGGCTTCAGGATCCGGAGCTCACGCTGTTACCTGAAAAACTGAT
ACACAAATACAGCTGGATCAAGCAGTGGAAACTTGGGCTGAAATTTGATGGGAAGAACGAGGAC
CTGGTTGAAAAAATTAAGGAATCCCTCACCTTGCTAAGGAAGAAGTGGGCAAGCCTGGCTGAAA
TGAGAACTGCTGAAGCAAGGCAAATGGCTTGTGATGAACTGTTCACAAATGAAGAAGAGGAATA
CTGCCTCTATGAAGCTGTAAAATTTCTAATGCTAAACAGAGCCATTGAACTATATGATGATAAA
GAGAAGGGAAAGGAAGTGCCATTTTTCTCTGTGCTCCTGTTTGCTCGGGACACATCGAATGACC
CTGGACAGCTACTGAGGAACCACTTAAACCAGGTGGGACACACTGGTGGCCTTGAACAGGTTGA
AATGTTCCTTCTTGCCTATGCTGTGCGTCATACCATCCAGGTGTACCGGCTCTCCAAGTACAAC
ACTGAGGAGTTCATTACAGTCTATCCCACTGACCCACCCAAGGACTGGCCGGTGGTGACCCTCA
TCGCTGAGGATGATCGGCACTATAATATCCCTGTCAGAGTATGTGAGGAGACAAGTCTGTGAGA
GACTCACCTGCCTGGACAGTCTGAGGACATGGCAAAAGTGCACAGGCAGCTCCTCAGCATGGGC
TCAGGCCTCTGCTGGTCTCTAAGAGCAGTCTGTGAGAACTCTTGGGCCCCTGGGAGCCAAGTTG
GACTGGGGTGTTCTGAAGACTAACTTTTCATAATAAGAACAACTGTTTTCCCTTATCTGGGACC
CAATGTGTTTCATTGGGACCTTCAGAGCATACCTTTGGAAAGTGCATACTGCATTTTCGTAAAG
CAAATACTTTGTTTTAGAGGAAACTCATTTTGAAGAATATGTTCATGGTCTCAAGTCAAAATTC
TCTCTACTGATCTGCCCCTGAAACCACCCCCAAAGCAGCTACGCATCTGAATGTTCAGCACTCA
TACATATAAATGGAGGAAAAGCCGCTCTGAGGAAGCATGTAAGGACTTGTCCCTGTGCGGGGCA
CATCTGAGGGGCACCAGGTGCCCCAAAGCGGGAATGCAGCCCTGTGAGGTTCACAGCCACCTTT
ATGTCCTTACAGCCTTTTTTCTCTGAGGAACAGTATGGGTACACAGCACTGAAAACAATAAACA
CAACAGGACCGCC

hide sequence

Protein Sequences


Protein RefSeqs	XP_013218994	(Get FASTA)	NCBI Sequence Viewer
	XP_021589880	(Get FASTA)	NCBI Sequence Viewer
	XP_040128530	(Get FASTA)	NCBI Sequence Viewer
	XP_040128531	(Get FASTA)	NCBI Sequence Viewer
	XP_040128532	(Get FASTA)	NCBI Sequence Viewer
	XP_040128533	(Get FASTA)	NCBI Sequence Viewer
	XP_040128534	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000013100.3
GenBank Protein	KAG3266869	(Get FASTA)	NCBI Sequence Viewer
	KAG3266870	(Get FASTA)	NCBI Sequence Viewer
	KAG3266871	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_013218994 ⟸ XM_013363540
- Peptide Label:	isoform X2
- UniProtKB:	I3MN98 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKEGHQGYEEVSQKFTSIRRVRGDNYCALRATLFQAMSQLAALPLWLQDPELTLLPEKLIHKYS WIKQWKLGLKFDGKNEDLVEKIKESLTLLRKKWASLAEMRTAEARQMACDELFTNEEEEYCLYE AVKFLMLNRAIELYDDKEKGKEVPFFSVLLFARDTSNDPGQLLRNHLNQVGHTGGLEQVEMFLL AYAVRHTIQVYRLSKYNTEEFITVYPTDPPKDWPVVTLIAEDDRHYNIPVRICP hide sequence

RefSeq Acc Id:

XP_021589880 ⟸ XM_021734205

- Peptide Label:

isoform X3

- Sequence:

show sequence

MKEGHQGYEEVSQKFTSIRRVRGDNYCALRATLFQAMSQLAALPLWLQDPELTLLPEKLIHKYS
WIKQWKLGLKFDGKNEDLVEKIKESLTLLRKKWASLAEMRTAEARQMACDELFTNEEEEYCLYE
AVKFLMLNRAIELYDDKEKGKEVPFFSVLLFARDTSNDPGQLLRNHLNQVGHTGGLEQVEMFLL
AYAVRHTIQVYRLSKYNTEEFITVYPTDPPKDWPVVTLIAEDDRHYNIPVRVCEETSL

hide sequence

RefSeq Acc Id:	XP_040128531 ⟸ XM_040272597
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_040128532 ⟸ XM_040272598
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_040128534 ⟸ XM_040272600
- Peptide Label:	isoform X5

RefSeq Acc Id:	XP_040128533 ⟸ XM_040272599
- Peptide Label:	isoform X5

RefSeq Acc Id:	XP_040128530 ⟸ XM_040272596
- Peptide Label:	isoform X1
- UniProtKB:	I3MN98 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSSTOP00000013100 ⟸ ENSSTOT00000014623

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000014627	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000014623.3	UniProtKB/TrEMBL
InterPro	FAM105	UniProtKB/TrEMBL
	Otulin	UniProtKB/TrEMBL
NCBI Gene	Otulin	ENTREZGENE
PANTHER	PTHR33662	UniProtKB/TrEMBL
	UBIQUITIN THIOESTERASE OTULIN	UniProtKB/TrEMBL
Pfam	Peptidase_C101	UniProtKB/TrEMBL
PRINTS	PROTEINF105	UniProtKB/TrEMBL
	PROTEINF105B	UniProtKB/TrEMBL
UniProt	I3MN98	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM