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G |
Dhodh |
dihydroorotate dehydrogenase (quinone) |
multiple interactions increases oxidation increases metabolic processing |
ISO EXP |
2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-hepten-6-ynamide inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]]; teriflunomide inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]]; Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]; X 910279 inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]] 2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-hepten-6-ynamide inhibits the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]; 2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-hepten-6-ynamide inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]]; azastene inhibits the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]; brequinar inhibits the reaction [DHODH protein results in increased metabolism of 4,5-dihydroorotic acid]; brequinar inhibits the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]; Ciprofloxacin inhibits the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]; HR 325 inhibits the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]; teriflunomide inhibits the reaction [DHODH protein results in increased metabolism of 4,5-dihydroorotic acid]; teriflunomide inhibits the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]; teriflunomide inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]]; toltrazuril inhibits the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]; Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]; X 910279 inhibits the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]; X 910279 inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]] |
CTD |
PMID:9776318 PMID:9802339 PMID:11248707 |
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NCBI chr19:37,551,858...37,573,327
Ensembl chr19:37,558,177...37,591,654
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G |
Acly |
ATP citrate lyase |
increases expression |
EXP |
Orotic Acid results in increased expression of ACLY mRNA |
CTD |
PMID:17203948 |
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NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320
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G |
Acsl4 |
acyl-CoA synthetase long-chain family member 4 |
increases expression |
EXP |
Orotic Acid results in increased expression of ACSL4 mRNA |
CTD |
PMID:17203948 |
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NCBI chr X:105,942,794...106,006,573
Ensembl chr X:105,942,799...106,006,427
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO |
Orotic Acid inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]; PIK3CA protein inhibits the reaction [Orotic Acid inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]] |
CTD |
PMID:25601987 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Apob |
apolipoprotein B |
increases expression |
EXP |
Orotic Acid results in increased expression of APOB mRNA |
CTD |
PMID:17203948 |
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NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497
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G |
Apoc3 |
apolipoprotein C3 |
decreases expression |
EXP |
Orotic Acid results in decreased expression of APOC3 mRNA |
CTD |
PMID:17203948 |
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NCBI chr 8:46,531,478...46,533,658
Ensembl chr 8:46,531,478...46,533,583
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G |
Ccnd3 |
cyclin D3 |
decreases expression |
EXP |
Orotic Acid results in decreased expression of CCND3 mRNA |
CTD |
PMID:17203948 |
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NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
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G |
Cdk5rap3 |
CDK5 regulatory subunit associated protein 3 |
increases expression |
EXP |
Orotic Acid results in increased expression of CDK5RAP3 mRNA |
CTD |
PMID:17203948 |
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NCBI chr10:81,894,393...81,903,581
Ensembl chr10:81,894,393...81,903,590
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G |
Cth |
cystathionine gamma-lyase |
decreases expression |
EXP |
Orotic Acid results in decreased expression of CTH mRNA |
CTD |
PMID:17203948 |
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NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234
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G |
Cyp2c6 |
cytochrome P450, family 2, subfamily C, polypeptide 6 |
decreases expression |
EXP |
Orotic Acid results in decreased expression of CYP2C6 protein |
CTD |
PMID:25786523 |
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NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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G |
Cyp4a1 |
cytochrome P450, family 4, subfamily a, polypeptide 1 |
multiple interactions |
EXP |
[Sucrose co-treated with Orotic Acid] results in increased expression of CYP4A1 mRNA |
CTD |
PMID:15670589 |
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NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464
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G |
Cyp4a2 |
cytochrome P450, family 4, subfamily a, polypeptide 2 |
multiple interactions |
EXP |
[Sucrose co-treated with Orotic Acid] results in increased expression of CYP4A2 mRNA |
CTD |
PMID:15670589 |
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NCBI chr 5:128,922,355...128,934,188
Ensembl chr 5:128,923,615...128,934,165
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G |
Edn1 |
endothelin 1 |
increases expression |
EXP |
Orotic Acid results in increased expression of EDN1 protein |
CTD |
PMID:25601987 |
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NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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G |
Egr1 |
early growth response 1 |
decreases expression |
EXP |
Orotic Acid results in decreased expression of EGR1 mRNA |
CTD |
PMID:17203948 |
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NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
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G |
Eif5 |
eukaryotic translation initiation factor 5 |
decreases expression |
EXP |
Orotic Acid results in decreased expression of EIF5 mRNA |
CTD |
PMID:17203948 |
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NCBI chr 6:130,589,162...130,597,656
Ensembl chr 6:130,589,143...130,597,656
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G |
Fasn |
fatty acid synthase |
increases expression |
EXP |
Orotic Acid results in increased expression of FASN mRNA |
CTD |
PMID:17203948 |
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NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
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G |
Fgfr2 |
fibroblast growth factor receptor 2 |
increases expression |
EXP |
Orotic Acid results in increased expression of FGFR2 mRNA |
CTD |
PMID:17203948 |
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NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626
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G |
Fn1 |
fibronectin 1 |
increases expression |
EXP |
Orotic Acid results in increased expression of FN1 mRNA |
CTD |
PMID:17203948 |
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NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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G |
Gpat3 |
glycerol-3-phosphate acyltransferase 3 |
increases expression |
EXP |
Orotic Acid results in increased expression of GPAT3 mRNA |
CTD |
PMID:17203948 |
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NCBI chr14:8,715,367...8,768,051
Ensembl chr14:8,714,373...8,766,490
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G |
Hsp90b1 |
heat shock protein 90 beta family member 1 |
increases expression |
EXP |
Orotic Acid results in increased expression of HSP90B1 mRNA |
CTD |
PMID:17203948 |
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NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788
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G |
Hyou1 |
hypoxia up-regulated 1 |
increases expression |
EXP |
Orotic Acid results in increased expression of HYOU1 mRNA |
CTD |
PMID:17203948 |
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NCBI chr 8:44,706,073...44,718,189
Ensembl chr 8:44,706,263...44,718,186
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G |
Ins2 |
insulin 2 |
multiple interactions |
ISO |
[Orotic Acid inhibits the reaction [INS protein results in increased phosphorylation of NOS3 protein]] which results in decreased abundance of Nitric Oxide; Orotic Acid inhibits the reaction [INS protein results in increased abundance of Nitric Oxide]; Orotic Acid inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]; Orotic Acid inhibits the reaction [INS protein results in increased phosphorylation of NOS3 protein]; PIK3CA protein inhibits the reaction [[Orotic Acid inhibits the reaction [INS protein results in increased phosphorylation of NOS3 protein]] which results in decreased abundance of Nitric Oxide]; PIK3CA protein inhibits the reaction [Orotic Acid inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]]; PIK3CA protein inhibits the reaction [Orotic Acid inhibits the reaction [INS protein results in increased phosphorylation of NOS3 protein]] |
CTD |
PMID:25601987 |
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NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
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G |
Klf10 |
KLF transcription factor 10 |
decreases expression |
EXP |
Orotic Acid results in decreased expression of KLF10 mRNA |
CTD |
PMID:17203948 |
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NCBI chr 7:69,467,658...69,473,726
Ensembl chr 7:69,465,619...69,473,994
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G |
Lepr |
leptin receptor |
affects abundance |
ISO |
LEPR affects the abundance of Orotic Acid |
CTD |
PMID:20567778 |
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NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
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G |
Lox |
lysyl oxidase |
decreases expression |
EXP |
Orotic Acid results in decreased expression of LOX mRNA |
CTD |
PMID:17203948 |
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NCBI chr18:45,964,544...45,977,431
Ensembl chr18:45,967,343...46,041,477
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G |
Mapk14 |
mitogen activated protein kinase 14 |
increases expression |
EXP |
Orotic Acid results in increased expression of MAPK14 mRNA |
CTD |
PMID:17203948 |
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NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
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G |
Mt1 |
metallothionein 1 |
increases expression |
EXP |
Orotic Acid results in increased expression of MT1 mRNA |
CTD |
PMID:17203948 |
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NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049 Ensembl chr17:10,826,032...10,827,049
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G |
Nos3 |
nitric oxide synthase 3 |
multiple interactions |
ISO |
[Orotic Acid inhibits the reaction [INS protein results in increased phosphorylation of NOS3 protein]] which results in decreased abundance of Nitric Oxide; [Orotic Acid inhibits the reaction [Metformin results in increased phosphorylation of NOS3 protein]] which results in decreased abundance of Nitric Oxide; Orotic Acid inhibits the reaction [INS protein results in increased phosphorylation of NOS3 protein]; Orotic Acid inhibits the reaction [Metformin results in increased phosphorylation of NOS3 protein]; PIK3CA protein inhibits the reaction [[Orotic Acid inhibits the reaction [INS protein results in increased phosphorylation of NOS3 protein]] which results in decreased abundance of Nitric Oxide]; PIK3CA protein inhibits the reaction [Orotic Acid inhibits the reaction [INS protein results in increased phosphorylation of NOS3 protein]] |
CTD |
PMID:25601987 |
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NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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G |
Pc |
pyruvate carboxylase |
decreases expression |
EXP |
Orotic Acid results in decreased expression of PC mRNA |
CTD |
PMID:17203948 |
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NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:201,804,267...201,898,380
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G |
Pdia4 |
protein disulfide isomerase family A, member 4 |
increases expression |
EXP |
Orotic Acid results in increased expression of PDIA4 mRNA |
CTD |
PMID:17203948 |
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NCBI chr 4:76,803,198...76,822,245
Ensembl chr 4:76,803,198...76,822,107
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G |
Phgdh |
phosphoglycerate dehydrogenase |
increases expression |
EXP |
Orotic Acid results in increased expression of PHGDH mRNA |
CTD |
PMID:17203948 |
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NCBI chr 2:185,906,962...185,936,054
Ensembl chr 2:185,906,966...185,935,944
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G |
Pik3ca |
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha |
multiple interactions |
ISO |
PIK3CA protein inhibits the reaction [[Orotic Acid inhibits the reaction [INS protein results in increased phosphorylation of NOS3 protein]] which results in decreased abundance of Nitric Oxide]; PIK3CA protein inhibits the reaction [Orotic Acid inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]]; PIK3CA protein inhibits the reaction [Orotic Acid inhibits the reaction [INS protein results in increased phosphorylation of NOS3 protein]] |
CTD |
PMID:25601987 |
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NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
multiple interactions |
EXP |
[Sucrose co-treated with Orotic Acid] results in decreased expression of PPARA protein |
CTD |
PMID:15670589 |
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NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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G |
Prkaa1 |
protein kinase AMP-activated catalytic subunit alpha 1 |
multiple interactions |
ISO |
Orotic Acid inhibits the reaction [Metformin results in increased phosphorylation of PRKAA1 protein] |
CTD |
PMID:25601987 |
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NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978
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G |
Psat1 |
phosphoserine aminotransferase 1 |
increases expression |
EXP |
Orotic Acid results in increased expression of PSAT1 mRNA |
CTD |
PMID:17203948 |
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NCBI chr 1:213,196,709...213,218,564
Ensembl chr 1:213,196,709...213,218,682
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G |
Pygl |
glycogen phosphorylase L |
decreases expression |
EXP |
Orotic Acid results in decreased expression of PYGL mRNA |
CTD |
PMID:17203948 |
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NCBI chr 6:88,697,598...88,740,260
Ensembl chr 6:88,697,593...88,740,310
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G |
Rpl5 |
ribosomal protein L5 |
increases expression |
EXP |
Orotic Acid results in increased expression of RPL5 mRNA |
CTD |
PMID:17203948 |
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NCBI chr14:1,843,856...1,850,301
Ensembl chr14:1,843,770...1,850,290
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G |
Rps24 |
ribosomal protein S24 |
increases expression |
EXP |
Orotic Acid results in increased expression of RPS24 mRNA |
CTD |
PMID:17203948 |
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NCBI chr16:89,538...94,267
Ensembl chr16:89,604...94,279
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G |
Rps6kb1 |
ribosomal protein S6 kinase B1 |
increases phosphorylation multiple interactions |
ISO |
Orotic Acid results in increased phosphorylation of RPS6KB1 protein Orotic Acid inhibits the reaction [STK11 protein results in decreased phosphorylation of RPS6KB1 protein]; Sirolimus inhibits the reaction [Orotic Acid results in increased phosphorylation of RPS6KB1 protein] |
CTD |
PMID:22863860 |
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NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
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G |
Rptor |
regulatory associated protein of MTOR, complex 1 |
decreases phosphorylation multiple interactions |
ISO |
Orotic Acid results in decreased phosphorylation of RPTOR protein Orotic Acid inhibits the reaction [STK11 protein results in increased phosphorylation of RPTOR protein]; Sirolimus inhibits the reaction [Orotic Acid results in decreased phosphorylation of RPTOR protein] |
CTD |
PMID:22863860 |
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NCBI chr10:104,878,487...105,176,986
Ensembl chr10:104,878,487...105,176,983
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G |
Rxra |
retinoid X receptor alpha |
multiple interactions |
EXP |
[Sucrose co-treated with Orotic Acid] results in decreased expression of RXRA protein |
CTD |
PMID:15670589 |
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NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
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G |
Scd |
stearoyl-CoA desaturase |
decreases expression |
EXP |
Orotic Acid results in decreased expression of SCD mRNA |
CTD |
PMID:17203948 |
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NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
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G |
Slc22a7 |
solute carrier family 22 member 7 |
multiple interactions increases export |
ISO EXP |
4-Aminobenzoic Acid promotes the reaction [SLC22A7 protein results in increased export of Orotic Acid]; [Orotic Acid co-treated with Benzoic Acid] promotes the reaction [SLC22A7 protein results in increased export of Orotic Acid]; Benzoic Acid promotes the reaction [SLC22A7 protein results in increased export of Orotic Acid]; cinnamic acid promotes the reaction [SLC22A7 protein results in increased export of Orotic Acid]; gamma-Aminobutyric Acid promotes the reaction [SLC22A7 protein results in increased export of Orotic Acid]; Niacin promotes the reaction [SLC22A7 protein results in increased export of Orotic Acid]; Orotic Acid promotes the reaction [SLC22A7 protein results in increased export of Orotic Acid]; phenylpyruvic acid promotes the reaction [SLC22A7 protein results in increased export of Orotic Acid]; Salicylic Acid promotes the reaction [SLC22A7 protein results in increased export of Orotic Acid] 4-Aminobenzoic Acid promotes the reaction [SLC22A7 protein results in increased export of Orotic Acid]; [Orotic Acid co-treated with Benzoic Acid] promotes the reaction [SLC22A7 protein results in increased export of Orotic Acid]; Benzoic Acid promotes the reaction [SLC22A7 protein results in increased export of Orotic Acid]; cinnamic acid promotes the reaction [SLC22A7 protein results in increased export of Orotic Acid]; Niacin promotes the reaction [SLC22A7 protein results in increased export of Orotic Acid]; Orotic Acid promotes the reaction [SLC22A7 protein results in increased export of Orotic Acid]; phenylacetic acid promotes the reaction [SLC22A7 protein results in increased export of Orotic Acid]; Salicylic Acid promotes the reaction [SLC22A7 protein results in increased export of Orotic Acid] |
CTD |
PMID:22981274 |
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NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921
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G |
Stk11 |
serine/threonine kinase 11 |
multiple interactions |
ISO |
Orotic Acid inhibits the reaction [STK11 protein results in decreased phosphorylation of RPS6KB1 protein]; Orotic Acid inhibits the reaction [STK11 protein results in increased phosphorylation of RPTOR protein] |
CTD |
PMID:22863860 |
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NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315
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G |
Tmed10 |
transmembrane p24 trafficking protein 10 |
increases expression |
EXP |
Orotic Acid results in increased expression of TMED10 mRNA |
CTD |
PMID:17203948 |
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NCBI chr 6:104,991,843...105,026,705
Ensembl chr 6:104,991,838...105,026,753
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G |
Top2a |
DNA topoisomerase II alpha |
increases expression |
EXP |
Orotic Acid results in increased expression of TOP2A mRNA |
CTD |
PMID:17203948 |
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NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874
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