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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620683
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rps6kb1
Name: ribosomal protein S6 kinase B1
Acc ID: CHEBI:16742
Term: orotic acid
Definition: A pyrimidinemonocarboxylic acid that is uracil bearing a carboxy substituent at position C-6.
Chemical ID: MESH:D009963
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rps6kb1increases phosphorylationISORGD:7316446480464CTDOrotic Acid results in increased phosphorylation of RPS6KB1 protein

PMID:22863860
Rps6kb1multiple interactionsISORGD:7316446480464CTDOrotic Acid inhibits the reaction [STK11 protein results in decreased phosphorylation of RPS6KB1 protein] Sirolimus inhibits the reaction [Orotic Acid results in increased phosphorylation of RPS6KB1 protein]

PMID:22863860
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