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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1311784
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rptor
Name: regulatory associated protein of MTOR, complex 1
Acc ID: CHEBI:16742
Term: orotic acid
Definition: A pyrimidinemonocarboxylic acid that is uracil bearing a carboxy substituent at position C-6.
Chemical ID: MESH:D009963
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rptordecreases phosphorylationISORGD:16030196480464CTDOrotic Acid results in decreased phosphorylation of RPTOR protein

PMID:22863860
Rptormultiple interactionsISORGD:16030196480464CTDOrotic Acid inhibits the reaction [STK11 protein results in increased phosphorylation of RPTOR protein] Sirolimus inhibits the reaction [Orotic Acid results in decreased phosphorylation of RPTOR protein]

PMID:22863860
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