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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:halothane
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Accession:CHEBI:5615 term browser browse the term
Definition:A haloalkane comprising ethane having three flouro substituents at the 1-position as well as bromo- and chloro substituents at the 2-position.
Synonyms:related_synonym: 1,1,1-trifluoro-2-bromo-2-chloroethane;   1,1,1-trifluoro-2-chloro-2-bromoethane;   1-bromo-1-chloro-2,2,2-trifluoroethane;   2,2,2-trifluoro-1-chloro-1-bromoethane;   2-bromo-2-chloro-1,1,1-trifluoroethane;   Fluothane;   Formula=C2HBrClF3;   InChI=1S/C2HBrClF3/c3-1(4)2(5,6)7/h1H;   InChIKey=BCQZXOMGPXTTIC-UHFFFAOYSA-N;   Narcotane;   Phthorothanum;   Rhodialothan;   SMILES=[H]C(Cl)(Br)C(F)(F)F;   bromochlorotrifluoroethane
 xref: Beilstein:1736947;   CAS:151-67-7;   DrugBank:DB01159;   Drug_Central:1356;   Gmelin:793752;   KEGG:C07515;   KEGG:D00542
 xref_mesh: MESH:D006221
 xref: PMID:7519986;   VSDB:1806;   Wikipedia:Halothane


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halothane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALB albumin affects binding EXP Halothane binds to ALB protein CTD PMID:17242087 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 ISO Halothane results in increased expression of BAX mRNA
[Ryanodine co-treated with Halothane] results in increased expression of BAX mRNA; Dantrolene inhibits the reaction [Halothane results in increased expression of BAX mRNA]		 CTD PMID:32795494 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BCL2L11 BCL2 like 11 multiple interactions
increases expression		 ISO [Ryanodine co-treated with Halothane] results in increased expression of BCL2L11 mRNA; Dantrolene inhibits the reaction [Halothane results in increased expression of BCL2L11 mRNA] CTD PMID:32795494 NCBI chr 2:111,120,914...111,168,445
Ensembl chr 2:111,119,378...111,168,444 		JBrowse link
G CALR calreticulin affects metabolic processing ISO Halothane metabolite affects the metabolism of CALR CTD PMID:1504264 NCBI chr19:12,938,609...12,944,489
Ensembl chr19:12,938,578...12,944,489 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 decreases expression ISO Halothane results in decreased expression of CCL2 mRNA CTD PMID:15564938 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G CD69 CD69 molecule increases expression ISO Halothane results in increased expression of CD69 protein CTD PMID:21245496 NCBI chr12:9,752,486...9,760,901
Ensembl chr12:9,752,486...9,760,901 		JBrowse link
G CXCL1 C-X-C motif chemokine ligand 1 decreases expression
multiple interactions
increases expression		 ISO Halothane results in decreased expression of CXCL1 mRNA
Estradiol inhibits the reaction [Halothane results in increased expression of CXCL1 mRNA]; fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Halothane results in increased expression of CXCL1 mRNA]]; gadolinium chloride inhibits the reaction [Progesterone promotes the reaction [Halothane results in increased expression of CXCL1 mRNA]]; Mifepristone inhibits the reaction [Halothane results in increased expression of CXCL1 mRNA]; Mifepristone inhibits the reaction [Progesterone promotes the reaction [Halothane results in increased expression of CXCL1 mRNA]]; Progesterone promotes the reaction [Halothane results in increased expression of CXCL1 mRNA]; U 0126 inhibits the reaction [Progesterone promotes the reaction [Halothane results in increased expression of CXCL1 mRNA]]
Halothane results in increased expression of CXCL1 mRNA; Halothane results in increased expression of CXCL1 protein		 CTD PMID:15564938 PMID:21501669 PMID:22157104 PMID:24598351 NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308 		JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 decreases expression ISO Halothane results in decreased expression of CXCL10 mRNA CTD PMID:15564938 NCBI chr 4:76,021,118...76,023,497
Ensembl chr 4:76,021,118...76,023,497 		JBrowse link
G CXCL2 C-X-C motif chemokine ligand 2 increases expression
multiple interactions
decreases expression		 ISO Halothane results in increased expression of CXCL2 mRNA
Halothane results in increased expression of CXCL2 mRNA; Halothane results in increased expression of CXCL2 protein
[Progesterone co-treated with Halothane] results in increased expression of CXCL2 mRNA; [Progesterone co-treated with Halothane] results in increased expression of CXCL2 protein; Dantrolene inhibits the reaction [Halothane results in increased expression of CXCL2 mRNA]; Estradiol inhibits the reaction [Halothane results in increased expression of CXCL2 mRNA]; Fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Halothane results in increased expression of CXCL2 mRNA]]; gadolinium chloride inhibits the reaction [[Progesterone co-treated with Halothane] results in increased expression of CXCL2 mRNA]; Mifepristone inhibits the reaction [Halothane results in increased expression of CXCL2 mRNA]; Mifepristone inhibits the reaction [Progesterone promotes the reaction [Halothane results in increased expression of CXCL2 mRNA]]; Progesterone promotes the reaction [Halothane results in increased expression of CXCL2 mRNA]; Ryanodine promotes the reaction [Halothane results in increased expression of CXCL2 mRNA]; U 0126 inhibits the reaction [[Progesterone co-treated with Halothane] results in increased expression of CXCL2 mRNA]
Halothane results in decreased expression of CXCL2 mRNA		 CTD PMID:10422944 PMID:15564938 PMID:19633216 PMID:21501669 PMID:22157104 More... NCBI chr 4:74,097,040...74,099,195
Ensembl chr 4:74,097,040...74,099,196 		JBrowse link
G CYB5A cytochrome b5 type A multiple interactions
increases metabolic processing		 EXP diisopropyl 1,3-dithiol-2-ylidenemalonate results in increased expression of [CYB5A protein results in increased metabolism of Halothane] CTD PMID:3689822 NCBI chr18:74,250,846...74,291,963
Ensembl chr18:74,250,846...74,291,973 		JBrowse link
G CYP2A6 cytochrome P450 family 2 subfamily A member 6 increases metabolic processing
affects metabolic processing		 EXP CYP2A6 protein results in increased metabolism of Halothane
CYP2A6 protein affects the metabolism of Halothane		 CTD PMID:8886607 PMID:9103523 PMID:12487152 NCBI chr19:40,843,541...40,850,447
Ensembl chr19:40,843,541...40,850,447 		JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 increases metabolic processing EXP CYP2B6 protein results in increased metabolism of Halothane CTD PMID:11684365 NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 increases metabolic processing
increases response to substance
multiple interactions
increases oxidation
affects metabolic processing		 EXP
ISO		 CYP2E1 protein results in increased metabolism of Halothane
CYP2E1 protein results in increased susceptibility to Halothane
Disulfiram inhibits the reaction [CYP2E1 protein results in increased oxidation of Halothane]
CYP2E1 protein affects the metabolism of Halothane		 CTD PMID:9103523 PMID:10805064 PMID:11684365 PMID:12464242 PMID:12803597 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 increases metabolic processing EXP CYP3A4 protein results in increased metabolism of Halothane CTD PMID:8886607 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248 		JBrowse link
G DDIT3 DNA damage inducible transcript 3 multiple interactions
increases expression		 ISO Dantrolene inhibits the reaction [Halothane results in increased expression of DDIT3 mRNA]; Ryanodine promotes the reaction [Halothane results in increased expression of DDIT3 mRNA] CTD PMID:32795494 NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737 		JBrowse link
G FKBP1A FKBP prolyl isomerase 1A multiple interactions
increases expression		 ISO Dantrolene inhibits the reaction [Halothane results in increased expression of FKBP1A mRNA]; Ryanodine promotes the reaction [Halothane results in increased expression of FKBP1A mRNA] CTD PMID:32795494 NCBI chr20:1,368,978...1,393,054
Ensembl chr20:1,368,977...1,393,164 		JBrowse link
G FKBP1B FKBP prolyl isomerase 1B increases expression
multiple interactions		 ISO Halothane results in increased expression of FKBP1B mRNA
[Ryanodine co-treated with Halothane] results in increased expression of FKBP1B mRNA; Dantrolene inhibits the reaction [Halothane results in increased expression of FKBP1B mRNA]		 CTD PMID:32795494 NCBI chr 2:24,033,206...24,063,681
Ensembl chr 2:24,049,701...24,063,681 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Halothane results in increased expression of FOS protein CTD PMID:7970238 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,283,190 		JBrowse link
G GPT glutamic--pyruvic transaminase increases expression
multiple interactions		 ISO Halothane results in increased expression of GPT protein
Dantrolene inhibits the reaction [Halothane results in increased expression of GPT protein]; eritoran inhibits the reaction [Halothane results in increased expression of GPT protein]; Ryanodine promotes the reaction [Halothane results in increased expression of GPT protein]		 CTD PMID:24598351 PMID:24747151 PMID:32795494 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174 		JBrowse link
G HMGB1 high mobility group box 1 increases expression ISO Halothane results in increased expression of HMGB1 protein CTD PMID:21245496 PMID:24747151 NCBI chr13:30,456,704...30,617,597
Ensembl chr13:30,456,704...30,617,597 		JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions
increases expression		 ISO [Ryanodine co-treated with Halothane] results in increased expression of HMOX1 mRNA; Dantrolene inhibits the reaction [Halothane results in increased expression of HMOX1 mRNA] CTD PMID:32795494 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
G HOMER1 homer scaffold protein 1 multiple interactions
increases expression		 ISO Dantrolene inhibits the reaction [Halothane results in increased expression of HOMER1 mRNA]; Ryanodine promotes the reaction [Halothane results in increased expression of HOMER1 mRNA] CTD PMID:32795494 NCBI chr 5:79,372,636...79,514,134
Ensembl chr 5:79,372,636...79,514,134 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 decreases expression
increases expression
multiple interactions		 ISO Halothane results in decreased expression of ICAM1 mRNA; Halothane results in decreased expression of ICAM1 protein
Halothane results in increased expression of ICAM1 mRNA
[Progesterone co-treated with Halothane] results in increased expression of ICAM1 mRNA; [U 0126 co-treated with Halothane] results in increased expression of ICAM1 mRNA; Estradiol inhibits the reaction [Halothane results in increased expression of ICAM1 mRNA]; fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Halothane results in increased expression of ICAM1 mRNA]]; gadolinium chloride inhibits the reaction [[Progesterone co-treated with Halothane] results in increased expression of ICAM1 mRNA]; Mifepristone inhibits the reaction [Halothane results in increased expression of ICAM1 mRNA]; Mifepristone inhibits the reaction [Progesterone promotes the reaction [Halothane results in increased expression of ICAM1 mRNA]]; Progesterone promotes the reaction [Halothane results in increased expression of ICAM1 mRNA]; U 0126 inhibits the reaction [[Progesterone co-treated with Halothane] results in increased expression of ICAM1 mRNA]		 CTD PMID:15564938 PMID:21501669 PMID:22157104 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615 		JBrowse link
G IFNG interferon gamma multiple interactions
increases response to substance
increases expression		 ISO PRF1 protein affects the reaction [Halothane results in increased expression of IFNG protein]; TLR4 protein affects the reaction [Halothane results in increased expression of IFNG protein]
IFNG protein results in increased susceptibility to Halothane
Halothane results in increased expression of IFNG mRNA		 CTD PMID:10422944 PMID:21245496 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G IL17A interleukin 17A increases expression
multiple interactions		 ISO Halothane results in increased expression of IL17A protein
Estradiol inhibits the reaction [Halothane results in increased expression of IL17A protein]; fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Halothane results in increased expression of IL17A protein]]; Mifepristone inhibits the reaction [Progesterone promotes the reaction [Halothane results in increased expression of IL17A protein]]; Progesterone promotes the reaction [Halothane results in increased expression of IL17A protein]		 CTD PMID:19633216 PMID:21501669 NCBI chr 6:52,186,375...52,190,638
Ensembl chr 6:52,186,375...52,190,638 		JBrowse link
G IL1B interleukin 1 beta multiple interactions
increases expression		 ISO Halothane affects the reaction [IL1B protein affects the susceptibility to Phenylephrine]; Halothane affects the reaction [IL1B protein affects the susceptibility to Potassium Chloride]; Halothane inhibits the reaction [IL1B protein results in increased abundance of Cyclic GMP]; Halothane inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA]; Halothane inhibits the reaction [IL1B protein results in increased expression of NOS2 protein]; Halothane inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]
Halothane results in increased expression of IL1B mRNA
[Ryanodine co-treated with Halothane] results in increased expression of IL1B mRNA; Dantrolene inhibits the reaction [Halothane results in increased expression of IL1B mRNA]; Estradiol inhibits the reaction [Halothane results in increased expression of IL1B mRNA]; Fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Halothane results in increased expression of IL1B mRNA]]; Mifepristone inhibits the reaction [Progesterone promotes the reaction [Halothane results in increased expression of IL1B mRNA]]; Progesterone promotes the reaction [Halothane results in increased expression of IL1B mRNA]		 CTD PMID:10422944 PMID:11506125 PMID:21501669 PMID:24747151 PMID:32795494 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL6 interleukin 6 increases expression
multiple interactions		 ISO Halothane results in increased expression of IL6 mRNA
Estradiol inhibits the reaction [Halothane results in increased expression of IL6 mRNA]; fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Halothane results in increased expression of IL6 mRNA]]; Mifepristone inhibits the reaction [Progesterone promotes the reaction [Halothane results in increased expression of IL6 mRNA]]; Progesterone promotes the reaction [Halothane results in increased expression of IL6 mRNA]		 CTD PMID:21501669 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G ITGAM integrin subunit alpha M multiple interactions
increases expression		 ISO Ryanodine promotes the reaction [Halothane results in increased expression of ITGAM mRNA] CTD PMID:32795494 NCBI chr16:31,259,975...31,332,877
Ensembl chr16:31,259,967...31,332,892 		JBrowse link
G ITPR1 inositol 1,4,5-trisphosphate receptor type 1 increases expression ISO Halothane results in increased expression of ITPR1 mRNA CTD PMID:32795494 NCBI chr 3:4,493,348...4,847,506
Ensembl chr 3:4,493,345...4,847,506 		JBrowse link
G ITPR3 inositol 1,4,5-trisphosphate receptor type 3 increases expression ISO Halothane results in increased expression of ITPR3 mRNA CTD PMID:32795494 NCBI chr 6:33,621,322...33,696,562
Ensembl chr 6:33,620,365...33,696,574 		JBrowse link
G KCNJ2 potassium inwardly rectifying channel subfamily J member 2 affects response to substance ISO KCNJ2 affects the susceptibility to Halothane CTD PMID:17546530 NCBI chr17:70,169,532...70,180,044
Ensembl chr17:70,168,673...70,180,044 		JBrowse link
G KCNK10 potassium two pore domain channel subfamily K member 10 multiple interactions EXP Halothane promotes the reaction [KCNK10 protein results in increased transport of Potassium] CTD PMID:16075240 NCBI chr14:88,180,108...88,326,912
Ensembl chr14:88,180,103...88,326,907 		JBrowse link
G KCNK2 potassium two pore domain channel subfamily K member 2 multiple interactions EXP Halothane promotes the reaction [KCNK2 protein results in increased transport of Potassium] CTD PMID:16075240 NCBI chr 1:215,005,542...215,237,090
Ensembl chr 1:215,005,775...215,237,090 		JBrowse link
G KCNK9 potassium two pore domain channel subfamily K member 9 multiple interactions EXP Halothane promotes the reaction [KCNK9 protein results in increased transport of Potassium] CTD PMID:11249964 NCBI chr 8:139,600,838...139,703,123
Ensembl chr 8:139,600,838...139,704,109 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions ISO [Progesterone co-treated with Halothane] results in increased phosphorylation of MAPK1 protein; U 0126 inhibits the reaction [[Progesterone co-treated with Halothane] results in increased phosphorylation of MAPK1 protein] CTD PMID:22157104 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK14 mitogen-activated protein kinase 14 increases expression
decreases expression		 ISO Halothane results in increased expression of MAPK14 mRNA
Halothane results in decreased expression of MAPK14 protein		 CTD PMID:24598351 NCBI chr 6:36,027,808...36,124,214
Ensembl chr 6:36,027,752...36,122,511 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions ISO [Progesterone co-treated with Halothane] results in increased phosphorylation of MAPK3 protein; U 0126 inhibits the reaction [[Progesterone co-treated with Halothane] results in increased phosphorylation of MAPK3 protein] CTD PMID:22157104 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MIR106B microRNA 106b decreases expression ISO Halothane results in decreased expression of MIR106B mRNA CTD PMID:24598351 NCBI chr 7:100,093,993...100,094,074
Ensembl chr 7:100,093,993...100,094,074 		JBrowse link
G MIR21 microRNA 21 affects expression ISO Halothane affects the expression of MIR21A mRNA CTD PMID:24598351 NCBI chr17:59,841,266...59,841,337
Ensembl chr17:59,841,266...59,841,337 		JBrowse link
G MPO myeloperoxidase decreases activity ISO Halothane results in decreased activity of MPO protein CTD PMID:15564938 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935 		JBrowse link
G NFKBIA NFKB inhibitor alpha increases phosphorylation
multiple interactions		 ISO Halothane results in increased phosphorylation of NFKBIA protein
Propofol inhibits the reaction [Halothane results in increased phosphorylation of NFKBIA protein]		 CTD PMID:16965849 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749 		JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions
increases expression		 ISO Halothane inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA]; Halothane inhibits the reaction [IL1B protein results in increased expression of NOS2 protein]; Propofol inhibits the reaction [Halothane results in increased expression of NOS2 protein] CTD PMID:11506125 PMID:16965849 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G POMC proopiomelanocortin increases secretion ISO Halothane results in increased secretion of POMC protein CTD PMID:2846107 NCBI chr 2:25,160,860...25,168,580
Ensembl chr 2:25,160,853...25,168,903 		JBrowse link
G PRF1 perforin 1 affects response to substance
multiple interactions		 ISO PRF1 protein affects the susceptibility to Halothane
PRF1 protein affects the reaction [Halothane results in increased expression of IFNG protein]		 CTD PMID:21245496 NCBI chr10:70,597,348...70,602,741
Ensembl chr10:70,597,348...70,602,759 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Halothane inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA] CTD PMID:11506125 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G PTK2 protein tyrosine kinase 2 decreases phosphorylation EXP Halothane results in decreased phosphorylation of PTK2 protein CTD PMID:18215454 NCBI chr 8:140,657,900...141,002,079
Ensembl chr 8:140,657,900...141,002,216 		JBrowse link
G REN renin multiple interactions EXP [Halothane co-treated with Nitroprusside] results in increased activity of REN protein CTD PMID:3281763 NCBI chr 1:204,154,819...204,166,337
Ensembl chr 1:204,154,819...204,190,324 		JBrowse link
G RYR1 ryanodine receptor 1 increases activity
increases expression
increases response to substance
multiple interactions		 EXP
ISO		 Halothane results in increased activity of RYR1 protein
Halothane results in increased expression of RYR1 mRNA
RYR1 protein mutant form results in increased susceptibility to Halothane
[Halothane results in increased activity of RYR1 protein] which affects the localization of Calcium		 CTD PMID:14641996 PMID:15210166 PMID:21485675 PMID:32795494 NCBI chr19:38,433,691...38,587,564
Ensembl chr19:38,433,691...38,595,273 		JBrowse link
G S100A8 S100 calcium binding protein A8 increases expression
multiple interactions		 ISO
EXP		 Halothane results in increased expression of S100A8 mRNA
Dantrolene inhibits the reaction [Halothane results in increased expression of S100A8 mRNA]; Ryanodine promotes the reaction [Halothane results in increased expression of S100A8 mRNA]		 CTD PMID:24747151 PMID:28138970 PMID:32795494 NCBI chr 1:153,390,032...153,422,583
Ensembl chr 1:153,390,032...153,391,073 		JBrowse link
G S100A9 S100 calcium binding protein A9 increases expression
multiple interactions		 ISO Halothane results in increased expression of S100A9 mRNA
Dantrolene inhibits the reaction [Halothane results in increased expression of S100A9 mRNA]; Ryanodine promotes the reaction [Halothane results in increased expression of S100A9 mRNA]		 CTD PMID:24747151 PMID:32795494 NCBI chr 1:153,357,854...153,361,023
Ensembl chr 1:153,357,854...153,361,023 		JBrowse link
G SFTPC surfactant protein C decreases expression
increases expression		 ISO Halothane results in decreased expression of SFTPC mRNA
Halothane results in increased expression of SFTPC mRNA		 CTD PMID:10969314 NCBI chr 8:22,157,383...22,164,479
Ensembl chr 8:22,156,913...22,164,479 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 multiple interactions
increases expression		 ISO Halothane results in increased expression of and results in increased phosphorylation of STAT3 protein
Halothane results in increased expression of STAT3 mRNA		 CTD PMID:24598351 NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568 		JBrowse link
G TLR4 toll like receptor 4 multiple interactions ISO TLR4 protein affects the reaction [Halothane results in increased expression of IFNG protein] CTD PMID:21245496 NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735 		JBrowse link
G TNF tumor necrosis factor increases expression
multiple interactions
decreases expression		 ISO Halothane results in increased expression of TNF mRNA
Dantrolene inhibits the reaction [Halothane results in increased expression of TNF mRNA]; Estradiol inhibits the reaction [Halothane results in increased expression of TNF mRNA]; Fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Halothane results in increased expression of TNF mRNA]]; Mifepristone inhibits the reaction [Halothane results in increased expression of TNF mRNA]; Mifepristone inhibits the reaction [Progesterone promotes the reaction [Halothane results in increased expression of TNF mRNA]]; Progesterone promotes the reaction [Halothane results in increased expression of TNF mRNA]; Ryanodine promotes the reaction [Halothane results in increased expression of TNF mRNA]
Halothane results in decreased expression of TNF mRNA		 CTD PMID:10422944 PMID:15564938 PMID:21501669 PMID:22157104 PMID:24598351 More... NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G VCAM1 vascular cell adhesion molecule 1 increases expression
multiple interactions		 ISO Halothane results in increased expression of VCAM1 mRNA
Dantrolene inhibits the reaction [Halothane results in increased expression of VCAM1 mRNA]; Ryanodine promotes the reaction [Halothane results in increased expression of VCAM1 mRNA]		 CTD PMID:32795494 NCBI chr 1:100,719,742...100,739,045
Ensembl chr 1:100,719,742...100,739,045 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 26504
    chemical entity 26484
      molecular entity 26466
        polyatomic entity 26301
          heteroatomic molecular entity 25937
            halide 21161
              organohalogen compound 21027
                organochlorine compound 20089
                  halothane 55
                    (R)-halothane 0
                    (S)-halothane 0
Path 2
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  CHEBI ontology 26504
    subatomic particle 26480
      composite particle 26480
        hadron 26480
          baryon 26480
            nucleon 26480
              atomic nucleus 26480
                atom 26480
                  main group element atom 26217
                    main group molecular entity 26217
                      s-block molecular entity 25456
                        hydrogen molecular entity 24862
                          hydrides 23079
                            organic hydride 22039
                              organic fundamental parent 22039
                                hydrocarbon 21483
                                  halohydrocarbon 16419
                                    haloalkane 13409
                                      halothane 55
                                        (R)-halothane 0
                                        (S)-halothane 0
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