CALR (calreticulin) - Rat Genome Database
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Gene: CALR (calreticulin) Homo sapiens
Analyze
Symbol: CALR
Name: calreticulin
RGD ID: 731575
HGNC Page HGNC
Description: Exhibits several functions, including calcium ion binding activity; signaling receptor binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including negative regulation of cellular macromolecule biosynthetic process; negative regulation of signal transduction; and regulation of cell migration. Localizes to several cellular components, including endoplasmic reticulum; perinuclear region of cytoplasm; and polysome. Implicated in essential thrombocythemia; myelofibrosis; sideroblastic anemia; and thrombocytosis. Biomarker of acute myeloid leukemia and pancreatic ductal carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: autoantigen Ro; calregulin; cC1qR; CRP55; CRT; endoplasmic reticulum resident protein 60; epididymis secretory sperm binding protein Li 99n; ERp60; FLJ26680; grp60; HACBP; HEL-S-99n; RO; Sicca syndrome antigen A (autoantigen Ro, calreticulin); SSA
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1912,938,578 - 12,944,489 (+)EnsemblGRCh38hg38GRCh38
GRCh381912,938,609 - 12,944,489 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371913,049,414 - 13,055,304 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361912,910,423 - 12,916,303 (+)NCBINCBI36hg18NCBI36
Build 341912,910,422 - 12,916,303NCBI
Celera1912,939,147 - 12,945,035 (+)NCBI
Cytogenetic Map19p13.13NCBI
HuRef1912,621,315 - 12,627,203 (+)NCBIHuRef
CHM1_11913,049,914 - 13,055,824 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (EXP)
(Z)-3-butylidenephthalide  (EXP)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2,2-tetramine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3-dimethoxynaphthalene-1,4-dione  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (EXP)
4-methylumbelliferyl acetate  (EXP)
7,12-dimethyltetraphene  (ISO)
8-Br-cAMP  (EXP)
aflatoxin B1  (EXP)
aflatoxin B2  (EXP)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
alpha-naphthoflavone  (ISO)
ammonium chloride  (ISO)
ampicillin  (EXP)
arsenous acid  (EXP)
avobenzone  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (EXP)
beta-D-glucosamine  (ISO)
bexarotene  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
boric acid  (EXP)
bortezomib  (EXP,ISO)
Brodifacoum  (ISO)
bucladesine  (ISO)
buspirone  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
calcium atom  (ISO)
calcium(0)  (ISO)
calyculin a  (ISO)
captan  (ISO)
carbon nanotube  (EXP,ISO)
cefaloridine  (ISO)
chloropicrin  (EXP)
chloroquine  (EXP,ISO)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium atom  (EXP)
chromones  (EXP)
cisplatin  (EXP,ISO)
clobetasol  (ISO)
clofibrate  (ISO)
clofibric acid  (ISO)
cobalt dichloride  (EXP)
cocaine  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
CU-O LINKAGE  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (ISO)
diallyl trisulfide  (EXP)
diarsenic trioxide  (EXP)
diazinon  (EXP)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
dinophysistoxin 1  (EXP)
doxorubicin  (EXP,ISO)
dutasteride  (EXP)
elemental selenium  (EXP)
ellagic acid  (EXP)
endosulfan  (ISO)
enzyme inhibitor  (EXP)
ethanol  (ISO)
fenbuconazole  (EXP)
flutamide  (ISO)
folic acid  (ISO)
gamma-hexachlorocyclohexane  (ISO)
gentamycin  (ISO)
glafenine  (ISO)
glucose  (ISO)
halothane  (ISO)
homocysteine  (ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (EXP,ISO)
ionomycin  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
isoprenaline  (ISO)
kojic acid  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lithium atom  (ISO)
lithium chloride  (ISO)
lithium hydride  (ISO)
lithocholic acid  (ISO)
lovastatin  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
methotrexate  (EXP)
mitoxantrone  (ISO)
monosodium L-glutamate  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (EXP)
nicotine  (EXP)
Nonidet P-40  (EXP)
okadaic acid  (EXP)
oxidopamine  (ISO)
paracetamol  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
pirinixic acid  (ISO)
potassium dichromate  (EXP)
procymidone  (ISO)
progesterone  (EXP,ISO)
Propiverine  (ISO)
resveratrol  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
salubrinal  (ISO)
selenium atom  (EXP)
sodium arsenite  (EXP)
sodium fluoride  (ISO)
streptozocin  (ISO)
sunitinib  (EXP)
tacrolimus hydrate  (ISO)
tamoxifen  (EXP,ISO)
Tautomycin  (ISO)
tert-butyl hydroperoxide  (EXP)
testosterone  (EXP,ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
titanium dioxide  (EXP,ISO)
tributylstannane  (EXP)
trichloroethene  (ISO)
triphenylstannane  (EXP)
tunicamycin  (EXP,ISO)
urethane  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vitamin E  (EXP)
vorinostat  (EXP)
warfarin  (ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  (TAS)
antigen processing and presentation of peptide antigen via MHC class I  (TAS)
ATF6-mediated unfolded protein response  (TAS)
cardiac muscle cell differentiation  (IEA)
cellular calcium ion homeostasis  (TAS)
cellular response to lithium ion  (IEA)
cellular response to organic substance  (ISO)
cellular senescence  (IGI)
cortical actin cytoskeleton organization  (IEA)
endoplasmic reticulum unfolded protein response  (IBA)
glucocorticoid receptor signaling pathway  (TAS)
negative regulation of cell cycle arrest  (IGI)
negative regulation of intracellular steroid hormone receptor signaling pathway  (IDA)
negative regulation of neuron differentiation  (IDA)
negative regulation of retinoic acid receptor signaling pathway  (IDA)
negative regulation of transcription by RNA polymerase II  (IDA)
negative regulation of transcription, DNA-templated  (IDA)
negative regulation of translation  (IDA,TAS)
negative regulation of trophoblast cell migration  (IMP)
peptide antigen assembly with MHC class I protein complex  (ISS)
positive regulation of cell cycle  (IGI)
positive regulation of cell population proliferation  (IGI)
positive regulation of dendritic cell chemotaxis  (IMP)
positive regulation of endothelial cell migration  (IMP)
positive regulation of gene expression  (IEA)
positive regulation of NIK/NF-kappaB signaling  (IEA)
positive regulation of phagocytosis  (ISS)
positive regulation of substrate adhesion-dependent cell spreading  (IMP)
protein export from nucleus  (IDA)
protein folding  (IBA,IEA,TAS)
protein folding in endoplasmic reticulum  (TAS)
protein localization to nucleus  (IDA)
protein maturation by protein folding  (TAS)
protein stabilization  (ISS,TAS)
receptor-mediated endocytosis  (TAS)
regulation of apoptotic process  (TAS)
regulation of meiotic nuclear division  (IEA)
regulation of transcription, DNA-templated  (TAS)
response to drug  (IEA)
response to estradiol  (IEA)
response to organic substance  (ISO)
response to testosterone  (IEA)
sequestering of calcium ion  (TAS)
spermatogenesis  (IEA)
vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane  (TAS)

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
1. Ahmad S, etal., J Proteomics. 2015 Sep 8;127(Pt A):178-84. doi: 10.1016/j.jprot.2015.04.035. Epub 2015 May 14.
2. GOA_HUMAN data from the GO Consortium
3. Guo H, etal., PLoS One. 2015 Sep 16;10(9):e0138250. doi: 10.1371/journal.pone.0138250. eCollection 2015.
4. Hong SH, etal., Cancer Res. 2004 Aug 1;64(15):5504-10.
5. Kageyama K, etal., J Biol Chem 2002 May 31;277(22):19255-64.
6. Kypreou KP, etal., Proteomics. 2008 Jun;8(12):2407-19.
7. Lee D and Michalak M, BMB Rep. 2010 Mar;43(3):151-7.
8. Li B, etal., Haematologica. 2014 Nov;99(11):1697-700. doi: 10.3324/haematol.2014.109249. Epub 2014 Jul 4.
9. Marty C, etal., Blood. 2016 Mar 10;127(10):1317-24. doi: 10.1182/blood-2015-11-679571. Epub 2015 Nov 25.
10. Nangalia J, etal., N Engl J Med. 2013 Dec 19;369(25):2391-405. doi: 10.1056/NEJMoa1312542. Epub 2013 Dec 10.
11. OMIM Disease Annotation Pipeline
12. Park S, etal., Cancer Genet. 2015 Dec;208(12):630-5. doi: 10.1016/j.cancergen.2015.11.001. Epub 2015 Nov 10.
13. Pipeline to import KEGG annotations from KEGG into RGD
14. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. RGD automated import pipeline for gene-chemical interactions
16. RGD automated import pipeline for human HPO-to-gene-to-disease annotations
17. Tefferi A, etal., Leukemia. 2014 Jul;28(7):1494-500. doi: 10.1038/leu.2014.57. Epub 2014 Feb 5.
18. Theocharides AP, etal., Blood. 2016 Jun 23;127(25):3253-9. doi: 10.1182/blood-2016-02-696310. Epub 2016 Mar 24.
19. Yao QM, etal., Hematology. 2015 Oct;20(9):517-22. doi: 10.1179/1607845415Y.0000000009. Epub 2015 Apr 10.
Additional References at PubMed
PMID:1286667   PMID:1286669   PMID:1733953   PMID:1911778   PMID:1919005   PMID:1939344   PMID:2332496   PMID:2365822   PMID:2400400   PMID:3260607   PMID:7559457   PMID:7592883  
PMID:7622522   PMID:7841019   PMID:7876246   PMID:7923996   PMID:8006073   PMID:8050453   PMID:8062452   PMID:8107808   PMID:8107809   PMID:8125298   PMID:8418194   PMID:8537405  
PMID:8550632   PMID:8662691   PMID:8666824   PMID:8769474   PMID:8805302   PMID:8904349   PMID:8910335   PMID:9036970   PMID:9089287   PMID:9150948   PMID:9312001   PMID:9359841  
PMID:9427624   PMID:9525969   PMID:9545232   PMID:9640257   PMID:9671507   PMID:9693955   PMID:9694898   PMID:9988700   PMID:10198260   PMID:10358038   PMID:10364189   PMID:10436013  
PMID:10508608   PMID:10513896   PMID:10547375   PMID:10581245   PMID:10605026   PMID:10887119   PMID:10929008   PMID:11149926   PMID:11322874   PMID:11327697   PMID:11378243   PMID:11765911  
PMID:11823531   PMID:11825569   PMID:11842004   PMID:11859136   PMID:11891802   PMID:12047747   PMID:12052826   PMID:12065601   PMID:12147682   PMID:12196561   PMID:12235131   PMID:12239218  
PMID:12242300   PMID:12324449   PMID:12362238   PMID:12383251   PMID:12397072   PMID:12477932   PMID:12538033   PMID:12584332   PMID:12646570   PMID:12704787   PMID:12740382   PMID:12821648  
PMID:14624761   PMID:14726956   PMID:14732231   PMID:14980518   PMID:14985176   PMID:15056662   PMID:15057824   PMID:15231747   PMID:15236594   PMID:15351734   PMID:15371419   PMID:15383281  
PMID:15474971   PMID:15489334   PMID:15494401   PMID:15596044   PMID:15634883   PMID:15855281   PMID:15893733   PMID:15896298   PMID:15952740   PMID:15998798   PMID:16130169   PMID:16140380  
PMID:16236267   PMID:16502470   PMID:16522185   PMID:16522924   PMID:16527813   PMID:16542777   PMID:16951181   PMID:16951317   PMID:16974078   PMID:17009399   PMID:17055437   PMID:17215244  
PMID:17353931   PMID:17390051   PMID:17499031   PMID:17563366   PMID:17655857   PMID:17947714   PMID:17959730   PMID:17982021   PMID:18022694   PMID:18029348   PMID:18177377   PMID:18221019  
PMID:18303019   PMID:18417548   PMID:18559259   PMID:18641393   PMID:18653767   PMID:18765291   PMID:18791162   PMID:18795239   PMID:18801343   PMID:18925427   PMID:19050968   PMID:19054761  
PMID:19100874   PMID:19154346   PMID:19199708   PMID:19299420   PMID:19322201   PMID:19470730   PMID:19490893   PMID:19524015   PMID:19567621   PMID:19580784   PMID:19608864   PMID:19659458  
PMID:19684620   PMID:19760677   PMID:19913121   PMID:19946888   PMID:20000738   PMID:20360068   PMID:20480531   PMID:20533543   PMID:20551380   PMID:20562859   PMID:20624402   PMID:20628086  
PMID:20699648   PMID:20834237   PMID:20855873   PMID:20861015   PMID:20929309   PMID:21075854   PMID:21115737   PMID:21142150   PMID:21178137   PMID:21182888   PMID:21263072   PMID:21319273  
PMID:21423176   PMID:21423620   PMID:21447409   PMID:21590275   PMID:21630459   PMID:21652723   PMID:21723904   PMID:21873635   PMID:21900206   PMID:21911577   PMID:21996511   PMID:22013210  
PMID:22024156   PMID:22079093   PMID:22083347   PMID:22174317   PMID:22190034   PMID:22242185   PMID:22304920   PMID:22377355   PMID:22415225   PMID:22415851   PMID:22429966   PMID:22492046  
PMID:22507216   PMID:22511615   PMID:22572157   PMID:22586326   PMID:22658674   PMID:22661095   PMID:22773372   PMID:22810586   PMID:22844112   PMID:22863883   PMID:22915645   PMID:22939629  
PMID:22952844   PMID:23011799   PMID:23222517   PMID:23233327   PMID:23272104   PMID:23334957   PMID:23364915   PMID:23375593   PMID:23376485   PMID:23395171   PMID:23464991   PMID:23465222  
PMID:23535532   PMID:23564462   PMID:23585889   PMID:23587357   PMID:23667531   PMID:23771121   PMID:23791743   PMID:23814025   PMID:23874603   PMID:23972286   PMID:24035512   PMID:24169561  
PMID:24205998   PMID:24214877   PMID:24244333   PMID:24252779   PMID:24264800   PMID:24321043   PMID:24325356   PMID:24365789   PMID:24366362   PMID:24371211   PMID:24402162   PMID:24421250  
PMID:24441291   PMID:24457600   PMID:24458922   PMID:24476766   PMID:24476767   PMID:24480782   PMID:24504025   PMID:24514146   PMID:24523226   PMID:24531734   PMID:24553179   PMID:24557008  
PMID:24569778   PMID:24593306   PMID:24618731   PMID:24639526   PMID:24711643   PMID:24732593   PMID:24749731   PMID:24753125   PMID:24764562   PMID:24791854   PMID:24797263   PMID:24850292  
PMID:24884814   PMID:24895336   PMID:24986690   PMID:24988887   PMID:24999758   PMID:25005031   PMID:25015052   PMID:25015940   PMID:25023898   PMID:25068507   PMID:25103330   PMID:25115510  
PMID:25115511   PMID:25118376   PMID:25139350   PMID:25147182   PMID:25173966   PMID:25176567   PMID:25187353   PMID:25189720   PMID:25212275   PMID:25223992   PMID:25231404   PMID:25231745  
PMID:25241761   PMID:25249012   PMID:25277244   PMID:25288151   PMID:25301336   PMID:25305205   PMID:25316523   PMID:25322686   PMID:25323688   PMID:25323779   PMID:25366168   PMID:25378661  
PMID:25398833   PMID:25413337   PMID:25429433   PMID:25482134   PMID:25499808   PMID:25540065   PMID:25544563   PMID:25553276   PMID:25567134   PMID:25573593   PMID:25579178   PMID:25637689  
PMID:25661444   PMID:25682604   PMID:25686645   PMID:25704851   PMID:25729726   PMID:25745188   PMID:25746303   PMID:25761617   PMID:25794131   PMID:25838280   PMID:25858548   PMID:25873496  
PMID:25908558   PMID:25918716   PMID:25921289   PMID:25934766   PMID:25946468   PMID:25959795   PMID:25963833   PMID:25976465   PMID:26071474   PMID:26119186   PMID:26130950   PMID:26162987  
PMID:26186194   PMID:26220041   PMID:26281713   PMID:26290216   PMID:26294037   PMID:26307067   PMID:26344197   PMID:26370832   PMID:26377485   PMID:26452990   PMID:26469323   PMID:26473532  
PMID:26481236   PMID:26499835   PMID:26506232   PMID:26514267   PMID:26555437   PMID:26573090   PMID:26614694   PMID:26618866   PMID:26638075   PMID:26641092   PMID:26646311   PMID:26668133  
PMID:26754830   PMID:26768689   PMID:26777583   PMID:26817954   PMID:26825145   PMID:26826378   PMID:26890983   PMID:26951227   PMID:26994960   PMID:27009537   PMID:27018326   PMID:27025967  
PMID:27163789   PMID:27173435   PMID:27177927   PMID:27185380   PMID:27195812   PMID:27209416   PMID:27247323   PMID:27310876   PMID:27315113   PMID:27342126   PMID:27352261   PMID:27365140  
PMID:27376361   PMID:27384487   PMID:27423004   PMID:27427771   PMID:27432908   PMID:27453224   PMID:27462432   PMID:27477402   PMID:27486987   PMID:27521277   PMID:27560107   PMID:27561105  
PMID:27566291   PMID:27566407   PMID:27662324   PMID:27686171   PMID:27689957   PMID:27716741   PMID:27730343   PMID:27740635   PMID:27751915   PMID:27758825   PMID:27777122   PMID:27802968  
PMID:27825129   PMID:27855276   PMID:27875935   PMID:27880917   PMID:28029004   PMID:28031530   PMID:28106543   PMID:28161773   PMID:28168700   PMID:28205126   PMID:28209773   PMID:28232234  
PMID:28260038   PMID:28298427   PMID:28314843   PMID:28330616   PMID:28340692   PMID:28347227   PMID:28366632   PMID:28385780   PMID:28411309   PMID:28415571   PMID:28422716   PMID:28470469  
PMID:28514442   PMID:28581483   PMID:28625126   PMID:28675297   PMID:28676668   PMID:28692057   PMID:28711709   PMID:28714945   PMID:28741795   PMID:28747287   PMID:28751563   PMID:28766534  
PMID:28778674   PMID:28894229   PMID:28938427   PMID:28990497   PMID:29117863   PMID:29146710   PMID:29180619   PMID:29217833   PMID:29266414   PMID:29288169   PMID:29306106   PMID:29390868  
PMID:29420262   PMID:29464483   PMID:29507755   PMID:29521158   PMID:29534592   PMID:29704455   PMID:29773794   PMID:29791485   PMID:29847812   PMID:29934356   PMID:29946189   PMID:29956451  
PMID:29981820   PMID:29997244   PMID:30021884   PMID:30053596   PMID:30080988   PMID:30082822   PMID:30084272   PMID:30097573   PMID:30108113   PMID:30188326   PMID:30193773   PMID:30194290  
PMID:30292681   PMID:30304655   PMID:30315236   PMID:30409794   PMID:30429217   PMID:30444198   PMID:30463901   PMID:30503554   PMID:30551188   PMID:30575818   PMID:30592274   PMID:30612140  
PMID:30639474   PMID:30833329   PMID:30833792   PMID:30846848   PMID:30890647   PMID:30948266   PMID:31046837   PMID:31056421   PMID:31092433   PMID:31128484   PMID:31174435   PMID:31248375  
PMID:31266769   PMID:31300519   PMID:31332222   PMID:31375263   PMID:31462733   PMID:31536960   PMID:31554376   PMID:31562135   PMID:31568485   PMID:31586073   PMID:31612071   PMID:31617661  
PMID:31681999   PMID:31710700   PMID:31725767   PMID:31747968   PMID:31848992   PMID:31882869   PMID:32000382   PMID:32070814   PMID:32081398   PMID:32164591   PMID:32203420   PMID:32296183  
PMID:32798420   PMID:32814053   PMID:32908058   PMID:33060197  


Genomics

Comparative Map Data
CALR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1912,938,578 - 12,944,489 (+)EnsemblGRCh38hg38GRCh38
GRCh381912,938,609 - 12,944,489 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371913,049,414 - 13,055,304 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361912,910,423 - 12,916,303 (+)NCBINCBI36hg18NCBI36
Build 341912,910,422 - 12,916,303NCBI
Celera1912,939,147 - 12,945,035 (+)NCBI
Cytogenetic Map19p13.13NCBI
HuRef1912,621,315 - 12,627,203 (+)NCBIHuRef
CHM1_11913,049,914 - 13,055,824 (+)NCBICHM1_1
Calr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39885,568,717 - 85,573,560 (-)NCBIGRCm39mm39
GRCm38884,842,088 - 84,846,931 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl884,841,850 - 84,846,934 (-)EnsemblGRCm38mm10GRCm38
MGSCv37887,365,987 - 87,370,830 (-)NCBIGRCm37mm9NCBIm37
MGSCv36887,731,955 - 87,736,972 (-)NCBImm8
Celera889,141,243 - 89,146,089 (-)NCBICelera
Cytogenetic Map8C3NCBI
cM Map841.21NCBI
Calr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01925,956,771 - 25,961,666 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1925,956,771 - 25,961,666 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01936,932,394 - 36,937,289 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41924,964,775 - 24,969,670 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11924,969,631 - 24,974,494 (+)NCBI
Celera1922,865,445 - 22,870,340 (+)NCBICelera
Cytogenetic Map19q11NCBI
Calr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541531,985,147 - 31,989,372 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541531,985,147 - 31,989,372 (+)NCBIChiLan1.0ChiLan1.0
CALR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11913,242,900 - 13,249,416 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1913,242,900 - 13,249,416 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01912,501,013 - 12,506,909 (+)NCBIMhudiblu_PPA_v0panPan3
CALR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2049,251,777 - 49,255,245 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12049,251,390 - 49,255,291 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Calr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366591,994,695 - 1,999,070 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CALR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl266,098,225 - 66,102,340 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1266,098,263 - 66,102,074 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2266,283,767 - 66,287,604 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CALR
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl611,618,396 - 11,623,792 (+)Ensembl
ChlSab1.1611,618,691 - 11,624,299 (+)NCBI
Calr
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624901511,295 - 515,208 (+)NCBI

Position Markers
STS-M84739  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37X27,769,716 - 27,770,249UniSTSGRCh37
GRCh371913,054,738 - 13,054,982UniSTSGRCh37
Build 36X27,679,637 - 27,680,170RGDNCBI36
CeleraX31,898,190 - 31,898,723RGD
Celera1912,944,469 - 12,944,713UniSTS
Cytogenetic Map19p13.3-p13.2UniSTS
Cytogenetic Map19p13.2UniSTS
HuRef1912,626,638 - 12,626,881UniSTS
GeneMap99-GB4 RH Map1971.27UniSTS
CALR_3945  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371913,054,534 - 13,055,400UniSTSGRCh37
Build 361912,915,534 - 12,916,400RGDNCBI36
Celera1912,944,265 - 12,945,131RGD
HuRef1912,626,434 - 12,627,299UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2581
Count of miRNA genes:753
Interacting mature miRNAs:918
Transcripts:ENST00000316448, ENST00000586760, ENST00000586803, ENST00000586967, ENST00000587486, ENST00000588454, ENST00000590325
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 128 71 635 120 336 118 233 30 79 102 274 779 11 32 8 3 1
Medium 2311 2919 1091 504 1615 347 4124 2166 3655 317 1186 834 164 1 1172 2780 3 1
Low 1 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_029662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_004343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB451408 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC092069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AD000092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF087986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK130190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK223060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK295230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK304492 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY047586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC002500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC007911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC020493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC107102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT007448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR457070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS288581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ224311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ900919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JA462404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JC990121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KU639671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KU639672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KU639673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KU639674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KU639675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KU639676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KU639677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KU639678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KU639679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KU639680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KU639681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KU639682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KU639683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KU639684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KU639685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KU639686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KU639687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KU639688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LN835768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M32294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M84739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000316448   ⟹   ENSP00000320866
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1912,938,609 - 12,944,489 (+)Ensembl
RefSeq Acc Id: ENST00000586760   ⟹   ENSP00000465918
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1912,940,397 - 12,944,403 (+)Ensembl
RefSeq Acc Id: ENST00000586803
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1912,943,213 - 12,943,962 (+)Ensembl
RefSeq Acc Id: ENST00000586967   ⟹   ENSP00000466037
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1912,943,873 - 12,944,489 (+)Ensembl
RefSeq Acc Id: ENST00000587486
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1912,938,578 - 12,940,147 (+)Ensembl
RefSeq Acc Id: ENST00000588454   ⟹   ENSP00000465105
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1912,938,645 - 12,940,872 (+)Ensembl
RefSeq Acc Id: ENST00000590325
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1912,938,614 - 12,940,370 (+)Ensembl
RefSeq Acc Id: NM_004343   ⟹   NP_004334
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381912,938,609 - 12,944,489 (+)NCBI
GRCh371913,049,414 - 13,055,304 (+)ENTREZGENE
Build 361912,910,423 - 12,916,303 (+)NCBI Archive
HuRef1912,621,315 - 12,627,203 (+)ENTREZGENE
CHM1_11913,049,914 - 13,055,824 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_004334 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA36582 (Get FASTA)   NCBI Sequence Viewer  
  AAA51916 (Get FASTA)   NCBI Sequence Viewer  
  AAB51176 (Get FASTA)   NCBI Sequence Viewer  
  AAH02500 (Get FASTA)   NCBI Sequence Viewer  
  AAH07911 (Get FASTA)   NCBI Sequence Viewer  
  AAH20493 (Get FASTA)   NCBI Sequence Viewer  
  AAL13126 (Get FASTA)   NCBI Sequence Viewer  
  AAP36116 (Get FASTA)   NCBI Sequence Viewer  
  ACI46003 (Get FASTA)   NCBI Sequence Viewer  
  ADO22436 (Get FASTA)   NCBI Sequence Viewer  
  AMR60705 (Get FASTA)   NCBI Sequence Viewer  
  AMR60706 (Get FASTA)   NCBI Sequence Viewer  
  AMR60707 (Get FASTA)   NCBI Sequence Viewer  
  AMR60708 (Get FASTA)   NCBI Sequence Viewer  
  AMR60709 (Get FASTA)   NCBI Sequence Viewer  
  AMR60710 (Get FASTA)   NCBI Sequence Viewer  
  AMR60711 (Get FASTA)   NCBI Sequence Viewer  
  AMR60712 (Get FASTA)   NCBI Sequence Viewer  
  AMR60713 (Get FASTA)   NCBI Sequence Viewer  
  AMR60714 (Get FASTA)   NCBI Sequence Viewer  
  AMR60715 (Get FASTA)   NCBI Sequence Viewer  
  AMR60716 (Get FASTA)   NCBI Sequence Viewer  
  AMR60717 (Get FASTA)   NCBI Sequence Viewer  
  AMR60718 (Get FASTA)   NCBI Sequence Viewer  
  AMR60719 (Get FASTA)   NCBI Sequence Viewer  
  AMR60720 (Get FASTA)   NCBI Sequence Viewer  
  AMR60721 (Get FASTA)   NCBI Sequence Viewer  
  AMR60722 (Get FASTA)   NCBI Sequence Viewer  
  BAD96780 (Get FASTA)   NCBI Sequence Viewer  
  BAG58223 (Get FASTA)   NCBI Sequence Viewer  
  BAG65301 (Get FASTA)   NCBI Sequence Viewer  
  BAG70222 (Get FASTA)   NCBI Sequence Viewer  
  CAG33351 (Get FASTA)   NCBI Sequence Viewer  
  CAK18761 (Get FASTA)   NCBI Sequence Viewer  
  CCD35250 (Get FASTA)   NCBI Sequence Viewer  
  CEO43494 (Get FASTA)   NCBI Sequence Viewer  
  CRH09108 (Get FASTA)   NCBI Sequence Viewer  
  EAW84330 (Get FASTA)   NCBI Sequence Viewer  
  EAW84331 (Get FASTA)   NCBI Sequence Viewer  
  EAW84332 (Get FASTA)   NCBI Sequence Viewer  
  P27797 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_004334   ⟸   NM_004343
- Peptide Label: precursor
- UniProtKB: P27797 (UniProtKB/Swiss-Prot),   V9HW88 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000466037   ⟸   ENST00000586967
RefSeq Acc Id: ENSP00000465918   ⟸   ENST00000586760
RefSeq Acc Id: ENSP00000465105   ⟸   ENST00000588454
RefSeq Acc Id: ENSP00000320866   ⟸   ENST00000316448

Promoters
RGD ID:6795236
Promoter ID:HG_KWN:29042
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_004343
Position:
Human AssemblyChrPosition (strand)Source
Build 361912,909,746 - 12,910,527 (+)MPROMDB
RGD ID:6852420
Promoter ID:EP74019
Type:initiation region
Name:HS_CALR
Description:Calreticulin.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Mammalian gene collection (MGC) full-length cDNA cloning
Position:
Human AssemblyChrPosition (strand)Source
Build 361912,910,433 - 12,910,493EPD
RGD ID:6811518
Promoter ID:HG_ACW:40066
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:CALR.CAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 361912,911,196 - 12,912,672 (+)MPROMDB
RGD ID:6795239
Promoter ID:HG_KWN:29043
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:UC002MVV.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361912,915,189 - 12,915,689 (+)MPROMDB
RGD ID:7238753
Promoter ID:EPDNEW_H25122
Type:initiation region
Name:CALR_1
Description:calreticulin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381912,938,609 - 12,938,669EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_004343.3(CALR):c.1092_1143del52 (p.Leu367Thrfs) deletion Myelofibrosis [RCV000083256]|Thrombocythemia 1 [RCV000083257] Chr19:12943751..12943802 [GRCh38]
Chr19:13054565..13054616 [GRCh37]
Chr19:19p13.13
pathogenic|other
GRCh38/hg38 19p13.2-13.13(chr19:8831147-13331227)x3 copy number gain See cases [RCV000052908] Chr19:8831147..13331227 [GRCh38]
Chr19:8941823..13442041 [GRCh37]
Chr19:8802823..13303041 [NCBI36]
Chr19:19p13.2-13.13
likely pathogenic
GRCh38/hg38 19p13.2-13.12(chr19:10315258-14048994)x3 copy number gain See cases [RCV000052909] Chr19:10315258..14048994 [GRCh38]
Chr19:10425934..14159806 [GRCh37]
Chr19:10286934..14020806 [NCBI36]
Chr19:19p13.2-13.12
pathogenic
GRCh38/hg38 19p13.2-13.12(chr19:12132052-14751798)x3 copy number gain See cases [RCV000052910] Chr19:12132052..14751798 [GRCh38]
Chr19:12242867..14862610 [GRCh37]
Chr19:12103867..14723610 [NCBI36]
Chr19:19p13.2-13.12
pathogenic
GRCh38/hg38 19p13.13(chr19:12850595-13290954)x3 copy number gain See cases [RCV000052911] Chr19:12850595..13290954 [GRCh38]
Chr19:12961409..13401768 [GRCh37]
Chr19:12822409..13262768 [NCBI36]
Chr19:19p13.13
pathogenic
GRCh38/hg38 19p13.13(chr19:12813597-13119698)x3 copy number gain See cases [RCV000054144] Chr19:12813597..13119698 [GRCh38]
Chr19:12924411..13230512 [GRCh37]
Chr19:12785411..13091512 [NCBI36]
Chr19:19p13.13
uncertain significance
GRCh38/hg38 19p13.2-13.12(chr19:11227942-14532135)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053944]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053944]|See cases [RCV000053944] Chr19:11227942..14532135 [GRCh38]
Chr19:11338618..14642947 [GRCh37]
Chr19:11199618..14503947 [NCBI36]
Chr19:19p13.2-13.12
pathogenic
GRCh38/hg38 19p13.2-13.13(chr19:11517825-13225287)x1 copy number loss See cases [RCV000053945] Chr19:11517825..13225287 [GRCh38]
Chr19:11628640..13336101 [GRCh37]
Chr19:11489640..13197101 [NCBI36]
Chr19:19p13.2-13.13
pathogenic
NM_005053.3(RAD23A):c.754C>T (p.Pro252Ser) single nucleotide variant Malignant melanoma [RCV000071939] Chr19:12949349 [GRCh38]
Chr19:13060163 [GRCh37]
Chr19:12921163 [NCBI36]
Chr19:19p13.13
not provided
GRCh38/hg38 19p13.2-q13.31(chr19:11227942-44626354)x3 copy number gain See cases [RCV000133888] Chr19:11227942..44626354 [GRCh38]
Chr19:11338618..45129651 [GRCh37]
Chr19:11199618..49821491 [NCBI36]
Chr19:19p13.2-q13.31
pathogenic
GRCh38/hg38 19p13.2-13.12(chr19:12580427-14742673)x1 copy number loss See cases [RCV000135937] Chr19:12580427..14742673 [GRCh38]
Chr19:12691241..14853485 [GRCh37]
Chr19:12552241..14714485 [NCBI36]
Chr19:19p13.2-13.12
pathogenic|likely pathogenic
GRCh38/hg38 19p13.2-13.12(chr19:11525163-14155021)x1 copy number loss See cases [RCV000136909] Chr19:11525163..14155021 [GRCh38]
Chr19:11635978..14265833 [GRCh37]
Chr19:11496978..14126833 [NCBI36]
Chr19:19p13.2-13.12
pathogenic
GRCh38/hg38 19p13.2-13.13(chr19:10319474-13777860)x1 copy number loss See cases [RCV000141568] Chr19:10319474..13777860 [GRCh38]
Chr19:10430150..13888674 [GRCh37]
Chr19:10291150..13749674 [NCBI36]
Chr19:19p13.2-13.13
pathogenic
GRCh37/hg19 19p13.2(chr19:12204632-13497073)x1 copy number loss See cases [RCV000449161] Chr19:12204632..13497073 [GRCh37]
Chr19:19p13.2
pathogenic
GRCh37/hg19 19p13.2-13.12(chr19:9678768-14853426) copy number gain See cases [RCV000446985] Chr19:9678768..14853426 [GRCh37]
Chr19:19p13.2-13.12
pathogenic
GRCh37/hg19 19p13.2-13.12(chr19:12574343-14726197)x1 copy number loss See cases [RCV000511130] Chr19:12574343..14726197 [GRCh37]
Chr19:19p13.2-13.12
pathogenic
GRCh37/hg19 19p13.2-13.12(chr19:11608072-14543046)x3 copy number gain See cases [RCV000511013] Chr19:11608072..14543046 [GRCh37]
Chr19:19p13.2-13.12
uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)x3 copy number gain See cases [RCV000511289] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic|uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888) copy number gain See cases [RCV000512296] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:68029-59110290)x3 copy number gain not provided [RCV000752439] Chr19:68029..59110290 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-59097160)x3 copy number gain not provided [RCV000752444] Chr19:260912..59097160 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
NM_004343.4(CALR):c.1011A>G (p.Ala337=) single nucleotide variant not provided [RCV000973594] Chr19:12943587 [GRCh38]
Chr19:13054401 [GRCh37]
Chr19:19p13.13
benign
NM_004343.4(CALR):c.1142A>C (p.Glu381Ala) single nucleotide variant not provided [RCV000950840] Chr19:12943801 [GRCh38]
Chr19:13054615 [GRCh37]
Chr19:19p13.13
benign
NM_004343.4(CALR):c.231G>T (p.Leu77=) single nucleotide variant not provided [RCV000939767] Chr19:12939465 [GRCh38]
Chr19:13050279 [GRCh37]
Chr19:19p13.13
likely benign
NM_004343.4(CALR):c.606C>T (p.Phe202=) single nucleotide variant not provided [RCV000879909] Chr19:12940356 [GRCh38]
Chr19:13051170 [GRCh37]
Chr19:19p13.13
benign
NM_004343.4(CALR):c.170A>G (p.Tyr57Cys) single nucleotide variant not provided [RCV000943310] Chr19:12939212 [GRCh38]
Chr19:13050026 [GRCh37]
Chr19:19p13.13
benign
NM_004343.4(CALR):c.750C>G (p.Pro250=) single nucleotide variant not provided [RCV000967781] Chr19:12940588 [GRCh38]
Chr19:13051402 [GRCh37]
Chr19:19p13.13
likely benign
GRCh37/hg19 19p13.2(chr19:12354642-13424014)x1 copy number loss not provided [RCV000846538] Chr19:12354642..13424014 [GRCh37]
Chr19:19p13.2
pathogenic
NM_004343.4(CALR):c.817-9C>T single nucleotide variant not provided [RCV000966065] Chr19:12940735 [GRCh38]
Chr19:13051549 [GRCh37]
Chr19:19p13.13
benign
NM_004343.4(CALR):c.507A>T (p.Thr169=) single nucleotide variant not provided [RCV000917333] Chr19:12940257 [GRCh38]
Chr19:13051071 [GRCh37]
Chr19:19p13.13
likely benign

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:1455 AgrOrtholog
COSMIC CALR COSMIC
Ensembl Genes ENSG00000179218 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000320866 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000465105 UniProtKB/TrEMBL
  ENSP00000465918 UniProtKB/TrEMBL
  ENSP00000466037 UniProtKB/TrEMBL
Ensembl Transcript ENST00000316448 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000586760 UniProtKB/TrEMBL
  ENST00000586967 UniProtKB/TrEMBL
  ENST00000588454 UniProtKB/TrEMBL
Gene3D-CATH 2.10.250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000179218 GTEx
HGNC ID HGNC:1455 ENTREZGENE
Human Proteome Map CALR Human Proteome Map
InterPro Calret/calnex UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Calret/calnex_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Calreticulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Calreticulin/calnexin_P_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ConA-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:811 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 811 ENTREZGENE
OMIM 109091 OMIM
  187950 OMIM
  254450 OMIM
PANTHER PTHR11073 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Calreticulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA26046 PharmGKB
PIRSF Calreticulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS CALRETICULIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CALRETICULIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CALRETICULIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CALRETICULIN_REPEAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ER_TARGET UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49899 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF63887 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Hs.515162 ENTREZGENE
UniProt A0A0F7W2W6_HUMAN UniProtKB/TrEMBL
  A0A0F7WAP3_HUMAN UniProtKB/TrEMBL
  A0A142IK94_HUMAN UniProtKB/TrEMBL
  A0A142IKA1_HUMAN UniProtKB/TrEMBL
  A0A142IKA2_HUMAN UniProtKB/TrEMBL
  CALR_HUMAN UniProtKB/Swiss-Prot
  K7EJB9_HUMAN UniProtKB/TrEMBL
  K7EL50_HUMAN UniProtKB/TrEMBL
  K7ELE2_HUMAN UniProtKB/TrEMBL
  P27797 ENTREZGENE
  V9HW88 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q6IAT4 UniProtKB/Swiss-Prot
  Q9UDG2 UniProtKB/Swiss-Prot