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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:gadodiamide hydrate
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Accession:CHEBI:31642 term browser browse the term
Definition:The hydrate of gadodiamide.
Synonyms:exact_synonym: [N,N-bis(2-{[(carboxy-kappaO)methyl][2-(methylamino)-2-(oxo-kappaO)ethyl]amino-kappaN}ethyl)glycinato(3-)-kappa(2)N,O]gadolinium--water (1/1)
 related_synonym: Formula=C16H28GdN5O9;   Gadodiamide;   InChI=1S/C16H29N5O8.Gd.H2O/c1-17-12(22)7-20(10-15(26)27)5-3-19(9-14(24)25)4-6-21(11-16(28)29)8-13(23)18-2;;/h3-11H2,1-2H3,(H,17,22)(H,18,23)(H,24,25)(H,26,27)(H,28,29);;1H2/q;+3;/p-3;   InChIKey=XPCLDSMKWNNKOM-UHFFFAOYSA-K;   Omniscan;   SMILES=[H]O[H].CNC1=[O][Gd+3]234567[O-]C(=O)C[N]2(CC[N]3(CC(=O)[O-]4)C1)CC[N]5(CC(=O)[O-]6)CC(NC)=[O]7;   gadodiamida;   gadodiamidum;   gadolinium 5,8-bis(carboxylatomethyl)-11-[2-(methylamino)-2-oxoethyl]-3-oxo-2,5,8,11-tetraazatridecan-13-oate hydrate;   gadolinium [bis(2-{(carboxylatomethyl)[2-(methylamino)-2-oxoethyl]amino}ethyl)amino]acetate--water (1/1)
 xref: CAS:122795-43-1;   DrugBank:DB00225;   Gmelin:898533;   KEGG:C13106;   KEGG:D01645
 xref_mesh: MESH:C064925


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gadodiamide hydrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing decreases expression ISO gadodiamide results in decreased expression of ADIPOQ mRNA; gadodiamide results in decreased expression of ADIPOQ protein CTD PMID:37437671 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions		 ISO gadodiamide results in increased phosphorylation of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [gadodiamide results in increased phosphorylation of AKT1 protein]		 CTD PMID:19561517 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression ISO gadodiamide results in increased expression of ALDH1A1 mRNA CTD PMID:20959327 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961 		JBrowse link
G Ankrd22 ankyrin repeat domain 22 increases expression ISO gadodiamide results in increased expression of ANKRD22 mRNA CTD PMID:20959327 NCBI chr 1:231,639,035...231,670,537
Ensembl chr 1:231,639,314...231,670,381 		JBrowse link
G Atm ATM serine/threonine kinase increases expression ISO gadodiamide results in increased expression of ATM mRNA CTD PMID:20959327 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Atp8b1 ATPase phospholipid transporting 8B1 increases expression ISO gadodiamide results in increased expression of ATP8B1 mRNA CTD PMID:20959327 NCBI chr18:58,016,382...58,157,213
Ensembl chr18:58,018,268...58,157,396 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression
increases secretion		 ISO
EXP		 gadodiamide results in increased expression of CCL2 mRNA
gadodiamide results in increased secretion of CCL2 protein
gadodiamide results in increased expression of CCL2 mRNA; gadodiamide results in increased expression of CCL2 protein		 CTD PMID:20938346 PMID:20959327 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression EXP gadodiamide results in increased expression of CCL4 protein CTD PMID:20938346 NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231 		JBrowse link
G Ccl7 C-C motif chemokine ligand 7 increases expression EXP gadodiamide results in increased expression of CCL7 protein CTD PMID:20938346 NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303 		JBrowse link
G Cep15 centrosomal protein 15 increases expression ISO gadodiamide results in increased expression of CEP15 mRNA CTD PMID:20959327 NCBI chr15:12,815,159...12,835,115
Ensembl chr15:12,818,385...12,833,838 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression
increases secretion		 ISO
EXP		 gadodiamide results in increased expression of CXCL10 mRNA
gadodiamide results in increased secretion of CXCL10 protein
gadodiamide results in increased expression of CXCL10 protein		 CTD PMID:20938346 PMID:20959327 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 increases secretion
increases expression		 ISO gadodiamide results in increased secretion of CXCL11 protein
gadodiamide results in increased expression of CXCL11 mRNA		 CTD PMID:20959327 NCBI chr14:15,689,432...15,692,207
Ensembl chr14:15,689,424...15,692,271 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 increases expression ISO gadodiamide results in increased expression of CXCL12 mRNA CTD PMID:20959327 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168 		JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 increases expression ISO gadodiamide results in increased expression of CXCL9 mRNA CTD PMID:20959327 NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435 		JBrowse link
G Fabp4 fatty acid binding protein 4 decreases expression ISO gadodiamide results in decreased expression of FABP4 mRNA; gadodiamide results in decreased expression of FABP4 protein CTD PMID:37437671 NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578 		JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 increases expression ISO gadodiamide results in increased expression of IDO1 mRNA CTD PMID:20959327 NCBI chr16:67,430,654...67,442,726
Ensembl chr16:67,430,578...67,442,730 		JBrowse link
G Ifi44l interferon-induced protein 44-like increases expression ISO gadodiamide results in increased expression of IFI44L mRNA CTD PMID:20959327 NCBI chr 2:240,668,742...240,706,425
Ensembl chr 2:240,668,713...240,706,359 		JBrowse link
G Ifit3 interferon-induced protein with tetratricopeptide repeats 3 increases expression ISO gadodiamide results in increased expression of IFIT3 mRNA CTD PMID:20959327 NCBI chr 1:232,114,166...232,119,311
Ensembl chr 1:232,114,166...232,119,307 		JBrowse link
G Ifng interferon gamma increases expression ISO gadodiamide results in increased expression of IFNG mRNA; gadodiamide results in increased expression of IFNG protein CTD PMID:19404939 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il13 interleukin 13 increases expression ISO gadodiamide results in increased expression of IL13 mRNA; gadodiamide results in increased expression of IL13 protein CTD PMID:19404939 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il1a interleukin 1 alpha increases expression EXP gadodiamide results in increased expression of IL1A protein CTD PMID:20938346 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il4 interleukin 4 increases expression
affects expression		 ISO gadodiamide results in increased expression of IL4 protein
gadodiamide affects the expression of IL4 mRNA		 CTD PMID:19404939 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il4i1 interleukin 4 induced 1 increases expression ISO gadodiamide results in increased expression of IL4I1 mRNA CTD PMID:20959327 NCBI chr 1:95,299,457...95,324,564
Ensembl chr 1:95,295,601...95,324,562 		JBrowse link
G Il6 interleukin 6 affects expression
increases expression		 ISO gadodiamide affects the expression of IL6 protein
gadodiamide results in increased expression of IL6 mRNA		 CTD PMID:19404939 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Kitlg KIT ligand increases expression EXP gadodiamide results in increased expression of KITLG protein CTD PMID:20938346 NCBI chr 7:34,896,075...34,977,215
Ensembl chr 7:34,896,053...34,977,214 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [gadodiamide results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [gadodiamide results in increased phosphorylation of MAPK1 protein] CTD PMID:19561517 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [gadodiamide results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [gadodiamide results in increased phosphorylation of MAPK3 protein] CTD PMID:19561517 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions
increases expression		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [gadodiamide results in increased expression of MMP1 protein]; U 0126 inhibits the reaction [gadodiamide results in increased expression of MMP1 protein]
gadodiamide results in increased expression of MMP1 mRNA; gadodiamide results in increased expression of MMP1 protein		 CTD PMID:19561517 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression ISO gadodiamide results in increased expression of NOS2 protein CTD PMID:20959327 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nxpe3 neurexophilin and PC-esterase domain family, member 3 increases expression ISO gadodiamide results in increased expression of NXPE3 mRNA CTD PMID:20959327 NCBI chr11:44,726,905...44,777,694
Ensembl chr11:44,727,069...44,777,694 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression ISO gadodiamide results in decreased expression of PPARG mRNA; gadodiamide results in decreased expression of PPARG protein CTD PMID:37437671 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases localization ISO gadodiamide results in increased localization of RELA protein CTD PMID:20959327 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rhoq ras homolog family member Q increases expression ISO gadodiamide results in increased expression of RHOQ mRNA CTD PMID:20959327 NCBI chr 6:7,613,632...7,652,047 JBrowse link
G Rit1 Ras-like without CAAX 1 increases expression ISO gadodiamide results in increased expression of RIT1 mRNA CTD PMID:20959327 NCBI chr 2:174,180,742...174,195,455
Ensembl chr 2:174,180,848...174,195,455 		JBrowse link
G Rnf125 ring finger protein 125 increases expression ISO gadodiamide results in increased expression of RNF125 mRNA CTD PMID:20959327 NCBI chr18:12,254,066...12,275,719
Ensembl chr18:12,253,852...12,275,983 		JBrowse link
G Rsad2 radical S-adenosyl methionine domain containing 2 increases expression ISO gadodiamide results in increased expression of RSAD2 mRNA CTD PMID:20959327 NCBI chr 6:43,046,514...43,059,737
Ensembl chr 6:43,047,658...43,059,699 		JBrowse link
G Slc39a10 solute carrier family 39 member 10 increases expression ISO gadodiamide results in increased expression of SLC39A10 mRNA CTD PMID:20959327 NCBI chr 9:54,836,841...54,960,325
Ensembl chr 9:54,876,141...54,960,325 		JBrowse link
G Spn sialophorin increases expression ISO gadodiamide results in increased expression of SPN mRNA CTD PMID:20959327 NCBI chr 1:181,746,937...181,759,564
Ensembl chr 1:181,746,429...181,759,628 		JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression EXP gadodiamide results in increased expression of SPP1 protein CTD PMID:20938346 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO
EXP		 gadodiamide results in increased expression of TGFB1 mRNA; gadodiamide results in increased expression of TGFB1 protein CTD PMID:19404939 PMID:20938346 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression
multiple interactions		 ISO
EXP		 gadodiamide results in increased expression of TIMP1 mRNA; gadodiamide results in increased expression of TIMP1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [gadodiamide results in increased expression of TIMP1 protein]; U 0126 inhibits the reaction [gadodiamide results in increased expression of TIMP1 protein]		 CTD PMID:19561517 PMID:20938346 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Ubd ubiquitin D increases expression ISO gadodiamide results in increased expression of UBD mRNA CTD PMID:20959327 NCBI chr20:1,385,487...1,387,438
Ensembl chr20:1,385,864...1,408,639
Ensembl chr20:1,385,864...1,408,639 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO
EXP		 gadodiamide results in increased expression of VEGFA mRNA; gadodiamide results in increased expression of VEGFA protein CTD PMID:19404939 PMID:20938346 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Wdr5 WD repeat domain 5 increases expression ISO gadodiamide results in increased expression of WDR5 mRNA CTD PMID:20959327 NCBI chr 3:10,836,964...10,856,682
Ensembl chr 3:10,837,025...10,856,671 		JBrowse link
G Xiap X-linked inhibitor of apoptosis increases expression ISO gadodiamide results in increased expression of XIAP mRNA CTD PMID:20959327 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700 		JBrowse link
G Zfp652 zinc finger protein 652 increases expression ISO gadodiamide results in increased expression of ZNF652 mRNA CTD PMID:20959327 NCBI chr10:80,626,555...80,706,397
Ensembl chr10:80,649,400...80,698,674 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      chemical role 19420
        greenhouse gas 12864
          water 737
            hydrate 704
              gadodiamide hydrate 46
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    main group molecular entity 19756
                      s-block molecular entity 19595
                        hydrogen molecular entity 19582
                          hydrides 19095
                            inorganic hydride 18093
                              chalcogen hydride 2569
                                oxygen hydride 798
                                  water 737
                                    hydrate 704
                                      gadodiamide hydrate 46
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