Rhoq (ras homolog family member Q)

	Submit Data \| Help \| Video Tutorials \| News \| Publications \| FTP Download \| REST API \| Citing RGD \| Contact
	Search RGD Grant Resources Citing RGD About Us Contact Us Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References FTP Download Submit Data OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer ACP Haplotyper Genome Scanner Aging & Age-Related Disease Cancer Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease Find Models new Genetic Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive Pathways Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
	Advanced Search (OLGA)

Gene: Rhoq (ras homolog family member Q) Rattus norvegicus

Analyze

Symbol:

Rhoq

Name:

ras homolog family member Q

RGD ID:

621626

Description:

Predicted to have several functions, including GBD domain binding activity; GTP binding activity; and profilin binding activity. Predicted to be involved in several processes, including GTP metabolic process; positive regulation of filopodium assembly; and positive regulation of glucose import. Localizes to plasma membrane. Orthologous to human RHOQ (ras homolog family member Q); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; insulin signaling pathway; Rho/Rac/Cdc42 mediated signaling pathway; INTERACTS WITH (+)-schisandrin B; 1-benzylpiperazine; 1-naphthyl isothiocyanate.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

ras homolog gene family, member Q; ras-like protein; ras-like protein TC10; ras-related GTP-binding protein TC10; rho-related GTP-binding protein RhoQ; Tc10

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RHOQ (ras homolog family member Q)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Rhoq (ras homolog family member Q)	HGNC	Treefam, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Rhoq (ras homolog family member Q)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	RHOQ (ras homolog family member Q)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	RHOQ (ras homolog family member Q)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Rhoq (ras homolog family member Q)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	RHOQ (ras homolog family member Q)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	RHOQ (ras homolog family member Q)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Rhoq (ras homolog family member Q)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	RHOJ (ras homolog family member J)	HGNC	OrthoDB
Alliance orthologs ³
Mus musculus (house mouse):	Rhoq (ras homolog family member Q)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Homo sapiens (human):	RHOQ (ras homolog family member Q)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Danio rerio (zebrafish):	rhoq (ras homolog family member Q)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Saccharomyces cerevisiae (baker's yeast):	CDC42	Alliance	DIOPT (OrthoFinder\|PANTHER\|TreeFam)

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	6	10,533,151 - 10,568,582 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	10,533,151 - 10,568,581 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	20,521,668 - 20,557,099 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	10,414,042 - 10,449,472 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	6	10,414,041 - 10,449,471 (+)	NCBI
Celera	6	7,350,412 - 7,385,836 (-)	NCBI		Celera
Cytogenetic Map	6	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Experimental Liver Cirrhosis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,2-dimethylhydrazine (ISO)

1-benzylpiperazine (EXP)

1-naphthyl isothiocyanate (EXP)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2,4,6-trinitrobenzenesulfonic acid (EXP)

2-butoxyethanol (ISO)

4,4'-diaminodiphenylmethane (EXP)

6-propyl-2-thiouracil (EXP)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP,ISO)

butanal (ISO)

cadmium dichloride (EXP)

carbamazepine (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

clofibrate (ISO)

clofibric acid (EXP)

copper atom (EXP)

copper(0) (EXP)

copper(II) sulfate (ISO)

coumestrol (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

diarsenic trioxide (ISO)

diazinon (ISO)

dibutyl phthalate (ISO)

diclofenac (ISO)

dorsomorphin (ISO)

endosulfan (EXP)

Enterolactone (ISO)

entinostat (ISO)

ethanol (EXP)

fumonisin B1 (ISO)

gadodiamide hydrate (ISO)

genistein (ISO)

isobutanol (ISO)

methylmercury chloride (ISO)

microcystin-LR (ISO)

N-methyl-4-phenylpyridinium (ISO)

N-nitrosodiethylamine (EXP)

ochratoxin A (EXP)

paracetamol (ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

resveratrol (ISO)

SB 431542 (ISO)

Soman (EXP)

succimer (ISO)

sunitinib (ISO)

tamibarotene (ISO)

tamoxifen (ISO)

tetrachloroethene (ISO)

tetrachloromethane (EXP,ISO)

trichostatin A (ISO)

tunicamycin (ISO)

urethane (ISO)

valproic acid (ISO)

vincristine (ISO)

vitamin E (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell migration (IBA)

cell projection assembly (IBA)

cellular response to insulin stimulus (ISO)

cortical actin cytoskeleton organization (IBA,ISO)

endocytosis (IBA)

GTP metabolic process (ISO)

insulin receptor signaling pathway (ISO)

negative regulation of protein localization to plasma membrane (ISO)

positive regulation of filopodium assembly (ISO)

positive regulation of glucose import (ISO)

positive regulation of transcription by RNA polymerase II (ISO)

regulation of cell shape (ISO)

small GTPase mediated signal transduction (IEA)

Cellular Component

actin filament (ISO)

cytoplasm (IEA)

membrane raft (ISO)

plasma membrane (IDA,ISO)

Molecular Function

GBD domain binding (ISO)

GTP binding (IBA)

GTPase activity (IBA,ISO)

profilin binding (ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

insulin responsive facilitative sugar transporter mediated glucose transport pathway (ISO)

insulin signaling pathway (IEA,ISO)

Rho/Rac/Cdc42 mediated signaling pathway (ISO)

References

References - curated


1.	Bernard JR, etal., Metabolism. 2006 Feb;55(2):203-12.
2.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	GOA data from the GO Consortium
4.	MGD data from the GO Consortium
5.	NCBI rat LocusLink and RefSeq merged data July 26, 2002
6.	Pipeline to import KEGG annotations from KEGG into RGD
7.	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
8.	RGD automated data pipeline
9.	RGD automated import pipeline for gene-chemical interactions
10.	Satoh T Small GTPases. 2014;5:e28102. doi: 10.4161/sgtp.28102. Epub 2014 Mar 10.
11.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
12.	Tanabe K, etal., J Neurosci 2000 Jun 1;20(11):4138-44.

Additional References at PubMed

PMID:10445846	PMID:10967094	PMID:11309621	PMID:11821390	PMID:15489334	PMID:16105861	PMID:23533145	PMID:24297911

Genomics

Comparative Map Data

Rhoq
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	6	10,533,151 - 10,568,582 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	10,533,151 - 10,568,581 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	20,521,668 - 20,557,099 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	10,414,042 - 10,449,472 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	6	10,414,041 - 10,449,471 (+)	NCBI
Celera	6	7,350,412 - 7,385,836 (-)	NCBI		Celera
Cytogenetic Map	6	q12	NCBI

RHOQ
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	2	46,541,806 - 46,584,688 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	2	46,542,409 - 46,584,688 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	2	46,769,867 - 46,811,827 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	46,623,371 - 46,665,331 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	2	46,681,525 - 46,721,071	NCBI
Celera	2	46,608,550 - 46,650,502 (+)	NCBI
Cytogenetic Map	2	p21	NCBI
HuRef	2	46,508,355 - 46,549,243 (+)	NCBI		HuRef
CHM1_1	2	46,700,205 - 46,742,118 (+)	NCBI		CHM1_1

Rhoq
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	87,270,539 - 87,307,497 (+)	NCBI	GRCm39		mm39
GRCm38	17	86,963,111 - 87,000,069 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	86,963,082 - 87,000,069 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	87,362,451 - 87,399,409 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	17	86,871,437 - 86,908,395 (+)	NCBI			mm8
MGSCv36	17	86,286,620 - 86,323,731 (+)	NCBI			mm8
Celera	17	91,341,979 - 91,379,066 (+)	NCBI		Celera
Cytogenetic Map	17	E4	NCBI
cM Map	17	56.9	NCBI

Rhoq
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955441	13,457,757 - 13,495,221 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955441	13,457,757 - 13,495,221 (+)	NCBI	ChiLan1.0	ChiLan1.0

RHOQ
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	2A	47,589,343 - 47,629,200 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
Mhudiblu_PPA_v0	2A	46,657,884 - 46,698,604 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

RHOQ
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	10	48,768,191 - 48,804,129 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	10	48,766,623 - 48,807,198 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Rhoq
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936508	5,692,482 - 5,727,608 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RHOQ
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	93,973,622 - 94,012,580 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	93,970,545 - 94,012,660 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	100,054,930 - 100,097,052 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RHOQ
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1 Ensembl	14	60,608,998 - 60,648,193 (-)	Ensembl
ChlSab1.1	14	60,605,881 - 60,648,444 (-)	NCBI

Rhoq
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624738	27,997,493 - 28,031,840 (+)	NCBI

Position Markers

AW534145

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	6	10,531,772 - 10,531,952	NCBI	Rnor6.0
Rnor_5.0	6	20,520,289 - 20,520,469	UniSTS	Rnor5.0
RGSC_v3.4	6	10,412,663 - 10,412,843	UniSTS	RGSC3.4
Celera	6	7,387,044 - 7,387,224	UniSTS
Cytogenetic Map	6	q12	UniSTS

RH141769

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	6	10,567,148 - 10,567,339	NCBI	Rnor6.0
Rnor_5.0	6	20,555,665 - 20,555,856	UniSTS	Rnor5.0
Celera	1	100,835,165 - 100,835,356	UniSTS
Celera	6	7,351,655 - 7,351,846	UniSTS
Cytogenetic Map	6	q12	UniSTS

UniSTS:483156

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	1	114,174,716 - 114,175,376	NCBI	Rnor6.0
Rnor_5.0	1	115,180,824 - 115,181,484	UniSTS	Rnor5.0
RGSC_v3.4	1	107,158,581 - 107,159,241	UniSTS	RGSC3.4
Cytogenetic Map	6	q12	UniSTS
Cytogenetic Map	1	q22	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1598843	Cm63	Cardiac mass QTL 63	2.6		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	6	1	23620518	Rat
1578758	Tcas9	Tongue tumor susceptibility QTL 9	3.29		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	6	1	25048718	Rat
738023	Alc17	Alcohol consumption QTL 17	3.1	0.003	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	6	1	35623029	Rat
1354616	Despr12	Despair related QTL 12		0.0012	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	6	1	35623029	Rat
1549905	Stresp10	Stress response QTL 10	6.83	0.0066	stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	6	1	35623029	Rat
2300176	Bmd51	Bone mineral density QTL 51	11.7	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	6	1	35623029	Rat
2300190	Bmd52	Bone mineral density QTL 52	11.2	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	6	1	35623029	Rat
1331743	Uae28	Urinary albumin excretion QTL 28	4.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	6	1	41917988	Rat
9589048	Scfw3	Subcutaneous fat weight QTL 3	4.57	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	6	1	42388212	Rat
9589129	Insul24	Insulin level QTL 24	19.06	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	6	1	42388212	Rat
7411603	Foco13	Food consumption QTL 13	5.5	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	6	1	42388212	Rat
7411542	Bw127	Body weight QTL 127	5.5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	1	42388212	Rat
8552962	Pigfal16	Plasma insulin-like growth factor 1 level QTL 16	9.4		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	6	1	42388212	Rat
2293709	Bss23	Bone structure and strength QTL 23	5.18	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	6	1	43665660	Rat
2293650	Bss31	Bone structure and strength QTL 31	5.05	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	6	1	43665660	Rat
2293656	Bss28	Bone structure and strength QTL 28	6.79	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	6	1	43665660	Rat
7411584	Foco4	Food consumption QTL 4	4.3	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	6	1	44015370	Rat
738024	Sach5	Saccharine consumption QTL 5	3.9	0.00039	consumption behavior trait (VT:0002069)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	6	1	44570292	Rat
2301972	Bp325	Blood pressure QTL 325	4.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	1	75623393	Rat
8693645	Alc31	Alcohol consumption QTL 31	3.7	0.038	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	6	135053	23600274	Rat
1359023	Bp272	Blood pressure QTL 272	2.5		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	6	1120393	28706721	Rat
2292589	Emca10	Estrogen-induced mammary cancer QTL 10		0.048	mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	6	1120393	46120393	Rat
1354664	Slep2	Serum leptin concentration QTL 2	4.49		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	6	1120393	75023446	Rat
1576309	Emca7	Estrogen-induced mammary cancer QTL 7	4		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	6	2537030	111715717	Rat
1578665	Bss16	Bone structure and strength QTL 16	4.4		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	6	6161722	76002731	Rat
1578668	Bmd14	Bone mineral density QTL 14	3.8		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	6	6161722	76002731	Rat
4145119	Mcs25	Mammary carcinoma susceptibility QTL 25		0.0001	mammary gland integrity trait (VT:0010552)	ratio of deaths to total study population during a period of time (CMO:0001023)	6	7009971	115379601	Rat
1358190	Ept1	Estrogen-induced pituitary tumorigenesis QTL 1	4.4		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	6	8083222	21515439	Rat
2292616	Ept15	Estrogen-induced pituitary tumorigenesis QTL 15	4.4		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	6	8083222	21515439	Rat
8693699	Alc37	Alcohol consumption QTL 37	2.6	0.224	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	6	9974277	22477622	Rat
8693690	Alc35	Alcohol consumption QTL 35	2.2	0.606	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	6	9974277	22477622	Rat
634322	Bw12	Body weight QTL 12	0		body mass (VT:0001259)	body weight (CMO:0000012)	7	10173862	55173862	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	450
Count of miRNA genes:	228
Interacting mature miRNAs:	305
Transcripts:	ENSRNOT00000020822
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	30	14	19	14	8	11	73	35	36	11	8
Low			27	27		27			1		5
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053522	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AABR07062819	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AAHX01041529	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB031482	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC061760	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473947	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000020822 ⟹ ENSRNOP00000020822

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	6	10,533,151 - 10,568,581 (+)	Ensembl

RefSeq Acc Id:

NM_053522 ⟹ NP_445974

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	6	10,533,151 - 10,568,582 (+)	NCBI
Rnor_5.0	6	20,521,668 - 20,557,099 (+)	NCBI
RGSC_v3.4	6	10,414,042 - 10,449,472 (+)	RGD
Celera	6	7,350,412 - 7,385,836 (-)	RGD

Sequence:

show sequence

CCGGCGGATCCTCCTGGGGAGGCCGGGCCGGGGAGCGGGTTCGGGCGCCGAGCGGCGGGGCCAG
CAGCCGGGCGCGGCGAGCGGGACCAGGGCGGGGAGCGGGGTAGCGATCGAAGCGGCGGCGGCTG
CGCTCCGGGCCCGCCGCACCTTCCCCTCCGGTCAGGGGAACCGCTGCATGGGGCCGGGGGGGCG
GCCCTGCTGCGCCGAGCGGCGGCGACGGCGGACCCCCCAGGCGGGCTGGGGCTGAGCCCGGGGC
CGGGGCGGGGGCTCCGGGGGGACCATGCCCCGAGGCCGGCCGGCCGCAGCATGGCTCACGGGCC
CGGCGCGCTGATGCTCAAGTGCGTGGTGGTCGGCGACGGGGCGGTGGGTAAGACGTGCCTGCTC
ATGAGCTATGCCAACGACGCCTTCCCCGAGGAGTACGTGCCCACTGTCTTCGACCACTACGCAG
TCAGCGTCACCGTGGGGGGCAAGCAGTACCTCTTGGGACTCTATGACACAGCTGGACAGGAAGA
CTATGATCGTCTGAGGCCTTTATCTTACCCCATGACTGACGTCTTCCTCATATGCTTCTCTGTG
GTAAATCCAGCCTCATTTCAAAATGTAAAGGAGGAATGGGTACCAGAACTAAAGGAATATGCAC
CAAATGTCCCCTTCTTGTTAATAGGAACTCAGATTGATCTCCGAGATGACCCCAAAACTTTAGC
AAGACTGAATGACATGAAAGAAAAACCTGTCTGTGTGGAACAAGGACAGAAACTAGCAAAAGAG
ATCGGCGCATGCTGCTATGTGGAATGCTCAGCTCTGACCCAGAAGGGTTTGAAGACTGTGTTTG
ACGAGGCTATCATAGCCATTTTAACTCCAAAGAAACACACAGTAAAAAAGAGAATAGGATCAAG
ATGTATAAACTGTTGTTTGATTACGTGAGAAACATCTTTAGTGGCCAAGGAAACTGTCATTTCT
CCCAGAAAGCATTTGAAATGCTACAGCAATGTCCTGACCTCTTACAATGAAGCAGTTTAACTTG
AGGGGGGAGGGAGCCTGTCCTCAGCATCCTACAGAGTTCATTGAGAATGTTTCATAAAGGTCTA
AGCGGCAGCGAACAGCATCTGAAGCCACAATCTACTATAAATACTTTATTTCAACTAGAAGGTA
CAATCTCTCAGGGGTTTCATAGTTAAAAAGCTACAATCACATCATGTTGAAATGACATTTAGAA
AACCACAGTGCTGTAAATGGACGGCTCGGCTTTGACCACGTACACTTCTGCACAGCCCTTATGG
ACTCTGCACAAAGAAATCACTTCTCTCCCTTCTCCTCTTAATTGTTCTTGTATGTAAGTTGCTT
TCTATTCCAGTATATCCAGAGTGGCGAGATAACCAGGCCAGCCACGTAGCCAAAGGTCGCTCCG
AGTGTACAGGAGATGGGCCACACCTAAGGAAAGAATTGAGATCTAAGCCAACCGATGCTTTATT
ACACTTGAGCACAAATGAAGTGTACTGCACACATTTCTATAGTGAAGCTTAGTGTGCTTCATAA
AGAATGCCAAGTTTAATAGGTCATGACTGCATTGATCATAACACTAAAAGTGTCCACATTTTAG
TTAATGTGCATTAAACAGTAACATGGCCTCTGGCAACTGTAGCTCTAGTTTGCTTTTATCTAAA
CTGCATGAAATACATGCAAAAGTAACATGTAAAAATGGGTCATTGTTTACCATAATCCTGAACT
CAGTTTGGCTCTGAATTAGTTGGCCATTTTTCTAACTCCTACACTGGCTGTGTACATCAAATGA
AATAAGTGAGCAAACCTTAGAAACGTTCAGTCGTGTGAGAGGAAAGACGTGGGATGCGAGCATG
TCACGTGGAATTTGTGGTTATCTCTTCCATGGTAAGCTGATGGCCACTTGGAGCTGCAGATAGT
GTGTCCACAGCAGAAGGTCTACACACCACAGCTTACGTACACACCTAGAGCGTGAGGCAAGAAC
ACACTCCCCACGCTACATCTCACTAAGCCAGAAATAGAGGAGACTTTTTAATGCCACAGACAGG
GTGTGTGTGTAAAGTCTTGCAGACACCTTCATGTCCTTTGTAAAGCTTATCTGGTGTACTGCAG
CCTTTCTTACCCTTCTCTGGGGAATCGGCCATCCAAGTGTACTGGAGGGAAACCATCCTAATAA
CTGGCTGCTACCTCGTTGGCTTTCTTCTTCCGTCTGCTATGGATCTGCCTTATTCTAAATGCCA
TGCAACAGACAGTAGTGTAGGCAAAGCTTCCATGAACCACCTCATGCAGTCTGGGGAAGCGCAA
GCAGATCCACACATTGGCACCAGCCTCCCTTAGGTTCAAAGTTGCTGTTGCTTAAACTACGACA
TCTGTCTTTAGCAAGCTTCTGTTATCTTCCATGGTTTGTGCTTAAGCTTGGTCTAGTGCACAGA
TTGGGTAATGGAACACTAAACATTTATACTTGAAAATGACAGCCTTAAATGTTCATACCAGTCA
CAAATCTAGATGTACTGTCTTGCATGTGAGCTTTGTAGGAGTTTTTAAAATATGAGCACCACAC
TCCCCACGCGGTAGCAGACCGTCTACTGACAAGAGCTCTCTTGGAAGTGGACGCAGGATGTCCT
CAGGCAGTGGCGGTTCACATTAGGTATATCATGGCCTTATTTATGTATGCTCAAATGGGACTTC
TGTAATTTTCCCATTTAGTTTCGGTCTGTTTTTAGATAGAATTGAAAGAAATTGTATAGTCGGC
TAACGTACTAGCTAAGTTGTCAAACCTATGATATGAAGGAATCAAGACAGTAAAGTATTATTCA
TTTCCAAGTTGCCTTTGGAGATTTGATGGTTTGTTTTTTTCTTCAAATCTACATCTGTGAAACC
CTTGACACTCGGTGTGTTAGCAATGAGATAAAGTCAAGGACTTGCCTGCTTCAAGAGAAAAGGA
TTAAGAATCTAAAGGTGCAGTGGTGTCACCTCAGTCTCCTCATGTGTGGCCGTGGGGGGACGAC
CGTGTGTCCTAGTCATTCTTGAGCGCTTATCACTCTCTCCTAGTTGACAGCAGTCCGTTGGGCT
TCAGCTTCTCCAGATGGTAAGAATCATGTACACAGACTGTTTGAACTCTAAGCAGACGATTGTA
TCATCTGAACCTGAGGTGCCTTAGGTACTCTACTTACCTTGATGGGGTTTGGAGTTTCCCATTG
CTTGTTAAGAGCTCTTTGTGTTTGTTATTTAATATTTCTTTTTGCAAAATCTTCTCTGCCACTT
TAAGCAGAAAACCAAAGATTTGTTTTCTATTCATGAACAGATTATAGAGAGACTGCCTTATTTT
CAGACGCATGTCTTCATTAATGGCTTAGGTTGCCACAGAAATTCAGACTAATCTCTGGAATAAC
TCTTTCAAACTAGTGAAATATCTGGGAAAGAAAATTCTTCTCAATGTTTTATTAATATGAACTG
TGTTAGTAAGAACACTGCTTCAAATAAGGTCATGTGTGAAAGAACATACAACAAATTATAGTTG
GTTAGTGTTTGCATAGAAAATCTGTTCTAAAGCCCTTTAAAATGTTGAGGGGAATCCTGCACTC
TAACAGCCTCTCTTTGCTAACGTATGCCCTTCCTGTCCTTGCAGGTACATTGTAGCTCACTCGT
GATGAATTATCATATTTCAATACACAGAGCTTGAGTTCATACTACTTGTTATCTTAGTTATTTT
ACATACTGCTTCCGTTTGACTTTCAATGATTGGTTTTAAATACCAAATTAAATGCTGGTTTGTT
GGTTGTTGTTTTTAAATGATTGTTACTTCAATAGCATCCCCTCCTGACATATGGAGTCATAATA
AAATGAGATGCATAGTTTAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_445974	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH61760	(Get FASTA)	NCBI Sequence Viewer
	BAA96292	(Get FASTA)	NCBI Sequence Viewer
	EDM02657	(Get FASTA)	NCBI Sequence Viewer
	Q9JJL4	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_445974 ⟸ NM_053522
- Peptide Label:	precursor
- UniProtKB:	Q9JJL4 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MAHGPGALMLKCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYAVSVTVGGKQYLLGLYDT AGQEDYDRLRPLSYPMTDVFLICFSVVNPASFQNVKEEWVPELKEYAPNVPFLLIGTQIDLRDD PKTLARLNDMKEKPVCVEQGQKLAKEIGACCYVECSALTQKGLKTVFDEAIIAILTPKKHTVKK RIGSRCINCCLIT hide sequence

RefSeq Acc Id:

ENSRNOP00000020822 ⟸ ENSRNOT00000020822

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13694388

Promoter ID:

EPDNEW_R4913

Type:

initiation region

Name:

Rhoq_1

Description:

ras homolog family member Q

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	6	10,533,143 - 10,533,203	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

Visual

CSV

TAB

Printer

Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621626	AgrOrtholog
Ensembl Genes	ENSRNOG00000015415	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein	ENSRNOP00000020822	ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000020822	ENTREZGENE, UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:5621223	IMAGE-MGC_LOAD
InterPro	P-loop_NTPase	UniProtKB/Swiss-Prot
	Small_GTP-bd_dom	UniProtKB/Swiss-Prot
	Small_GTPase	UniProtKB/Swiss-Prot
	Small_GTPase_Rho	UniProtKB/Swiss-Prot
KEGG Report	rno:85428	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:72358	IMAGE-MGC_LOAD
NCBI Gene	85428	ENTREZGENE
Pfam	Ras	UniProtKB/Swiss-Prot
PhenoGen	Rhoq	PhenoGen
PROSITE	RHO	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF52540	UniProtKB/Swiss-Prot
TIGRFAMs	small_GTP	UniProtKB/Swiss-Prot
UniGene	Rn.4169	ENTREZGENE
UniProt	Q9JJL4	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2012-10-15	Rhoq	ras homolog family member Q	Rhoq	ras homolog gene family, member Q	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Rhoq	ras homolog gene family, member Q	Tc10	ras-like protein	Symbol and Name updated	1299863	APPROVED
2002-08-07	Tc10	ras-like protein			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_product	member of the Rho family of GTPases	634077

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)