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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:eplerenone
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Accession:CHEBI:31547 term browser browse the term
Definition:A steroid acid ester that has formula C24H30O6.
Synonyms:exact_synonym: 7alpha-methoxycarbonyl-3-oxo-9,11alpha-epoxy-17alpha-pregn-4-ene-21,17-carbolactone
 related_synonym: Epoxymexrenone;   Formula=C24H30O6;   InChI=1S/C24H30O6/c1-21-7-4-14(25)10-13(21)11-15(20(27)28-3)19-16-5-8-23(9-6-18(26)30-23)22(16,2)12-17-24(19,21)29-17/h10,15-17,19H,4-9,11-12H2,1-3H3/t15-,16+,17-,19+,21+,22+,23-,24-/m1/s1;   InChIKey=JUKPWJGBANNWMW-VWBFHTRKSA-N;   Inspra;   SMILES=COC(=O)[C@@H]1CC2=CC(=O)CC[C@]2(C)[C@@]23O[C@@H]2C[C@@]2(C)[C@@H](CC[C@@]22CCC(=O)O2)[C@H]13
 alt_id: MESH:C414690
 xref: CAS:107724-20-9;   DrugBank:DB00700;   Drug_Central:1032;   KEGG:C12512;   KEGG:D01115
 xref_mesh: MESH:C414690
 xref: Wikipedia:Eplerenone


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eplerenone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO eplerenone inhibits the reaction [Aldosterone results in increased expression of ACTA2 mRNA]; eplerenone inhibits the reaction [Aldosterone results in increased expression of ACTA2 protein] CTD PMID:17596522 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Agt angiotensinogen multiple interactions ISO eplerenone inhibits the reaction [AGT protein results in increased phosphorylation of OSR1 protein]; eplerenone inhibits the reaction [AGT protein results in increased phosphorylation of SLC12A3 protein] CTD PMID:20175999 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Cat catalase increases expression EXP eplerenone results in increased expression of CAT protein CTD PMID:17324946 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cd80 Cd80 molecule multiple interactions EXP Eplerenone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of CD80 mRNA] CTD PMID:27773435 NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030 		JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO eplerenone inhibits the reaction [Aldosterone results in decreased expression of CDH1 mRNA]; eplerenone inhibits the reaction [Aldosterone results in decreased expression of CDH1 protein] CTD PMID:17596522 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP Eplerenone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of COL1A1 mRNA] CTD PMID:27773435 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions EXP Eplerenone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of COL3A1 mRNA] CTD PMID:27773435 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547 		JBrowse link
G Col4a1 collagen type IV alpha 1 chain multiple interactions
decreases expression		 EXP [eplerenone co-treated with Enalapril] inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of COL4A1 mRNA]]; [eplerenone co-treated with Enalapril] results in decreased expression of COL4A1 mRNA; [eplerenone co-treated with Enalapril] results in decreased expression of COL4A1 protein; eplerenone inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of COL4A1 mRNA]]
eplerenone results in decreased expression of COL4A1 mRNA; eplerenone results in decreased expression of COL4A1 protein		 CTD PMID:18682491 NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412 		JBrowse link
G Cyba cytochrome b-245 alpha chain decreases expression
multiple interactions		 EXP eplerenone results in decreased expression of CYBA mRNA
[trandolapril co-treated with eplerenone] results in decreased expression of CYBA mRNA		 CTD PMID:17324946 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases abundance
increases metabolic processing		 ISO CYP3A4 protein results in increased abundance of Eplerenone metabolite
CYP3A4 protein results in increased metabolism of Eplerenone		 CTD PMID:31408697 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases abundance
increases metabolic processing		 ISO CYP3A5 protein results in increased abundance of Eplerenone metabolite
CYP3A5 protein results in increased metabolism of Eplerenone		 CTD PMID:31408697 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422 		JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP [trandolapril co-treated with eplerenone] results in decreased expression of FN1 protein CTD PMID:17324946 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Il18 interleukin 18 multiple interactions EXP eplerenone inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA] CTD PMID:18660453 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1b interleukin 1 beta decreases expression EXP eplerenone decreases expression of protein in hippocampus of post-surgical rats RGD PMID:33390808 RGD:401965467 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 decreases expression EXP eplerenone decreases expression of protein in hippocampus of post-surgical rats RGD PMID:33390808 RGD:401965467 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO eplerenone inhibits the reaction [Aldosterone results in increased phosphorylation of and results in increased activity of MAPK1 protein] CTD PMID:17596522 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO eplerenone inhibits the reaction [Aldosterone results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:17596522 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 decreases expression
multiple interactions		 EXP eplerenone results in decreased expression of NCF1 mRNA; eplerenone results in decreased expression of NCF1 protein
[trandolapril co-treated with eplerenone] results in decreased expression of NCF1 mRNA; [trandolapril co-treated with eplerenone] results in decreased expression of NCF1 protein		 CTD PMID:17324946 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
decreases expression
increases expression
increases activity		 EXP [Enalapril co-treated with eplerenone] results in decreased expression of NOS3 mRNA
Eplerenone results in decreased expression of NOS3 mRNA; Eplerenone results in decreased expression of NOS3 protein
eplerenone results in increased expression of NOS3 mRNA
eplerenone results in increased activity of NOS3 protein		 CTD PMID:15974890 PMID:20571278 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 multiple interactions
decreases expression		 EXP eplerenone binds to and results in decreased activity of NR3C2 protein
eplerenone decreases expression of protein in hippocampus of post-surgical rats		 CTD
RGD		 PMID:15974890 PMID:33390808 RGD:401965467 NCBI chr19:30,715,634...31,059,885
Ensembl chr19:30,715,648...31,059,885 		JBrowse link
G Osr1 odd-skipped related transcription factor 1 multiple interactions ISO eplerenone inhibits the reaction [AGT protein results in increased phosphorylation of OSR1 protein] CTD PMID:20175999 NCBI chr 6:32,369,561...32,380,822
Ensembl chr 6:32,373,816...32,380,817 		JBrowse link
G Oxsr1 oxidative stress responsive kinase 1 multiple interactions ISO [eplerenone co-treated with Sodium Chloride, Dietary] results in decreased phosphorylation of OXSR1 protein CTD PMID:22949526 NCBI chr 8:118,972,754...119,062,102
Ensembl chr 8:118,972,754...119,062,027 		JBrowse link
G Serpine1 serpin family E member 1 multiple interactions
decreases expression		 EXP [eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 mRNA]; [eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 protein]; [eplerenone co-treated with Enalapril] results in decreased expression of SERPINE1 mRNA; [eplerenone co-treated with Enalapril] results in decreased expression of SERPINE1 protein; eplerenone inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 mRNA]; eplerenone inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 protein]
eplerenone results in decreased expression of SERPINE1 mRNA; eplerenone results in decreased expression of SERPINE1 protein		 CTD PMID:18682491 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Slc12a3 solute carrier family 12 member 3 multiple interactions ISO [eplerenone co-treated with Sodium Chloride, Dietary] results in decreased phosphorylation of SLC12A3 protein; eplerenone inhibits the reaction [AGT protein results in increased phosphorylation of SLC12A3 protein] CTD PMID:20175999 PMID:22949526 NCBI chr19:10,630,651...10,679,250
Ensembl chr19:10,631,393...10,669,091 		JBrowse link
G Slc9a1 solute carrier family 9 member A1 multiple interactions EXP eplerenone inhibits the reaction [Aldosterone results in increased expression of SLC9A1 mRNA] CTD PMID:16373419 NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624 		JBrowse link
G Snai1 snail family transcriptional repressor 1 multiple interactions ISO eplerenone inhibits the reaction [Aldosterone results in increased expression of SNAI1 mRNA] CTD PMID:17596522 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969 		JBrowse link
G Sod1 superoxide dismutase 1 increases expression EXP eplerenone results in increased expression of SOD1 protein CTD PMID:17324946 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression EXP eplerenone results in increased expression of SOD2 protein CTD PMID:17324946 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Stk39 serine threonine kinase 39 multiple interactions ISO [eplerenone co-treated with Sodium Chloride, Dietary] results in decreased phosphorylation of STK39 protein CTD PMID:22949526 NCBI chr 3:52,913,583...53,179,060
Ensembl chr 3:52,913,585...53,179,060 		JBrowse link
G Tbx1 T-box transcription factor 1 decreases expression EXP Eplerenone decreases expression of Tbx1 mRNA and protein in infarcted heart RGD PMID:27422448 RGD:155882497 NCBI chr11:82,409,275...82,419,058
Ensembl chr11:82,409,275...82,418,380 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases expression		 EXP [Eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased secretion of TGFB1 protein]; [Eplerenone co-treated with Enalapril] inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of TGFB1 mRNA]]; [Eplerenone co-treated with Enalapril] results in decreased expression of TGFB1 mRNA; [Eplerenone co-treated with Enalapril] results in decreased expression of TGFB1 protein; Eplerenone inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased secretion of TGFB1 protein]; Eplerenone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of TGFB1 mRNA]; Eplerenone inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of TGFB1 mRNA]]
eplerenone results in decreased expression of TGFB1 mRNA; eplerenone results in decreased expression of TGFB1 protein		 CTD PMID:18682491 PMID:27773435 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfbi transforming growth factor, beta induced decreases secretion
multiple interactions		 EXP eplerenone results in decreased secretion of TGFBI protein
[eplerenone co-treated with Enalapril] results in decreased secretion of TGFBI protein		 CTD PMID:18682491 NCBI chr17:7,955,603...7,984,903
Ensembl chr17:7,955,603...7,985,240 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression		 EXP Eplerenone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of TNF mRNA]
eplerenone decreases expression of protein in hippocampus of post-surgical rats		 CTD
RGD		 PMID:27773435 PMID:33390808 RGD:401965467 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
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  CHEBI ontology 19848
    role 19824
      application 19668
        fuel 11354
          methanol 3964
            methyl ester 3910
              eplerenone 33
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  CHEBI ontology 19848
    subatomic particle 19846
      composite particle 19846
        hadron 19846
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              atomic nucleus 19846
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                  main group element atom 19796
                    p-block element atom 19796
                      carbon group element atom 19741
                        carbon atom 19737
                          organic molecular entity 19737
                            organic molecule 19690
                              organic cyclic compound 19501
                                organic heterocyclic compound 18878
                                  organic heteromonocyclic compound 17804
                                    saturated organic heteromonocyclic parent 11296
                                      oxirane 11276
                                        epoxide 11275
                                          epoxy steroid 144
                                            eplerenone 33
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