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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:epoxy steroid
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Accession:CHEBI:145217 term browser browse the term
Definition:Any steroid whose structure includes an epoxy group.
Synonyms:related_synonym: epoxy-steroids



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5,6alpha-epoxy-5alpha-cholestan-3beta-ol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Egfr epidermal growth factor receptor increases phosphorylation EXP cholesterol alpha-oxide results in increased phosphorylation of EGFR protein CTD PMID:20466046 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Ephx1 epoxide hydrolase 1 increases metabolic processing
multiple interactions
ISO EPHX1 protein results in increased metabolism of cholesterol alpha-oxide
disparlure promotes the reaction [EPHX1 protein results in increased metabolism of cholesterol alpha-oxide]; Lanosterol analog inhibits the reaction [EPHX1 protein results in increased metabolism of cholesterol alpha-oxide]
CTD PMID:2043152 NCBI chr13:92,714,315...92,744,124
Ensembl chr13:92,714,315...92,790,235
JBrowse link
G Ephx2 epoxide hydrolase 2 multiple interactions ISO cholesterol alpha-oxide inhibits the reaction [EPHX2 protein results in increased metabolism of stilbene oxide analog] CTD PMID:2043152 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
EXP RTKI cpd inhibits the reaction [cholesterol alpha-oxide results in increased phosphorylation of MAPK1 protein] CTD PMID:20466046 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
EXP cholesterol alpha-oxide results in increased phosphorylation of MAPK3 protein
RTKI cpd inhibits the reaction [cholesterol alpha-oxide results in increased phosphorylation of MAPK3 protein]
CTD PMID:20466046 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mmp2 matrix metallopeptidase 2 increases expression EXP cholesterol alpha-oxide results in increased expression of MMP2 mRNA CTD PMID:20466046 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression EXP cholesterol alpha-oxide results in increased expression of MMP9 mRNA CTD PMID:20466046 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mtor mechanistic target of rapamycin kinase increases phosphorylation
multiple interactions
EXP cholesterol alpha-oxide results in increased phosphorylation of MTOR protein
RTKI cpd inhibits the reaction [cholesterol alpha-oxide results in increased phosphorylation of MTOR protein]
CTD PMID:20466046 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
bufogenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
multiple interactions
increases metabolic processing
increases activity
ISO bufogenin results in increased expression of CYP3A4 mRNA
bufogenin promotes the reaction [CYP3A4 protein results in increased metabolism of Midazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of bufogenin]
bufogenin results in increased activity of CYP3A4 protein
CTD PMID:22178124 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
eplerenone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO eplerenone inhibits the reaction [Aldosterone results in increased expression of ACTA2 mRNA]; eplerenone inhibits the reaction [Aldosterone results in increased expression of ACTA2 protein] CTD PMID:17596522 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Agt angiotensinogen multiple interactions ISO eplerenone inhibits the reaction [AGT protein results in increased phosphorylation of OSR1 protein]; eplerenone inhibits the reaction [AGT protein results in increased phosphorylation of SLC12A3 protein] CTD PMID:20175999 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Cat catalase increases expression EXP eplerenone results in increased expression of CAT protein CTD PMID:17324946 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cd80 Cd80 molecule multiple interactions EXP Eplerenone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of CD80 mRNA] CTD PMID:27773435 NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO eplerenone inhibits the reaction [Aldosterone results in decreased expression of CDH1 mRNA]; eplerenone inhibits the reaction [Aldosterone results in decreased expression of CDH1 protein] CTD PMID:17596522 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP Eplerenone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of COL1A1 mRNA] CTD PMID:27773435 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions EXP Eplerenone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of COL3A1 mRNA] CTD PMID:27773435 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
JBrowse link
G Col4a1 collagen type IV alpha 1 chain multiple interactions
decreases expression
EXP [eplerenone co-treated with Enalapril] inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of COL4A1 mRNA]]; [eplerenone co-treated with Enalapril] results in decreased expression of COL4A1 mRNA; [eplerenone co-treated with Enalapril] results in decreased expression of COL4A1 protein; eplerenone inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of COL4A1 mRNA]]
eplerenone results in decreased expression of COL4A1 mRNA; eplerenone results in decreased expression of COL4A1 protein
CTD PMID:18682491 NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412
JBrowse link
G Cyba cytochrome b-245 alpha chain decreases expression
multiple interactions
EXP eplerenone results in decreased expression of CYBA mRNA
[trandolapril co-treated with eplerenone] results in decreased expression of CYBA mRNA
CTD PMID:17324946 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases abundance
increases metabolic processing
ISO CYP3A4 protein results in increased abundance of Eplerenone metabolite
CYP3A4 protein results in increased metabolism of Eplerenone
CTD PMID:31408697 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases abundance
increases metabolic processing
ISO CYP3A5 protein results in increased abundance of Eplerenone metabolite
CYP3A5 protein results in increased metabolism of Eplerenone
CTD PMID:31408697 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP [trandolapril co-treated with eplerenone] results in decreased expression of FN1 protein CTD PMID:17324946 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Il18 interleukin 18 multiple interactions EXP eplerenone inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA] CTD PMID:18660453 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO eplerenone inhibits the reaction [Aldosterone results in increased phosphorylation of and results in increased activity of MAPK1 protein] CTD PMID:17596522 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO eplerenone inhibits the reaction [Aldosterone results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:17596522 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 decreases expression
multiple interactions
EXP eplerenone results in decreased expression of NCF1 mRNA; eplerenone results in decreased expression of NCF1 protein
[trandolapril co-treated with eplerenone] results in decreased expression of NCF1 mRNA; [trandolapril co-treated with eplerenone] results in decreased expression of NCF1 protein
CTD PMID:17324946 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
increases activity
increases expression
decreases expression
EXP [Enalapril co-treated with eplerenone] results in decreased expression of NOS3 mRNA
eplerenone results in increased activity of NOS3 protein
eplerenone results in increased expression of NOS3 mRNA
Eplerenone results in decreased expression of NOS3 mRNA; Eplerenone results in decreased expression of NOS3 protein
CTD PMID:15974890 PMID:20571278 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 multiple interactions EXP eplerenone binds to and results in decreased activity of NR3C2 protein CTD PMID:15974890 NCBI chr19:30,715,648...31,059,885
Ensembl chr19:30,715,648...31,059,885
JBrowse link
G Osr1 odd-skipped related transcription factor 1 multiple interactions ISO eplerenone inhibits the reaction [AGT protein results in increased phosphorylation of OSR1 protein] CTD PMID:20175999 NCBI chr 6:32,369,561...32,380,822
Ensembl chr 6:32,373,816...32,380,817
JBrowse link
G Oxsr1 oxidative stress responsive kinase 1 multiple interactions ISO [eplerenone co-treated with Sodium Chloride, Dietary] results in decreased phosphorylation of OXSR1 protein CTD PMID:22949526 NCBI chr 8:118,972,754...119,062,102
Ensembl chr 8:118,972,754...119,062,027
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions
decreases expression
EXP [eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 mRNA]; [eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 protein]; [eplerenone co-treated with Enalapril] results in decreased expression of SERPINE1 mRNA; [eplerenone co-treated with Enalapril] results in decreased expression of SERPINE1 protein; eplerenone inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 mRNA]; eplerenone inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 protein]
eplerenone results in decreased expression of SERPINE1 mRNA; eplerenone results in decreased expression of SERPINE1 protein
CTD PMID:18682491 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Slc12a3 solute carrier family 12 member 3 multiple interactions ISO [eplerenone co-treated with Sodium Chloride, Dietary] results in decreased phosphorylation of SLC12A3 protein; eplerenone inhibits the reaction [AGT protein results in increased phosphorylation of SLC12A3 protein] CTD PMID:20175999 PMID:22949526 NCBI chr19:10,630,649...10,679,250
Ensembl chr19:10,631,393...10,669,091
JBrowse link
G Slc9a1 solute carrier family 9 member A1 multiple interactions EXP eplerenone inhibits the reaction [Aldosterone results in increased expression of SLC9A1 mRNA] CTD PMID:16373419 NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624
JBrowse link
G Snai1 snail family transcriptional repressor 1 multiple interactions ISO eplerenone inhibits the reaction [Aldosterone results in increased expression of SNAI1 mRNA] CTD PMID:17596522 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
JBrowse link
G Sod1 superoxide dismutase 1 increases expression EXP eplerenone results in increased expression of SOD1 protein CTD PMID:17324946 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 increases expression EXP eplerenone results in increased expression of SOD2 protein CTD PMID:17324946 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Stk39 serine threonine kinase 39 multiple interactions ISO [eplerenone co-treated with Sodium Chloride, Dietary] results in decreased phosphorylation of STK39 protein CTD PMID:22949526 NCBI chr 3:52,913,583...53,179,060
Ensembl chr 3:52,913,585...53,179,060
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases expression
EXP [Eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased secretion of TGFB1 protein]; [Eplerenone co-treated with Enalapril] inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of TGFB1 mRNA]]; [Eplerenone co-treated with Enalapril] results in decreased expression of TGFB1 mRNA; [Eplerenone co-treated with Enalapril] results in decreased expression of TGFB1 protein; Eplerenone inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased secretion of TGFB1 protein]; Eplerenone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of TGFB1 mRNA]; Eplerenone inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of TGFB1 mRNA]]
eplerenone results in decreased expression of TGFB1 mRNA; eplerenone results in decreased expression of TGFB1 protein
CTD PMID:18682491 PMID:27773435 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgfbi transforming growth factor, beta induced decreases secretion
multiple interactions
EXP eplerenone results in decreased secretion of TGFBI protein
[eplerenone co-treated with Enalapril] results in decreased secretion of TGFBI protein
CTD PMID:18682491 NCBI chr17:7,955,603...7,984,903
Ensembl chr17:7,955,603...7,985,240
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Eplerenone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of TNF mRNA] CTD PMID:27773435 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
marinobufagenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col1a1 collagen type I alpha 1 chain increases expression EXP marinobufagenin results in increased expression of COL1A1 mRNA CTD PMID:26702050 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Mir101a microRNA 101a decreases expression EXP marinobufagenin results in decreased expression of MIR101A mRNA CTD PMID:26702050 NCBI chr 5:115,966,332...115,966,406
Ensembl chr 5:115,966,328...115,966,410
JBrowse link
G Mir106b microRNA 106b decreases expression EXP marinobufagenin results in decreased expression of MIR106B mRNA CTD PMID:26702050 NCBI chr12:17,043,344...17,043,425
Ensembl chr12:17,043,344...17,043,425
JBrowse link
G Mir122 microRNA 122 increases expression EXP marinobufagenin results in increased expression of MIR122 mRNA CTD PMID:26702050 NCBI chr18:58,758,703...58,758,787 JBrowse link
G Mir130a microRNA 130a decreases expression EXP marinobufagenin results in decreased expression of MIR130A mRNA CTD PMID:26702050 NCBI chr 3:69,822,542...69,822,629
Ensembl chr 3:69,822,542...69,822,629
JBrowse link
G Mir140 microRNA 140 decreases expression EXP marinobufagenin results in decreased expression of MIR140 mRNA CTD PMID:26702050 NCBI chr19:35,465,577...35,465,675
Ensembl chr19:35,465,577...35,465,675
JBrowse link
G Mir141 microRNA 141 decreases expression EXP marinobufagenin results in decreased expression of MIR141 mRNA CTD PMID:26702050 NCBI chr 4:157,523,239...157,523,332
Ensembl chr 4:157,523,239...157,523,332
JBrowse link
G Mir142 microRNA 142 decreases expression EXP marinobufagenin results in decreased expression of MIR142 mRNA CTD PMID:26702050 NCBI chr10:72,557,864...72,557,950
Ensembl chr10:72,557,857...72,557,967
JBrowse link
G Mir144 microRNA 144 decreases expression EXP marinobufagenin results in decreased expression of MIR144 mRNA CTD PMID:26702050 NCBI chr10:62,961,348...62,961,430
Ensembl chr10:62,961,348...62,961,430
JBrowse link
G Mir185 microRNA 185 decreases expression EXP marinobufagenin results in decreased expression of MIR185 mRNA CTD PMID:26702050 NCBI chr11:82,664,716...82,664,795
Ensembl chr11:82,664,716...82,664,795
JBrowse link
G Mir18a microRNA 18a decreases expression EXP marinobufagenin results in decreased expression of MIR18A mRNA CTD PMID:26702050 NCBI chr15:92,180,765...92,180,860
Ensembl chr15:92,180,765...92,180,860
JBrowse link
G Mir196a microRNA 196a decreases expression EXP marinobufagenin results in decreased expression of MIR196A mRNA CTD PMID:26702050 NCBI chr 7:134,110,400...134,110,509
Ensembl chr 7:134,110,400...134,110,509
JBrowse link
G Mir196b microRNA 196b decreases expression EXP marinobufagenin results in decreased expression of MIR196B mRNA CTD PMID:26702050 NCBI chr 4:81,330,487...81,330,571
Ensembl chr 4:81,330,487...81,330,571
JBrowse link
G Mir210 microRNA 210 decreases expression EXP marinobufagenin results in decreased expression of MIR210 mRNA CTD PMID:26702050 NCBI chr 1:196,326,343...196,326,452
Ensembl chr 1:196,326,337...196,326,454
JBrowse link
G Mir222 microRNA 222 decreases expression EXP marinobufagenin results in decreased expression of MIR222 mRNA CTD PMID:26702050 NCBI chr  X:3,428,904...3,429,006
Ensembl chr  X:3,428,904...3,429,006
JBrowse link
G Mir23a microRNA 23a increases expression EXP marinobufagenin results in increased expression of MIR23A mRNA CTD PMID:26702050 NCBI chr19:23,954,997...23,955,071
Ensembl chr19:23,954,997...23,955,071
JBrowse link
G Mir29b1 microRNA 29b-1 decreases expression EXP marinobufagenin results in decreased expression of MIR29B1 mRNA CTD PMID:26702050 NCBI chr 4:59,650,987...59,651,067
Ensembl chr 4:59,650,986...59,651,067
JBrowse link
G Mir32 microRNA 32 decreases expression EXP marinobufagenin results in decreased expression of MIR32 mRNA CTD PMID:26702050 NCBI chr 5:71,596,083...71,596,152
Ensembl chr 5:71,596,083...71,596,152
JBrowse link
G Mir320a microRNA 320a decreases expression EXP marinobufagenin results in decreased expression of MIR320A mRNA CTD PMID:26702050 NCBI chr15:45,516,392...45,516,473
Ensembl chr15:45,516,392...45,516,473
JBrowse link
G Mir322 microRNA 322 increases expression EXP marinobufagenin results in increased expression of MIR322 mRNA CTD PMID:26702050 NCBI chr  X:132,806,594...132,806,688
Ensembl chr  X:132,806,594...132,806,688
JBrowse link
G Mir324 microRNA 324 decreases expression EXP marinobufagenin results in decreased expression of MIR324 mRNA CTD PMID:26702050 NCBI chr10:54,734,680...54,734,762
Ensembl chr10:54,734,678...54,734,766
JBrowse link
G Mir375 microRNA 375 decreases expression EXP marinobufagenin results in decreased expression of MIR375 mRNA CTD PMID:26702050 NCBI chr 9:76,457,911...76,457,985
Ensembl chr 9:76,457,911...76,457,985
JBrowse link
G Mir423 microRNA 423 decreases expression EXP marinobufagenin results in decreased expression of MIR423 mRNA CTD PMID:26702050 NCBI chr10:61,914,142...61,914,220
Ensembl chr10:61,914,133...61,914,226
JBrowse link
G Mir93 microRNA 93 decreases expression EXP marinobufagenin results in decreased expression of MIR93 mRNA CTD PMID:26702050 NCBI chr12:17,043,135...17,043,221
Ensembl chr12:17,043,135...17,043,221
JBrowse link
G Mir96 microRNA 96 decreases expression EXP marinobufagenin results in decreased expression of MIR96 mRNA CTD PMID:26702050 NCBI chr 4:58,788,411...58,788,516
Ensembl chr 4:58,788,411...58,788,516
JBrowse link
trilostane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein multiple interactions EXP trilostane inhibits the reaction [Dihydrotestosterone promotes the reaction [Trenbolone Acetate analog results in increased expression of APP protein modified form]] CTD PMID:25461682 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Casp3 caspase 3 multiple interactions EXP trilostane inhibits the reaction [Dihydrotestosterone promotes the reaction [Trenbolone Acetate analog results in increased activity of CASP3 protein]] CTD PMID:25461682 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Esr2 estrogen receptor 2 increases expression ISO trilostane results in increased expression of ESR2 mRNA CTD PMID:20981412 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Fgf9 fibroblast growth factor 9 multiple interactions ISO FGF9 protein inhibits the reaction [[FSHB protein co-treated with IGF1 protein co-treated with trilostane] results in increased abundance of Pregnenolone] CTD PMID:22798350 NCBI chr15:32,208,993...32,254,952
Ensembl chr15:32,210,074...32,253,309
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions ISO [FSHB protein co-treated with IGF1 protein co-treated with trilostane] results in increased abundance of Pregnenolone; FGF9 protein inhibits the reaction [[FSHB protein co-treated with IGF1 protein co-treated with trilostane] results in increased abundance of Pregnenolone] CTD PMID:22798350 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
JBrowse link
G Hsd3b3 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3 increases expression ISO trilostane results in increased expression of HSD3B3 mRNA CTD PMID:19117688 NCBI chr 2:186,138,044...186,144,024
Ensembl chr 2:186,138,044...186,144,033
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO [FSHB protein co-treated with IGF1 protein co-treated with trilostane] results in increased abundance of Pregnenolone; FGF9 protein inhibits the reaction [[FSHB protein co-treated with IGF1 protein co-treated with trilostane] results in increased abundance of Pregnenolone] CTD PMID:22798350 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Pomc proopiomelanocortin decreases expression ISO trilostane results in decreased expression of POMC protein CTD PMID:19117688 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Psen1 presenilin 1 multiple interactions EXP trilostane inhibits the reaction [Trenbolone Acetate analog inhibits the reaction [Dihydrotestosterone results in increased expression of PSEN1 protein]] CTD PMID:25461682 NCBI chr 6:103,323,014...103,375,088
Ensembl chr 6:103,323,120...103,371,650
JBrowse link
withaferin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO withaferin A inhibits the reaction [[ABCB1 protein results in decreased susceptibility to Doxorubicin] promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of ABCB1 mRNA]] CTD PMID:20438634 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Acaca acetyl-CoA carboxylase alpha multiple interactions ISO withaferin A promotes the reaction [Ethanol results in decreased expression of ACACA mRNA] CTD PMID:34995708 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Adam17 ADAM metallopeptidase domain 17 multiple interactions ISO withaferin A inhibits the reaction [IL1B protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of ADAM17 protein]; withaferin A inhibits the reaction [TNF protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]] CTD PMID:24632454 NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639
JBrowse link
G Atf4 activating transcription factor 4 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [withaferin A results in increased expression of ATF4 protein] CTD PMID:21266191 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions ISO withaferin A results in decreased expression of and results in decreased phosphorylation of BAD protein CTD PMID:20438634 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO withaferin A results in decreased expression of BCL2 protein CTD PMID:20438634 PMID:21256832 PMID:21964475 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bcl2a1 BCL2-related protein A1 multiple interactions ISO withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BCL2A1 mRNA] CTD PMID:20438634 NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998
JBrowse link
G Bcl2l11 Bcl2-like 11 decreases expression ISO withaferin A results in decreased expression of BCL2L11 protein CTD PMID:20438634 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCL2 mRNA] CTD PMID:20438634 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCND1 mRNA] CTD PMID:20438634 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A affects binding
multiple interactions
increases expression
ISO withaferin A binds to CDKN1A protein
withaferin A results in increased expression of and affects the localization of CDKN1A protein
withaferin A results in increased expression of CDKN1A mRNA
CTD PMID:22973447 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn2aip CDKN2A interacting protein decreases expression ISO withaferin A results in decreased expression of CDKN2AIP protein CTD PMID:22973447 NCBI chr16:44,536,147...44,546,216
Ensembl chr16:44,536,234...44,540,033
JBrowse link
G Cldn1 claudin 1 decreases response to substance
decreases expression
ISO CLDN1 protein results in decreased susceptibility to withaferin A
withaferin A results in decreased expression of CLDN1 mRNA; withaferin A results in decreased expression of CLDN1 protein
CTD PMID:33665778 NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724
JBrowse link
G Cpt1c carnitine palmitoyltransferase 1c multiple interactions ISO withaferin A inhibits the reaction [Ethanol results in decreased expression of CPT1C mRNA] CTD PMID:34995708 NCBI chr 1:95,442,814...95,457,347
Ensembl chr 1:95,442,817...95,457,342
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 affects response to substance
multiple interactions
increases expression
ISO DDIT3 mRNA affects the susceptibility to withaferin A
Acetylcysteine inhibits the reaction [withaferin A results in increased expression of DDIT3 protein]
CTD PMID:21266191 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [withaferin A results in increased expression of DDIT4 protein] CTD PMID:21266191 NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105
JBrowse link
G Dnmt1 DNA methyltransferase 1 decreases expression ISO withaferin A results in decreased expression of DNMT1 mRNA; withaferin A results in decreased expression of DNMT1 protein CTD PMID:23593078 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha decreases expression ISO withaferin A results in decreased expression of DNMT3A mRNA CTD PMID:23593078 NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687
JBrowse link
G Dnmt3b DNA methyltransferase 3 beta decreases expression ISO withaferin A results in decreased expression of DNMT3B mRNA CTD PMID:23593078 NCBI chr 3:142,130,592...142,169,124
Ensembl chr 3:142,130,592...142,169,124
JBrowse link
G Edil3 EGF like repeats and discoidin domains 3 decreases expression ISO withaferin A results in decreased expression of EDIL3 mRNA CTD PMID:33665778 NCBI chr 2:19,890,396...20,405,028
Ensembl chr 2:19,890,373...20,405,008
JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase multiple interactions ISO withaferin A promotes the reaction [Ethanol results in decreased expression of EHHADH mRNA] CTD PMID:34995708 NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188
JBrowse link
G Eif2a eukaryotic translation initiation factor 2A increases phosphorylation ISO withaferin A results in increased phosphorylation of EIF2A protein CTD PMID:21266191 NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068
JBrowse link
G Ezr ezrin multiple interactions ISO [withanone co-treated with withaferin A] results in decreased expression of EZR protein CTD PMID:25236891 NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO withaferin A inhibits the reaction [Ethanol results in increased expression of FASN mRNA] CTD PMID:34995708 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression ISO withaferin A results in increased expression of FOSL1 mRNA CTD PMID:33665778 NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO withaferin A inhibits the reaction [Ethanol results in increased expression of GCLC mRNA] CTD PMID:34995708 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO withaferin A inhibits the reaction [Ethanol results in increased expression of GPT protein] CTD PMID:34995708 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Hdac1 histone deacetylase 1 decreases expression ISO withaferin A results in decreased expression of HDAC1 protein CTD PMID:23593078 NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111
JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K multiple interactions ISO [withanone co-treated with withaferin A] results in decreased expression of HNRNPK protein; withaferin A binds to and results in decreased activity of HNRNPK protein CTD PMID:25236891 NCBI chr17:6,262,936...6,275,001
Ensembl chr17:6,262,998...6,274,997
JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO withaferin A results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 affects binding
multiple interactions
ISO withaferin A binds to HSPA9 protein
[withaferin A inhibits the reaction [HSPA9 protein binds to TP53 protein]] which affects the localization of and results in increased activity of TP53 protein; [withanone co-treated with withaferin A] results in decreased expression of HSPA9 protein; withaferin A inhibits the reaction [HSPA9 protein binds to TP53 protein]
CTD PMID:22973447 PMID:25236891 NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO withaferin A inhibits the reaction [IL1B protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]] CTD PMID:24632454 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL6 mRNA]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of IL6 protein] CTD PMID:20438634 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Krt13 keratin 13 decreases expression ISO withaferin A results in decreased expression of KRT13 mRNA CTD PMID:33665778 NCBI chr10:85,052,122...85,056,032
Ensembl chr10:85,051,889...85,056,084
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [withaferin A results in increased phosphorylation of MAPK1 protein]; [withanone co-treated with withaferin A] results in decreased expression of MAPK1 protein; Acetylcysteine inhibits the reaction [withaferin A results in increased phosphorylation of MAPK1 protein]; SOD2 protein inhibits the reaction [withaferin A results in increased phosphorylation of MAPK1 protein]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein] CTD PMID:24019090 PMID:24632454 PMID:25236891 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [withaferin A results in increased phosphorylation of MAPK3 protein]; [withanone co-treated with withaferin A] results in decreased expression of MAPK3 protein; Acetylcysteine inhibits the reaction [withaferin A results in increased phosphorylation of MAPK3 protein]; SOD2 protein inhibits the reaction [withaferin A results in increased phosphorylation of MAPK3 protein]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein] CTD PMID:24019090 PMID:24632454 PMID:25236891 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation ISO withaferin A results in increased phosphorylation of MAPK8 protein CTD PMID:21964475 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions
increases expression
ISO MCL1 mutant form promotes the reaction [withaferin A results in increased cleavage of PARP1 protein]
withaferin A results in increased expression of MCL1 protein
CTD PMID:24019090 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Mecp2 methyl CpG binding protein 2 decreases expression ISO withaferin A results in decreased expression of MECP2 protein CTD PMID:23593078 NCBI chr  X:151,781,177...151,844,687
Ensembl chr  X:151,789,930...151,844,689
JBrowse link
G Mettl7a methyltransferase like 7A decreases expression ISO withaferin A results in decreased expression of METTL7A mRNA CTD PMID:33665778 NCBI chr 7:131,452,099...131,460,154
Ensembl chr 7:131,451,641...131,460,154
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO [withanone co-treated with withaferin A] results in decreased expression of MMP2 protein CTD PMID:25236891 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects binding ISO withaferin A binds to NFE2L2 protein CTD PMID:22973447 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein] CTD PMID:20438634 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO withaferin A inhibits the reaction [Ethanol results in increased expression of NQO1 mRNA] CTD PMID:34995708 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nt5e 5' nucleotidase, ecto increases expression ISO withaferin A results in increased expression of NT5E mRNA CTD PMID:33665778 NCBI chr 8:89,271,046...89,314,918
Ensembl chr 8:89,270,696...89,314,881
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO Dithiothreitol inhibits the reaction [withaferin A results in increased cleavage of PARP1 protein]; MCL1 mutant form promotes the reaction [withaferin A results in increased cleavage of PARP1 protein] CTD PMID:20438634 PMID:24019090 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Procr protein C receptor multiple interactions ISO withaferin A inhibits the reaction [IL1B protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]; withaferin A inhibits the reaction [TNF protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]] CTD PMID:24632454 NCBI chr 3:144,254,596...144,258,863
Ensembl chr 3:144,254,380...144,258,903
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO withaferin A inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; withaferin A inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA] CTD PMID:21396905 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of RELA protein] CTD PMID:20438634 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Slco4a1 solute carrier organic anion transporter family, member 4a1 increases expression ISO withaferin A results in increased expression of SLCO4A1 mRNA CTD PMID:33665778 NCBI chr 3:167,559,177...167,578,307
Ensembl chr 3:167,559,316...167,578,305
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO SOD2 protein inhibits the reaction [withaferin A results in increased phosphorylation of MAPK1 protein]; SOD2 protein inhibits the reaction [withaferin A results in increased phosphorylation of MAPK3 protein] CTD PMID:24019090 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO withaferin A inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA] CTD PMID:34995708 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 multiple interactions ISO withaferin A inhibits the reaction [Ethanol results in increased expression of SREBF2 mRNA] CTD PMID:34995708 NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO withaferin A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased localization of and results in increased activity of STAT1 protein] CTD PMID:21396905 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO withaferin A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of STAT3 protein] CTD PMID:21396905 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases activity
ISO withaferin A inhibits the reaction [TNF protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]
withaferin A results in decreased activity of TNF protein
CTD PMID:20438634 PMID:24632454 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfaip3 TNF alpha induced protein 3 multiple interactions ISO withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFAIP3 mRNA] CTD PMID:20438634 NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282
JBrowse link
G Tp53 tumor protein p53 increases expression
affects binding
multiple interactions
ISO withaferin A results in increased expression of TP53 mRNA
withaferin A binds to TP53 protein
[withaferin A inhibits the reaction [HSPA9 protein binds to TP53 protein]] which affects the localization of and results in increased activity of TP53 protein; withaferin A inhibits the reaction [HSPA9 protein binds to TP53 protein]
CTD PMID:22973447 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tuba1a tubulin, alpha 1A decreases expression ISO withaferin A results in decreased expression of TUBA1A mRNA CTD PMID:24297176 NCBI chr 7:130,113,214...130,116,880
Ensembl chr 7:130,081,032...130,196,186
JBrowse link
G Tubb5 tubulin, beta 5 class I decreases expression ISO withaferin A results in decreased expression of TUBB mRNA CTD PMID:24297176 NCBI chr20:2,912,779...2,916,928
Ensembl chr20:2,912,778...2,916,940
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
decreases expression
ISO [withanone co-treated with withaferin A] results in decreased secretion of VEGFA protein; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA]
withaferin A results in decreased expression of VEGFA protein
CTD PMID:20438634 PMID:25236891 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Xbp1 X-box binding protein 1 increases expression
increases splicing
ISO withaferin A results in increased expression of XBP1 protein
withaferin A results in increased splicing of XBP1 mRNA
CTD PMID:21266191 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19659
    chemical entity 19658
      molecular entity 19658
        main group molecular entity 19649
          gas molecular entity 18170
            oxirane 11103
              epoxide 11121
                epoxy steroid 126
                  (22E,24R)-ergosta-5alpha,6alpha-epoxide-8,22-diene-3beta,7alpha-diol 0
                  (24S,25)-epoxy-7alpha-hydroxycholesterol 0
                  (3beta,24R,24'R)-fucosterol epoxide 0
                  17alpha-hydroxywithaferin A 0
                  17alpha-hydroxywithanolide D 0
                  17alpha-sitoindoside IX 0
                  2,3-dihydro-3beta-O-sulfate withaferin A 0
                  2,3-dihydro-3beta-methoxy withaferin A 0
                  2,3-dihydrowithaferin A 0
                  20-hydroxytubocapsanolide A 0
                  23-hydroxytubocapsanolide A 0
                  24(S),25-epoxycholesterol 0
                  27-hydroxywithanone 0
                  3beta-hydroxy-16alpha,17alpha-epoxypregnenolone + 0
                  3beta-hydroxy-16alpha,17alpha-epoxypregnenolone 3-beta-D-glucoside 0
                  5,6alpha-epoxy-5alpha-cholestan-3beta-ol 8
                  5,6alpha-epoxy-5alpha-cholestane 0
                  5,6beta-epoxy-5alpha-cholestan-3beta-ol 0
                  7-deacetyl-7-benzoylepoxyazadiradione 0
                  9,11alpha-epoxypregn-4-ene-3,20-dione 0
                  bufogenin 1
                  cholestanol 7alpha,8alpha-epoxide 0
                  cholesterol beta-epoxide 0
                  deacetyltanghinin 0
                  eplerenone 30
                  marinobufagenin 25
                  physalin F 0
                  resibufagenin 0
                  sitoindoside IX 0
                  tanghinigenin + 0
                  trilostane 9
                  tubocapsanolide A + 0
                  tubocapsanolide F 0
                  viscosalactone B 0
                  withaferin A + 62
                  withalongolide A 0
                  withalongolide B 0
                  withalongolide C 0
                  withalongolide D 0
                  withalongolide E 0
                  withalongolide G 0
                  withalongolide H 0
                  withanolide D + 0
                  withanone 27-O-beta-D-glucoside 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19659
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19700
                atom 19658
                  main group element atom 19607
                    p-block element atom 19607
                      carbon group element atom 19550
                        carbon atom 19547
                          organic molecular entity 19588
                            organic molecule 19506
                              organic cyclic compound 19324
                                organic heterocyclic compound 18682
                                  organic heteromonocyclic compound 17501
                                    saturated organic heteromonocyclic parent 11123
                                      oxirane 11103
                                        epoxide 11121
                                          epoxy steroid 126
                                            (22E,24R)-ergosta-5alpha,6alpha-epoxide-8,22-diene-3beta,7alpha-diol 0
                                            (24S,25)-epoxy-7alpha-hydroxycholesterol 0
                                            (3beta,24R,24'R)-fucosterol epoxide 0
                                            17alpha-hydroxywithaferin A 0
                                            17alpha-hydroxywithanolide D 0
                                            17alpha-sitoindoside IX 0
                                            2,3-dihydro-3beta-O-sulfate withaferin A 0
                                            2,3-dihydro-3beta-methoxy withaferin A 0
                                            2,3-dihydrowithaferin A 0
                                            20-hydroxytubocapsanolide A 0
                                            23-hydroxytubocapsanolide A 0
                                            24(S),25-epoxycholesterol 0
                                            27-hydroxywithanone 0
                                            3beta-hydroxy-16alpha,17alpha-epoxypregnenolone + 0
                                            3beta-hydroxy-16alpha,17alpha-epoxypregnenolone 3-beta-D-glucoside 0
                                            5,6alpha-epoxy-5alpha-cholestan-3beta-ol 8
                                            5,6alpha-epoxy-5alpha-cholestane 0
                                            5,6beta-epoxy-5alpha-cholestan-3beta-ol 0
                                            7-deacetyl-7-benzoylepoxyazadiradione 0
                                            9,11alpha-epoxypregn-4-ene-3,20-dione 0
                                            bufogenin 1
                                            cholestanol 7alpha,8alpha-epoxide 0
                                            cholesterol beta-epoxide 0
                                            deacetyltanghinin 0
                                            eplerenone 30
                                            marinobufagenin 25
                                            physalin F 0
                                            resibufagenin 0
                                            sitoindoside IX 0
                                            tanghinigenin + 0
                                            trilostane 9
                                            tubocapsanolide A + 0
                                            tubocapsanolide F 0
                                            viscosalactone B 0
                                            withaferin A + 62
                                            withalongolide A 0
                                            withalongolide B 0
                                            withalongolide C 0
                                            withalongolide D 0
                                            withalongolide E 0
                                            withalongolide G 0
                                            withalongolide H 0
                                            withanolide D + 0
                                            withanone 27-O-beta-D-glucoside 0
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