Casp8 (caspase 8) - Rat Genome Database

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Gene: Casp8 (caspase 8) Rattus norvegicus
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Symbol: Casp8
Name: caspase 8
RGD ID: 620945
Description: Enables cysteine-type endopeptidase activity; death receptor binding activity; and tumor necrosis factor receptor binding activity. Involved in several processes, including response to anesthetic; response to estradiol; and response to lipopolysaccharide. Located in cell body and cytosol. Part of CD95 death-inducing signaling complex. Used to study epilepsy and pre-malignant neoplasm. Biomarker of several diseases, including alcohol use disorder; brain disease (multiple); heart disease (multiple); kidney disease (multiple); and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including autoimmune lymphoproliferative syndrome type 2B; breast cancer; endocrine gland cancer (multiple); esophagus adenocarcinoma; and lung cancer. Orthologous to human CASP8 (caspase 8); PARTICIPATES IN FasL mediated signaling pathway; ceramide signaling pathway; extrinsic apoptotic pathway; INTERACTS WITH (R)-lipoic acid; (R)-noradrenaline; (S)-colchicine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CASP-8; caspase-8
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8967,747,109 - 67,806,699 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl967,758,033 - 67,806,699 (+)EnsemblGRCr8
mRatBN7.2960,263,863 - 60,312,542 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl960,264,075 - 60,312,542 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx968,759,278 - 68,807,629 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0973,875,236 - 73,923,588 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0972,193,497 - 72,241,846 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0965,614,142 - 65,662,624 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl965,614,142 - 65,662,106 (+)Ensemblrn6Rnor6.0
Rnor_5.0965,420,843 - 65,469,468 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4957,389,353 - 57,437,803 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera957,705,001 - 57,753,027 (+)NCBICelera
RGSC_v3.1957,536,334 - 57,584,785 (+)NCBI
Cytogenetic Map9q31NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
Acute Liver Failure  (ISO)
Acute Lung Injury  (IEP)
acute lymphoblastic leukemia  (ISO)
adenocarcinoma  (ISO)
alcohol use disorder  (IEP)
Alcohol-Related Disorders  (IEP)
allergic contact dermatitis  (ISO)
Alzheimer's disease  (IEP,ISO)
atopic dermatitis  (ISS)
autoimmune disease  (ISO)
autoimmune lymphoproliferative syndrome  (ISO)
autoimmune lymphoproliferative syndrome type 2B  (ISO,ISS)
bacterial infectious disease  (ISO)
Brain Contusion  (IEP)
Brain Hypoxia-Ischemia  (IEP)
Brain Injuries  (IEP)
breast cancer  (ISO)
Breast Cancer, Familial  (ISO)
Breast Neoplasms  (ISO)
bronchopulmonary dysplasia  (IEP)
Cerebral Hemorrhage  (IEP,ISO)
Chemical and Drug Induced Liver Injury  (IEP)
chronic obstructive pulmonary disease  (IEP)
Colorectal Neoplasms  (ISO)
contact dermatitis  (ISO)
Diabetic Cardiomyopathies  (IEP)
Diabetic Nephropathies  (IEP)
dilated cardiomyopathy  (IEP)
Edema  (ISO)
epilepsy  (IMP)
Esophageal Neoplasms  (ISO)
esophagus adenocarcinoma  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Autoimmune Encephalomyelitis  (IEP)
Experimental Autoimmune Myocarditis  (ISO)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Mammary Neoplasms  (IEP)
Experimental Radiation Injuries  (IEP)
Familial Prostate Cancer  (ISO)
genetic disease  (ISO)
head and neck squamous cell carcinoma  (ISO)
heart disease  (IEP)
Hemorrhagic Shock  (IEP)
hepatocellular carcinoma  (IEP,ISO)
Huntington's disease  (ISO)
hyperglycemia  (ISO)
hypertension  (IEP)
Insulin Resistance  (IEP)
kidney disease  (IEP)
liver cirrhosis  (ISO)
Liver Reperfusion Injury  (IEP,ISO)
lung cancer  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
melanoma  (ISO)
mitochondrial metabolism disease  (ISO)
Myocardial Reperfusion Injury  (IEP,ISO)
nephritis  (IEP)
Osteoarthritis, Experimental  (IEP)
pancreatic cancer  (ISO)
papillomavirus infectious disease  (ISO)
pre-malignant neoplasm  (IDA)
primary immunodeficiency disease  (ISO)
Reperfusion Injury  (ISO)
retinal detachment  (IEP)
sciatic neuropathy  (IEP)
Sepsis  (IEP)
Skin Neoplasms  (ISO)
status epilepticus  (IEP,ISO)
Stomach Neoplasms  (ISO)
transient cerebral ischemia  (IEP)
traumatic brain injury  (IEP)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
Uterine Cervical Neoplasms  (ISO)
Viral Myocarditis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-viniferin  (ISO)
(+)-catechin  (ISO)
(+)-dexrazoxane  (ISO)
(+)-Tetrandrine  (ISO)
(-)-anisomycin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(-)-gambogic acid  (ISO)
(1->4)-beta-D-glucan  (ISO)
(20S)-ginsenoside Rg3  (ISO)
(R)-carnitine  (ISO)
(R)-lipoic acid  (EXP,ISO)
(R)-noradrenaline  (EXP)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-colchicine  (EXP)
(S)-nicotine  (EXP)
(Z)-3-butylidenephthalide  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-Dinitropyrene  (ISO)
1,4-benzoquinone  (ISO)
1,4-dithiothreitol  (ISO)
1,4-naphthoquinone  (ISO)
1-nitropyrene  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-D  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,5-hexanedione  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (EXP)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
2-methoxy-17beta-estradiol  (ISO)
25-hydroxycholesterol  (EXP)
28-deoxonimbolide  (ISO)
3',4'-dimethoxyflavone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetraiodothyroacetic acid  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide  (ISO)
3-chloropropane-1,2-diol  (EXP,ISO)
3-hydroxybutyric acid  (ISO)
3-methyladenine  (ISO)
3-Nitrofluoranthene  (ISO)
3-nitropropanoic acid  (EXP)
3-phenylprop-2-enal  (ISO)
4'-epidoxorubicin  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4,5,6,7-TETRABROMOBENZOTRIAZOLE  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitro-m-cresol  (ISO)
4-nonylphenol  (EXP,ISO)
4-phenylbutyric acid  (ISO)
5-aminolevulinic acid  (ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
5-Geranyloxy-7-methoxycoumarin  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-(cyclohexylmethoxy)-5-nitrosopyrimidine-2,4-diamine  (ISO)
6-bromoindirubin-3'-oxime  (ISO)
6-formylpterin  (ISO)
7-ketocholesterol  (EXP)
9'-cis-neoxanthin  (ISO)
9-cis-retinoic acid  (ISO)
9-hydroxycanthin-6-one  (ISO)
9-Methoxycamptothecin  (ISO)
abexinostat  (ISO)
ABT-737  (ISO)
acetamide  (EXP)
acetylleucyl-leucyl-norleucinal  (ISO)
acetylsalicylic acid  (ISO)
aclacinomycin A  (ISO)
acrolein  (ISO)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
adenosine  (EXP,ISO)
aflatoxin B1  (ISO)
agomelatine  (EXP)
Ala-Gln  (ISO)
alantolactone  (ISO)
alborixin  (ISO)
aldehydo-D-glucose  (EXP,ISO)
alginic acid  (ISO)
all-trans-acitretin  (ISO)
all-trans-neoxanthin  (ISO)
all-trans-retinoic acid  (ISO)
Aloe emodin  (ISO)
alpha-mangostin  (ISO)
alpha-naphthoflavone  (ISO)
alvocidib  (ISO)
amiloride  (ISO)
amiodarone  (EXP,ISO)
amlodipine  (EXP,ISO)
ammonium chloride  (EXP)
amphibole asbestos  (ISO)
andrographolide  (EXP,ISO)
anthocyanin  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
apigenin  (EXP,ISO)
apocynin  (EXP)
arachidonic acid  (ISO)
arecoline  (EXP)
arjunolic acid  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
asarone  (ISO)
atorvastatin calcium  (EXP,ISO)
atrazine  (ISO)
auranofin  (ISO)
Auriculasin  (ISO)
azadirachtin A  (ISO)
azadiradione  (ISO)
bafilomycin A1  (EXP,ISO)
baicalein  (ISO)
BAPTA  (ISO)
Bardoxolone methyl  (ISO)
bathocuproine disulfonic acid  (ISO)
beauvericin  (ISO)
belinostat  (ISO)
bellidifolin  (ISO)
benzalkonium chloride  (ISO)
benzene  (EXP)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (EXP,ISO)
benzophenanthridine  (ISO)
berberine  (ISO)
beta-hexachlorocyclohexane  (EXP)
Beta-Solamarine  (ISO)
betaxolol  (ISO)
betulin  (ISO)
betulinic acid  (ISO)
BI-2536  (ISO)
bifenthrin  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A glycidylmethacrylate  (ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
borrelidin  (ISO)
bortezomib  (ISO)
Brevetoxin B  (ISO)
bromoacetate  (ISO)
Brusatol  (ISO)
Bufotalin  (ISO)
bupropion  (ISO)
busulfan  (ISO)
butein  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (ISO)
cadmium acetate  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfide  (ISO)
cadmium telluride  (ISO)
caffeine  (ISO)
Calcimycin  (ISO)
calcitriol  (ISO)
Calpeptin  (ISO)
camptothecin  (EXP,ISO)
cannabidiol  (ISO)
Cannabidivarin  (ISO)
cannabigerol  (ISO)
cantharidic acid  (ISO)
cantharidin  (ISO)
capsaicin  (ISO)
capsazepine  (ISO)
carbamazepine  (ISO)
carbon atom  (ISO)
carbon monoxide  (EXP,ISO)
carbon nanotube  (EXP,ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
carnosic acid  (ISO)
carnosine  (ISO)
carvedilol  (EXP)
casticin  (EXP,ISO)
catechol  (ISO)
celastrol  (ISO)
celecoxib  (ISO)
cerivastatin  (ISO)
ceruletide  (EXP)
chalcone  (ISO)
chalcones  (ISO)
chlorambucil  (ISO)
chloroacetaldehyde  (ISO)
chlorogenic acid  (ISO)
chloroquine  (ISO)
chlorothalonil  (ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (EXP)
choline  (ISO)
chromium atom  (EXP)
chromium trioxide  (ISO)
chromium(3+) trichloride  (ISO)
chromium(6+)  (ISO)
chromone  (ISO)
chrysazin  (ISO)
chrysin  (ISO)
ciglitazone  (ISO)
cilostazol  (EXP)
cimetidine  (ISO)
Cinobufotalin  (ISO)
ciprofloxacin  (ISO)
cisplatin  (EXP,ISO)
cladribine  (ISO)
clavulone II  (ISO)
clofibrate  (ISO)
clomipramine  (ISO)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
clotrimazole  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP,ISO)
coenzyme Q10  (EXP)
colistin  (ISO)
conjugated linoleic acid  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (EXP,ISO)
cordycepin  (ISO)
corticosterone  (EXP)
coumarin  (ISO)
crizotinib  (ISO)
crocidolite asbestos  (ISO)
crocin-1  (ISO)
cucurbitacin I  (ISO)
curcumin  (EXP,ISO)
cyanocob(III)alamin  (EXP)
cyclizine  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (ISO)
cytarabine  (ISO)
D-glucitol  (EXP)
D-gluconic acid  (ISO)
D-glucose  (EXP,ISO)
D-penicillamine  (ISO)
dacarbazine  (ISO)
daunorubicin  (ISO)
DDE  (EXP,ISO)
deguelin  (ISO)
delphinidin  (ISO)
demethoxycurcumin  (ISO)
demethoxyfumitremorgin C  (ISO)
deoxynivalenol  (EXP,ISO)
Deoxyshikonin  (ISO)
desferrioxamine B  (ISO)
Destruxin B  (ISO)
dexamethasone  (EXP,ISO)
dexmedetomidine  (ISO)
dextran sulfate  (ISO)
Di-n-hexyl phthalate  (ISO)
Di-n-octyl phthalate  (ISO)
diallyl disulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP,ISO)
dibenziodolium  (EXP,ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (EXP,ISO)
dieckol  (ISO)
dieldrin  (EXP)
diepoxybutane  (ISO)
diethyl phthalate  (ISO)
diethyldithiocarbamic acid  (ISO)
diethylstilbestrol  (EXP,ISO)
digitoxin  (ISO)
Dihydrotanshinone I  (ISO)
diisobutyl phthalate  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
Dimethyl phthalate  (EXP)
dimethylarsinic acid  (EXP)
dioscin  (ISO)
dioxygen  (ISO)
dipyridamole  (ISO)
diquat  (ISO)
disodium selenite  (EXP,ISO)
docebenone  (ISO)
donepezil hydrochloride  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
Echimidine  (ISO)
Echinocystic acid  (ISO)
eckol  (ISO)
edaravone  (EXP)
elemental carbon  (ISO)
elemental selenium  (ISO)
ellipticine  (ISO)
emodin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
enzalutamide  (ISO)
epichlorohydrin  (ISO)
epoxiconazole  (ISO)
eritoran  (ISO)
esculetin  (ISO)
etacrynic acid  (ISO)
ethanol  (EXP,ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
etoposide  (ISO)
Evodiamine  (ISO)
fangchinoline  (ISO)
fenbendazole  (ISO)
fenpropathrin  (EXP)
fingolimod hydrochloride  (ISO)
fisetin  (ISO)
flavanone  (ISO)
flavones  (ISO)
flavonols  (ISO)
fluoxetine  (ISO)
fluticasone  (ISO)
fluvastatin  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (EXP)
formononetin  (ISO)
fructose  (EXP)
furan  (EXP)
furosemide  (EXP)
Fusarenone X  (ISO)
gallic acid  (ISO)
gallium atom  (ISO)
gardenin B  (ISO)
gedunin  (ISO)
gefitinib  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP,ISO)
Gentiopicrin  (ISO)
geraniol  (EXP,ISO)
gibberellin A3  (EXP)
gingerol  (ISO)
glabridin  (ISO)
glucose  (EXP,ISO)
glutaraldehyde  (ISO)
glutathione  (ISO)
glycochenodeoxycholic acid  (EXP,ISO)
glycyrrhizinic acid  (EXP,ISO)
glyphosate  (EXP,ISO)
gold atom  (ISO)
gold(0)  (ISO)
Grifolin  (ISO)
GSK2656157  (ISO)
guggulsterone  (ISO)
Harpagoside  (ISO)
helenalin  (ISO)
Heliotrine  (ISO)
hexachlorobenzene  (EXP)
homocysteine  (ISO)
Honokiol  (ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
hydroxyurea  (ISO)
hyperforin  (ISO)
icariside II  (ISO)
idelalisib  (ISO)
Ilimaquinone  (ISO)
imipramine  (ISO)
indirubin-3'-monoxime  (ISO)
indometacin  (EXP,ISO)
ionomycin  (ISO)
irinotecan  (ISO)
iron dichloride  (ISO)
iron trichloride  (ISO)
iron(III) nitrilotriacetate  (EXP)
isoflavones  (EXP)
isoflurane  (ISO)
isoliquiritigenin  (ISO)
isoprenaline  (EXP)
isotretinoin  (ISO)
ivermectin  (ISO)
juglone  (ISO)
kojic acid  (EXP)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (EXP,ISO)
L-methionine  (ISO)
lactacystin  (ISO)
lead diacetate  (ISO)
lead nitrate  (ISO)
Licochalcone A  (ISO)
Licochalcone B  (ISO)
Liensinine  (ISO)
linalool  (ISO)
linderalactone  (ISO)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
Lipstatin  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
lithocholic acid  (ISO)
lonafarnib  (ISO)
lonidamine  (ISO)
loratadine  (ISO)
losartan  (EXP)
lovastatin  (ISO)
lupeol  (ISO)
Lupiwighteone  (ISO)
luteolin  (EXP,ISO)
Luteolin 7-methyl ether  (EXP)
luteolin 7-O-beta-D-glucoside  (ISO)
LY294002  (EXP,ISO)
lycopene  (EXP,ISO)
Maduramicin  (EXP)
magnesium oxide  (ISO)
malathion  (ISO)
mancozeb  (ISO)
maneb  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
mangiferin  (ISO)
masoprocol  (ISO)
MeIQx  (ISO)
melatonin  (EXP,ISO)
melittin  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
metformin  (ISO)
methotrexate  (EXP,ISO)
methoxsalen  (ISO)
methoxychlor  (ISO)
methylmercury chloride  (ISO)
Methylone  (EXP)
methylphenidate  (EXP)
methylseleninic acid  (ISO)
metiram  (ISO)
mevalonic acid  (ISO)
microcystin-LR  (ISO)
mifepristone  (ISO)
minocycline  (EXP)
mitomycin C  (ISO)
Mitoquinone  (EXP)
MitoTEMPO  (ISO)
mitoxantrone  (ISO)
ML-7  (ISO)
molybdenum atom  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monoethyl phthalate  (ISO)
morphine  (ISO)
myricetin  (ISO)
myristicin  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide  (ISO)
N-(p-amylcinnamoyl)anthranilic acid  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-Acetyl-S-(1,2-dichlorovinyl)-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosomorpholine  (EXP)
NCX-4040  (ISO)
nelfinavir  (ISO)
neohesperidin dihydrochalcone  (ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (EXP)
niclosamide  (ISO)
nicotine  (EXP)
Niflumic acid  (ISO)
nifuroxazide  (EXP)
nimesulide  (ISO)
nimustine  (ISO)
nitric oxide  (EXP,ISO)
nitroprusside  (EXP,ISO)
nobiletin  (ISO)
nocodazole  (ISO)
Nodularin  (EXP,ISO)
NORCANTHARIDIN  (ISO)
norfloxacin  (ISO)
notoginsenoside R1  (ISO)
NS-398  (ISO)
Nutlin-3  (ISO)
nystatin  (ISO)
Obacunone  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
olaparib  (ISO)
oleandrin  (ISO)
oleanolic acid  (ISO)
omeprazole  (ISO)
omethoate  (ISO)
orlistat  (EXP,ISO)
oroxylin A  (ISO)
osthole  (ISO)
ouabain  (ISO)
oxaliplatin  (ISO)
ozone  (EXP)
p-chloromercuribenzoic acid  (ISO)
p-cresol  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
Panduratin A  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraoxon  (ISO)
paraquat  (EXP,ISO)
paroxetine  (ISO)
Parthenin  (ISO)
parthenolide  (ISO)
patulin  (ISO)
Pendulone  (ISO)
pentachlorophenol  (EXP)
pentobarbital  (EXP)
Pentoxifylline  (ISO)
pepstatin A  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perifosine  (ISO)
phenethyl caffeate  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP)
phenol  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidylcholine  (ISO)
phylloquinone  (ISO)
pifithrin-alpha hydrobromide  (EXP,ISO)
Pinacidil  (EXP)
pinostrobin  (ISO)
pirinixic acid  (ISO)
pitavastatin  (ISO)
pitavastatin(1-)  (ISO)
platycodin D  (ISO)
plumbagin  (ISO)
poly(I:C)  (ISO)
pomalidomide  (ISO)
porphyrins  (ISO)
potassium chromate  (ISO)
Pranoprofen  (ISO)
prazosin  (ISO)
prodigiosin  (ISO)
progesterone  (EXP,ISO)
propylparaben  (ISO)
prostaglandin E2  (ISO)
protoporphyrin  (ISO)
psoralen  (ISO)
Psymberin  (ISO)
pterostilbene  (ISO)
puerarin  (ISO)
punicalagin  (ISO)
Pyridostigmine bromide  (ISO)
pyridoxine  (ISO)
pyrimethamine  (ISO)
pyrogallol  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
quercitrin  (ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
regorafenib  (ISO)
reserpine  (EXP)
resveratrol  (EXP,ISO)
Rhein  (ISO)
ribavirin  (ISO)
riboflavin  (ISO)
ricolinostat  (ISO)
rifampicin  (ISO)
Riluzole  (ISO)
Risedronate sodium  (EXP)
Ro 31-8220  (ISO)
rolipram  (EXP)
rosmarinic acid  (ISO)
rotenone  (EXP,ISO)
rubimaillin  (ISO)
rubitecan  (ISO)
rutin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-allylcysteine  (EXP,ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
S-nitrosoglutathione  (ISO)
safrole  (ISO)
Salinomycin  (ISO)
Salmeterol xinafoate  (ISO)
sanguinarine  (ISO)
sappanchalcone  (ISO)
SB 203580  (ISO)
SB 415286  (ISO)
SB 431542  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
selenium atom  (ISO)
selenocystine  (ISO)
selumetinib  (ISO)
semilicoisoflavone B  (ISO)
senecionine  (ISO)
Senkirkine  (ISO)
Sesamol  (ISO)
sesquiterpene  (ISO)
silibinin  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
SNX-2112  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (EXP,ISO)
sodium cyanate  (ISO)
sodium dichromate  (ISO)
sodium disulfite  (EXP,ISO)
sodium fluoride  (ISO)
sodium propionate  (ISO)
Sodium salicylate  (EXP)
sorafenib  (ISO)
spermine  (ISO)
spironolactone  (EXP)
Spiruchostatin A  (ISO)
spiruchostatin B  (ISO)
staurosporine  (ISO)
streptozocin  (EXP)
styrene  (EXP)
Suillin  (ISO)
sulforaphane  (ISO)
sulfur dioxide  (EXP,ISO)
sulindac  (ISO)
sulindac sulfide  (ISO)
sulindac sulfone  (ISO)
swainsonine  (EXP)
syringic acid  (ISO)
T-2 toxin  (EXP,ISO)
tacedinaline  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
tanespimycin  (ISO)
tangeretin  (ISO)
Tanshinone I  (ISO)
taurocholic acid  (EXP)
tellurium atom  (EXP)
temozolomide  (ISO)
Terfenadine  (EXP,ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetramethylpyrazine  (EXP)
tetrathiomolybdate(2-)  (EXP)
tetrazolium violet  (ISO)
thalidomide  (ISO)
thapsigargin  (ISO)
Theaflavin 3,3'-digallate  (ISO)
thiabendazole  (EXP)
thiazoles  (ISO)
thioacetamide  (EXP)
thiosalicylic acid  (EXP)
thymol  (EXP,ISO)
thymol sulfate(1-)  (EXP,ISO)
thymoquinone  (EXP)
tioguanine  (ISO)
Tiron  (ISO)
titanium dioxide  (EXP)
Tomentosin  (ISO)
topotecan  (ISO)
Torularhodin  (ISO)
torulene  (ISO)
tranilast  (EXP)
trans-chalcone  (ISO)
triamcinolone acetonide  (EXP)
tributylstannane  (EXP)
Tributyltin oxide  (ISO)
trichostatin A  (ISO)
trifluridine  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
ursodeoxycholic acid  (EXP,ISO)
ursolic acid  (ISO)
usnic acid  (ISO)
valproic acid  (ISO)
vanillic acid  (EXP)
vemurafenib  (ISO)
venom  (ISO)
verapamil  (ISO)
Vernodalol  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
VX nerve agent  (ISO)
WIN 55212-2  (ISO)
wogonin  (ISO)
wortmannin  (EXP,ISO)
xanthohumol  (ISO)
Y-27632  (ISO)
zearalenone  (EXP,ISO)
zebularine  (ISO)
zidovudine  (ISO)
zinc atom  (ISO)
zinc oxide  (ISO)
zinc protoporphyrin  (ISO)
zinc pyrithione  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)
ziram  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO,ISS)
apoptotic process  (IBA,IEA,ISO)
apoptotic signaling pathway  (IEA,ISO)
cellular response to mechanical stimulus  (IEA,ISO)
execution phase of apoptosis  (IEA,ISO,ISS)
extrinsic apoptotic signaling pathway  (IEA,ISO,ISS)
extrinsic apoptotic signaling pathway via death domain receptors  (IBA,IEA,ISO)
heart development  (ISO,ISS)
hepatocyte apoptotic process  (ISO)
macrophage differentiation  (IBA,ISO)
negative regulation of canonical NF-kappaB signal transduction  (IEA,ISO)
negative regulation of necroptotic process  (IEA,ISO,ISS)
neural tube formation  (ISO)
positive regulation of apoptotic process  (IEA,ISO,ISS)
positive regulation of canonical NF-kappaB signal transduction  (IEA,ISO)
positive regulation of cell migration  (IEA,ISO)
positive regulation of execution phase of apoptosis  (IEA,ISO)
positive regulation of extrinsic apoptotic signaling pathway  (ISO)
positive regulation of interleukin-1 beta production  (IEA,ISO)
positive regulation of macrophage differentiation  (IEA,ISO)
positive regulation of neuron apoptotic process  (IBA,IMP)
positive regulation of proteolysis  (IEA,ISO)
protein maturation  (IEA,ISO)
protein processing  (IDA,ISO,ISS)
proteolysis  (IEA,ISO)
proteolysis involved in protein catabolic process  (IEA,ISO,ISS)
pyroptotic inflammatory response  (ISO,ISS)
regulation of apoptotic process  (IEA)
regulation of apoptotic signaling pathway  (ISO)
regulation of cytokine production  (ISO,ISS)
regulation of innate immune response  (ISO,ISS)
regulation of thymocyte apoptotic process  (ISO)
response to anesthetic  (IEP)
response to auditory stimulus  (ISO)
response to cobalt ion  (IEP)
response to estradiol  (IEP)
response to ethanol  (IDA,IEP)
response to lipopolysaccharide  (IEP)
response to tumor necrosis factor  (IEA,ISO)
self proteolysis  (ISO,ISS)
TRAIL-activated apoptotic signaling pathway  (IEA,ISO)

Cellular Component
CD95 death-inducing signaling complex  (IBA,IDA,IEA,ISO)
cell body  (IDA)
cytoplasm  (IBA,IEA,ISO)
cytosol  (IDA,IEA,ISO)
death-inducing signaling complex  (IDA,IEA,ISO)
lamellipodium  (IEA,ISO)
Noc1p-Noc2p complex  (ISO)
nucleus  (IEA,ISO)
plasma membrane  (IEA,ISO)
protein-containing complex  (IDA,IEA,ISO)
ripoptosome  (IEA,ISO,ISS)

References

References - curated
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3. Caspase 8-mediated cleavage of plectin precedes F-actin breakdown in acinar cells during pancreatitis. Beil M, etal., Am J Physiol Gastrointest Liver Physiol 2002 Mar;282(3):G450-60.
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10. Time-dependent increases in protease activities for neuronal apoptosis in spinal cords of Lewis rats during development of acute experimental autoimmune encephalomyelitis. Das A, etal., J Neurosci Res. 2008 Oct;86(13):2992-3001.
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73. The many roles of FAS receptor signaling in the immune system. Strasser A, etal., Immunity. 2009 Feb 20;30(2):180-92.
74. Apigetrin inhibits gastric cancer progression through inducing apoptosis and regulating ROS-modulated STAT3/JAK2 pathway. Sun Q, etal., Biochem Biophys Res Commun. 2018 Mar 25;498(1):164-170. doi: 10.1016/j.bbrc.2018.02.009. Epub 2018 Mar 5.
75. Novel cardiac apoptotic pathway: the dephosphorylation of apoptosis repressor with caspase recruitment domain by calcineurin. Tan WQ, etal., Circulation. 2008 Nov 25;118(22):2268-76. doi: 10.1161/CIRCULATIONAHA.107.750869. Epub 2008 Nov 10.
76. The natural compound n-butylidenephthalide derived from Angelica sinensis inhibits malignant brain tumor growth in vitro and in vivo. Tsai NM, etal., J Neurochem. 2006 Nov;99(4):1251-62. Epub 2006 Sep 20.
77. Neuroprotective effects of caffeic acid phenethyl ester against sevoflurane‑induced neuronal degeneration in the hippocampus of neonatal rats involve MAPK and PI3K/Akt signaling pathways. Wang LY, etal., Mol Med Rep. 2016 Oct;14(4):3403-12. doi: 10.3892/mmr.2016.5586. Epub 2016 Aug 4.
78. Transient Receptor Potential Channel, Vanilloid 5, Induces Chondrocyte Apoptosis in a Rat Osteoarthritis Model Through the Mediation of Ca2+ Influx. Wei Y, etal., Cell Physiol Biochem. 2018;46(2):687-698. doi: 10.1159/000488725. Epub 2018 Mar 29.
79. Contribution of caspase-8 to apoptosis of axotomized rat retinal ganglion cells in vivo. Weishaupt JH, etal., Neurobiol Dis 2003 Jul;13(2):124-35.
80. Evaluation of apoptotic pathways in dorsal root ganglion neurons following peripheral nerve injury. Wiberg R, etal., Neuroreport. 2018 Jun 13;29(9):779-785. doi: 10.1097/WNR.0000000000001031.
81. Association between polymorphisms in cancer-related genes and early onset of esophageal adenocarcinoma. Wu IC, etal., Neoplasia. 2011 Apr;13(4):386-92. doi: 10.1593/neo.101722.
82. XZ-1 regulates cell apoptosis of gastric epithelial dysplasia via NF-¿B/p53/Ki67 signaling pathway. Xu B, etal., Biosci Rep. 2018 Jun 12;38(3). pii: BSR20171529. doi: 10.1042/BSR20171529. Print 2018 Jun 29.
83. Activation of caspase-12 at early stage contributes to cardiomyocyte apoptosis in trauma-induced secondary cardiac injury. Yan Z, etal., Sheng Li Xue Bao. 2017 Aug 25;69(4):367-377.
84. Effects of Lignans from Schisandra chinensis Rattan Stems against Aß1-42-Induced Memory Impairment in Rats and Neurotoxicity in Primary Neuronal Cells. Yang BY, etal., Molecules. 2018 Apr 10;23(4). pii: molecules23040870. doi: 10.3390/molecules23040870.
85. Anti-apoptotic effect of San Huang Shel Shin Tang cyclodextrin complex (SHSSTc) on CCl -induced hepatotoxicity in rats. Yang CH, etal., Environ Toxicol. 2014 Nov 28. doi: 10.1002/tox.22078.
86. Functional variants in cell death pathway genes and risk of pancreatic cancer. Yang M, etal., Clin Cancer Res. 2008 May 15;14(10):3230-6.
87. Neonatal bronchopulmonary dysplasia increases neuronal apoptosis in the hippocampus through the HIF-1alpha and p53 pathways. Yin R, etal., Respir Physiol Neurobiol. 2016 Jan;220:81-7. doi: 10.1016/j.resp.2015.09.011. Epub 2015 Sep 30.
88. Titanium dioxide induces apoptotic cell death through reactive oxygen species-mediated Fas upregulation and Bax activation. Yoo KC, etal., Int J Nanomedicine. 2012;7:1203-14. doi: 10.2147/IJN.S28647. Epub 2012 Mar 5.
89. Apoptosis and cell proliferation in short-term and long-term effects of radioiodine-131-induced kidney damage: an experimental and immunohistochemical study. Yumusak N, etal., Nucl Med Commun. 2018 Feb;39(2):131-139. doi: 10.1097/MNM.0000000000000788.
90. Caspase 8 small interfering RNA prevents acute liver failure in mice. Zender L, etal., Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7797-802. doi: 10.1073/pnas.1330920100. Epub 2003 Jun 16.
91. Hypoxic preconditioning attenuates necroptotic neuronal death induced by global cerebral ischemia via Drp1-dependent signaling pathway mediated by CaMKIIa inactivation in adult rats. Zhan L, etal., FASEB J. 2018 Aug 27:fj201800111RR. doi: 10.1096/fj.201800111RR.
92. Protective effect of mild-induced hypothermia against moderate traumatic brain injury in rats involved in necroptotic and apoptotic pathways. Zhang HB, etal., Brain Inj. 2017;31(3):406-415. doi: 10.1080/02699052.2016.1225984. Epub 2017 Jan 31.
93. H3 Relaxin Protects Against Myocardial Injury in Experimental Diabetic Cardiomyopathy by Inhibiting Myocardial Apoptosis, Fibrosis and Inflammation. Zhang X, etal., Cell Physiol Biochem. 2017;43(4):1311-1324. doi: 10.1159/000481843. Epub 2017 Oct 9.
94. [Effects of vascular endothelial growth factor on apoptosis of sinusoidal endothelial cells caused by ethanol: experiment with rats] Zhang YJ, etal., Zhonghua Yi Xue Za Zhi. 2007 Nov 27;87(44):3138-42.
95. Caspase-8: a key role in the pathogenesis of diabetic embryopathy. Zhao Z, etal., Birth Defects Res B Dev Reprod Toxicol. 2009 Feb;86(1):72-7.
96. Sublytic C5b-9 Induces Glomerular Mesangial Cell Apoptosis through the Cascade Pathway of MEKK2-p38 MAPK-IRF-1-TRADD-Caspase 8 in Rat Thy-1 Nephritis. Zhu G, etal., J Immunol. 2017 Feb 1;198(3):1104-1118. doi: 10.4049/jimmunol.1600403. Epub 2016 Dec 30.
Additional References at PubMed
PMID:9654089   PMID:10521396   PMID:10588860   PMID:10638761   PMID:11101870   PMID:11369777   PMID:11684016   PMID:11717445   PMID:12011074   PMID:12065591   PMID:12404118   PMID:12761501  
PMID:12884866   PMID:12888622   PMID:13679576   PMID:14657025   PMID:14993216   PMID:15069192   PMID:15075251   PMID:15322156   PMID:15456877   PMID:15640164   PMID:16127148   PMID:16169070  
PMID:16183742   PMID:16465389   PMID:16524172   PMID:16730193   PMID:16920334   PMID:17047155   PMID:17167422   PMID:17170703   PMID:17431085   PMID:17599062   PMID:18045865   PMID:18387192  
PMID:18614015   PMID:19240112   PMID:19407976   PMID:19467786   PMID:19593445   PMID:19621461   PMID:19740745   PMID:20448356   PMID:20824644   PMID:21368763   PMID:21402742   PMID:21737330  
PMID:21785459   PMID:21788490   PMID:21803845   PMID:21903094   PMID:21980415   PMID:22037414   PMID:22089168   PMID:22267217   PMID:22427665   PMID:22675671   PMID:22891283   PMID:23386613  
PMID:23466459   PMID:24097299   PMID:24938610   PMID:25024200   PMID:25714912   PMID:25738414   PMID:29063319   PMID:29568969   PMID:31511692   PMID:31827280   PMID:32802876   PMID:33434617  
PMID:33456665   PMID:33847039   PMID:34314869   PMID:36567583  


Genomics

Comparative Map Data
Casp8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8967,747,109 - 67,806,699 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl967,758,033 - 67,806,699 (+)EnsemblGRCr8
mRatBN7.2960,263,863 - 60,312,542 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl960,264,075 - 60,312,542 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx968,759,278 - 68,807,629 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0973,875,236 - 73,923,588 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0972,193,497 - 72,241,846 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0965,614,142 - 65,662,624 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl965,614,142 - 65,662,106 (+)Ensemblrn6Rnor6.0
Rnor_5.0965,420,843 - 65,469,468 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4957,389,353 - 57,437,803 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera957,705,001 - 57,753,027 (+)NCBICelera
RGSC_v3.1957,536,334 - 57,584,785 (+)NCBI
Cytogenetic Map9q31NCBI
CASP8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382201,233,463 - 201,287,711 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2201,233,443 - 201,361,836 (+)Ensemblhg38GRCh38
GRCh372202,098,186 - 202,152,432 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362201,806,411 - 201,860,679 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342201,923,718 - 201,972,144NCBI
Celera2195,852,777 - 195,904,249 (+)NCBICelera
Cytogenetic Map2q33.1NCBI
HuRef2193,949,530 - 194,000,819 (+)NCBIHuRef
CHM1_12202,104,145 - 202,158,454 (+)NCBICHM1_1
T2T-CHM13v2.02201,716,914 - 201,768,369 (+)NCBIT2T-CHM13v2.0
Casp8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39158,834,553 - 58,886,663 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl158,834,533 - 58,886,662 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38158,795,233 - 58,847,503 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl158,795,374 - 58,847,503 (+)Ensemblmm10GRCm38
MGSCv37158,852,218 - 58,904,347 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36158,740,040 - 58,791,559 (+)NCBIMGSCv36mm8
Celera159,314,392 - 59,366,511 (+)NCBICelera
Cytogenetic Map1C1.3NCBI
cM Map129.19NCBI
Casp8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955403322,555 - 347,053 (-)Ensembl
ChiLan1.0NW_004955403322,082 - 348,591 (-)NCBIChiLan1.0ChiLan1.0
CASP8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213103,859,979 - 103,910,906 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B103,874,960 - 103,924,789 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B88,490,611 - 88,542,132 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B206,645,803 - 206,696,468 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B206,669,544 - 206,696,468 (+)EnsemblpanPan2panpan1.1
CASP8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13710,362,071 - 10,402,108 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3710,391,048 - 10,401,822 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3711,274,820 - 11,285,607 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03710,285,147 - 10,307,094 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3710,287,599 - 10,308,036 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13710,276,467 - 10,287,238 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03710,255,470 - 10,266,223 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03710,248,774 - 10,259,550 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Casp8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303158,584,293 - 158,626,147 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936726554,758 - 595,922 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936726554,627 - 596,334 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CASP8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15104,923,953 - 104,948,468 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.115104,923,659 - 104,948,470 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215116,337,232 - 116,340,859 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CASP8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11086,888,654 - 86,944,159 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1086,916,527 - 86,943,829 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666040112,478,130 - 112,535,645 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Casp8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624899424,363 - 451,087 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624899427,064 - 450,931 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Casp8
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14133,627,869 - 133,647,363 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Casp8
405 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:251
Count of miRNA genes:139
Interacting mature miRNAs:153
Transcripts:ENSRNOT00000016613
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)94002992585029925Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)93125043268875676Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)92956766474567664Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)94445825685262605Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92956766483835942Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)94172029586720295Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)93922018684220186Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)94002992585029925Rat
1598849Memor17Memory QTL 172.2exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)95746049778547958Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)93496059079960590Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 91 90 59 92 59 6 356 192 11 139 81 91 31 13 13

Sequence


Ensembl Acc Id: ENSRNOT00000016613   ⟹   ENSRNOP00000016613
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl967,764,059 - 67,806,699 (+)Ensembl
mRatBN7.2 Ensembl960,264,075 - 60,312,542 (+)Ensembl
Rnor_6.0 Ensembl965,614,142 - 65,662,106 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000084498   ⟹   ENSRNOP00000069982
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl965,620,658 - 65,661,869 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000140357   ⟹   ENSRNOP00000103046
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl967,758,033 - 67,806,699 (+)Ensembl
RefSeq Acc Id: NM_022277   ⟹   NP_071613
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8967,758,021 - 67,806,181 (+)NCBI
mRatBN7.2960,263,863 - 60,312,024 (+)NCBI
Rnor_6.0965,614,142 - 65,662,106 (+)NCBI
Rnor_5.0965,420,843 - 65,469,468 (+)NCBI
RGSC_v3.4957,389,353 - 57,437,803 (+)RGD
Celera957,705,001 - 57,753,027 (+)RGD
Sequence:
RefSeq Acc Id: XM_006245015   ⟹   XP_006245077
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8967,764,291 - 67,806,699 (+)NCBI
mRatBN7.2960,268,667 - 60,312,542 (+)NCBI
Rnor_6.0965,620,091 - 65,662,624 (+)NCBI
Rnor_5.0965,420,843 - 65,469,468 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039084164   ⟹   XP_038940092
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8967,764,538 - 67,806,699 (+)NCBI
mRatBN7.2960,268,666 - 60,312,542 (+)NCBI
RefSeq Acc Id: XM_039084165   ⟹   XP_038940093
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8967,793,441 - 67,806,699 (+)NCBI
mRatBN7.2960,299,283 - 60,312,542 (+)NCBI
RefSeq Acc Id: XM_039084166   ⟹   XP_038940094
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8967,791,780 - 67,806,699 (+)NCBI
mRatBN7.2960,297,636 - 60,312,542 (+)NCBI
RefSeq Acc Id: XM_063267672   ⟹   XP_063123742
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8967,747,109 - 67,806,699 (+)NCBI
RefSeq Acc Id: NP_071613   ⟸   NM_022277
- UniProtKB: Q9JHX4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006245077   ⟸   XM_006245015
- Peptide Label: isoform X1
- UniProtKB: Q9JHX4 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069982   ⟸   ENSRNOT00000084498
Ensembl Acc Id: ENSRNOP00000016613   ⟸   ENSRNOT00000016613
RefSeq Acc Id: XP_038940092   ⟸   XM_039084164
- Peptide Label: isoform X1
- UniProtKB: Q9JHX4 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038940094   ⟸   XM_039084166
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038940093   ⟸   XM_039084165
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063123742   ⟸   XM_063267672
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000103046   ⟸   ENSRNOT00000140357
Protein Domains
DED

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JHX4-F1-model_v2 AlphaFold Q9JHX4 1-482 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696703
Promoter ID:EPDNEW_R7218
Type:single initiation site
Name:Casp8_1
Description:caspase 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0965,620,640 - 65,620,700EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620945 AgrOrtholog
BioCyc Gene G2FUF-27433 BioCyc
Ensembl Genes ENSRNOG00000012331 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000016613 ENTREZGENE
  ENSRNOT00000016613.5 UniProtKB/Swiss-Prot
  ENSRNOT00000140357 ENTREZGENE
Gene3D-CATH 1.10.533.10 UniProtKB/Swiss-Prot
  3.40.50.1460 UniProtKB/Swiss-Prot
InterPro Caspase-8 UniProtKB/Swiss-Prot
  Caspase-like_dom_sf UniProtKB/Swiss-Prot
  Caspase_cys_AS UniProtKB/Swiss-Prot
  Caspase_his_AS UniProtKB/Swiss-Prot
  DEATH-like_dom_sf UniProtKB/Swiss-Prot
  DED_dom UniProtKB/Swiss-Prot
  Pept_C14_caspase UniProtKB/Swiss-Prot
  Pept_C14_p10 UniProtKB/Swiss-Prot
  Pept_C14_p20 UniProtKB/Swiss-Prot
  Pept_C14A UniProtKB/Swiss-Prot
KEGG Report rno:64044 UniProtKB/Swiss-Prot
NCBI Gene 64044 ENTREZGENE
PANTHER CASPASE 10 UniProtKB/Swiss-Prot
  DED DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot
Pfam DED UniProtKB/Swiss-Prot
  Peptidase_C14 UniProtKB/Swiss-Prot
PharmGKB CASP8 RGD
PhenoGen Casp8 PhenoGen
PRINTS IL1BCENZYME UniProtKB/Swiss-Prot
PROSITE CASPASE_CYS UniProtKB/Swiss-Prot
  CASPASE_HIS UniProtKB/Swiss-Prot
  CASPASE_P10 UniProtKB/Swiss-Prot
  CASPASE_P20 UniProtKB/Swiss-Prot
  DED UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000012331 RatGTEx
SMART CASc UniProtKB/Swiss-Prot
  DED UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47986 UniProtKB/Swiss-Prot
  SSF52129 UniProtKB/Swiss-Prot
UniProt CASP8_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Casp8  caspase 8    caspase-8  Name updated 1299863 APPROVED
2002-08-07 Casp8  caspase-8      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease may contribute to cell injury during pancreatitis 632452
gene_function cysteine-aspartic acid protease (caspase) 628545
gene_regulation activated by cholecystokinin (CCK) in pancreatic acinar cells 625521
gene_regulation activated during Tnf alpha mediated cell death in vascular smooth muscle cells 628545