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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620945
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp8
Name: caspase 8
Acc ID: CHEBI:73468
Term: masoprocol
Definition: The meso-form of nordihydroguaiaretic acid. An antioxidant found in the creosote bush, Larrea divaricata, it is a potent lipoxygenase inhibitor that interferes with arachidonic acid metabolism. It also inhibits (though to a lesser extent) formyltetrahydrofolate synthetase, carboxylesterase, and cyclooxygenase.
Chemical ID: MESH:D009637
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp8increases expressionISOCASP8 (Homo sapiens)6480464CTDMasoprocol results in increased expression of CASP8 proteinPMID:17645780
Casp8multiple interactionsISOCASP8 (Homo sapiens)6480464CTD[Masoprocol co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP8 proteinPMID:17645780
Casp8multiple interactionsISOCasp8 (Mus musculus)6480464CTDMasoprocol inhibits the reaction [FASL protein results in increased activity of CASP8 protein]PMID:10203695
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