GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Casp8 | increases activity | ISO | CASP8 (Homo sapiens) | 6480464 | CTD | Paclitaxel results in increased activity of CASP8 protein | PMID:11716366 | Casp8 | increases cleavage | ISO | CASP8 (Homo sapiens) | 6480464 | CTD | Paclitaxel results in increased cleavage of CASP8 protein | PMID:18071906 PMID:18098270 PMID:24126434 | Casp8 | increases expression | ISO | CASP8 (Homo sapiens) | 6480464 | CTD | Paclitaxel results in increased expression of CASP8 mRNA; Paclitaxel results in increased expression of CASP8 protein; Paclitaxel results in increased expression of CASP8 protein modified form | PMID:15907983 PMID:18058816 PMID:34272796 | Casp8 | increases expression | ISO | Casp8 (Mus musculus) | 6480464 | CTD | Paclitaxel results in increased expression of CASP8 mRNA | PMID:26091902 | Casp8 | multiple interactions | ISO | CASP8 (Homo sapiens) | 6480464 | CTD | [Doxorubicin co-treated with Paclitaxel co-treated with Fluorouracil] results in increased activity of CASP8 protein; [Doxorubicin co-treated with Paclitaxel] results in increased activity of CASP8 protein; [esculetin co-treated with Paclitaxel] results in increased cleavage of and results in increased activity of CASP8 protein; [Luteolin co-treated with Paclitaxel] results in increased cleavage of CASP8 protein; [Paclitaxel co-treated with Metformin] results in increased expression of CASP8 mRNA; [Resveratrol co-treated with Paclitaxel] results in increased cleavage of and results in increased activity of CASP8 protein; [Tretinoin co-treated with Paclitaxel] results in increased cleavage of CASP8 protein; [TYMP mutant form co-treated with Paclitaxel] results in increased cleavage of CASP8 protein; Paclitaxel promotes the reaction [norcantharidin results in increased expression of CASP8 protein modified form]; Paclitaxel promotes the reaction [NSC 74859 results in decreased expression of CASP8 protein] | PMID:14749477 PMID:15492279 PMID:16051289 PMID:16168113 PMID:18098270 PMID:24525192 PMID:29309887 PMID:34272796 | | ||||||||||||||||||||||
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