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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620945
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp8
Name: caspase 8
Acc ID: CHEBI:29073
Term: L-ascorbic acid
Definition: The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.
Chemical ID: MESH:D001205
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp8multiple interactionsEXP 6480464CTD[Ascorbic Acid co-treated with INS1 protein] results in increased expression of CASP8 mRNA; [Ascorbic Acid co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CASP8 mRNAPMID:18544905 PMID:20400526
Casp8increases expressionISOCASP8 (Homo sapiens)6480464CTDAscorbic Acid results in increased expression of CASP8 mRNAPMID:30597948
Casp8multiple interactionsISOCASP8 (Homo sapiens)6480464CTDAscorbic Acid inhibits the reaction [TNFSF10 protein results in increased activity of CASP8 protein]PMID:23711929
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