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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620945
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp8
Name: caspase 8
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp8increases activityEXP 6480464CTDStreptozocin results in increased activity of CASP8 proteinPMID:29606028
Casp8increases cleavageEXP 6480464CTDStreptozocin results in increased cleavage of CASP8 proteinPMID:25541178
Casp8increases expressionEXP 6480464CTDStreptozocin results in increased expression of CASP8 mRNA; Streptozocin results in increased expression of CASP8 proteinPMID:23267840 PMID:28856781
Casp8multiple interactionsEXP 6480464CTDAnthocyanins inhibits the reaction [Streptozocin results in increased expression of CASP8 protein]; Curcumin inhibits the reaction [Streptozocin results in increased cleavage of CASP8 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of CASP8 mRNA]; INS1 protein inhibits the reaction [Streptozocin results in increased expression of CASP8 mRNA]; nifuroxazide inhibits the reaction [Streptozocin results in increased activity of CASP8 protein]PMID:23267840 PMID:25541178 PMID:28856781 PMID:29606028
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