GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Casp8 | increases cleavage | EXP | | 6480464 | CTD | Lipopolysaccharides results in increased cleavage of CASP8 protein | PMID:31486215 | Casp8 | multiple interactions | EXP | | 6480464 | CTD | Honghua extract, Carthamus tinctorius inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP8 protein]; IGF1R protein affects the reaction [Honghua extract, Carthamus tinctorius inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP8 protein]] | PMID:31486215 | Casp8 | decreases expression | ISO | Casp8 (Mus musculus) | 6480464 | CTD | Lipopolysaccharides results in decreased expression of CASP8 mRNA; Lipopolysaccharides results in decreased expression of CASP8 protein | PMID:35833596 | Casp8 | increases activity | ISO | Casp8 (Mus musculus) | 6480464 | CTD | Lipopolysaccharides results in increased activity of CASP8 protein | PMID:23170834 | Casp8 | increases cleavage | ISO | Casp8 (Mus musculus) | 6480464 | CTD | Lipopolysaccharides results in increased cleavage of CASP8 protein | PMID:30776389 | Casp8 | increases expression | ISO | CASP8 (Homo sapiens) | 6480464 | CTD | Lipopolysaccharides results in increased expression of CASP8 protein | PMID:21844306 | Casp8 | increases expression | ISO | Casp8 (Mus musculus) | 6480464 | CTD | Lipopolysaccharides results in increased expression of CASP8 mRNA | PMID:23107598 | Casp8 | multiple interactions | ISO | Casp8 (Mus musculus) | 6480464 | CTD | 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP8 protein]; [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Lipopolysaccharides promotes the reaction [Polystyrenes results in decreased expression of CASP8 mRNA]]; [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Lipopolysaccharides promotes the reaction [Polystyrenes results in decreased expression of CASP8 protein]]; [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Polystyrenes promotes the reaction [Lipopolysaccharides results in decreased expression of CASP8 mRNA]]; [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Polystyrenes promotes the reaction [Lipopolysaccharides results in decreased expression of CASP8 protein]]; [Galactosamine co-treated with Lipopolysaccharides] results in increased activity of CASP8 protein; [Galactosamine co-treated with Lipopolysaccharides] results in increased cleavage of and results in increased activity of CASP8 protein; [Galactosamine co-treated with Lipopolysaccharides] results in increased expression of CASP8 protein modified form; [Lipopolysaccharides co-treated with benzyloxycarbonyl-valyl-alanyl-aspartic acid] results in decreased expression of CASP8 protein; [Lipopolysaccharides co-treated with Galactosamine] results in increased expression of CASP8 protein modified form; [triptolide co-treated with Lipopolysaccharides] results in increased expression of CASP8 protein modified form; baicalein inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of CASP8 protein modified form]; dihydrotanshinone I inhibits the reaction [[Lipopolysaccharides co-treated with benzyloxycarbonyl-valyl-alanyl-aspartic acid] results in decreased expression of CASP8 protein]; gentiopicroside inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased cleavage of and results in increased activity of CASP8 protein]; gentiopicroside inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of CASP8 protein modified form]; Indirubin E804 inhibits the reaction [Lipopolysaccharides results in increased expression of CASP8 mRNA]; Lipopolysaccharides inhibits the reaction [Indirubin E804 results in increased expression of CASP8 mRNA]; Lipopolysaccharides promotes the reaction [Polystyrenes results in decreased expression of CASP8 mRNA]; Lipopolysaccharides promotes the reaction [Polystyrenes results in decreased expression of CASP8 protein]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased activity of CASP8 protein]; Polystyrenes promotes the reaction [Lipopolysaccharides results in decreased expression of CASP8 mRNA]; Polystyrenes promotes the reaction [Lipopolysaccharides results in decreased expression of CASP8 protein]; Silymarin inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of CASP8 protein modified form]; Ursodeoxycholic Acid analog inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased activity of CASP8 protein] | PMID:20558151 PMID:20850421 PMID:21146893 PMID:23107598 PMID:23170834 PMID:29496522 PMID:30633930 PMID:30776389 PMID:35833596 | | ||||||||||||||||||||||
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