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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620945
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp8
Name: caspase 8
Acc ID: CHEBI:25434
Term: bis(2-chloroethyl) sulfide
Definition: An ethyl sulfide that is diethyl sulfide in which a hydrogen from each of the terminal methyl groups is replaced by a chlorine. It is a powerful vesicant regulated under the Chemical Weapons Convention.
Chemical ID: MESH:D009151
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp8increases activityISOCASP8 (Homo sapiens)6480464CTDMustard Gas results in increased activity of CASP8 proteinPMID:16738803 PMID:20226831
Casp8increases expressionISOCasp8 (Mus musculus)6480464CTDMustard Gas results in increased expression of CASP8 mRNAPMID:18955075
Casp8multiple interactionsISOCASP8 (Homo sapiens)6480464CTDbenzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [Mustard Gas results in increased activity of CASP8 protein]; CALM1 protein promotes the reaction [Mustard Gas results in increased cleavage of and results in increased activity of CASP8 protein]; FADD protein affects the reaction [Mustard Gas results in increased cleavage of CASP8 protein]; Mustard Gas results in increased cleavage of and results in increased activity of CASP8 proteinPMID:12482751 PMID:16935404 PMID:18161513 PMID:20226831
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