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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620945
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp8
Name: caspase 8
Acc ID: CHEBI:15738
Term: staurosporine
Definition: An indolocarbazole alkaloid that has formula C28H26N4O3.
Chemical ID: MESH:D019311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp8increases activityISOCASP8 (Homo sapiens)6480464CTDStaurosporine results in increased activity of CASP8 proteinPMID:19352495 PMID:29458164 PMID:31926150
Casp8increases cleavageISOCASP8 (Homo sapiens)6480464CTDStaurosporine results in increased cleavage of CASP8 proteinPMID:24658017
Casp8multiple interactionsISOCASP8 (Homo sapiens)6480464CTDbenzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Staurosporine results in increased cleavage of CASP8 protein]; Staurosporine results in increased cleavage of and results in increased activity of CASP8 proteinPMID:16007152 PMID:24658017
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