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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620945 Species: Rattus norvegicus RGD Object: Gene Symbol: Casp8 Name: caspase 8

Acc ID: CHEBI:9513 Term: thalidomide Definition: A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group. CasRN: 50-35-1 Chemical ID: MESH:D013792

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases cleavage	ISO	RGD:730846	6480464	CTD	Thalidomide analog results in increased cleavage of CASP8 protein	PMID:15858615